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      • Coated tube를 사용한 CA19-9 측정용 IRMA 시약의 평가

        이현주,장현영,신선영,김희선,김태훈,이호영,Lee, Hyun-Ju,Jang, Hyun-Young,Shin, Sun-Young,Kim, Hee-Sun,Kim, Tae-Hoon,Lee, Ho-Young 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.2

        현재 본원은 TFB사의 CA19-9 항체가 bead에 코팅되어있는 CA19-9 IRMA 시약을 사용하고있다. 이번에 TFB사에서 새로 개발된 CA19-9 항체가 polystyrene test tube에 코팅된 CA 19-9 IRMA 시약이 기존 TFB사의 bead를 사용하는 시약을 대체하여 사용할 수 있는지 시약의 성능을 평가하였다. 본원과 서울대학교병원 환자 56명의 검체를 대상으로 하여 TFB사의 기존 bead 방법을 사용한 시약과 새로 개발된 coated tube를 사용한 시약을 비교하여 상관계수와 회귀식을 구하고 coated tube를 사용한 시약의 정밀도, 회수율, 직선성, 민감도, Hook effect 를 확인하였다. 저, 중, 고역가 검체의 검사내 정밀도는 4.1%, 4.0%, 4.2%이고 검사간 정밀도는 7.6%, 4.3%, 7.8%이며 회수율은 모두 $100{\pm}10%$이다. 직선성은 우수하였고 분석적민감도는 0.3U/mL이었으며 9,020,000 U/mL 농도에서는 Hook effect가 나타나지 않았다. 또한 TFB사의 기존 bead를 사용한 방법과 비교하여 상관관계를 분석한 결과, y=0.9185x-0.953, 상관계수 $R^2$=0.9779이었다. 이번 연구를 통해 본원은 TFB사에서 새로 개발된 coated tube CA19-9 IRMA 시약이 검사 시간과 검사 과정에서 간편화되고 검사시 자동화기기를 사용할 수 있으며 기존 bead를 사용한 시약에 대체하여 사용할 수 있다고 판단하였다. Purpose: $TFB^{(R)}$ CA19-9 IRMA kit uses beads coated with CA19-9 antibody. However, this mathod can not use automated equipment, and requires a long time test. Recently, CA19-9 IRMA kit developed by $TFB^{(R)}$ is coated with CA19-9 antibody to the polystyrene test tube and reaction at room temperature, and also reduced test time. This study evaluated the performance of a newly developed $TFB^{(R)}$ CA19-9 IRMA kit. Materials and Methods: This study were measured by using 56 patients sample of Boramae Medical Center and Seoul National University Hospital. We evaluated intra-and inter-assay precision, recovery rate, linearity, sensitivity and high dose hook effect of coated tube CA19-9 IRMA kit developed by $TFB^{(R)}$. The values of CA19-9 measured by $TFB^{(R)}$ bead kit were compared with those measured by $TFB^{(R)}$ coated tube kit. Results: ntra-assay coefficients of variation on three different levels were 4.1%, 4.0% and 4.2%. Inter-assay coefficients of variation were 7.6%, 4.3% and 7.8%. Recovery tests on all three different levels showed within $100{\pm}10%$. Linearity was good and sensitivity was 0.3 U/mL. High dose hook effect is not observed. There was strong correlation between bead kit and coated tube kit by $TFB^{(R)}$ CA19-9 IRMA kit. (y=0.9185x-0.953, $R^2$=0.9779) Conclusion: Coated tube CA19-9 IRMA kit developed by $TFB^{(R)}$ showed satisfactory precision, recovery rate, linearity, sensitivity and high dose hook effect.

      • KCI등재

        기(氣)현상에 대한 철학적 고찰

        이현주 ( Hyun Ju Lee ) 경희대학교 동서간호학연구소 1998 동서간호학연구지 Vol.3 No.1

        When recognition of the Ghi(氣) which exist in all things, is changed on the aspects of the science of nursing, the view of health and nursing well be more efficient and can be developed as the proper concept for Korean culture. I think it is nessary to confirm which philosophical basis of the well be applicable to nursing and how to it has to be developed. Therefore I can for the research of the Ghi phenomena to attain the Thoughts of philosophy that is appropriate to expound those phenomena. And I attempt to induct the fusion of horizons to unify the view of the world between Korea and the West. The Ghi is very energetic and omnipresent among the universe, Nature, and the human being. So it can organize all the primary elements of mental and physical function of human as like life, mind, breath, feeling, energy, etc, A feneral concept of the Ghi is described as follows; ① The Ghi is the origin and essence to organize the universe, Nature, and the human being. ② It is the perpetually movable thing. ③ And there are continuous transmission between the Ghi of the universe and the human through body, mind, and soul. For review on the philosophic basis of the Ghi, I studied out the identity of the doctrine of Li and Chi리(理氣論) in the field of philosophy of Korea and the West, In Korea the concept of the Vigor is based on Ch`i mongolism(기일원론) and Li Ch`I dualism (이기이원론) of Yul-gok Lee`s, Hwa-dam`s, and/or Hekang`s, These are indispensable for the view of the world of Korea as Metaphysical ideology, Conerete science, Materialism, Ontology, and Epistemology. From the viewpoint of the philosophy of the West, the doctrine of Li and Ch`i(이기론) of Korea is identical with the doctrine of Joo-ja, Idea of Plato, Metaphysics of Aristotle, World Spirit(Weltgeist) of Hegel, and Existentialism of Heidegger. In the nursing theory of the West, some of them referred to the Ghi as like Energy field theory of Rogers and Energy exchange of Neuman. Though there are different in terminlolgy, energy and the Ghi are induced comparable therapeutic action between the human and the environments. With the nursing theory of Korea, I have made an attempt to compare the Ghi with metaparadigm of nursing-the human being, the environment, the health, and the nursing. For the most part, the alternative therapy is reasonable to the frame of the nursing theory of Korea. It is easy to apply alternative therapy on the every spot of nursing, So this therapy could be a kind of forms as nursing therapy in the nursing centers In result, independent nursing intervention will be activated by the nurse who puts up with the major parts, It is available to apply this therapy to palliation of pain, insomnia of infant, Sanhujori(산후조리), pain of menstruation, arthritis. And the alternative therapy makes it possible to propose the nursing model which represent originality, tradition, and history of the nursing of Korea. Additionally, in the field of the nursing, it is indispensable to choose a suitable methodology which is considered whether it is matched with a theory of philosophy in the boundary and object of the research. Because there are many to get the knowledge of nursing related to the Ghi. In the science of nursing, context of sociocultural background and frame are required to understand the person who need to take care of (nursing client). But the value systems of the West and the East are distinctive each other as well as the behavior of health pursuance. Therefore it is the basic research data of great worth to review philosophical the Ghi phenomena which is well known to Korean.

      • KCI등재

        가스 하이드레이트 형성 원리를 이용한 연소전 탈탄소화 연구

        이현주,이주동,김양도,Lee, Hyun-Ju,Lee, Ju-Dong,Kim, Yang-Do 한국재료학회 2008 한국재료학회지 Vol.18 No.12

        The emission of carbon dioxide from the burning of fossil fuels has been identified as a major contributor to green house emissions and subsequent global warming and climate changes. For these reasons, it is necessary to separate and recover $CO_2$ gas. A new process based on gas hydrate crystallization is proposed for the $CO_2$ separation/recovery of the gas mixture. In this study, gas hydrate from $CO_2/H_2$ gas mixtures was formed in a semi-batch stirred vessel at a constant pressure and temperature. This mixture is of interest to $CO_2$ separation and recovery in Integrated Coal Gasification (IGCC) plants. The impact of tetrahydrofuran (THF) on hydrate formation from the $CO_2/H_2$ was observed. The addition of THF not only reduced the equilibrium formation conditions significantly but also helped ease the formation of hydrates. This study illustrates the concept and provides the basic operations of the separation/recovery of $CO_2$ (pre-combustion capture) from a fuel gas ($CO_2/H_2$) mixture.

      • KCI등재

        『蓬萊酬唱錄』 (「附東萊府治圖」)에 관한 일고찰

        이현주 ( Lee Hyun-ju ) 동아시아문물연구학술재단 2016 文物硏究 Vol.- No.30

        『蓬萊酬唱錄』은 1725년 음력 3월 동래부사 趙錫命이 주관하여 여러 智人 들과 동래부에서 수창한 시문을 그림과 함께 장황한 총 35장의 서화첩이다. 서화첩 구성은 권두에 접위관 洪晟이 大字로 蓬萊, 酬唱이라 題名을 쓰고 다음 장에는 「東萊府治圖」를 배치하였으며, 다음으로 星州의 문사 鄭錫儒가 지은 <蓬萊酬唱錄序>가 있다. 그 뒤로 당시의 동래부사 조석명이 지은 책 제목 에 가늠하는 권두사에 해당되는 <題詞>를 두었고, 이어 본문에 해당되는 조석 명, 정석유, 洪晟, 趙駿命, 범어사 승려 存覺이 지은 시문 55수를 李仲寬이 행 서로 필사하였다. 卷末은 홍성이 짓고 쓴 <後記>가 장황되어 있다. 1725년(영조 1)년 당시의 동래부사 조석명은 나이가 52세로 이 벼슬을 마지막 으로 관직에서 물러날 뜻을 이미 갖고 있었는데, 여러 날에 걸친 酬唱詩를 서화 첩으로 묶어 후일 동래에서의 일을 回憶하고 破寂하기 위하여 제작한 것이며 또한 네 집안의 자제들이 뒷날 볼 수 있기를 희망하였다. 『봉래수창록』에서 특히 주목되는 것은「동래부치도」이다. 현재 알려진 대부분 의 동래부 관련 그림들이 후기동래읍성을 배경으로 제작된 반면 이 그림은 1731 년 정언섭의 후기읍성 축조 이전의 모습을 반영하고 있기 때문이다. 더욱이 묘사 된 관아시설과 주변지형의 공간배치는 상당히 정확하고 사실적이다. 묘사된 동래 부 내의 관아시설이 아주 상세하고 화풍에서도 18세기 동래부 무임화사계열의 화풍이 엿보이고 있을 뿐 아니라 그 그림의 주문자가 동래부사였다는 점을 감안 해볼 때 이 그림의 제작자는 동래부 무임화사일 가능성이 크다. 『봉래수창록』의 전반적인 내용에 관해서는 해제를 덧붙여 고찰하였다. 이 작품 은 18세기 동래지역에서의 수창교유와 시화첩의 제작배경을 확인할 수 있을 뿐 아니라 새로운 동래부 화사를 발굴할 중요한 사료이다. Bongraesuchangrok is a collection of poems and paintings containing 35 sheets of paper. It was arranged by Dongraebu Magistrate Seokmyeong Cho in March of the lunar calendar, 1725 and includes poetry with paintings the Magistrate and his acquaintances recited in Dongraebu. On the opening page of the collection are large characters, Bongrae and Suchang by Diplomat Seong Hong, which is followed by Dongraebuchido, preface by Seokyou Cheong from Seongju and J aesa, introductory remarks whose title is known by. In the body part of the collection, 55 poems by Seokmyeong Cho, Seokyou Cheong, Seong Hong, Junmyeong Cho and Monk Jonggak of Boemeo Temple were transcribed in the semicursive style of writing by JungGwan Lee. At the end was a postface by Seong Hong. In 1725 (King Youngjo 1st year), Dongraebu Magistrate Seokmyeong Cho was thinking of withdrawing from his office of Dongrae. He made the collection for recalling the experiences in Dongrae later and hoping that offsprings of 4 families involved would read it. Dongraebichido is especially noticeable in Bongraesuchangrok. While most known pictures of Dongraebu at this time are with the latter part settings of Dongrae Eupsung, this picture in Bongraesuchangrok reflects the time before EonSeop Cheong built the latter part settings of Dongrae Eupsung in 1731. Moreover, it was verified that governmental facilities and space arrangement in the picture are considerably accurate and realistic. There is a very strong possibility that the picture Dongraebuchido was produced by Muimhwasa in Dongraebu, given the fact that described governmental facilities are in great detail; the painting style of Muimwhasa in Dongraebu in the 18th century is shown; its orderer is Dongraebu Magistrate. This paper covers overall contents of Bongraesuchangrok with a bibliography. This collection is a very historical source not only for checking a poem recitation in Dongrae and the background of producing the collections of poems and paintings, but also for discovering new Dongrabuhwasa.

      • 한방진단명의 질병분류체계 분석과 개선방안 연구

        이현주,박수복,김수진,고승연,Lee, Hyun Ju,Park, Su Bock,Kim, Su Jin,Ko, Seung Yeon 한국의료질향상학회 2006 한국의료질향상학회지 Vol.12 No.2

        Background : To examine the difference between ICD-10 and The Korean standard classification of disease(oriental medicine), and to aim at improve the practical use as statistical data. It is one of the reason of disease classification. On that account we convert the many to many correspondence presenting classification of oriental medicine into many to one correspondence. Method : The study tracked out 155 patients discharged from the university hospital which is located in Gyeonggi Province and managing hospital and oriental medicine hospital from July to October this year. The period of this study was from August 1 to November 18. We compared correspondence between the two services' diagnosis(hospital services and oriental medicine hospital services) at the same time and attempted many to one correspondence classification. That is for production of statistical data. Result : We investigated the group which have had medical treatment experience of two kinds of services at the same time. The result of this investigation was that the same oriental medicine diagnosis used differently in western medicine diagnosis. 44.5% was accorded with western medicine diagnosis. Correspondence of the western medicine diagnose with the top of the Korean standard classification of disease(oriental medicine) list's western medicine diagnosis was 13.5%. For many to one correspondence classification for statistics, one western medicine diagnosis was selected for one oriental medicine diagnosis. In case of the main diagnosis(I sign) was not enough to explain oriental medicine diagnosis' characteristic, we chose multiple other diagnosis, so other diagnosis(II sign) about patient's cause of disease could be selected for supplement after we examined the patient's records. The statistics was possible with this many to one correspondence. Conclusion : The result of this study about correspondence between western medicine diagnoses and those of oriental medicine confirms that The Korean standard classification of disease(oriental medicine) is hard to be standardized with western medicine diagnosis. Therefore, according to this study, we use new many to one correspondence classification, multiple oriental medicine diagnoses with one ICD-10, which can be used by statistical data.

      • KCI등재

        고구마에 존재하는 mushroom tyrosinase 저해제의 특성

        이현주,이민경,박인식,Lee Hyun-Ju,Lee Min-Kyung,Park In-Shik 한국생명과학회 2006 생명과학회지 Vol.16 No.3

        고구마(품종: 생미)추출액에 tyrosinase의 활성을 저해하는 저해 물질이 존재함을 확인하였으며, 고구마 추출물의 첨가농도를 증가시킬수록 tyrosinase 활성의 저해도가 증가하였다. 그리고 고구마 추출물에 존재하는 tyrosinase 저해제는 $95^{\circ}C$에서 20분간 열처리에 의하여 37.3%의 활성이 잔존하여 열에 비교적 안정하였으며, pH 5.0-7.0에서 가장 안정하였다. 그리고 고구마 추출물은 투석에 의하여 tyrosinase에 대한 저해활성이 유의적으로 감소하였으며, 따라서 고구마 추출물에 존재하는 tyrosinase의 저해활성은 저분자 물질로 추정된다. Crude extract prepared from sweet potato possessed inhibitory activity toward mushroom tyrosinase. The inhibitory activity was dependent upon the addition amount of sweet potato extract. After heating the sweet potato extract at $95^{\circ}C$ for 20 min, its inhibitory activity retained 37.3%. Its optimum activity was shown at pH ranges of 5.0-7.0. The tyrosinase inhibitory activity was disappeared by dialysis, which suggests the inhibitory activity of sweet potato extract is caused by some compounds of low molecular weight.

      • KCI등재

        가방 끈 길이 차이가 상지 근활성도, 압력중심 및 체중분포에 미치는 영향

        이현주,김민수,김아연,강현구,태기식,Lee, Hyun Ju,Kim, Min Su,Kim, Ah Yeon,kang, Hyun Gu,Tae, Ki Sik 대한의용생체공학회 2021 의공학회지 Vol.42 No.5

        The purpose of this study was to investigate the effect on the activity of the upper trapezius and erector spinae according to the length difference of the backpack using electromyogram (EMG). We also conducted a study comparing the center of pressure (COP) and weight distribution before and after using Wii® balance board. Thirty individuals were randomly assigned to the experimental group (n=14) wearing a backpack with a short right strap length and a control group (n=16) wearing a backpack with the same strap length. Data were collected by dividing into groups, carring a 15% weight backpack and walking for 20 minutes on a treadmill. As a result of analyzing the EMG data, there was no significant change in the upper extremity muscle activity of the control group, but it was significantly decreased in the right upper trapezius activity of the experimental group (p<0.05). In addition, there was a significant change of COP in the experimental group (p<0.05), but there was no significant difference of the weight distribution in both groups. Recognizing mechanical changes in the body that may occur due to the asymmetry of the strap length is thought to be helpful for systematic ergonomic intervention according to changes in the external environment in the future.

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