유아 기본동작 운동능력 발달에 관한 연구

이영심 ( Young Sim Lee ) 한국유아체육학회 2004 한국유아체육학회지 Vol.5 No.-

양막파수가 선행되지 않은 만삭산모에서 포도상구균이 동반된 융모 양막염으로 인한 사산아 분만 1례

이영심(Young Sim Lee),차동수(Dong Soo Cha),임지훈(Ji Hoon Lim),이영진(Young Jin Lee),정인배(In Bai Chung),박광화(Kwang Hwa Park),김태헌(Tae Heon Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5

It has been believed that the intact placental membranes are a good barrier to ascending infection, but this may be only partly true.` Neonatal infection without premature rupture of the amniotic membranes occurs in 1-2% of births. The prevalence of membranes inflammation among births at term is approximately 10%.2-4. Chorioamnionitis is a frequent cause of fetal death mostly as a silent chorioamnionitis without maternal signs of infection. 4 Below we present a case of subclinical acute chorioamnionitis in a woman admitted because of labor pain at 39weeks with intact membranes and subsequent sudden intrauterine fetal death. Culture specimens from the endometrium and uterine cervix showed growth of Staphylococcus aureus.

체외수정 및 배아이식술후 임신과 자연 임신된 임신부에서 임신중기 삼중표지물질 검사결과의 비교분석

이정렬(Jeong Lyol Lee),이영심(Young Sim Lee),이상학(Sang Hag Lee),최중호(Jung Ho Choi),정인배(In Bai Chung),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9

N/A Objective : To compare and analysis the result of second trimester maternal serum triple marker screening test for Down syndrome and open neural tube defects in singleton pregnancies conceived by conventional in vitro fertilization- embryo transfer (IVF-ET) with that of the naturally conceived pregnancies. Methods : Maternal serum screening tests during the second trimester in 49 singleton pregnancies conceived by IVF-ET and 813 singleton pregnancies conceived naturally of whom delivery outcome was normal in each other were analyzed from April 1997 to June 2000. Results : 4 (8.2%) out of 49 cases of IVF-ET singleton pregnancies compared with 62 (7.6%) out of 813 cases of naturally conceived pregnancies had a positive results for Down syndrome or open neural tube defects. The median level of the triple markers were 1.03 0.47 multiples of the median (MoM) in IVF-ET pregnancies vs 1.05±0.39 MoM in natural pregnancies for alpha-fetoprotein (AFP), 1.11±0.64 vs 1.19±1.13 MoM for unconjugated estriol (uE3) and 1.21±0.56 vs 1.11±0.59 MoM for human chorionic gonadotropin (hCG). Conclusion : The positive rate of triple test and the median values of triple markers for Down syndrome and open neural tube defect between two groups were not different in terms of statistical significance. To provide an objective assessment of an individual patient's risk of fetal abnormality, the impact of IVF-ET on triple marker biochemistry should be studied further in larger samples and adjustments made if appropriate.

발육제한 태아에서 placental ratio 와 신생아 이환률과의 관계

이준희(Jun Hee Lee),정인배(In Bai Chung),이영심(Young Sim Lee),최중호(Jung Ho Choi),이정렬(Jeong Yel Lee),한혁동(Hyuck Dong Han),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

N/A An increased placental ratio has known to be associated with the occurrence of cardiovascular complications in adulthood among the intrauterine fetal growth restriction. A retrospective study on 202 singleton growth-restricted infants without major congenital anomalies born from Jan. 1995 to Feb. 2001 was performed to determine the relationship between placental ratio and neonatal morbidity. The cases were categorized into three groups according to the placental ratio (<1SD below the mean, within 1SD of the mean, >1SD above the mean). There were no differences in the maternal characteristics and antenatal complications except pregnancy induced hypertension between high placental ratio group and the other groups. It presented the trend that was toward the increase of placental weight and the decrease of birth weight in high placental ratio group. The infants with a high placental ratio had increasing tendencies of meconium stained amnionic fluid, hypocalcemia, phototherapy, asphyxia.

면역성혈소판감소성자반증이 동반된 기왕제왕절개술 임신부에서 성공적인 질식 분만 1 예

이흥순(Heung Sun Lee),이영심(Young Sim Lee),정인배(In Bai Chung),장정호(Chung Ho Chang),황명증(Myung Jung Hwang),이영진(Young Jin Lee),어영(Young Uh) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8

Thrombocytopenia is hematologic disorder commonly occurs during pregnancy (5%) with different severity. It doesn`t cause severe problem during pregnancy and after the delivery if it is not below certain level which will cause spontaneous bleeding. But in this case, patient was previous cesarean section status and platelet number didn`t arise more than 20,000/μl even after transfusion which will cause spontaneous bleeding. Vaginal delivery was done because transverse cesarean section was considered relatively safe although there was the risk of rupture of uterus, and was successful-both mother and baby is in good health condition. Here now we report this case because vaginal delivery of Immunologic thrombocytopenic purpuric woman with prior history of cesarean section has not reported.

자궁동맥 색전술 후 자궁근종의 질 탈출 1 예

고양순(Yang Soon Ko),홍민(Min Hong),차동수(Dong Soo Cha),한혁동(Hyuck Dong Han),이영심(Young Sim Lee),김영주(Young Ju Kim),송지선(Ji Sun Song),정순희(Soon Hee Jung) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

Uterine myomas are the most common benign tumor of the female genitalia tract. Traditional therapy for symptomatic fibroids has been either myomectomy or hysterectomy, depending on whether further fertility is desired. Myomectomy is a surgical alternative, it is associated with greater morbidity and a higher blood transfusion rate. Arterial embolization of myomas is non surgical treatment option, is cheaper than myomectomy, permits preservation of reproductive potential, may be associated with less morbidity than myomectomy, and may not cause adhesions which could compromise fertility. A promised new alternative therapy-embolization of the uterine arteries is now available. A 26 year-old woman was diagnosed as submucosal uterine fibroid by ultrasonogram. We have recognized uterine arterial embolization is an effective therapy in the management of symptomatic myomas. Now we report vaginal passing of uterine fibroid after uterine arterial embolization.

태반 영양모세포주의 혈관내피성장인자 분비에 미치는 Th1형 사이토카인들의 영향

정인배(In Bai Chung),최선주(Sun Ju Choi),홍민(Min Hong),최현일(Hyun Il Choi),이영심(Young Sim Lee),고춘명(Choon Myung Koh),박주영(Joo Young Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5

N/A Embryo implantation and development are critically dependent upon the regulation of angiogenesis and adequate immunologic acceptance. These local angiogenesis and vascular permeability are regulated by the interaction between fetal trophoblast, uterine decidua, and endothelial cells through the key mediator, vascular endothelial growth factor (VEGF). Problem : The mechanism through which VEGF regulation occurs at the feto-maternal interface is poorly understood. The Th1 type cytokines are known to be harmful to the successful maintenance of early pregnancy at the feto-maternal interface. Objective : To clarify whether the Th1 type cytokines could be involved in the regulation of VEGF secretion at the feto-maternal interface. Method of Study : we investigated the effects of Th1 type cytokines on VEGF secretion in human first trimester trophoblast cell-line by using reverse transcription polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay (ELISA). Results : The trophoblast cells expressed VEGF constitutively and the main isoforms were VEGF121 and VEGF165. When cultured in the presence of IFN-γ or IL-2, VEGF secretion was most significantly increased by IFN-γ treatment but not affected by IL-2 treatment. The level of intracellular VEGF was also increased by IFN-γ treatment. Conclusion : These results suggest that IFN-γ, despite of harmful Th1 type cytokine to the maintenance of early pregnancy, may regulate the production of VEGF in early gestational trophoblasts.

인슐린 치료가 요구되어지는 당뇨가 합병된 임신에서 태반크기와 과체중아와의 상관성

이영심,정인배,임지훈,이흥순,이영진,최현일 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.5

목적 : 인슐린 치료가 요구되어지는 임신성 당뇨 (GDM A2)가 합병된 임신부에서 재태기간에 비해 신생아의 출생체중이 증가된 군에서 신생아의 출생체중과 태반크기의 증가의 상관관계를 조사하고, 과체중아와 거대태반의 발생에 영향을 미치는 요인들을 조사하여, 과체중아의 출산을 예측 또는 예방함으로써 과체중아 출산으로 인해 주산기에 발생할 수 있는 임신부와 신생아의 합병증을 감소시키는데 도움을 받고자 하였다. 대상 및 방법 : 인슐린 치료가 요구되어지는 임신성 당뇨 (GDM A2)가 합병된 104명의 단태 생존아를 출산한 임신부를 대상으로 하여, 신생아의 출생체중, 태반의 무게, 출산당시의 모체의 혈색소 수치, 50 gm 당부하 1시간후 혈당치, 100 gm 당부하후 혈당치, 분만직후의 식전과 식후 2시간째의 혈당수치 및 임신부와 신생아의 체질량 지수 등을 재태기간에 따른 신생아의 출생체중별로 분류한 각 군별로 후향적으로 비교하였다. 결과 : 재태기간에 비해 신생아의 출생체중이 증가된 군에서 신생아의 체질량 지수와 태반의 무게 등은 통계학적으로 의미있게 증가하였으며, placental ratio는 재태기간에 비해 신생아의 출생체중이 감소된 군에서 가장 작은 수치를 보였으며, 이는 통계학적으로 유의하였다. 50 gm 당부하 1시간후 모체 혈당치, 100 gm 당부 하 후 모체 혈당치와 HbA1C, 산모의 체질량 지수 등은 재태기간에 따른 신생아의 출생체중별로 분류한 각 군간에 차이가 없었고, 분만직후 모체의 식전과 식후 2시간째의 혈당수치는 각 군간에 통계학적으로 유의한 차이를 보여, 출생체중이 증가할수록 그 수치가 높았다. 결론 : 인슐린 치료에 의한 혈당조절에도 불구하고 재태기간에 비해 신생아의 출생체중이 감소된 군에서 placental ratio가 통계학적으로 의미있게 증가하는 것은 태반무게 증가와 신생아의 출생체중의 증가가 불균형을 이루고 있음을 보여주는 것이며, 이는 당뇨가 합병된 임신에 있어서 태반과 태아의 성장에 영향을 미치는 것은 모체의 혈당수치 이외의 요인이 있음을 시사하는 것으로 모체의 체질량지수의 증가정도가 거대아발생을 예견 할 수 있는 인자가 될 수 있을 것이며, 출산직후의 모체의 고혈당치 또한 비만등의 모체인자에 의한 이차적 변화로 생각될 수 있다. 따라서 향후 거대아 출산을 예측할 수 있는 모체 혈당치의 역치결정을 위한 연구와 임신성 당뇨시, 태반크기의 증가원인, placental ratio의 결정원인 등의 태반생물학적 연구와 보다 많은 인슐린 치료 실시군을 대상으로 한 연구 등이 지속되어야 할 것이다.

제7차 교육과정에 따른 고등학교 과학교과서 생물단원 STS 내용 분석

이영심,조운복 부산대학교 사범대학 과학교육연구소 2004 科學敎育硏究報 Vol.31 No.-

The purpose of this study is to provide the basic data of educational activities on the school scene, by finding the extent of agreement between the educational purposes of high school science textbooks by the 7th curriculum and those of science curriculum, and by dividing the contents of STS into the subject and activity area. In the study, the contents of STS were analyzed by e eight elements in STS course as Yager and student activities of SATIS. The results are as follows ; 1. The STS material are included average 20.8%, the highest 26.2%(textbook G) and the lowest 15.6% (textbook E) and the STS material are included 67.9% in the chapter of Biological concentration, 19.9% in Reproduction, 13.1% in metabolism, 9.9% in Stimulation and Reaction. 2. The contents of STS were analyzed by the STS standards presented by Yager(1984, 1989). The majority of the STS contents integrated 'application of science' and 'practice with decision - making strategies', 'social problem', relation of local communities', but didn't include evaluation concerned getting and using information. 3. The STS program suggested by SATE in the textbooks are mostly 'data analysis', 'practical work' and survey. But there is no case study. In STS material, 'application of science' were heavily concentrated while the activity category geared towards 'data analysis' and 'practical work', which leads to the conclusion that less diversity of STS contents and activity were included. 본 연구의 목적은 제7차 교육과정에 의한 고등학교 과학과 STS 내용의 교과서 분포상황을 분석하여 각 교과서가 교육과정의 교육목표에 얼마나 부합되었는지를 알아보고, 학교 현장에서의 교육활동에 필요한 기초 자료를 제공하는데 있다. 본 연구에서 STS 내용은 Yager(1984)가 제시한 8가지 요소와 SATIS program에 나타난 활동유형을 기준으로 분석하였다. 결과는 다음과 같다. 1. 과학 교과서의 '생물'영역에서 STS 교육 내용의 포함률은 평균 20.9%로 최고 26.2%(교과서 G)에서 최저 15.6%(교과서 E)의 지면을 할애하고 있다. 그리고 중단원별 포함률은 생물농축 단원이 67.6%로 가장 높고, 생식 단원 19.9%, 물질대사 단원 13.1%, 자극과 반응 단원이 9.9%로 나타났다. 2. 과학 교과서 '생물'영역에 포함된 STS 내용 포함 횟수는 평균 24.7회로 최고 31회에서 최저 15회로 나타났는데, 과학의 응용성에 관한 것이 가장 많았고, 실제 문제의 협동작업, 사회적 문제, 지역사회와의 관련성, 과학과 관련된 직업 선택, 과학의 다면성, 의사결정 함양 능력 순으로 나타나며, 정보의 선택 및 이용에 관한 내용은 거의 다루어지지 않았다. 3. 과학 교과서 '생물'영역의 STS 내용을 SATIS 활동 영역에 따라 분석한 결과 평균 38회로, 최고 46회에서 최저 30회인데 자료 분석이 가장 많았고, 실제 활동(실험), 조사 활동, 구조화된 토론, 역할놀이 및 모의실험, 문제 해결 및 의사 결정과 연구 설계 순으로 나타났고, 사례 연구는 한번도 제시되지 않았다.

유전성 철적모구성 빈혈 임신부의 산전관리 및 분만

이상학,김병욱,이영심,정인배,이영진,한혁동,이건영 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9

Anemia is the one of the most common complications among pregnant women, but sideroblastic anemia is very rare condition. The sideroblastic anemias have diverse etiologies but have in common an impaired biosynthesis of heme in the erythroid cells of the marrow. The ringed sideroblasts in the bone marrow aspirate is diagnostic hallmark of sideroblastic anemia. We report here a prenatal care and delivery in a pregnant woman complicated by hereditary sideroblastic anemia. This patient was treated with 200mg of pyridoxine per day during entire pregnancy period and further more, 4mg of oral folate per day was supplemented because concomitant folate deficiency is frequent in case of erythroid hyperplasia. Intermittently, the transfusions of packed red blood cells were required to maintain the hemoglobin level in the 9 to 10gm/dl range. We have experienced healthy maternal and perinatal outcome.