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- 저자 : 이정렬(Jeong Lyol Lee) (검색결과 4 건)
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체외수정 및 배아이식술후 임신과 자연 임신된 임신부에서 임신중기 삼중표지물질 검사결과의 비교분석
이정렬(Jeong Lyol Lee),이영심(Young Sim Lee),이상학(Sang Hag Lee),최중호(Jung Ho Choi),정인배(In Bai Chung),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : To compare and analysis the result of second trimester maternal serum triple marker screening test for Down syndrome and open neural tube defects in singleton pregnancies conceived by conventional in vitro fertilization- embryo transfer (IVF-ET) with that of the naturally conceived pregnancies. Methods : Maternal serum screening tests during the second trimester in 49 singleton pregnancies conceived by IVF-ET and 813 singleton pregnancies conceived naturally of whom delivery outcome was normal in each other were analyzed from April 1997 to June 2000. Results : 4 (8.2%) out of 49 cases of IVF-ET singleton pregnancies compared with 62 (7.6%) out of 813 cases of naturally conceived pregnancies had a positive results for Down syndrome or open neural tube defects. The median level of the triple markers were 1.03 0.47 multiples of the median (MoM) in IVF-ET pregnancies vs 1.05±0.39 MoM in natural pregnancies for alpha-fetoprotein (AFP), 1.11±0.64 vs 1.19±1.13 MoM for unconjugated estriol (uE3) and 1.21±0.56 vs 1.11±0.59 MoM for human chorionic gonadotropin (hCG). Conclusion : The positive rate of triple test and the median values of triple markers for Down syndrome and open neural tube defect between two groups were not different in terms of statistical significance. To provide an objective assessment of an individual patient's risk of fetal abnormality, the impact of IVF-ET on triple marker biochemistry should be studied further in larger samples and adjustments made if appropriate.
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이정렬(Jeong Lyol Lee),김병재(Byoung Jae Kim),김대호(Dae Ho Kim),지병철(Byung Chul Jee),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),문신용(Shin Yong Moon),신희철(Hee Chul Syn) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
The 13q deletion syndrome was described firstly by Allderdice et al. in 1969. Common findings include fetal growth restriction, microcephaly, other central nervous system malformations, eye abnormalities, characteristic facial appearance, congenital heart defects, gastrointestinal anomalies, vertebral, limb, and perineal defects, and varying degrees of mental retardation. We report a case of terminal deletion of chromosome 13q. Conventional cytogenetic result from amniocytes was 46,XY,del(13)(q32). The prenatal ultrasonographic findings were fetal growth restriction, oligohydramnios, microcephaly, ventriculomegaly and clubfoot. Gross anomalies after delivery included microcephaly, low set ears, absent thumbs, club foot, partial syndactyly of 4th and 5th toes, ambiguous genitalia, and imperforate anus. In addition to characteristic features of 13q terminal deletion, cleft lip and palate was found in our case. Cytogenetic abnormality probably results from phenotypically normal mother, whose karyotype was 46,XX,inv(3)(p26q13.1),t(13;20)(q32;p13) from lymphocytes.
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난자 세포질내 정자 주입술시 정자 기원에 따른 산과적 결과와 선천성 기형에 관한 연구
강지현 ( Ji Hyun Kang ),강경화 ( Kyoung Hwa Kang ),최영식 ( Young Sik Choi ),이정렬 ( Jeong Lyol Lee ),정연경 ( Youn Kyung Chung ),지병철 ( Byung Chul Jee ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),최영민 ( Young Min Ch 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10
목적: 본 연구는 난자 세포질내 정자 주입술 (intracytoplasmic sperm injection, ICSI) 후 임신된 예 및 태어난 신생아들을 대상으로 하여 정자의 기원별로 산과적 결과, 선천성 기형 및 염색체 이상의 빈도를 비교 분석하고자 하였다. 연구 방법: 1995년 1월부터 2004년 1월까지 ICSI 시술 후 임신된 예는 105예이었으며, 출생한 신생아는 103명이었고 정자의 기원에 따라 사정 정자군 (n=77), 부고환 정자군 (n=15), 고환 정자군 (n=13)으로 나누었다. 정자 기원에 따른 임신율, 조산율, 유산율, 다태아 임신율, 출생 시 임신주수, 출생 시 체중, 저체중아의 빈도 등 산과적 결과에 대하여 분석하였으며, 정자 기원에 따른 기형 및 염색체 이상의 빈도에 대하여 분석하였다. 결과: 임신율, 조산율, 유산율, 다태 임신율, 출생 시 임신 주수, 출생 체중은 세 군 간에 유의한 차이가 없었다. 저체중아의 출생률, 극저체중아의 출생률도 세 군 간에 유의한 차이가 없었다. 주 기형은 사정 정자군에서 2예 (2.7%), 고환 정자군에서 1예 (7.7%)이었고 2예는 소화기기형이었고, 1예는 구순열이었다. 부 기형은 사정 정자군에서 3예 (4.1%), 고환 정자군에서 1예 (7.7%)이었다. 염색체 이상은 105 임신 중 6예 (5.7%)에서 관찰되었고 모두 사정 정자군이었다. 상염색체수의 이상이 2예, 구조적 이상이 4예이었으며 성염색체 이상은 없었다. 결론: ICSI 시술 후 임신한 경우 정자 기원에 따른 산과적 결과의 차이는 없었으며, 선천성 기형아의 발생률, 염색체 이상의 빈도도 정자 기원에 따른 차이가 없었다. 선천성 기형과 염색체 이상에 대한 보다 정확한 연구 결과를 얻기 위해서는 향후 장기간의 대규모 추적조사 연구가 필요할 것으로 사료된다. Objective: To analyze the obstetric outcomes, the incidence of congenital malformations and chromosomal anomalies of neonates born after intracytoplasmic sperm injection (ICSI) according to the origin of sperm. Methods: A total of 103 neonates born from ICSI between January 1995 and January 2004 was included. They were divided into three groups: ejaculated (n=73), epididymal (n=17) and testicular (n=13) groups. We compared obstetric outcomes such as pregnancy rates, preterm birth rates, abortion rates, multiple pregnancy rates, gestational age at birth, birth-weight, and the incidence of congenital malformations and chromosomal anomalies. Results: There were no differences among the three groups in terms of pregnancy rates, preterm birth rates, abortion rates, multiple pregnancy rates, gestational age at birth and birth-weight. There were no differences in the incidence of low birth-weight babies and very low birth-weight babies. Major malformations were observed in two cases of ejaculatory group (2.7%) and one of testicular group (7.7%). Major malformations included two gastrointestinal malformations and one cleft lip. Minor malformations were observed in three cases of ejaculatory group (4.1%) and one of testicular group (7.7%). Chromosomal anomalies were observed in 6 cases of 105 pregnancies (5.7%), and all of them were from the ejaculatory group. Two cases had autosomal numerical anomalies and 4 cases autosomal structural anomalies. However, sex chromosomal anomalies were not detected in this study. Conclusion: The obstetric outcomes, the incidence of congenital malformations and chromosomal anomalies in ICSI babies were not different according to the origin of sperm. These findings should be further investigated in larger long-term studies.
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최중호(Jung Ho Choi),최현일(Hyun Il Choi),이정렬(Jeong Lyol Lee),이준희(Jun Hee Lee),차동수(Dong Su Cha),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10
N/A Objective : With the use of regular cervical cytologic screening, an increasing percent of patients with invasive cervical cancer are being diagnosed with early-stage disease. During the past two decades, there has been considerable interest in identifying a group of patients with early invasive cancer who have a minimal risk for extracervical spread. Method : From January 1993 to June 2000, we have experienced 26 cases with microinvasive cervical cancer. The data were collected retrospectively and all charts were reviewed. Result : The age ranged from 29 to 69 years and median age was 44.3 years. 18 cases incidentally found through the routine Pap smear, in symptomatic group most frequent initiating symptom was postcoital bleeding. The corresponding rate of Pap smear to histologic diagnosis was approximately 26.9%. However, corresponding rate within one histologic grade was about 69.2%. The modified radical abdominal hysterectomy was performed in 21 cases and modified radical abdominal hysterectomy with pelvic lymph node biopsy was performed in 4 cases and radical abdominal hysterectomy with pelvic node biopsy was done in 1 case with greater than 3 mm and no greater than 5 mm stromal invasion. There was no surgery-related deaths and recurrent cases in this study. Conclusion : The prognosis of stage Ia cervical cancer is relatively good and less radical therapeutic approach may be beneficial. But, further prospective study based on large numbers of cases with multi-institutional cooperation and designed protocol will be necessary.
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