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뇌교경색으로 인한 현훈 및 복시증상에 조간익뇌탕(助肝益腦湯)을 투여한 치험 1례
이윤재,이정섭,문미현,조영기,이성균,정현애,윤종민,신선호,임은경,Lee, Yun-Jae,Lee, Jung-Sub,Moon, Mi-Hyun,Cho, Young-Kee,Lee, Seong-Kyun,Jeong, Hyun-Ae,Yun, Jong-Min,Shin, Sun-Ho,Rhim, Eun-Kyung 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
Pontine infarction presents variable neurologic deficits because the pons is a very complicated organ with cranial nerve nuclei and several fiber tracts. A 65 year-old women with dizzness, ataxia and diplopia because of Pontine infarction was admitted at Wonkwang University Jeonju Oriental Medicine Hospital. She was treated with the herbal medicine Joganiknoe-tang(助肝益腦湯) and with acupunture. Improvement in these symptoms was observed, so the specifics of the process in which the patient was treated are here described. Results suggest that Joganiknoe-tang(助肝益腦湯) is an effective treatment for symptoms of pontine infarction.
Human Neuroblastoma Cell Line BE2에 대한 건비보신항암탕(健脾補腎抗癌湯)의 세포고사 기전 연구
조영기,문미현,이성균,정현애,이정섭,남상규,문구,신선호,김동웅,Cho, Young-Kee,Moon, Mi-Hyun,Lee, Seong-Kyun,Jeong, Hyun-Ae,Lee, Jung-Sub,Nam, Sang-Kyu,Moon, Goo,Shin, Sun-Ho,Kim, Dong-Woung 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Objective: In order to investigate cell death mechanisms by Gunbibosinhangam-Tang(G.B.H) in cancer cells, the activities of apoptosis signaling pathway were tested in human neuroblastoma cell line BE2. Methods: Viability of BE2 cells was markedly decreased by treatment of the water extract of G.B.H in a dose-dependent manner. G.B.H-induced cell death was confirmed as apoptosis characterized by chromatin condensation, We tested whether the water extract of G.B.H affects the anti-apoptotic proteins such as Bcl-$X_L$ Results: Bcl-$X_L$ was uneffected by the addition of the water extract of G.B.H in a time-dependent manner. Cleavage of PARP(poly-ADP-ribose polymerase) by activation of caspase-8 protease was also observed in BE2 cells by the treatment of the water extract of G.B.H. Conclusion: These results suggest that the water extract of G.B.H exerts anti-cancer effects on human neuroblastoma BE2 cells by inducing the apoptotic death via activation of intrinsic caspase cascades.
Caroli's Disease로 인한 담관염 환자 치험 1례
문미현,이성균,정현애,이정섭,임은경,이윤재,문구,신선호,김동웅,조영기,Moon, Mi-Hyun,Lee, Seong-Kyun,Jeong, Hyun-Ae,Lee, Jung-Sub,Rhim, Eun-Kyung,Lee, Yun-Jae,Moon, Goo,Shin, Sun-Ho,Kim, Dong-Woung,Cho, Young-Kee 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
Caroli's disease is a non-obstructive dilatation of the intrahepatic bile ducts. It is a rare congenital disorder that classically causes saccular ductal dilatation, which usually it segmental dilatation. Caroli's disease is associated with recurrent bacterial cholangitis and stone formation. A 57 years-old female inpatient suffering from cholangitis due to Caroli's disease was admitted at Wonkwang University Jeonju Oriental Medicine Hospital. The patient was treated with herbal medicine such as Yongdamsagan-tang and acupuncture. As result, there was improvement of symptoms. The process and content of treatment and the patient's recovery over general symptoms is described.