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      • KCI등재

        국산 Disposable Infusion Pump 내에서의 5-Fluorouracil의 안정성

        이윤덕,김은경,김재연,노환성 한국병원약사회 1999 병원약사회지 Vol.16 No.1

        The small, portable pump has given much-needed mobility to patients receiving prolonged continuous and intermittent infusion therapy. By using these devices, patients have been able to return to the familiar surroundings of home, family, and friends. In some cases, patients may even return to the work place while receiving therapy. One group of drug that is currently being administered by portable infusion pumps is the antineoplastic agents. The purpose of this study was to determine the effects of temperature, drug concentration, and flow rate of 5-fluorouracil in portable infusion pump. Commercially available fluorouracil aqueous solution (50㎎/㎖) was used. Drug reservoirs of portable infusion pumps were filled with 84㎖ of fluorouracil and 16.4㎖ of fluorouracil and 67.6㎖ D5W injection. Under conditions simulating actual use, the reservoirs were attached to the pumps and the solutions were pumped at a rate of 0.5㎖/hr over a seven-day period at 4℃, 25℃, 37℃. Samples at the distal end of extension tubing were collected at 24-hour intervals. Visual observation was made immediately to look for precipitation. Drug concentration was determined by UV-spectrophotometer (266㎚). Precipitate was not observed in all samples after two weeks. Under infusion conditions, no apparent changes in concentration.

      • 유선질환에서 Secretory Component와 Carcinoembryonic Antigen 출현도에 관한 관찰

        이윤덕,장자준,송계용,유재형 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.1

        To observe the reaction and relationship between the secretory component(SC) and the carcinoembryonic antigen(CEA) in the mammary diseaes, immounohistochemical studies were carried out. The studies consisted of 15 cases of infiltrating ductal carcinoma,5 cases of infiltrating colloid carcinoma, 10 cases of fibroadenoma and 15 cases of mammary dysplasia. The results were as follows: 1. Moderately or strongly positive reaction of CEA and weakly poaitive reaction of SC were observed in infiltrating ductal carcinoma. 2. Weakly poitive reactions of CEA and SC were observed in infiltrating colloid carcinoma. 3. Weakly poitive reactions of CEA and moderately positive reaction of SC were observed in infibroadenoma. 4. Weakly poitive reactions of CEA and moderately positive reaction of SC were observed in mammary dysplasia. 5. Therefore, reactivities of CEA were more increased in the carcinoma than benign condition of the breast in comtrasr with those of the SC which were more dominant in reactive or benign tumorous condition than in carconoma, suggesting dedifferentiation to the embryonal stage of carcinoma cells.

      • KCI등재

        리더 간섭에 의한 RFID 시스템의 인식 거리 감소에 관한 연구

        이윤덕,김도윤,윤현구,육종관,장병준,Lee, Yoon-Deock,Kim, Do-Yun,Yoon, Hyun-Goo,Yook, Jong-Gwan,Jang, Byung-Jun 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.7

        최근 UHF 대역에서 동작하는 RFID 시스템이 활발히 연구되고 있으며, 유통 물류 분야를 시작으로 다양한 분야에서 사용되고 있다. 본 연구에서는 UHF RFID 시스템의 주파수 간섭 중 RFID 시스템 설계시 가장 문제가 되고 있는 리더간 간섭을 인식 거리 측면에서 분석하였다. RFID 주파수 간섭를 정량적으로 분석하기 위하여 새로운 성능 지표로 IRRR을 정의하고, IRRR의 유용성을 보이기 위해 두 개의 RFID 리더와 하나의 태그로 구성된 측정 시스템을 구성하여 IRRR이 실제 환경의 특성을 반영하고 있음을 확인하였다. 따라서, 실제 다양한 RFID 시스템을 설치할 때 IRRR을 설계 파라미터로 사용함으로써 주파수 간섭 문제를 해결할 수 있을 것이다. Recently UHF RFID system has drawn a great deal of attention because of its potential to revolutionize supply chain management. In this article, RFID reader-to-reader interference is analyzed in terms of interrogation range. For evaluating RFID interference quantitatively, the new figure-of-merit, IRRR, is defined. In order to show the usefulness of IRRR, calculated IRRR is verified by measurement using two RFID readers and a tag in multiple-reader environment. IRRR can be referred to an important design parameter to analyze more complex interfering problems in actual RFID system deployments.

      • SCOPUSKCI등재

        $3Bi_2O_3.WO_3$ 고체전해질의 상안정성과 전기적 특성

        백현,이윤,박종욱 한국세라믹학회 1995 한국세라믹학회지 Vol.32 No.2

        The electrical conducton in the sintered 3Bi2O3.WO3 solid electrolyte was investigated by measuring the conductivity and ionic transport number. The electrical conductivity was about three to ten times higher than that of YSZ at temperatures between 300 and 80$0^{\circ}C$. D.C. polarization method confirmed that 3Bi2O3.WO3 was predominantly an ionic conductor. Unlike the instability of high conductive fcc phase in the rare-earth oxide-Bi2O3 or Y2O3-Bi2O3 systems at temperature below $700^{\circ}C$, fcc phase in the 3Bi2O3.WO3 exhibited no transformation even after annealing over 900 hrs at 600 and $650^{\circ}C$. Two samples which had different grain sizes showed almost the same conductivity. This result suggests that the electrical properties of grain and grain boundry were very similar.

      • KCI등재

        Effectiveness of Once-weekly Compared with Thrice-weekly Subcutaneous Epoetin Alpha for the Treatment of Chemotherapy-induced Anemia

        오정미,이윤덕,김영주,김경임,신완균 한국임상약학회 2009 한국임상약학회지 Vol.19 No.2

        Purpose : 본 연구의 목적은 항암치료로 인한 빈혈환자의 치료에서 epoetin alpha (rHuEPO) 피하주사 시, 주일회 요법과 주삼회요법의 헤모글로빈(hemoglobin, Hb) 상승 효과를 비교하는 것이다. Methods : 본 연구는 1999년 3월부터 2005년 3월까지 국립암센터에서 항암치료로 인한 빈혈로 epoetin alpha를 투여 받은 환자를 대상으로 의무기록의 자료를 후향적으로 수집하여 분석하였다. 연구에 포함된 환자는 rHuEPO 10,000 IU 주삼회투여군(n = 127)과 20,000 IU 주일회투여군(n = 81)으로 구분되었으며, 이들은 필요에 따라 경구용 철분보조제를 섭취하였다. Epoetin alpha 치료 시작 후 최대 8주까지 2주 간격으로 Hb 수치변화를 분석하였다. Results : 치료 시작 시점의 rHuEPO 10,000 IU 주삼회투여군과 20,000 IU 주일회투여군의 평균 Hb수치는 유사하였다 (9.4 g/dL vs. 9.7 g/dL). Epoetin alpha 치료 후 8주까지 두 그룹간의 헤모글로빈 수치의 상승 정도에는 유의한 차이가 없었다 (1.57±1.39 g/dL vs. 1.68±1.35 g/dL, p=0.59). 또한 경구용 철분보조제 투여여부, cisplatin 포함 항암제 투여여부 및 성별에 따른 군의 분류에 있어서도 rHuEPO 10,000 IU 주삼회투여군과 20,000 IU 주일회투여군의 평균 Hb 상승수치는 유의한 차이를 보이지 않았다. Conclusion : 한국인에서 항암치료로 인한 빈혈의 치료 시에 rHuEPO 20,000 IU 주일회투여 용법은 10,000 IU 주 삼회투여 용법과 유사한 Hb 상승효과를 가진다.

      • 태아 및 성인의 간에서 Glutathione S-Transferase출현도에 관한 면역조직화학적 관찰

        송계용,이윤덕,박상철 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.3

        Both acidic placental form(GST-Pi) and basic liver form(GST-L ) of human glutathione S-transferase were studied in the developing, normal and abnormal livers using immunohistochemical peroxidase and antiperoxidase method. Time of appearance, temporal change of the activity and distribution pattern were particularly examined using 27 cases of human fetuses of ranging in age from 12 to 32 gestation weeks, 5 cases of normal infant as well as 12 cases of cirrhosis or carcinomas of the liver. The results were as follows; 1. Expression of the GST-Pi in the liver was weak in fetuses between 12 to 16 weeks but became conspicuous between 17 to 21 weeks and then it decreased to show weak posititivy between 24 to 32 weeks. The staining reaction was mild in childhood and adult livers. Meanwhile GST-L was stained weakly in fetuses between 12 to 13 weeks but became conspicuous from 14th week and of staining reaction was mild to moderate noted thereafter, in childhood and adult. 2. Expression of the GST-Pi in the bile ducts was weak in fetus between 12 to 16 weeks and became conspicuous in 17 to 24 weeks and stained strongly between 26 to 32 weeks and the strong of reaction was noted in childhood and adult intrahepatie bild ducts. GST-L was not demonstrated through the fetal period from 12 to 32 weeks but weakly positive in the large bile duct epithelium of childhood and adult. 3.Expression of the GST-Pi was the same degree of positivity as the normal in the hepatocytes and bile ducts adjacent to the hepatocellular carcinoma. GST-Pi showed moderately in the hepatocytes of regenerating nodule and adjacent proliferatinf bile ducts. It was weak to strong in trabe cular and acinar hepatocellular hepatoblastoma. Meanwhile, GST-L was of positive as the normal hepatocytes and bild ducts adjacent to the hepatocellular carcinoma of the liver. GST-L is weakly positive in regenerating nodule and weak to moderate in trabecular hepatocellular caricinoma, and negligible in acinar type. In conclusion, It was suggested that maturation and distribution pattern of GST-Pi and GST-L are significantly different between normal and neoplastic condition, and a possibility of dianostic application of isozymes of glutathione S-transferase in the differential diagnosis of neoplasms of hepatobiliary system could be raised.

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