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자연 유산에서 드물게 관찰된 Jumping translocation 2례
이연우(Yeon Woo Lee),이봄이(Bom Yi Lee),박주연(Ju Yeon Park),최은영(Eun Young Choi),오아름(Ah Rum Oh),이신영(Shin Young Lee),류현미(Hyun Mee Ryu),강인수(Inn Soo Kang),양광문(Kwang Moon Yang),박소연(So Yeon Park) 대한의학유전학회 2010 대한의학유전학회지 Vol.7 No.1
Jumping translocation (JT)은 여러 세포주에서 하나의 공여 염색체가 둘 이상의 수여 염색체와 염색체 재배열을 보이는 염색체의 구조적 이상으로 종양 세포인 림프성 혈액암에서 빈번하게 관찰되는 획득성(acquired) JT에 비해 체질성(con-stitutional) JT는 매우 드물게 보고되고 있다. 본 증례에서는 자연 유산된 수태산물에서 관찰된 체질성 JT 2례를 보고하고자 한다. 증례 1은 임신 7주 유산아 조직의 세포유전학적 검사에서 핵형분석 결과는 46,XY,add(18)(p11.1)[61]/45,XY,der(18;21)(q10;q10)[32]/46,XY,-18,+mar[16]/46,XY,i(18)(q10)[9]/45,XY,der(15;18)(q10;q10)[6]/46,XY,+1,dic(1;18)(p22;p11.1)[2]/45,XY,der(13;18)(q10;q10)[1]/46,XY[32]로 관찰되었다. 공여 염색체는 18번이고 수여 염색체는 1, 13, 15, 18, 21번이었다. 증례 2는 임신 6주째 자연 유산된 유산아 조직으로부터 세포 유전학적 검사를 실시한 결과, 핵형은 46,XY,der(22)t(9;22)(q12;q13)[22]/46,XY,der(22)t(1;22)(q21;q13)[13]/46,XY,add(22)(q13)[5]/46,XY[23]고 관찰되었다. 공여 염색체는 22번이고 수여 염색체는 1, 9번이었다. 2례 모두 de novo였고 acrocentric 염색체를 수반하였으며 절단점은 대부분 중심절과 중심절 주위, 말단체에 존재하였다. 본 증례는 매우 드물게 관찰되는 체질성 JT로서 임신 초기 세포 분열 단계에서 발생했고 다양한 세포주에서 나타난 비정상 핵형으로 인해 정상적인 배발달이 이루어지지 못하여 자연 유산된 것으로 생각된다. Jumping translocations (JT) are chromosomal rearrangements involving one donor chromosome and several recipient chromosomes. While JTs are frequently observed as acquired chromosomal abnormalities in hematologic malignancies, constitutional JTs are only rarely reported. We report two cases of constitutional JT in chorionic villi derived from the products of conception. The karyotype of the first case was 46,XY,add(18)(p11.1)[61]/45,XY,der(18;21)(q10;q10)[32]/46,XY,-18,+mar[16]/46,XY,i(18)(q10)[9]/45,XY,der(15;18)(q10;q10)[6]/46,XY,+1,dic(1;18)(p22;p11.1)[2]/45,XY,der(13;18)(q10;q10)[1]/46,XY[32]. The donor was a chromosome 18. The recipient chromosomes were chromosomes 1, 13, 15, 18 and 21. In the second case, the karyotype was 46,XY,der(22)t(9;22)(q12;q13)[22]/46,XY,der(22)t(1;22)(q21;q13)[13]/46,XY,add(22)(q13)[5]/46,XY[23]. The donor was a chromosome 22 and recipients were chromosomes 1 and 9. Both cases were de novo. The breakpoints of chromosomes were mostly in centromeric regions, pericentromeric regions, or telomeric regions. Normal cell lines were observed in both cases. This report supports the prior findings that the unstable nature of JT, resulting in chromosomal imbalance, most likely contributed to these early miscarriages.
진공 플라즈마 용사법을 통해 형성된 NiCoCrAlY 오버레이 코팅의 반복 산화 거동
유연우(Yeon Woo Yoo),남욱희(Uk Hee Nam),박훈관(Hunkwan Park),박영진(Youngjin Park),이성훈(Sunghun Lee),변응선(Eungsun Byon) 한국표면공학회 2019 한국표면공학회지 Vol.52 No.6
MCrAlY overaly coatings are used as oxidation barrier coatings to prevent degradation of the underlying substrate in high temperature and oxidizing environment of the hot section of gas turbines. Therefore, oxidation resistance in high temperature is important property of MCrAlY coatings. Also, coefficients of thermal expansion (CTE) of MCrAlY have middle value of that of Ni-based superalloys and oxides, which have the effect of preventing the delamination of the surface oxides. Cyclic oxidation test is one of the most useful methods for evaluating the high temperature durability of coatings used in gas turbines. In this study, NiCoCrAlY overlay coatings were formed on Inconel 792(IN 792) substrates by vacuum plasma spraying process. Vacuum plasma sprayed NiCoCrAlY coatings and IN 792 susbstrates were exposed to 1000℃ one-hour cyclic oxidation environment. NiCoCrAlY coatings showed lower weight gain in short-term oxidation. In long-term oxidation, IN 792 substrates showed higher weight loss due to delamination of surface oxide but NiCoCrAlY coatings showed lower weight loss. X-ray diffraction (XRD) analysis showed α-Al2O3 and NiCr₂O₄ was formed during the cyclic oxidation test. Through cross-section observation using scanning electron microscopy (SEM) and electron back scatter diffraction (EBSD) analysis, thermally grown oxide (TGO) layer composed of α-Al₂O₃ and NiCr₂O₄ was formed and the thickness of TGO increased during 1000℃ cyclic oxidation test. β phase in upper side of NiCoCrAlY coating was depleted due to oxidation of Al and outer beta depletion zone thickness also increased as the cyclic oxidation time increased.
포스트모던 그림책 읽기활동에서 나타나는 교사-유아의 상호작용 분석
전연우 ( Yeon Woo Jun ),이현경 ( Hyun Kyung Lee ),조희숙 ( Hea Soog Jo ) 한국어린이문학교육학회 2012 어린이문학교육연구 Vol.13 No.1
본 연구는 포스트모던 그림책 읽기 활동에서 나타난 교사-유아간의 상호작용을 알아보는데 그 목적이 있다. 이를 위해 우선 P지역에 소재한 공립 및 사립 유치원 각 4곳씩 총 8곳의 만 5세반 담임교사 8명과 그들이 지명한 학급당 8-12명의 유아들을 연구 참여 대상으로 선정하였다. 자료수집 기간은 2011년 7월 18일부터 9월 14일까지이며 이 기간 동안 8곳의 유치원을 각 유치원당 1주에 3회씩 총 24회 방문하여 그림책의 포스트모던적 특성을 중심으로 포스트모던 그림책 읽기 활동에서 나타나는 교사-유아 간 상호작용을 관찰하였다. 연구 결과, 교사-유아의 상호작용은 크게 이항 대립적인 교사-유아 그림책 읽기, 교사와 유아의 공동 세계 창출하기, 유아가 주도하고 교사가 따라가는 그림책 읽기의 세 가지 유형으로 드러났다. 이러한 연구는 교사와 부모들에게 유아와의 그림책 읽기과정에 대한 이해와 통찰력을 가지게 하며 문해력 지도, 문학 활동을 위한 교수법 개발에 중요한 기초자료가 될 것으로 보인다. The purpose of this study was to investigate modes of interaction between teachers and young children during the reading of the postmodern picturebook. The subjects of the study were young children, 5 years of age, and their teachers, who were enrolled in public and private kindergartens in Pusan, Korea. The study involved 24 sessions covering a period of 8 weeks from July to September, 2011. The results of this study indicate that teachers and young children displayed incompatible interaction at times, alongside periods of mutual cooperation, and effective sessions of teacher-following young children-led readings when using the postmodern picturebook. This study provides insights and a new understanding about interaction between teacher and young children during the reading of the postmodern picturebook.
항응고제/항혈소판제와 프로톤펌프억제제 병용의 경제성 평가에 대한 체계적 문헌고찰
이연우(Yeon-Woo Lee),권순홍(Sun-Hong Kwon),김나현(Na-Hyun Kim),이의경(Eui-Kyung Lee) 대한약학회 2022 약학회지 Vol.66 No.5
Anticoagulants/antiplatelets are effective in preventing cardiovascular diseases (CVDs). However, as an adverse effect, the risk of upper gastrointestinal bleeding (UGIB) leads to additional costs due to increased treatment and decreased quality of life. Accordingly, the administration of proton pump inhibitors (PPI) is recommended to prevent UGIB. We conducted a systematic review of economic evaluations of PPI co-therapy for patients taking long-term anticoagulants/ antiplatelets to prevent CVDs to examine the cost effectiveness of PPI co-therapy. We searched literature from PubMed and EMBASE with keywords including types of economic evaluations and active ingredients of anticoagulants and antiplatelets on 13/07/2022. Two independent reviewers conducted a systematic review. As a result, six economic evaluation studies were identified. All studies compared PPI co-therapy with low-dose aspirin to prevent CVDs. We confirmed the cost-effectiveness of PPI co-therapy with the respective incremental cost-effectiveness ratio (ICER) in each base case. In the sensitivity analyses, the PPI cost and adherence influenced the ICER the most. The quality of reporting, which was assessed using the Consolidated Health Economic Evaluation Reporting Standards checklist, was 87-96%. In the present study, we found that PPI co-therapy was cost-effective and tended to improve the patient’s life years and quality-adjusted life years. These results can be used as evidence for further economic evaluation studies to verify the costeffectiveness of anticoagulants/antiplatelets and PPI co-therapy.
허연우 ( Yeon-woo Heo ),문정욱 ( Jung-wook Moon ),이시황 ( Si-hwang Lee ),임경범 ( Kyung-beom Lim ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2
아두이노와 라즈베리 파이를 활용하여 건강 모니터링 단말기를 제작하고자 한다. 건강 모니터링 단말기는 인간이 건강하고 안심할 수 있는 일상생활을 돕는 데 큰 역할을 할 것으로 기대된다. 또한, 이를 활용하여 긴급 구조 요청 시스템을 구축함으로써 위급한 상황에 처한 사람들의 안전을 보장할 수 있다.
HIPS 복합재의 전기적 및 마모 특성에 미치는 다중벽 탄소나노튜브의 영향
정연우(Yeon-Woo Jeong),김경식(Kyung-Shik Kim),이현우(Hyun-Woo Lee),정만우(Man-Woo Jeong),이재혁(Jae-Hyeok Lee),김재현(Jae-Hyun Kim),이학주(Hak-Joo Lee),김광섭(Kwang-Seop Kim) 한국트라이볼로지학회 2015 한국윤활학회지(윤활학회지) Vol.31 No.3
Carbon nanotubes (CNTs) are widely used in polymer composites as filler materials to enhance various characteristics of the composites because of their remarkable mechanical, electrical, and thermal properties. In this study, we investigate the effects of MWCNTs on the electrical and wear characteristics of high-impact polystyrene (HIPS) composites, and compare the results with the effects of carbon black (CB). The HIPS composites are classified as Bare-HIPS, MWCNT-HIPS composites containing 2, 3, 4, and 5 wt% MWCNTs, and CB-HIPS containing 17 wt% CB. Electrical characteristics are evaluated by measuring the surface resistance using a 4-point probe. Wear characteristics are evaluated using the reciprocating wear test, and a chrome steel ball with a curvature of 6.3 mm is used as the counterpart. The results show that the addition of MWCNTs or CB can improve the electrical and wear characteristics of HIPS composites. In the case of MWCNT-HIPS composites, surface resistance, friction coefficient, and specific wear rate decrease as the concentrations of MWCNTs increase. Moreover, the addition of MWCNTs is more effective in improving the electrical and wear characteristics of HIPS composites compared to the addition of CB. To fabricate the HIPS composite with appropriate electrical and wear characteristics, more than 4 wt% MWCNTs is added to HIPS.