항경련제가 혈청 Carnitine 및 간 기능에 미치는 영향

이수중(Soo-Jung Lee),김종완(Jong-Wan Kim),황경태(Kyung-Tai Whang) 대한소아신경학회 1993 대한소아신경학회지 Vol.1 No.2

We measured the serum carnitine levels by means of radioisotopic assay in epileptic children receiving a various antiepileptic drugs, and assessed the effects of antiepileptic drugs on serum carnitine level together with a correlation between serum carnitine level and duration of treatment, and value of liver function. The study included 97 epileptic patients(54 males, 43 females ; ages 5-23 years) who were divided into four antiepileptic drug-treated groups : valproic acid(VPA) monotherapy, carbamazepine monotherapy, valproic acid polytherapy, and other antiepileptic drugs without VPA, and a control group of 52 children(33 males, 19 females ; ages 8-19 years). The results were as follows: 1. The serum levels of total and free carnitine were significantly reduced in the patients of VPA mono- and polytherapy groups, compared with the control group. The reduction was more significant in the patients of VPA polytherapy group than in those of VPA monotherapy group. 2. The number of patients whose serum level of total and free carnitine reduced by > 2SD below the mean of control group was 3 of 18 patients in VPA monotherapy group and 6 of 20 patients in VPA polytherapy group, respectively. 3. The duration of treatment was not correlated with the serum levels carnitine in both VPA mono- and polytherapy groups. 4. The blood level of ammonia was inversely correlated with the serum level of carnitine in both VPA mono- and polytherapy groups. It can be concluded that reduction of serum carnitine should be considered in epileptic patients taking VPA therapy, although the clinical symptoms of carnitine deficiency were not found in patients of our study, and the measurement of blood ammonia may be the useful parameter to predict hypocarnitinemia.

신생아실에서 수술을 요했던 환아들의 임상관찰

한지환 ( Ji Whan Han ),이수중 ( Soo Jung Lee ),전정식 ( Chung Sik Chun ),조성훈 ( Sung Hoon Cho ) 대한주산의학회 1991 大韓周産醫學會雜誌 Vol.2 No.2

천식 증상이 주증인 위식도 역류성 질환 1 례

한규승(Kyu Seung Han),이수중(Soo Jung Lee),이준성(Joon Sung Lee) 대한소아알레르기호흡기학회 1997 소아알레르기 및 호흡기학회지 Vol.7 No.1

Gastroesophageal reflux(GER) is a common clinical problem, classically manifested by regurgitation or nonprojectile vomiting. Other respiratory manifestations such as chronic cough, asthma, and recurrent pneumonia are being increasingly recognized; the so-called atypical or extraesophageal manifestations. The relationship between GER and pulmonary complications has been recognized since the 1960s. The association of GER and pulmonary disease is further supported by reports showing the relief of respiratory symptoms and improvement in results of pulmonary function tests after medical or surgical antireflux treatment in asthmatics. Two different mechanisms for GER-associated pulmonary diseases have been postulated: (1) microaspiration of gastric contents into the lung resulting in an inflammatory reaction, the reflux theory, and (2) activation by GER of a vagal reflex are from the esophagus to the lung resulting in bronchoconstriction, the reflex theory. Many diagnostic tests have been proposed to evaluate the presence of GER disease, 24-hour esophageal pH monitoring has been reported to have a higher sensitivity and specificity than any other single clinical test. It is considered as the gold standard method. We experienced a case of infantile asthma due to GER diagnosed by 24-hour esophageal pH monitoring in seven-month-old infant who presented wheezing and dyspnea. She was much improved clinically and at follow-up pH monitoring for respiratory symptoms and reflux with medical antireflux therapy(cisapride).

아토피성 천식 환자에서 특이적 면역요법이 말초혈액 단핵구의 IL-10 과 IL-13 mRNA 발현에 미치는 영향

이준성(Joon Sung Lee),이수중(Soo Jung Lee),이경수(Kyong Su Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1999 소아알레르기 및 호흡기학회지 Vol.9 No.1

목 적 : 알레르기 질환의 치료에서 특이적 면역요법이 임상적인 치료효과를 가저오는 면역학적 작용기전은 명확하지 않다. 본 연구에서는 집먼지진드기 항원으로 특이적 면역요법를 받고 있는 천식환자들의 말초혈액 단핵구를 집먼지진드기 항원으로 자극하였을 때 발현되는 cytokine mRNA 양상을, 정상 대조군과 집먼지진드기에 대한 알레르기가 있으나 면역요법를 받지 않은 천식환자들에서의 양상과 비교하여 cytokine의 발현과 면역요법의 임상적인 치료반응과의 상관관계를 알아보고자 하였다. 방 법 : 알레르기 병력이 없는 정상 대조군 8명, 집먼지진드기 알레르기에 의한 천식 증상을 보이나 면역요법을 받지 않은 비면역요법군 25명, 그리고 일년 이상 집먼지진드기 백신으로 면역요법을 시행하여 임상적으로 호전을 보이지 않은 면역요법 무반웅군 19명과 증상의 호전을 보인 면역요법 반응군 20명의 말초혈액 단핵구를 분리하여 집먼지진드기 항원으로 18시간 자극배양하고 RNA를 분리한 다음 RT-PCR을 시행하여 전기영동 한 후 IL-10, IL-13, IFN-γ, IL-4 mRNA 함량을 densitomet로 측정하였다. 결 과: 1) 면역요법을 받지 않은 천식환자에서 정상 대조군에 비해 IL-10 mRNA의 발현이 유의하게 낮고, 면역요법시 IL-10 mRNA의 발현이 증가되었다. 임상적 호전을 보인 면역요법 반웅군이 무반응군보다 유의하게 IL-10 mRNA 발현이 증가되며, 정상 대조군 수준으로 IL-10 mRNA의 발현이 증가되었다. 2) 면역요법을 받지 않은 천식환자에서 정상 대조군에 비해 IL-13 mRNA의 발현이 유의하게 높고, 면역요법시 IL-13 mRNA의 발현이 감소되었다. 임상적 호전을 보인 면역요법 반응군이 무반응군보다 유의하게 IL-13 mRNA 발현이 감소되며, 정상 대조군 수준으로 IL-13 mRNA의 발현이 감소되었다. 3) 면역요법을 받지 않은 천식환자에서 정상 대조군에 비해 IFN-γ mRNA의 발현이 유의하게 낮고, 면역요법시 IFN-γ mRNA의 발현이 증가되었다. 임상적 호전을 보인 면역요법 반응군이 무반응군보다 유의하게 IFN-γ mRNA 발현이 증가되며, 정상 대조군 수준으로 IFN-γ mRNA 발현이 증가되었다. 4) 면역요법을 받지 않은 천식환자에서 정상 대조군에 비해 IL-4 mRNA의 발현이 유의하게 높고, 면역요법시 IL-4 mRNA의 발현이 감소되었다. 임상적 호전을 보인 면역요법 반응군이 무반응군보다 유의하게 IL-4 mRNA 발현이 감소되며, 정상 대조군 수준으로 IL-4 mRNA의 발현이 감소되었다. 결 론 : 집먼지진드기 알레르기에 대한 특이적 면역요법은 T_H2(IL-4, IL-狀)에서 T_H1(IFN-γ)으로 cytokine 발현의 변화를 유도하며 또한 IL-10의 생성을 증가시킴을 알 수 있었다. 이러한 cytokine 발현의 변화가 면역요법의 임상적 효과를 초래하는데 일부 기여할 것으로 생각된다. Purpose : Allergen-specific immunotherapy(IT) has been shown to be effective in the treatment for allergic diseases. But the immunologic mechanism of IT effect has not been fully elucidated. We studied house dust mite(HDM)-specific cytokine mRNA expression in peripheral blood mononuclear cells(PBMC) from patient with HDM-sensitive asthma and determined whether alterations in cytokine mRNA expression correlated with the clinical outcome of IT. Methods : PBMC were obtained from 64 children with mite-sensitive asthma : 25 had never received HDM-IT(NIT), 39 had been receiving HDM-IT for more than 12 months. The 39 patients were divided into two groups according to the clinical response based on the asthma scores(symptom and medication scores) before and after IT. Good responders were those patients who showed an improvement greater than 50%, whereas poor responders were those who showed an improvement less than 50%. After a 18 hr culture with HDM, cytokine mRNA expression was analysed by RT-PCR and densitometry. Results : 1) IL-10 mRNA expression in NIT was significantly lower than that in the normal controls and was significantly increased by IT. IL-10 mRNA expression in the good responders was significantly higher than that in the poor responders and NIT. 2) Little or no IL-13 mRNA were detected in the good responders and the normal controls. IL-13 mRNA expression in the good responders was significantly lower than that in the poor responders and NIT. 3) IFN-γ mRNA expression in NIT was significantly lower than that in the normal controls and was significantly increased with IT. IFN-γ mRNA expression in the good responders was significantly higher than that in the poor responders and NIT. 4) Little IL-4 mRNA were detected in the good responders and the normal controls. IL-4 mRNA expression in the good responders was significantly lower than that in the poor responders and NIT. Conclusion : These results show that IT not only induces a shift in cytokine expression from T_H2(IL-4 and IL-13) to T_H1 cytokines(IFN-γ), but also leads to induction of the antiinflammatory cytokine IL-10. These changes in cytokine expression may be responsible for clinical effects by immunotherapy.

인공위성 이중화 아이템의 고장률 적용 방안 사례 연구

최효준(Hyo-Jun Choi),이수중(Soo-Jung Lee),안재현(Jae-Hyun Ahn),이정훈(Jung-Hoon Lee) 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.10

인공위성은 지상 무기체계와 달리 고장 시 하드웨어 정비가 제한적이다. 따라서, 신뢰성이 매우 중요하기 때문에 개발 단계에서 신뢰성을 높이기 위한 업무를 수행하고 있다. 신뢰도 목표값을 충족하는 설계가 되었는지 신뢰도 예측을 수행하고 있다. 신뢰도 예측 결과는 여러 가지 요소에 따라 영향을 받으며, 신뢰도 예측의 정확성을 높이기 위하여 이 요소들을 정확히 정의하고 분석하는 것이 매우 중요하다. 인공위성은 대부분의 구성품에 이중화 설계가 적용되어 있기 때문에, 본 연구에서는 신뢰도 예측의 정확성을 높이기 위한 한 요소로서 이중화 아이템 고장률 값을 연구 대상으로 선정하였다. 이중화 아이템의 고장률이 신뢰도 예측에 미치는 영향성과 고장률 적용 방안에 대하여 분석하였다. 첫째, 이중화 아이템 고장률 적용 기준에 대한 연구 사례를 확인하였다. 둘째, 고장률의 차이에 따른 신뢰도 예측 결과에 대한 영향성을 분석하였다. 또한, 이중화 아이템 고장률 적용 방안에 대한 이론적 3가지 방안을 확인하였다. 마지막으로 실제연구·개발된 인공위성의 데이터로 3가지 방안을 각각 적용하였을 때, 결과에 미치는 영향성과 가장 적절한 방안을 확인하였다. 이를 통해 본 연구는 인공위성 신뢰도 예측의 정확성을 높이기 위한 이중화 아이템 고장률 적용 방안을 제시하였다. Unlike ground weapon systems, artificial satellites are difficult to maintain in the case of failure. Therefore, work is being done to increase reliability in the development stage. In addition, it reviewed whether reliability prediction has become a design that satisfies the required reliability. The reliability prediction results are affected by various factors, and it is very important to accurately define and analyze these factors to increase the accuracy of reliability prediction. Because most components of satellites are designed with redundancy, this study evaluated the method of applying redundant item FIT (Failure in time) to increase the accuracy of reliability prediction. This study analyzed the influence of the FIT of redundant items on reliability prediction and the application of the FIT of redundant items. First, this study reviewed the cases applying the redundant item FIT. Second, the reliability prediction result was analyzed according to the FIT difference. In addition, three theoretical methods for applying the redundant item FIT were reviewed. Finally, this study found the impact on the reliability prediction results and the most appropriate method when each of the three methods was applied to the reliability data of satellites for which actual research/development was carried out. This paper proposed a method for applying the FIT of redundant items to increase the accuracy of satellite reliability predictions.

Asphyxiating Thoracic Dystrophy 1례

김영유,이승철,이수중,한지환,황성수,이경일 최신의학사 1992 最新醫學 Vol.35 No.6

만성 기침 환자에서 발견된 기관지 점액표피양 암종 1례

서경희,이수중,오진희,김종현,고대균 대한 소아알레르기 및 호흡기학회 1999 소아알레르기 및 호흡기학회지 Vol.9 No.2

Mucoepidermoid carcinoma of the bronchus is a very rare tumor comprising only 0.1-0.2% of primary lung cancers and characterized by mixture of mucus-secreting cells, squamous cells, and cells of intermediate type. It occurs in any age from 3 months to 78 years, but nearly half of the cases are younger than 30 years. It usually occurs in the main or lobar bronchi as a soft, vascular polypoid mass that induces bronchial obstruction, recurrent pneumonia, chronic cough, and/or hemoptysis. Although mucoepidermoid carcinomas of the bronchi are known to have malignant potential, generally appear to behave in benign fashion in children and making conservative pulmonary resection sufficient and adequate as a therapy. We describe a case of mucoepidermoid carcinoma of proximal left lower lobe bronchus in 10-year-old girl, nearly completely obstructing the lower lobe bronchus and partially obstructing the upper lobe bronchus.