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성장호르몬 결핍증 환아에서 성장호르몬 치료가 혈청 leptin 농도에 미치는 영향
오진희,이병철 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4
Background: Leptin the ob gene product is secreted by adipocytes and binds to specific receptors in the central nervous system regulating energe intake and expenditure. Correlation between fat mass and leptin level is well established. However, data on the hormonal regulation of the leptin in human are scarce. Growth hormone (GH) has lypolytic action and patients with growth hormone deficiency (GHD) have showed higher leptin levels than expected for the obesity We investigated the changes in serum leptin levels and body mass index in children with GHD during GH therapy. Methods: Thirty children with GHD participated. All subjects were 5~13 years old and in prepubertal stage. The causes of GHD were idiopathic in 15 and organic in 15 children. Patients received GH 0.6.7 IU/kg/week subcutaneously, in 67 divided doses and investigated at baseline and after 6 and 12 months of GH treatment. Serum leptin levels were determined with a human leptin and IGF-1 radioimmunoassay (Linco Research and Nichols Institute, USA). Results: The height velocity was increased significantly after 12 months of GH treatment. Serum leptin concentrations were significantly reduced after 6 and 12 months of treatment but revealed no significant differences in the sex and the causes of GHD. Body mass indices were significantly reduced after treatment. Serum leptin levels positively correlated with body mass index at baseline and after 6 and 12 months of GH treatment. The serum IGF-1 level were increased significantly after GH treatment and did not significantly correlated with leptin levels at baseline and after treatment. Conclusion: This study demonstrated that serum leptin and body mass index were decreased with significant positive correlation during GH treatment in children with GHD (J Kor Soc Endocrinol 15:493-501, 2000).
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오진희 한국사회법학회 2020 社會法硏究 Vol.0 No.41
이 글은 가사서비스를 제공하는 가사근로자의 법적 보호 및 사회보장권과의 관계 를 정부 및 의원들이 제출한 법률안을 비교 검토한 다음 정부안 적용 시 예상되는 노동법적 문제점을 분석하고 개선방안을 모색하였다. 사적인 영역에서 비공식으로 이루어지는 가사노동을 공식화하기 위한 정부법안은 우선 가사근로자의 고용안정 및 권익향상, 일자리의 질 제고를 통한 일자리창출에 목적을 두고, 가사서비스 제공방식은 종래의 직업소개소나 중개기관, 사인 간 알선 을 통한 비공개 가사서비스 부문을 그대로 두면서, 인증 받은 가사서비스 제공기관 을 새롭게 만들어 가사근로자를 직접고용하고, 가사서비스 이용자에게 가사서비스를 제공하는 방식을 채택하였다. 그리고 가사근로자와 근로기준법상 가사사용인의 구별 을 통한 근로기준법에 대한 특례규정을 두어 법적 보호를 강구하였다. 정부안이 갖는 문제점은 공식 비공식 가사근로자는 근로기준법상 제외되는 가사 사용인으로 남게 되어 정부안에 따른 공식 가사근로자와의 차별문제, 이용자와 비공 식 가사근로자간의 갈등 문제, 가사근로자가 두 개의 가사서비스 제공기관과 이중계 약을 할 경우 사회보장법상의 문제 등이 입법적으로 완전히 해결되었다고 볼 수 없 다. 공식 가사근로자와 비공식 가사근로자의 법상 차별을 해소하는 방안은 근로기준 법상의 가사사용인 적용배제조항을 삭제하는 것이지만, 가사근로자에 관한 특별법 제정이 근로기준법 적용제외를 전제로 하는 것이므로 이에 대해서는 사회적 합의가 필요하다. This article compared and reviewed legislation submitted by the government and lawmakers on the relationship between legal protection and social security rights of domestic workers providing household services. Based on this, the labor law problems expected in the application of the government bills were analyzed, and improvement measures were suggested. The government's legislation to formalize unofficial domestic labor in the private sector aims to create jobs by stabilizing employment and enhancing rights and interests of domestic workers, and improving job quality. While keeping the conventional job agency, private household service through mediation between unofficial route sector, the method of providing household service by creating a new certified household service provider or agency was also adopted. And legal protection was sought by establishing special provisions for the Labor Standards Act through the distinction between domestic workers and domestic workers under the Labor Standards Act. The problems of the government proposal are as follows. First, official and unofficial domestic workers are remain as excluded domestic workers under the Labor Standards Act, and there is a problem of discrimination against official domestic workers according to the government proposal. Second, there could be a conflict between the user and unofficial domestic worker. Lastly, if a domestic worker make a double contract with two household service providers, it cannot be considered that the problems under the Social Security Act have been completely resolved legislatively. The way to resolve discrimination under the law between official and unofficial domestic workers is to delete the exclusion clause for domestic workers under the Labor Standards Act. But since the enactment of a special law on domestic workers presupposes the exclusion of the Labor Standards Act, social consensus is required for this.
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Changes in Oral Malodor According to Menstrual Cycle for Women
오진희,조병근,박우령,조자원 대한예방치과학회 2014 International Journal of Clinical Preventive Denti Vol.10 No.2
Objective: The objective of this study is to investigate intraoral factors which take a severe part, general illness and smoking to exam the change of halitosis within the woman's menstural cycle. Methods: We examined the halitosis changes per menstruation cycle using the sensory evaluation and mechanical halitosis measurement. Results: According to the sensory evaluation, there were no significant changes per phase; menstruation, follicular, ovulation and luteal (p>0.05). According to the BB Checker (Tokuyama Soda Co. Ltd., Tokyo, Japan), there were no significant changes in the BB values per phase when it comes to the intra-oral gas, exhaled gas and nasal gas (p>0.05). According to the Oralchroma measurement, the mean of hydrogen sulfide was 1.46±2.25 ng/10 ml at the menstruation phase, 1.57±1.62 ng/10 ml at the follicular phase, 0.58±0.70 ng/10 ml at the ovulation phase and 1.25±2.57 ng/10 ml at the luteal phase, getting slightly lower, yet no statistical significance was recognized (p>0.05). According to the Oralchroma measurement, there was no significant change per phase in terms of the measured methyl mercaptan and dimethyl sulfide values (p>0.05). When the halitosis changes according to the menstruation cycle were checked, there were no significant periodic changes, yet H2S, the volatile sulfur compound, dropped a little during the ovulation phase. Conclusion: It is believed that the menstruation cycle may impact the halitosis changes as variables like systematic diseases and intra-oral factors are excluded; However, it may not have a great impact on the severity of halitosis.
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