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Expression of VEGF, p53, Apaf-1 and Caspase-9 in Head and Neck Squamous Cell Carcinoma
이성학,강여주,조의주,이연수,강창석,Lee, Sung Hak,Kang, Yeo Ju,Jo, Ui Ju,Lee, Youn Soo,Kang, Chang Suk The Korean Society for Head and Neck Oncology 2012 대한두경부 종양학회지 Vol.28 No.2
배 경 편평상피암은 두경부의 악성종양 중 가장 흔하며, 임상적인 경과가 불량하다. 따라서 나쁜 예후를 가지는 환자군을 조기에 선별하여 더 적극적인 치료의 시행을 결정짓는 표지자의 필요성이 대두된다. 우리는 일련의 두경부 편평세포암 검체에서 몇몇 분자 표지자의 예후적 유용성을 평가하고자 하였다. 방 법 23예의 두경부 편평세포암 검체를 대상으로 VEGF, p53, Apaf-1, caspase-9의 발현과 몇몇 임상병리학적 지표들간의 연관성을 면역조직화학염색을 통해 조사하였다. 결 과 환자군은 남성이 더 많았으며 평균연령은 63.7세였다. 1기가 5예, 2기가 2예, 3기가 8예, 4기가 8예였다. 평균생존기간은 37.3개월이었다. VEGF단백 발현은 종양의 크기와 통계적으로 유의한 연관성을 보였다. 이와 더불어 VEGF단백 발현은 병기, 그리고 림프관 침습과 연관적인 경향성을 보였다. 그러나 VEGF단백 발현과 생존기간과는 관련성이 없었다. 또한, Apaf-1과 caspase-9의 단백발현은 다른 임상지표, 환자의 생존기간과는 관련이 없었다. 결 론 VEGF단백 발현은 두경부 편평세포암 환자에서 나쁜 임상경과를 예측할 수 있게 하는 표지자로서의 역할을 할 수 있다. 또한 본 연구는 두경부 편평세포암에서 별로 연구되지 않은 Apaf-1과 caspase-9의 발현상태를 밝힌 점에서 의의가 있다.
청소년의 방과 후 스포츠 활동 참여가 심리적 변인(우울증, 공격성, 불안)에 미치는 영향
이성학(Sung Hak Lee),원주연(Joo Yeon Won),권정두(Jung Du Kwon) 한국청소년문화연구소 2012 청소년 문화포럼 Vol.- No.31
This study is aimed at studying the effect of After-school Sport Participation on Youth`s psychological variable(Depression, Aggression, Anxiety). The experiment carried out 619(middle school students) for 4hours per week for 12weeks through soccer, basketball, netball. After the experiment, data were collected by questionnaire. Through analyzing SPSS 14.0 statistical program, the results were as follows. 1, According to the studying of After-school Sports Participation on Youth`s Depression, statistically significant results appeared(p<.001). In Depression change between boys and girls, they are significant influenced by After-school Sport Participation but there is no change between each grade(p<.05). 2, According to the studying of After-school Sports Participation on Youth`s Aggression, statistically significant results appeared(p<.05) before and after this experiment. In Aggression change between grade, second grade students are higher than first grade students(p<.01). In Youth`s Aggression change between boys and girls, statistically significant results didn`t appear. 3, According to the studying of After-shool Sports Participation on Youth`s Anxiety, statistically significant results didn`t appear before and after this experiment. In Youth`s Anxiety change between boys and girls, statistically the level of girls is lower than boys(p<.01). In Anxiety change between grade, second grade students are lower than first grade(p<.01) In short, After-school Sports Participation have a positive effect on Youth`s psychological variable (Depression, Aggression, and Anxiety).
고에너지 전자빔 투사방법으로 제조된 VC / 탄소강 표면합금화 재료의 템퍼링에 의한 경도향상
이성학(Sung Hak Lee),어광준(Kwang Jun Euh),김용찬(Yong Chan Kim),신기삼(Kee Sam Shin),김락준(Nack J. Kim) 대한금속재료학회 ( 구 대한금속학회 ) 2002 대한금속·재료학회지 Vol.40 No.9
This study aimed at improving hardness by tempering of VC/carbon steel surface-alloyed material fabricated by high-energy electron-beam irradiation. The mixture of VC powders and flux (50%MgO-50%CaO) was placed on a plain carbon steel substrate, and then electron beam was irradiated on this mixture using an electron beam accelerator. The surface-alloyed layer of 1.8 mm in thickness was homogeneously formed without defects. The microstructural analysis indicated that VC particles were coarsely formed along solidification cell boundaries, and the matrix inside cells was mostly composed of lath-type martensite and fine cuboidal VC particles. A large amount (10.1 vol.%) of these VC particles in the lath-type martensitic matrix improved hardness four times greater than that of the substrate. When the VC/steel surface alloyed material was tempered, a number of fine VC particles were precipitated in, the tempered martensitic matrix, thereby leading to the additional hardness improvement. Therefore, the hardness of the surface-alloyed layer was further enhanced by tempering, while the residual stress in the layer could be removed and the fracture toughness could be increased.