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양한석(Han-Suk Young),서석수(Suk-Soo Suh),이경희(Kyung-Hee Lee),이지현(Ji-Hyon Lee),최재수(Jae-Sue Choi) 한국식품영양과학회 1992 한국식품영양과학회지 Vol.21 No.3
고들빼기의 부위별 메탄올 엑스가 고콜레스테롤 생쥐의 혈청 콜레스테롤농도에 미치는 영향을 살펴보았다. 고콜레스테롤 생쥐는 식이에 1% 콜레스테롤과 0.5% 답즙산을 첨가하므로서 유도하였으며, 잎의 메탄올 엑스를 투여한 군은 대조군에 비해 혈청 콜레스테롤 농도를 현저히 감소시켰으나 뿌리의 경우에는 효과가 나타나지 않았다 . 또한, 잎의 메탄올 엑스는 고콜레스테롤 흰쥐에 대해서도 100㎎/㎏ 투여 용량에서 혈청 콜레스테롤 농도를 현저히 감소 시켰으며 동맥경화성 지표를 개선시켰다. 반면에, 정상흰쥐에 대해서는 효과가 나타나지 않았다. 이상과 같은 결과로 잎의 메탄올 엑스는 과잉의 콜레스테롤을 섭취하였을때 체내대사 이용도를 증가시키므로서 혈청 콜레스테롤 농도를 감소시킨다고 생각된다. The methanol extracts from different parts of Ixeris sonchifolia (Compositae) were evaluated for their total cholesterol lowering effect in mice. Mice were rendered hypercholesterolemic with 1% cholesterol and 0.5% cholic acid. Significant lowering in serum cholesterol was observed in mice with the methanol extract from leaves (MeOH-LF), whereas the methanol extract from roots (MeOH-RT) was devoid of this effect. In rats with cholesterol-induced hyperlipidemia MeOH-LF in a dose of 100㎎/㎏ body weight caused significant decrease of total cholesterol, and the atherogenic index was also improved. On the other hand, total cholesterol in rats fed a stock diet was not affected by administration of the MeOH-LF. Thus, it is suggested that this MeOH-LF probably may increase the metabolic utilization only when fed with excess cholesterol.
Adenine 유발 신부전 흰쥐에서의 뇨중 Kallikrein의 변화
이태웅(Tae Woong Lee),서석수(Suk Soo Seo),이경희(Kyung Hee Lee),양한석(Han Suk Young),정준기(Joon Ki Chung),최재수(Jae Sue Choi) 大韓藥學會 1991 약학회지 Vol.35 No.6
In order to investigate whether the function of distal nephron is disturbed in adenine-induced renal failure rats, we measured the urinary kallikrein level in adenine-ingesting rats fed on 0.75% adenine diet for 1 to 10 days. Administration of 0.75% adenine to rats significantly increased blood urea nitrogen level and urine volume, while the level of kallikrein along with the urinary excretions of urea and inorganic phosphate were significantly decreased. From these results, it is suggested that adenine-induced renal failure is caused by early deterioration of distal nephron as well as proximal nephron.
토혈을 주소로 내원한 선천성 간섬유종 환자에서 내시경적 정맥류결찰술 치료 경험 1예
이승환,김현영,김승용,신영록,김연석,나비석,이석수,강길현,유철희 대한소화기학회 2000 대한소화기학회지 Vol.35 No.5
Congenital hepatic fibrosis (CHF) is characterized by periportal fibrosis with irregulary shaped proliferating bile ducts and is recognized as a member of the fibrocystic disease family. It is such a rare disorder that only about 200 patients with CHF has been reported. Affected children or adults often show portal hypertension and related complications, which may lead to bleeding from gastroesophageal varices. The diagnosis of CHF is usually confirmed by its typical histological features. The patients with portal hypertension due to CHF are ideal candidates for portosystemic shunt because most of them have good liver function. Recently, we experienced a case of CHF without hepatic and renal lesions presenting with hematemesis. Endoscopic variceal ligation was performed. We report this case with a review of relevant literatures.
이승환,김현영,김명환,이성구,서동완,민영일,유교상,손정민,나비석,이석수,심선진,전병민 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.3
A Pancreaticobiliary fistula is a rare complication of acute necrotizing pancreatitis or pancreatic abscess. One case is herein reported of pancreaticobiliary fistula that was found following removal of pancreatic duct stones by extracorporeal shock-wave lithotripsy and endoscopic sphincterotomy. The patient was a 53-year old woman who was admitted with epigastric pain and fever. Endoscopic retrograde pancreatography revealed multiple stones in the main pancreatic duct. Pus from the pancreatic duct was drained through the major papilla during cannulation. On balloon cholangiogram obtained after removal of the stones, a direct fistulous connection between the main pancreatic duct and distal common bile duct was noted. It is speculated that pancreatic abscess or mechanical compression of pancreatic duct stones may contribute to the destruction of the intrapancreatic bile duct, which leads to the formation of a pancreaticobiliary fistula.
각종 췌장질환에서 Somatostatin Analogue 사용 경험
김현영,김명환,박현주,이성구,서동완,민영일,신영록,이석수,전병민,표승일,유교상 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6
Background/Aims: Octreotide, long-acting analogue of somatostatin, has been used for symptomatic carcinoid syndrome and vasoactive intestinal peptide-producing tumors. In pancreatic diseases, however, the effect of octreotide has not been settled yet. The aim of this study was to evaluate the effect of octreotide in various pancreatic diseases which did not respond to conventional medical treatment. Methods: We reviewed retrospectively the medical records of 28 patients who were admitted at the Asan Medical Center from January 1997 to June 1999. Their diseases were pancreatic fistula (n=9), pancreatic pseudocysts (n=17), and pancreatic ascites (n=2). Octreotide was administered subcutaneously at a dose of 0.1 mg every 12 hours. Results: In the cases of pancreatic fistulas, the mean output of baseline fistula was 289 cc/day. This was decreased to 178 cc/day on the first day of octreotide therapy and to 49 cc/day on the seventh day. Five (56%) patients eventually closed their fistulas. In the cases of pancreatic pseudocysts, 11 (65%) cases had showed complete resolution of pseudocysts. The remaining 6 cases which showed no improvement were treated operatively. In the cases of pancreatic ascites, the two patients (100%) were successfully treated with octreotide. Conclusions: Octreotide seems to be a safe and useful alternative therapy in patients with pancreatic fistulas, pseudocysts or ascites who do not respond to conventional medical management. Further detailed study may be necessary for the establishment of the role of octreotide in the treatment of various pancreatic diseases.