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증 례 : 최소변화콩팥병증이 동반된 골수형성이상증후군 환자에서 스테로이드 치료
이상아 ( Sang Ah Lee ),임장환 ( Jang Hwan Lim ),장지훈 ( Ji Hun Jang ),장순희 ( Soon Hee Chang ),곽은경 ( Eun Kyoung Kwak ),이덕현 ( Duk Hyun Lee ),이선아 ( Sun Ah Lee ) 대한내과학회 2016 대한내과학회지 Vol.90 No.1
본 증례는 신증후군과 범혈구감소증이 있는 환자에서 골수형성이상증후군과 최소변화콩팥병증이 동시에 진단된 경우이다. 최소변화콩팥병증은 골수형성이상증후군에 동반된 방종양성 사구체신염으로 생각되며 면역억제제인 프레드니 솔론을 투여하면서 단백뇨의 호전 및 혈액, 골수 소견의 호전을 보인 것으로 보아 발병기전에서 면역체계의 이상이 중요하였음을 알 수 있다. 골수형성이상증후군 특히 모세포증가 불응빈혈-2에서 최소변화콩팥병증의 발생은 국내외에서 처음 보고하는 바이다. Glomerulonephritis associated with malignancy is deemed to be paraneoplastic glomerulonephritis. Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal hematopoietic stem cell disorders characterized by impaired hematopoietic cell differentiation and cytopenia. The pathophysiology of MDS is thought to be immune-mediated in part. A few reports have documented various forms of glomerulonephritis in patients with MDS and suggested that immune dysregulation is important in the development of paraneoplastic glomerulonephritis. Here, we report a patient with MDS and refractory anemia with excess blast-2 accompanied by minimal change nephrotic syndrome. The patient was treated with prednisolone, and the nephrotic-range proteinuria and pancytopenia improved markedly. (Korean J Med 2016;90:63-67)
이상학(Sang Hak Lee),은희철(Hee Chul Eun),이유신(Yoo Shin Lee) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.4
A 54-year-old male patient with acute lymphocytic leukemia was consulted to our department. He had had a few painful erythematous necrotic plaques on the chest, which suggested initslly vasculitis or pyoderma. On histological examination, characterisitic histological findings of non-septated large hyphae were observed in the dermis and subcutaneoustissue, Although organism was not isolated on Sabouraud agar media containing cycloheximide, the diagnosis of cutaneous mucormycosis was made by the characteristic histological nattlre. He died after 2 weeks with amphotericin B intravenous injections so that additional fungus culture was not performed.
이상일(Sang Il Lee),강형진(Hyung Jin Kang),이숙희(Sook Hee Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 소아알레르기 및 호흡기학회지 Vol.4 No.2
N/A Allergic rhinitis and sinusitis are independently common disorders, and their association is also recommended as the study, we observed cromoglycate and one very common. For the treatment of sinusitis, antibiotics is first choice, whether it is due to allergy or non-allergy. In this the effect of anti-allergic treatment (two weeks of disodium week of topical budesonide) for sinusitis in allergic rhinitis. Among 299 children with chronic nasal symptoms, 235(78.6%) children were allergic and 64(21.4%) children were non-allergic. One hundred fifty two(64.6%) children with allergic rhinitis had sinus problems on X-ray study. (Table 1) Firstly, we treated them with two weeks of anti-allergic drugs. Antihistamines and antibiotics were not included. One hundred seven(70.4%) children were improved clinically and radiologically. Forty five(29.6%) children who were not improved, received amoxicillin for 2 weeks, and 33 were improved. Among 12 children who did not responded to amoxicillin, cefaclor or reeducation were effective in 4 patients and anatomical deformities were found in 2 cases. In conclusion, anti-allergic treatment must be the first line up treatment for the sinusitis associated with allergic rhinitis.
이상인(Sang In Lee),김기황(Ki Hwang Kim),남수연(Su Youn Nam),박효진(Hyo Jin Pack),이희대(Hee Dai Lee),정우희(Woo Hee Jung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
Although the greater omentum is frequently the site of metastatic neoplasm, primary omental tumors are exeedingly rare. The authors report here, a case of primary omental leiomyosarcoma presented initially as a palpable abdominal mass and epigastic discomfort for one year in a 66 year-old rnale patient. At laparotomy, 21*15*2.5 cm rnass weighing 600 gram was found in the omentum which was adherent to the anterior wall of the lower body of the stomach and liver surface. In the histologic findings presence of tumor necrosis, increased cellularity, cellular atypia and pleomorphism as well as large size of mass were indicative of leiomyosarcoma. Surg cal resection has been known to be the principle treatment for this disease, In this case, excision of the tumor with omentectomy, radical subtotal gastrectomy and wedge resection of the liver were performed. Eight months later, a recurrence was detected and chemotherapy with doxorubicin, dacarhazine, vincris- tine, and cyclophosphamide was done.
이상은 ( Sang Eun Lee ),박미옥 ( Mi Ok Park ),김은희 ( Eun Hee Kim ),이수희 ( Su Hee Lee ),박선화 ( Seon Hwa Park ),김민정 ( Min Jung Kim ),안치영 ( Chi Young Ahn ),김윤영 ( Yun Young Kim ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Standardization of the manufacturing and processing of cell therapy products is necessary to ensure patient safety, establish efficacy, and demonstrate potency. Cell therapy products often involve small cell samples mostly to be used in patient-specific manner. And not for chemotherapy, have a distinct characteristic of time limitation from development to administration into patients and should be performed within short period. Pharmacopoeia sterility testing are not applicable for cell therapy products. The purpose of this study was to establish of appropriate sterility test(culture method) for cell therapy product. We investigated various sample size(number of tube), media amount and inoculation amount of pharmacopoeia sterility testing and suggested minimum sterility test suitable for cell therapy products under 2 samples, 2 mL media and 1% inoculating condition. Method validation was performed to demonstrate specificity and detection limit by Bacillus subtilis and Candida albicans. Compared to the pharmacopoeia sterility testing(10 CFU/mL), detection limit of suggested sterility test(100 CFU/mL) was more insensitive but time to detection of organisms was equivalent. Our data demonstrate that the assay system is a good tool for supporting the diagnosis of bacterial contamination, thereby being applicable as sterility test for evaluation contamination within cell therapy products.
Twin converter를 이용한 전자식 안정기에 관한 연구
이상집(Sang-Chip Lee),한홍일(Hong-Il Han),성낙규(Nark-Kuy Sung),백동현(Dong-Hyun Baek),김성남(Sung-Nam Kim),한경희(Kyung-Hee Han) 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11
The rectifier circuit has been used in the various fields of inverter progress. This is simple and low price. Otherwise, it has many problems in harmonic, low power factor and etc.<br/> This paper use the twin converter of two jewel booster. It doesn't need the detection of voltage, current and control PWM. The twin converter has stably the rectification source. Also, the circuit is used a half-bridge inverter in the electronic ballast for lighting. Therefore, this method is confirmed in high efficiency.