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      • KCI등재

        실험적 성대마비 개에서 자가이개연골의 성대근육내 주입 후 조직학적 변화 : 2년 후 결과

        이병주,이진춘,전경명,고의경,노환중,이창훈,왕수건,Lee Byung-Joo,Lee Jin-Choon,Chon Kyong-Myong,Goh Eui-Kyung,Roh Hwan-Jung,Lee Chang-Hun,Wang Soo-Geun 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.2

        Background and Objective : Vocal fold augmentation by injectable material under direct visual control is an easy and simple operation. However, when autologous fat or bovine collagen is used, the resoiption creates a problem. And autologous fascia is debating about absorption now days. We previously reported on the one year results of injected autologous auricular cartilage for volumetric augmentation in paralyzed canine vocal cord. This study evaluates the long-term histomorphologic results of injected autologous auricular cartilage for the augmentation of the paralyzed canine vocal fold at two year. Material and Methods . A prospective trial of autologous cartilage augmentation of vocal cord in animal model. Three dogs were operated upon. A piece of auricular cartilage was harvested from the ear and minced into tiny chips with a scalpel. Fat was harvested from inguinal area and minced with a scalpel. The minced cartilage and fat-paste (0.2ml) was injected using a pressure syringe into the paralyzed thyroarytenoid muscle using direct laryngoscopy. Three animals were sacrificed at 2 years. Each subject underwent laryngectomy and serial coronal sections of paraffin blocks from the posterior vocal fold were made. Results There was no significant complication perioperatively and during follow-up. The injected cartilage which appeared to have lost viability existed in the vocalis muscles until 24 months. Fibrotic change was exhibited in the surrounding injected cartilage. Conclusion : The autologous auricular cartilage graft is well tolerated and may be very effective material for volumetric augmentation on paralyzed vocal cord.

      • KCI등재

        소아의 단안 고도 근시성 부등시 눈에서 콘택트렌즈 착용과 약시 치료

        이병주,김정훈,유영석,Byung Joo Lee,Jeong Hun Kim,Young Suk Yu 대한안과학회 2010 대한안과학회지 Vol.51 No.1

        Purpose: To report the clinical outcome of children with unilateral high myopic anisometropic amblyopia who were treated with contact lenses (CL). Methods: Patients who had myopic anisometropia greater than -7 diopters and was treated with contact lenses combined with occlusion therapy during the period between 1998 and 2007 were retrospectively reviewed. Twenty-seven patients who were followed up for more than 1 year after treatment were included in the study. Initial and final best corrected visual acuities (BCVA) were compared and factors which influence the visual outcome were analyzed. Results: A total of 10 out of 27 patients (37%) acquired visual improvement of more than 2 lines. At the final examination, 6 patients (22.2%) had BCVA better than logMAR 0.3 and 10 patients (37.0%) had BCVA better than logMAR 0.7. Medullated nerve fiber and strabismus were the most commonly associated ocular pathologies among the patients. Patients without strabismus or medullated nerve fiber acquired greater visual improvement than patients with these comorbidities. Patients with lower initial refractive error (spherical equivalent) in the amblyopic eye acquired a better final vision. Poor compliance to CL wearing or occlusion therapy adversely affected the final vision. Conclusions: In the present study of children with unilateral severe myopic anisometropic amblyopia treated with CL combined with occlusion therapy, a third of the patients acquired visual improvement of more than 2 lines. The absence of medullated nerve fiber or strabismus was determined to be a good prognostic factor. J Korean Ophthalmol Soc 2010;51(1):88-94

      • KCI등재

        IEEE 802.15.3 Wireless PAN의 MAC에서 다중채널의 적용

        이병주,이승형,최웅철,정광수,이장연,조진웅,Lee Byung-Joo,Rhee Seung Hyong,Choi WoongChul,Chung Kwangsue,Lee Jang-Yeol,Cho Jin-Woong 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.8A

        본 논문에서는 IEEE 802.15.3 High-Rate WPAN (Wireless Personal Area Network) 환경에서 다중 채널을 사용하여 향상된 성능의 MAC 프로토콜을 제안한다. IEEE 802.15.3 High-Rate WPAN은 10m 내외의 거리에서 실시간 비디오 및 대용량 파일 전송을 목적으로 설계된 MAC과 PHY의 표준을 말한다. 현재 표준의 MAC 프로토콜은 하나의 무선 채널을 piconet 내의 모든 DEV가 공유하여 사용한다. 이 중 PNC(Piconet Coordinator)는 TDMA(Time Division Multiple Access)방식으로 DEV들에게 채널타임을 할당한다. 이런 경우 piconet내의 통신하는 DEV의 수가 많아지게 되면 superframe의 길이가 길어져 전송되는 데이터의 aggregate throughput이 떨어지고 QoS(Quality of Service)를 보장하지 못한다. 본 논문에서 하나의 piconet이 여러 개의 채널을 동시에 사용하여 aggregate throughput을 향상시키고 QoS를 보장하는 다중채널 MAC 프로토콜을 제안하고 시뮬레이션을 통해 향상된 성능을 증명한다. This paper presents a multi-channel enhancement scheme for the MAC protocol of IEEE 802.15.3 High-rate WPAN (Wireless Personal Area Network). The current MAC protocol of the IEEE 802.15.3 High-rate WPAN is designed for sharing a single channel among DEVs of a piconet; that is, within a single piconet, PNC prevents interference through MAC layer assignment of time slots to other DEVs using time-division multiple access. When the number of DEVs that communicate with each other frequently, is increased in a single WPAN, the size of the superframe becomes inevitably large, and this may result in a significant throughput drop or a failure to provide QoS guarantee. A multi-channel enhancement scheme for the MAC protocol of IEEE 802.15.3 High-rate WPAN is proposed to significantly increase the aguegate throughput and more reliably provide the QoS guarantees in a piconet

      • KCI등재

        Change of the Expression of Human Telomerase Reverse TranscriptasemRNA and Human Telomerase RNA after Cisplatin and 5-FluorouracilExposure in Head and Neck Squamous Cell Carcinoma Cell Lines

        이병주,Bae-Hyuk Lee,왕수건,이진춘,노환중,고의경,김철민,Eun-Sook Jun 대한의학회 2007 Journal of Korean medical science Vol.22 No.S

        Telomerase activity appears to be associated with cell immortalization and malignant progression. Understanding how telomerase activity is regulated in vivo is important not only for understanding the molecular biology of telomerase but also for the potential clinical application of anticancer drugs. This study evaluated telomerase activity and quantified the expression of human telomerase reverse transcriptase (hTERT) mRNA and human telomerase RNA (hTR) using a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method before and after the exposure of cisplatin and 5-fluorouracil (5-FU) in two head and neck squamous cell carcinoma (HNSCC) cell lines. Two human HNSCC cell lines (PNUH-12 and SNU- 899) were studied. Cell cytotoxicity, the change of telomerase activity, and hTERT mRNA and hTR expression by 5-FU and cisplatin exposure were assessed by MTT assay, TRAP assay, and real-time RT-PCR, respectively. In two cell lines, after cisplatin exposure, the telomerase activity and hTERT mRNA expression decreased, but hTR expression in- creased according to the concentration of drug. However, in both cell lines, the telomerase activity and hTR did not show any significant change after 5-FU treatment, but the expression of hTERT mRNA decreased. These results suggest that there may be other important regulating mechanism except hTERT mRNA as the regulation factor of telomerase activity in HNSCC cell lines.

      • SCOPUSKCI등재

        한국후박(韓國厚朴)(Machili Cortex)의 소화기계(消化器系)에 대한 약효연구(藥效硏究)

        이병주,정명현,Lee, Byoung-Joo,Chung, Myung-Hyun 한국생약학회 1994 생약학회지 Vol.25 No.3

        This study was attempted to investigate the effect of Machili Cortex extract(Machilus thunbergii Sieb. et Zucc. ) on digestive system in experimental animals. EtOH and MeOH extracts(E.E. and M.E.) were found to inhibit the charcoal transport rate in the small intestine of mice. E.E. exhibited the inhibition of spontaneous movement(motility) and tension in the ileum and colon strips of rabbit, and these actions were inhibited by action of acetylcholine. E.E. and M.E. given intraduodenaly(i.d.) exhibitied the significant decrease of gastric acid secretion in pylorus-ligated rats. E.E. and M.E. inhibited the formation of some experimental gastric ulcers(pylorus ligation-ulcer i.d., indomethacin-induced ulcer p.o. and aspirin-induced ulcer p.o. ) in rats, which are considered to relate to a protective action. E.E. and M.E. caused remarkable increase of bile excretion, compared with normal-control group, when adminstered through i.d., i.v. and p.o. The antibacterial activity against several intestinal microorganisms and other bacteria in vitro test was observed in the administration of E.E. and M.E.

      • KCI등재

        프레임 간 선명도 균일화를 위한 선명도 메트릭 기반의 동영상 디블러링 알고리즘

        이병주,이동복,송병철,Lee, Byung-Ju,Lee, Dong-Bok,Song, Byung Cheol 대한전자공학회 2013 전자공학회논문지 Vol.50 No.6

        본 논문은 동영상 프레임 간 선명도를 균일하게 유지하면서 블러를 제거하는 기법을 제안한다. 고정된 변수들을 이용하는 기존 기법들과 달리, 제안하는 동영상 디블러링 기법은 영상에 따라 디블러 변수들을 조절함으로써 선명도를 균일하게 만들어 준다. 먼저, 입력 프레임의 초기 블러 커널을 추정하고, 디컨볼루션을 수행한 뒤, 선명도를 측정한다. 그리고 균일한 선명도를 유지할 수 있도록 측정된 선명도에 기반하여 정규화 변수와 커널을 조절하고, 다시 디컨볼루션을 수행한다. 실험 결과를 통해 제안 기법이 상당히 균일한 선명도를 유지하면서 디블러링을 수행함을 확인할 수 있다. This paper proposes a video deblurring algorithm which maintains uniform sharpness between frames. Unlike the previous algorithms using fixed parameters, the proposed algorithm keeps uniform sharpness by adjusting parameters for each frame. First, we estimate the initial blur kernel and perform deconvolution, then measure the sharpness of the deblurred image. In order to maintain uniform sharpness, we adjust the regularization parameter and kernel according to the examined sharpness, and perform deconvolution again. The experimental results show that the proposed algorithm achieves outstanding deblurring results while providing consistent sharpness.

      • KCI등재

        성대 반흔에 대한 기초연구의 최신 경향

        이병주,Lee, Byung-Joo 대한후두음성언어의학회 2012 대한후두음성언어의학회지 Vol.23 No.1

        Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.

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