가연성 가스 인식을 위한 SnO₂ 계열의 박막 가스센서

이대식(Dae-Sik Lee),심창현(Chang-Hyun Shim),이덕동(Duk-Dong Lee) 한국진공학회(ASCT) 2001 Applied Science and Convergence Technology Vol.10 No.3

가연성 가스의 검지 및 인식을 위하여, SnO₂계열의 4가지 종류의 박막을 형성하였다. 감지막 형성을 위하여, Sn,Pt/Sn, Au/Sn, 그리고 Pt,Au/Sn 막을 Sn의 열증착과 귀금속의 스퍼터링으로 증착하였다. 증착된 박막들을 700℃ 정도에서 2 시간 열산화시켜 SnO₂ 계열의 감지막을 형성하였다. 제작된 박막은 tetragonal 구조의 SnO₂이었고, 가스 흡착을 위한 가스 흡착점과 기공도를 많이 갖고 있었다. 스퍼터로 형성된 박막보다 열산화법으로 형성된 박막이 고감도를 보였다. 제작 박막들은 작업환경기준치정도의 저농도에서 측정 가연성 가스(부탄, 프로판, LPG, 일산화탄소)에 대해 고감도와 재현성을 나타내었다. 특히, 백금(30 Å)을 첨가한 박막이 LPG와 부탄 가스에 대해, 순수 열산화된 SnO₂ 박막이 프로판과 일산화탄소에 대하여 가장 고감도를 나타내었다. 이들 센서들의 각 가스별로 차별화된 감도패턴을 이용하여 주성분 분석 기법을 통해 환경기준치(LEL, TLV) 범위에서 부탄, 프로판, LPG, 일산화탄소와 같은 가연성 가스의 종류 인식 및 정량을 인식할 수 있었다. Highly-porous SnO₂ thin films were prepared for recognizing and detecting of the inflammable gases, like butane, propane, LPG, carbon monoxide. To obtain sensing films, Sn, Pt/Sn, Au/Sn, and Pt,Au/Sn films were deposited employing a thermal evaporator for Sn film and a sputter for novel metals of Pt or/and Au. These films were annealed for 2 h at 700℃ to form SnO₂-based thin films. The films showed the tetragonal structure and also exhibited many defects and porosity, which could give high sensitivity to thin films. The thin films showed high sensitivity and reproductivity to the tested gases(butane, propane, LPG, and carbon monoxide) to even to low gas concentrations in range of workplace environmental standards. Especially, Pt/SnO₂ film showed the highest sensitivity to butane, LPG, and carbon monoxide. And pure SnO₂ film manifested the highest sensitivity to propane. By using the sensing patterns from the films, we could reliably recognize the kinds and the quantities of the tested inflammable gases within the range of the threshold limit values(TLV) and the lower explosion limit(LEL) through the principal component analysis(PCA).

다발성으로 침범한 조직구증식증의 一例

이영우(Lee Young Woo),최충신(Choi Chung Sin),심웅석(Shim Woong Suk),김용주(Kim Young Ju),김병직(Kim Byung Jik),서광윤(Seo Kwang Yun),이대일(Lee Dae Il) 대한정형외과학회 1974 대한정형외과학회지 Vol.9 No.4

새로운 방법으로 성장된 무핵 전복반형진주의 구조적 특성

김혜연,이대일,박종완,심광보,Kim, Hea-Yeon,Lee, Dae-Il,Park, Jong-Wan,Shim, Kwang-Bo 한국결정성장학회 2008 韓國結晶成長學會誌 Vol.18 No.2

새로운 전복반형 진주 양식법으로 진주를 성장시킨 후 그 구조적 특징을 분석하였다. 본 양식법은 기존방법과는 달리 핵을 넣지 않고 패각의 특정 부위를 파괴시켜 전복 내장의 형상대로 진주층을 유도하는 방법으로 진주의 모양이 자연스럽고 독특한 광택을 나타내었다. 전계방사형 주사전자현미경으로 분석 결과 진주층은 약 $0.34{\mu}m$의 균일한 층이 패각 표면에 수직으로 배열됨으로써 패각 표면에 피라미드 상의 돌기가 규칙적으로 형성되어 전형적인 1매패(권패)의 전복진주 특성을 나타내었다. 이러한 특징은 최근 진주보석의 자연스런 형태를 추구하는 시대에 부합되어 고부가가치의 한국형 진주보석으로 성장할 수 있으리라 사료된다. Non-nucleus Abalone half pearls were cultured by a new technique and their structural characteristics were analyzed using an electron microscopy. This technique was found to grow the pearls depending on the shape of the internal organ of an abalone because this technique induces the pearl layers without adding any nucleus on the specified damage region of a shell. The obtained pearls exhibit natural shapes with a specific luster. The SEM analysis shows that the pearl layers are about $0.34{\mu}m$ with an uniform thickness and the surface of the shell is characterized by the pyramid-shaped bulge with a regular arrangement, which is a typical feature of single-shell. These characteristics of the pearls are thought to develop in the highly-valued Korean gems.

운행자동차의 공회전 정지에 의한 CO₂ 저감량 산출 연구

심무경,임재명,이범호,홍성태,이대엽,Shim, Moo-Kyung,Rim, Jay-Myoung,Lee, Beom-Ho,Hong, Sung-Tae,Lee, Dae-Yup 대한기계학회 2009 大韓機械學會論文集B Vol.33 No.10

The effect of idling stop on $CO_2$ reduction was estimated, especially in the area of in-use vehicles. In order to know the fuel saving for each class of vehicles, a methodology to calculate the fuel saving was used along with a standard test using NIER-07 mode. Idling stop execution rate was estimated by analyzing the driving pattern of the in-use city buses, which shows about 75% at maximum. And this corresponds to about 5.4% reduction of the daily total fuel consumption. Finally, $CO_2$ reduction in the automotive sector was estimated, which concludes that, when idling stop device is used, about 480 thousand and 450 thousand tons of $CO_2$ could be reduced with in-use city buses and taxis, respectively. This amount corresponds to about 1.2% of $CO_2$ reduction in the automotive sector.

자궁경부암 환자 혈청에서 인유두종바이러스 16 DNA와 임상병리학적 예후인자들의 관계

이은숙 ( Eun Suk Lee ),정대훈 ( Dae Hoon Jeong ),김주란 ( Joo Ran Kim ),이대심 ( Dae Shim Lee ),김미성 ( Mi Sung Kim ),조유경 ( Yu Kyung Cho ),변정미 ( Jung Mi Byun ),박영미 ( Young Mi Park ),김영남 ( Young Nam Kim ),정철회 ( Chul 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12

목적: 자궁경부암 환자를 대상으로 혈청에서 human papillomavirus (HPV) DNA 상태를 확인하여 자궁경부암의 임상병리학적인 예후인자들과 비교 분석함으로써 혈청 HPV 16 DNA의 임상적인 중요성을 알아보고자 하였다. 연구 방법: 2002년 1월부터 2007년 2월까지 인제대학교 의과대학 부산백병원 산부인과에 내원한 환자들 중 자궁경부에 HPV16 감염된 자궁경부상피내암 환자 17명, 자궁경부에 HPV 16 감염된 편평상피세포암종으로 진단받고 치료 받은 환자 65명을 대상으로 혈청 HPV 16 DNA 상태를 HPV 16 specific E6 primer를 제작하여 PCR을 이용하여 확인한 후 임상병리학적인 예후인자들과 관계를 비교 분석하였다. 결과: 자궁경부 병변의 정도에 따른 혈청 HPV 16 DNA 상태를 확인한 결과 자궁경부상피내암 환자들에서는 혈청에서 HPV16 DNA 가 검출되지 않았으나, 자궁경부암 환자의 경우 총 65명 중 17명 (26.2%)에서 혈청 HPV 16 DNA가 검출되었다. 혈청에서의 HPV 16 DNA 검출은 환자의 나이 (P=0.0071), 혈청 SCC 항원 (P=0.0034), 종양의 크기 (P=0.0029), 임상적 병기(P<0.0001), 간질 침범의 정도 (P=0.0048), 조직 절단면의 종양세포 침범 (P=0.0008) 및 림프절 전이 (P=0.0040)와 연관이 있었다. 결론: 자궁경부암 환자에서의 혈청 HPV 16 DNA 양성 소견은 임상병리학적 예후인자들과 밀접한 관계가 있었다. Objective: To study the relationship between serum human papillomavirus (HPV) deoxyribonucleic acid (DNA) and clinicopathologic prognostic factors and the clinical usefulness of serum HPV 16 DNA in cervical cancer patients. Methods: All the patients were treated at our institution, from January, 2002 to February, 2007. DNA extracted from serum of 17 patients with HPV 16 infected carcinoma in situ and 65 patients with HPV 16 infected squamous cell carcinoma of the uterine cervix (stage IA-IIIB) were examined for HPV 16 DNA using polymerase chain reaction with types 16 specific E6 primer. Clinicopathological parameters were obtained from medical records, and the relationship between the discrete variables and serum HPV 16 DNA status were evaluated. Results: HPV 16 DNA was not detected in serum from all patients with carcinoma in situ. However, among the 65 patients with HPV 16 infected squamous cell carcinoma of the uterine cervix, we detected 17 HPV 16 DNA positive samples (26.2%) in serum. Positive HPV 16 DNA in serum was correlated with age (P=0.0071), serum squamous cell carcinoma (SCC) antigen (P=0.0034), tumor size (P=0.0029), clinical stage (P<0.0001), deep stromal invasion (P=0.0048), resection margin positivity (P=0.0008), and pelvic lymph nodal metastasis (P=0.0040). Conclusion: The serum HPV 16 DNA in patients with cervical cancer was correlated with poor prognostic factors that need adjuvant treatment.

악성 활액막종

최충신(Choi Chung Sin),윤번수(Youn Bern Soo),심웅석(Shim Woong Suk),김용주(Kim Yong Ju),이대일(Lee Dae Il) 대한정형외과학회 1975 대한정형외과학회지 Vol.10 No.3

2018 대한부정맥학회 심방세동 환자에서 NOAC 사용 지침: 처방의 시작과 유지

박진규 ( Jin-kyu Park ),김준 ( Jun Kim ),백용수 ( Yong Soo Baek ),이소령 ( So-ryoung Lee ),황유미 ( You Mi Hwang ),김태훈 ( Tae-hoon Kim ),이대인 ( Dae In Lee ),이기홍 ( Ki Hong Lee ),심재민 ( Jaemin Shim ),정보영 ( Boyoung Joung 대한내과학회 2019 대한내과학회지 Vol.94 No.1

Non-vitamin K antagonist oral anticoagulants (NOACs) are alternatives to vitamin K antagonists to prevent stroke in patients with non-valvular atrial fibrillation (AF) and have emerged as the preferred choice. The use of NOACs is rapidly increasing in Korea after coverage by insurance since 2015. However, the rate of prescribing anticoagulants in Korean patients with AF remains low compared to other countries. Most of the NOAC anticoagulant prescriptions are issued at hospitals. As the prevalence rate of AF in Korea is expected to increase rapidly with the increase in the elderly population, the need to prescribe NOACs in primary care clinics will also increase. Therefore, The Korean Heart Rhythm Society organized the Korean Atrial Fibrillation Management Guideline Committee and analyzed all available studies based on the 2018 European Heart Rhythm Association Practical Guide on the use of NOACs for managing AF, as well as studies on Korean patients. The authors would like to introduce practical guidelines for NOAC prescriptions in Korean patients with AF. (Korean J Med 2019;94:17-39)

온도 구배를 갖는 마이크로 가스센서 어레이의 제작 및 그 특성

이대식,강봉휘,이덕동,정완영,심창현,임준우,정호용 경북대학교 전자기술연구소 2001 電子技術硏究誌 Vol.22 No.1

A micro gas sensor array was fabricated by anodic bonding of the thin and insulating membrane of 125 ㎛-thick coming 7740 glass and the already-micromachined silicon substrate, as a supporter of the membrane. On the insulating membrane, two sensing films of SnO₂ and SnO₂+Pt sensing films on six pairs of electrodes, respectively, located symmetrically from the center part were deposited. The heating temperature-controlled method as an operating mode of sensor array was proposed to obtain the diverse sensing patterns. By controlling the temperature of a heater to the two steps of 450℃ and 200℃, 24 sensitivity patterns were obtained. From principal component analysis results, we confirmed that the classifying ability of the sensor array was enhanced by adding the 12 sensing signals obtained by controlling the heating temperature.

광범위한 골병변을 보였던 Hand-Schuller-Christian병 1례

전상남,심병안,황평한,조수철,이대열 의과학연구소 1988 全北醫大論文集 Vol.12 No.4

Hand-Schuller-Christian disease, originally referring to the classic triad of skull defects, exphthalmos and diabetes insipidus, is more broadly used to include instances in which there are multiple skeletal lesions or in which more than one system is involved. Authors experienced a case of Hand-schuller-Christian disease in a 6-year and 9 month-old female patient who had classic triad, multiple skeletal lesions and growth retardation. The diagnosis was confirmed by clinical symptoms, laboratory data, radiologic, and histopathologic findings. The patient was treated with vinblastine, prednisolone, and DDAVP for diabetes insipidus with good response. A breif review of literature was made.