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Cocaine에 依한 Norepinephrine Supersensitivity 發現에 關한 硏究
심병안,김기원,은홍배 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.1
The influence of cocaine on the response of isolated rat vas deferens to norepinephrine, oxymetazoline and angiotensin was examined. The results were as follows : 1. Cocaine produced a significant elevation of maximum response to norepinephrine as well as left shift of the dose-response curve. 2. Cocaine produced a shift to the dose-reponse curve and an increase of maximum response to oxymetazoline. 3. Potentiation of norepinephrine effect induced by cocaine was inhibited by verapamil. 4. Cocaine had no effect on the dose response curve to angiotensin. The results lead to the conclusion that the possible existence of at least two different mechanisms for the potentiation of norepinephrine effect on the isolated rat vas deferens. One is presynaptic inhibition of norepinephrine uptake, and the other is postsynaptic mechanism probably related to the improvement of intracellular calcium availability.
광범위한 골병변을 보였던 Hand-Schuller-Christian병 1례
전상남,심병안,황평한,조수철,이대열 의과학연구소 1988 全北醫大論文集 Vol.12 No.4
Hand-Schuller-Christian disease, originally referring to the classic triad of skull defects, exphthalmos and diabetes insipidus, is more broadly used to include instances in which there are multiple skeletal lesions or in which more than one system is involved. Authors experienced a case of Hand-schuller-Christian disease in a 6-year and 9 month-old female patient who had classic triad, multiple skeletal lesions and growth retardation. The diagnosis was confirmed by clinical symptoms, laboratory data, radiologic, and histopathologic findings. The patient was treated with vinblastine, prednisolone, and DDAVP for diabetes insipidus with good response. A breif review of literature was made.