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        Cryptococcus性 腦髓膜炎 1例

        李勳甲,田春瑞,辛圭萬,盧敬正,김춘원,李基燦,朱正和 대한신경외과학회 1973 Journal of Korean neurosurgical society Vol.2 No.2

        A case of cryptococcal meningitis is reported, which occured in a 25-year old female whose chief compaints ware severe headache, vomiting and double vision lasting one month. Neurological examination on admission (September 7, 1973) showed no significant abnormalities except for the bilateral papilledema and subjective horizontal diplopia. Simple skull and chest films including results of specific diagnostic procedures were grossly intact. Cerebrospinal fluid examination disclosed pleocytosis, increased protein, and decreased sugar and chloride, levels which was the finding compatible with those of tuberculous meningitis etc. The subject was treated under the diagnosis of tuberculous meningitis. Two weeks after the admisson, direct smear of the spinal fluid showed numerous yeast like cells, and cryptococcus neoformans was confirmed by India ink preparation and culture in Sabouraud's glucose agar. Amphotericin B was administered by slow intravenous drip over a span of several hours starting with 0.25㎎/㎏ of body weight and increasing gradually up to 1.25㎎/㎏ of body weight daily. Clinical improvements of the patient's condition along with disappearance of cryptococcus neoformans in CSF examination were obtained by the treatment with Amphoteric in B injection, although a fall in hemoglobin, hypopotassemia, moderate degree of fever and occasional vomiting were observed as side effects during the course of treatment. Cryptococcus is highly fatal infection caused by cryptococcus neoformans which is a special predilections for the central nervous system. Crytococcosis may also involve the lungs, bones and skin, and occurs with increased frequency in patients with leukemia or lymphomas. This infection is most common in male adult, and the protal entry is the respiratory tract.

      • SCOPUSSCIEKCI등재

        氣管切開術後의 重症合倂症

        張基永,金鍾悳,李基燦,朱正和 대한신경외과학회 1973 Journal of Korean neurosurgical society Vol.2 No.2

        Tracheotomy is a relatively simple operative procedure and should be recommended whenever the patient's ability to maintain an airway or remove secretion is seriously impaired. The complications that develop are generally due to faulty surgical technique. Although the risks of the operative procedure are negligible, the postoperative sequale and complications may produce disability with subsequent long period of treatment before recovery and sometimes fatal. Three adult patients who were complicated with difficult extubation and hemorrhage following tracheotomy for craniocerebral injury are presented. Difficult extubation of canula was seen in a patient whose lumen of the trachea was narrowed by granulation tissue. Whenever the canula was withdrawn the patient became cyanotic with difficulty in respiration. Removal of the granulations that formed on the anterior tracheal wall at the site of the opening and change of tracheotomy site could solve the difficulty. Sudden critical hemorrhage long after the tracheotomy were observed in two patients at the time of extubation of canula. One patient was tracheotomized for 13 days and the other 70 days when they died respectively of the fatal hemorrhage. No autopsy was done, but it could be suspected that the late hemorrhage might have to do with pressure erosion of a large vessel that had been pressing on by the end or the edge of canula.

      • SCOPUSSCIEKCI등재

        칼슘길항제가 혈관연축에 미치는 효과에 대한 실험적 연구

        김창선,이종오,이기찬,주정화 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2

        Cerebral vasospasm in subarachnoid hemorrhage is problem of great clinical importance, because its occurrence in the course of the illness is known to affect the outcome of patient. Many humoral and neural causative mechanisms have been postulated for the blood induced vasospasm. In spite of many studies, not only the prevention but also the true nature of causes and therapies remain unclear. Recent reports indicate that calcium antagonist may functions as a physiological cerebral vasodilatator. This present study was undertaken to clarify the effectiveness of calcium antagonist on the carotid arteries in the rabbit. In vitro, arterial constrictions were induced applying the vasoactive substances such as serum, prostaglandin F2α, norepinephine and potassium chloride. Inhibitor, Diltiazem was added in 1×10^(-4)M amount and responses of relaxation were recorded on the kymography. Sustainable contraction of carotid arteries developed with shortly after the addition of serum, 4×10^(-4)M norepinephrine, 1×10^(-4)M prostaglandin F2α and 2M KCl, and the maximum contraction of the arterial segment at each molar concentration was recorded at 60 min after the experiment. The contractile response to serum, norepinephrine and prostglandin F2α was considerable greater than that to KCl. Diltiazem in 1×10^(-4)M or 1×10^(-3)M concentration would relax completely the contracted carotid artery, however inhibitory action of Diltiazem(1×10^(-4)M) is highly sensitive to serum, norepinephrine induced contraction and is less sensitive to prostaglandin and KCl induced contraction. Based on this fact author confirmed that Diltiazem may play a significant role in the treatment of vasospasm following subarachnoid hemorrhage.

      • SCOPUSSCIEKCI등재

        악성 신경초종 1예

        최호익,주정화,이기찬,전동휘 대한신경외과학회 1977 Journal of Korean neurosurgical society Vol.6 No.2

        A rare case of malignant schwannoma is reported in which the patient, a 50 year-old man, received repeated surgical operations for frequent recurrences of the tumor masses in thoracolumbar region of his back. The masses were in the paravertebral, with involvement of spine compressing the cord and of neighbouring tissues and structures. Simple X-rays demonstrated a compression of the body of L₁ vertebra along with destruction of the spinous processes of T_(12) and L₁. At operation, most of the accessible tumor tissue was removed and an adequate decompression achieved for spinal cord. Histological studies of each specimens revealed malignant schwannoma involving the spine and surrounding tissues. According to pathological finding maligant schwannoma was confirmed. Malignant peripheral nerve tumors are very rare and highly malignant. They must be treated by surgical measures either by radical local resection or amputation when necessery. Radical local excision might be applicable as the first attempt on a low grade tumor while an amputation might be a necessery procedure for recurrent tumor or for one showing a high grade of malignancy. Radical excision at the first attempt at eradication is often the only golden opportunity for permanent cure. The high rate of local recurrence after inadequate excision has been emphasized.

      • 第4腦室에 發生한 Myxopapillary Ependymoma 1例

        全東輝,朴舜河,李基燦,李大一 中央醫學社 1973 中央醫學 Vol.24 No.3

        Many clinical and pathological studies of ependymoma have been studied in the past. Ependymomas were classified as follows by Kernohan; 1. Papilloma choroideum 2. Myxopapillary ependymoma 3. Epithelial ependymoma 4. Cellular ependymoma. Among them Myxopapillary type apparently arise from the film terminale andl very rarely found in the region of the ventricle of the brain. We are reporting this rare case of Myxopapillary ependymoma in 4th ventricle which has had vague clinical courses.and literature reviewed.

      • 內頸動脈-海線精脈洞瘻를 同伴한 Persistent Primitive Hypoglossal Artery 1例

        金潔,李勳甲,李基燦,朱正和 中央醫學社 1973 中央醫學 Vol.24 No.3

        In early embryonic development there are three vessels joining the carotid and basilar arterial system, namely the primitive trigeminal, acoustic and hypoglossal arteries. These vascular channels are usually obliterated by the time of embryo is -14mm in length. One of these channels may rarely persist into adult life, the result is referred to as a persistent primitive anastomstic vessel. About 15.8y, of persistent primitive hypoglossal arteries are associated with vascular anomalies. We are reporting one case of persistent primitine hypoglossal artery associated with carotid-cavernous fistula and the literature reviewed.

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