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이규신 ( Kyu Shin Lee ) 대한내과학회 1968 대한내과학회지 Vol.11 No.9
The electrocardiographic findings of hypopotassemia were studied in 122 patients with various conditions in which serum potassium levels were likely to be low, and the following results were obtained. Rather characteristic and common electrocardiographic f
이규신 ( Kyu Shin Lee ),이주원 ( Joo Won Lee ),박희명 ( Hi Myung Park ),최명부 ( Myung Boo Choi ),김경식 ( Kyung Shik Kim ),이상규 ( Sang Kay Lee ) 대한내과학회 1969 대한내과학회지 Vol.12 No.4
A review was made on 57 cases of so-called pseudoinfarction seen among 12,491 cases with various conditions subjected to electrocardiographic examination. In most of the cases the pseudoinfarction patterns were seen in the right precordial leads, and in ab
악성종양의 통계적 관찰 - 외래 및 입원환자 2,031 예에 대한 검토
이규신 ( Kyu Shin Lee ),이현우 ( Hyun Woo Lee ),김만재 ( Man Jae Kim ),최명부 ( Myung Boo Choi ),송석호 ( Suck Ho Song ),지창준 ( Chang Jun Jhi ),윤영길 ( Yung Kil Yoon ),황기석 ( Kee Suck Whang ),정극수 ( Keuk Soo Chung ) 대한내과학회 1969 대한내과학회지 Vol.12 No.4
A statistical study was done on 2,031 cases of various malignancies of over 15 years of age seen at Kyungpook National University Hospital during the 6 years from 1962 to 1967 and the following results were obtained. 1. Annual incidence of malignancies (me
이규신 ( Kyu Shin Lee ),이상계 ( Sang Kay Lee ),박희명 ( Hi Myung Park ),지창준 ( Chang Jun Jhi ),박갑석 ( Kab Suk Park ) 대한내과학회 1971 대한내과학회지 Vol.14 No.8
A case of hypokalemic periodic paralysis was presented and a review of literature made. The present case is a 17-year-old boy who has had repeated attacks of quadriplegia since the age of four: the attacks lasting for about 10 to 15 hours and recurring app
GATA-3 is a Key Factor for Th1/Th2 Balance Regulation by Myristicin in a Murine Model of Asthma
이규,이창민,정인덕,정영일,천성학,박희주,최일환,안순철,신용규,이상율,염석란,김종석,박영민,Lee, Kyu,Lee, Chang-Min,Jung, In-Duk,Jeong, Young-Il,Chun, Sung-Hak,Park, Hee-Ju,Choi, Il-Whan,Ahn, Soon-Cheol,Shin, Yong-Kyoo,Lee, Sang-Yull,Yeom, S Korean Society of Life Science 2007 생명과학회지 Vol.17 No.8
Myristicin은 육두구에서 발견되는 고농축 정유 중 하나인 물질이다. 하지만 Th1/Th2 면역반응에서 육두구의 항알레르기 효과는 아직 밝혀지지 않았다. 최근에 Th1/Th2 전사인자로서 T-bet, GATA-3가 밝혀졌는데 이번 실험에서 myristicin이 ovalbumin(OVA)으로 유도한 천식(asthma) 생쥐모델에서 Th1,Th2 싸이토카인과 유전자 발현을 조절할 수 있는가에 대하여 알아보았다. 또한 기관지 폐포 세척액을 회수하여 백혈구의 수적 변화, 제2형 협조T세포(Th2 cell)가 생산하는 IL-4, IL-5의 생산에 미치는 영향과 폐조직에서 matrix metalloproteinase (MMP)-9 활성을 측정하였다. 그 결과 기관지 폐포 세척액에서 OVA로 감작하여 천식을 유도한 실험군에서는 호산구의 현저한 증가, Th2 형 싸이토카인(IL-4, IL-5)의 증가가 관찰되었다. 그러나 myristicin을 투여한 그룹에서는 OVA의 감작에 의하여 증가한 각종 염증성 지표들이 감소하거나 정상화 되었다. 또한 OVA에 의하여 증가된 기도저항성이 myristicin 투여에 의하여 감소하였으며 폐조직의 염증성 소견도 뚜렷하게 감소되었다. 이와 같은 연구 결과는 myristicin이 천식의 치료에 유용하게 쓰일 수 있음을 시사해준다. Myristicin, l-allyl-3,4-methylenedioxy-5-methoxybenzene, was one of the major essential oils of nutmeg. However, its anti-allergic effect in the Th1/Th2 immune response was poorly understood. Recently, it was shown that T-bet and GATA-3 was master Th1 and Th2 regulatory transcription factors. In this study, we have attempted to determine whether myristicin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in ovalbumin (OVA)-induced asthma model mice. Myristicin reduced levels of IL-4, Th2 cytokine production in OVA-sensitized and challenged mice. In the other side, it increased $IFN-{\gamma}$, Th1 cytokine production in myristicin administrated mice. We also examined to ascertain whether myristicin could influence eosinophil peroxidase (EPO) activity. After being sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions. These reactions included an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration into the lung tissue around blood vessels and airways, and the development of airway hyper-responsiveness (AHR). The administration of myristicin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, these findings provide new insight into the immunopharmacological role of myristicin in terms of its effects in a murine model of asthma.
Kyu Seong Lee(李圭鍟,),Young Tae Lee(李暎泰),Mun Sik Shin(申文植),Hyun Tak Shin(申鉉卓),Byung Tae Jun(田炳泰) 한국육종학회 1990 한국육종학회지 Vol.22 No.3
The varieties which had relatively good viviparous germination under 25℃ constant temperature were Daeseongbyeo and Baegambyeo, but poor germination varieties were Sobaegbyeo, Odaebyeo and Unbongbyeo. The general combining ability(GCA) and specific combining ability(SCA) for viviparous germination showed highly significant respectively and mean sqare values of GCA was more greater than that of SCA were studied on F₂ seeds of 10 crosses from the partial dialler cross of 5 Japonica rice varieties. In analysis of general combining ability, Daeseongbyeo and Baegambyeo showed positive effect for the viviparous germination, but Sobaegbyeo, Odaebyeo and Unbongbyeo showed negative effect. In case of gene effect for the viviparous germination additive effect was greater than dominance effect in the inheritance of the pre-harvest sprouting germination and showed partial dominance, however the average dominant effect was comparative low.
류마티스 관절염 환자에서 발생된 비장의 비호지킨 림프종
이화정 ( Hwa Jung Lee ),고진우 ( Jin Woo Koh ),박정현 ( Jung Hyeon Park ),박성남 ( Sung Nam Park ),이규 ( Kyu Lee ),신현주 ( Hyeon Ju Shin ),이충원 ( Choong Won Lee ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.4
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder of unknown etiology. Inflammation may usually extend beyond the joints and involve other organs. Clinically detectable splenomegaly is present in 5~10% of RA. Methotrexate (MTX) is a structural analog of folic acid that inhibits the enzyme dihydrofolate reductase, so cellular proliferation is reduced. MTX has been proven to be effective in treating RA and is believed to be nononcogenic at low, weekly dose employed in the patients with RA. However, recently there has been increased concern about the oncogenic potential of MTX because of several case reports describing the occurrence of non-Hodgkin`s Lymphoma (NHL) in the patients with RA treated with MTX. A 65-year-old woman with RA was treated with low dose MTX (i.e. 10 mg/week) for 3 years. Because of prolonged left upper abdominal pain and thrombocytopenia associated with huge splenomegaly, splenectomy was performed. Biopsy revealed splenic B-cell NHL. We report a case of RA with splenomegaly who developed B-cell NHL in spleen during low dose MTX therapy.
李圭信 慶北大學校 醫科大學 1979 慶北醫大誌 Vol.20 No.1
著者는 1975年 1月부터 1978年 8月까지 滿 3年 8個月間 慶北大學校 醫科大學 附屬病院 胃鏡室에 來訪하여 食道內視鏡檢査를 施行한 患者 1346例를 對象으로 觀察하여 다음과 같은 成績을 얻었다. 1) 總 1346例中 食道疾患이 認定된 344例에서의 疾患別 頻度로서는 食道靜脈瘤가 60.5%로서 가장 많았고 다음이 食道癌 26.4% Mallory-Weiss 症候群 2.6% 等의 順位였다. 2) 食道癌 91例의 侵犯位置는 下 1/3部位에서 64.7%로서 가장 많았다. 3) 食道靜脈瘤 208例에서의 그 程度는 輕한 것과 中等度의 것이 73.6%를 차지하였으나 X線上 正診率은 61.4%였으나 輕한 例에 있어서는 33.3%밖에 되지 아니하였다. 4) Mallory-Weiss 症候群 9例는 全部가 男子이고 主訴는 吐血로서, 吐血後 2時間-6日內에 診斷되었고 모두 內科的으로 治療 可能하였다. 5) 其他疾患으로서 계실 12例, 食道炎 9例, 異物 8例, 양성협착 3例, esophageal ring 및 achalasia를 各 1例式 경험하였다. An observation on 1346 cases, who received esophagofiberscopic examination, was carried out from jan. 1975, to Aug, 1978 in the endoscopy room of Kyung Pook National University Hospital. The results obtained were as followings 1) Among 344 cases who showed abnormal endoscopical findings, esophageal varices were observed most prevalently in 60.5% then esophageal cancer in 26.4% and Mallory-Weiss syndrome in 2.6% etc in order respectively. 2) In 91 cases of esophageal cancer, 59 cases (64.8%) were mainly involved at lower 1/3 of the esophagus. 3) Diagnostic accuracy of X-ray examination in 208 cases which were also observed by endoscopical examination, was 61.4% and this revealed more lower rate in mild cases of esophageal varices. 4) In 9 cases of Mallory-Weiss syndrome, the chief complaints were hematemesis, occured after much drink and were treated well by medical regimen in all cases. 5) As another dislase, 12 cases of diverticulum, 8 cases of foreign bodies, 3 cases of benign stricture, 2 cases of moniliar infection and each 1 cases of achalasia and esophageal ring were observed.