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인진(茵蔯)의 에탄올 추출물이 담도암 세포주 SNU-1196의 apoptosis에 미치는 효과에 관한 연구
이경욱,우홍정,Lee, Kyung-Wook,Woo, Hong-Jung 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4
Objectives : This study was performed to elucidate the pro-apoptotic effect of Artemisiae capillaris herba extracted with ethanol on biliary tract cancer cells. Materials and Methods : The biliary tract cancer cell line SNU-1196 was used in this study. Cells were treated with different concentrations of Artemisiae capillaris herba for 24, 48 and 72 hours. After the treatment, cell viability, apoptosis, caspase activities and the mRNA expressions of the Bcl-2, Bax, P53, and P21 were measured by using MTT assay, cell cycle analysis, apoptosis assay, and RT-PCR. The cell cycle analysis was done by flow cytometry and apoptosis assay by cell death detection ELISA kit. Results : Artemisiae capillaris herba inhibited proliferation of SNU-1196 in long-time culture group with dose-dependent manner. All cells treated with Artemisiae capillaris herba showed increased apoptosis with dose- and time-dependent manner. Exposure of SNU-1196 to Artemisiae capillaris herba induced caspase-3 activation. However, apeoptosis was blocked when SNU-1196 was treated together with the pan-caspase inhibitor Z-VAD-FMK and the caspase-3 inhibitor Z-DEVE-FMK. After the treatment of Artemisiae capillaris herba, the mRNA expressions of caspase -3, -8, -9, p53, and p21 was increased in all cells. Artemisiae capillaris herba resulted in a significant decrease in Bcl-2 and an increase in Bax mRNA levels. Conclusions : These results suggest that Artemisiae capillaris herba would be beneficial in the treatment of biliary tract cancer.
이경욱,김영수,송인호,Lee, Kyoung wook,Kim, Young Soo,Song, In Ho 한국건축역사학회 2021 건축역사연구 Vol.30 No.5
The Don-am district is a residential area that was supplied in 1936 as a land readjustment project(Tojiguhoekjeongri). The Don-am district was newly supplied with residential areas and urban hanoks were built in large numbers. The Don-am district was influenced by urban planning and legislation at that time. These affected in the layout and plan of urban hanok. Residential block in the Don-am district were developed sequentially from the late 1930s to the 1960s. Residential block were divided by modern construction company and sold by individual lots. The blocks supplied to the Don-am district made uniformly the corner out-off(Ga gak) for creating a vehicle-centered road. So urban hanoks located in the corner plot was transformed in response to the road. Residential blocks in Don-am district was divided into three to four rows. Therefore, alleys were created inside the block. Newly made alleys consist of a privately owned road(Sa-do), a public road(Gong-Do), and open space in the site. And the alleys were used as an entry space for sharing with neighboring. Urban hanoks of Don-am district have had changed and adapted to the formation of these alleys.
정상 중력장하의 단일 액적연소에 있어서 매연 농도의 측정
이경욱,이창언,오수철,Lee, Gyeong-Uk,Lee, Chang-Eon,O, Su-Cheol 대한기계학회 1998 大韓機械學會論文集B Vol.22 No.4
The temporal and spatial distributions of soot volume fractions were measured for single toluene droplet flames as a function of pressure under the normal-gravity condition. In order to characterize the transient nature of the flame and sooting regions, a full-field light extinction and subsequent tomographic inversion technique was used. The reduction in sooting as a function of pressure was assessed by comparison of the maximum soot volume fractions at several vertical positions along the axis above the droplet. The maximum soot volume fraction was reduced by 70% when the pressure was reduced by 60% from 1 atm to 0.4 atm. The reduction in sooting is attributed to variation of the geometric configuration of flame which reduces the system Grashof number as well as only the change in the adiabatic flame temperature as the pressure decreases. The gravimetrically-measured total soot yield was also compared to the optically-measured soot volume fraction to obtain a correlation between the two measurements. As a result, the total soot yield was linearly proportional to the optically-measured maximum soot volume fraction and linearly reduced as the pressure decreased. Accordingly, the non-intrusive full-field light extinction-measurements were able to be calibrated not only to measure soot volume fraction, but to simultaneously evaluate the total soot yield emitted from the toluene droplet flame (which is useful in the practical application).
LTE-Advanced 표준을 지원하는 CMOS Active-RC 멀티채널 Low-Pass Filter
이경욱,김창완,Lee, Kyoung-Wook,Kim, Chang-Wan 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.3
This paper has proposed a multi-channel low pass filter (LPF) for LTE-Advanced systems. The proposed LPF is an active-RC 5th chebyshev topology with three cut-off frequencies of 5 MHz, 10 MHz, and 40 MHz. A 3-bit tuning circuit has been adopted to prevent variations of each cut-off frequency from process, voltage, and temperature (PVT). To achieve a high cut-off frequency of 40 MHz, an operational amplifier used in the proposed filter has employed a PMOS cross-connection load with a negative impedance. A proposed filter has been implemented in a 0.13-${\mu}m$ CMOS technology and consumes 20.2 mW with a 1.2 V supply voltage. 본 논문은 LTE-Advanced 시스템을 위한 멀티채널을 선택할 수 있는 저역통과 필터를 제안한다. 제안하는 저역통과 필터는 5 MHz, 10 MHz, 그리고 40 MHz의 3가지 모드의 차단주파수를 제공하며 Active-RC 5차 Chebyshev 구조로 설계되었다. 저전력을 확보하면서 40 MHz의 높은 차단 주파수를 확보하기 위해서 부성 저항을 가지는 PMOS Cross-Connection Load를 사용한 연산증폭기를 필터에 적용하였다. 더불어 공정, 전압, 그리고 온도에 의한 각각의 차단주파수 변화에 대응할 수 있도록 각각 3-bit 제어 가능한 튜닝회로를 추가하였다. 제안하는 필터는 0.13-${\mu}m$ CMOS 공정을 사용하여 설계하였으며 1.2 V 전압에서 총 20.9 mW 전력을 소모한다.
이경욱,이민정,김남주,정호경,곽상인,Kyeong Wook Lee,Min Joung Lee,Nam Ju Kim,Ho-Kyung Choung,Sang In Khwarg 대한안과학회 2009 대한안과학회지 Vol.50 No.2
Purpose: To report a rare case of solitary eyelid schwannoma. Case summary: A 60-year-old female visited our clinic with a small cyst-like mass of the left upper eyelid, which had developed 3 years earlier. A 3×3 mm-sized, nonpigmented, cyst-like mass was located in the lateral area of the left upper eyelid margin. We performed an excisional biopsy under local anesthesia. The tumor was well encapsulated, easily dissected, and could be completely removed. Histopathologic examination showed cellular areas of spindle cells with Verocay bodies forming palisades and less cellular myxoid areas. Immunohistochemical analysis for S-100 protein showed a strongly positive reaction. Based on the histopathologic features, a diagnosis of benign Schwannoma was made. Conclusions: Schwannoma should be also considered in the differential diagnosis of a well-circumscribed mass lesion in the eyelid.
문학텍스트에 대한 문학인류학적 해석 : 이청준의〈신화를 삼킨 섬〉론
이경욱(Lee Kyung-wook) 한국비평문학회 2010 批評文學 Vol.- No.38
This paper is an illustration attempting approach of comparative culture between literary text and literary anthropology and it analyzes Lee Chung-jun’ 〈The island swallow the mythology〉 quoting the sections of Poyatos’ methodology. This work enhances the inside view of human and the spirit of times and once being a journalist, the aspect of the anthropologist of the writer who completely tries to gather data to find folklore materials and culture of ‘shaman ritual drama(rite)’ and ‘regret(emotion)’ and ‘mythology(symbol)’ ready for the elements of traditional culture in itself, and so it’s enough for the explanation of literary anthropology. In order to interpret literary anthropological on literary text in detail the present writer adopted the necessary part of Poyatos’ methodology, an authority of this field to analyzes the work. Those are ‘intelligible systems’ on ‘anthropological realism’ and ‘[Documentary(Historical) realism]’. And also the material that gives awfully off the emotion of Korean tradition becomes one of the realism of culture on the subject of continuing the writer’s view of human looking at an shaman with the sight of humanity, the view of literature delivering lives of human putting love for mankind, the view of history criticizing of pressing the individual, the view of world(identity) through the experience of traditional culture. Expanding a literary study into the dimension of culturology, that is, mean that it develops the sense of the sight watching literature. On the contrary, there was more or less limitation in closer analyzes the text because literary anthropology is related to the outside the text of culture, not inside the text. In conclusion Lee Chung-jun’ 〈The island swallow the mythology〉, is rather an understanding about the lives of the people within the boundary of Korean history and traditional culture than deeply searches universal human problem of the whole mankind.