수유 요인에 따른 유치열의 치면별 우식패턴

임경욱,이광희,라지영,안소연,김윤희 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

연구목적은 모유 또는 분유 섭취 시 나타나는 유치열의 치면별 우식패턴에 차이가 없으며 수유기간에 따른 차이도 없다는 가설을 검증하는 것이었다. 익산시, 청주시, 울산광역시의 36-71 개 월 어린이 815명을 대상으로 구강검사로 치면별 우식경험도를 조사하고, 보호자들을 대상으로 설문지 조사법으로 모유와 분유 중에서 생후 1년간 주로 수유한 것과 수유 기간을 조사하였다. 모유군과 분유군 간 우식경험유치면수(dmf)의 차이는 유의하지 않았다. 모유군에서 분유군보다 우식경험도가 더 높았던 유치군은 상악 유전치이었고, 유치면군은 상악 유전치 협설면과 인접면이었으며, 유치는 상악 유절치와 상하악 제2유구치이었고, 유치면은 상악 유중절치의 협면과 원섬면, 상악 유측절치의 협설면, 인접면, 상악 제2유구치의 설면, 인접면, 교합면, 하악 제2유구치의 협면, 원심면이었다. 모유군에서 수유기간이 증가함에 따라 우식경험유치면수가 증가한 유치군은 상악 유전치와 상악 유구치이었고, 유치면군은 상악 유전치의 인접면, 상악 유구치의 협설면, 인접면, 교합면, 하악 유구치의 인접면이었으며, 유치는 상악 유전치, 상악 유구치, 하악 제 2유구치이었고, 유치면에서는 상악 유전치의 인접면, 상악 제 1유구치의 협설면, 인접면, 교합면, 상악 제 2유구치의 협면, 하악 제 2유구치의 근심면이었다. 분유군에서는 수유기간 3년 이상에서 우식경험유치면수가 증가하였으나 차이가 유의하지 않았다. 수유와 관련되어 발생하는 상악 유절치의 중증 유아기 우식증은 분유를 수유하는 경우보다 모유를 수유하는 경우에 더 많이 발생하였다. 모유 수유를 2년 이상 하는 경우에는 상악 유절치의 우식 예방을 위한 조치가 필요하다. The purpose of this study was to investigate the tooth surface caries patterns in the primary dentition according to breast or bottle feeding. The subjects of study were 815 children, 36 to 71 months old, in Iksan, Cheongju and Ulsan cities. The caregivers of the children were asked which they fed between the breast milk and the infant formula during the 1st year after birth and the duration of feeding. There was no significant difference in dmfs between the breast milk group and the infant formula group(significance level 0.05, same below). Tooth groups, tooth surface groups, teeth, and tooth surfaces which had significantly higher dmfs in the breast milk group than in the infant formula group were upper anterior teethttooth groups), upper incisors' buccal and proximal surfacesttooth surface groups), upper incisors and upper second molars (teeth), upper central incisors' buccal and distal surfaces, upper lateral incisors' buccolingual and proximal surfaces, upper 2nd molars' lingual. proximal. and occlusal surfaces, and lower 2nd molars' buccal and distal surfaces. In the breast milk group, tooth groups, tooth surface groups, teeth, and tooth surfaces which dmfs significantly increased as the duration of the feeding increased were upper anterior teeth and upper molars (tooth groups), upper anterior teeth's proximal surfaces, upper molars' buccolingual, proximal, and occlusal surfaces, lower molars' proximal surfacesttooth surface groups), upper anterior teeth, upper molars, lower 2nd molars (teeth), upper anterior teeth's proximal surfaces, upper 1st molars' buccolingual, proximal. and occlusal surfaces, upper 2nd molars' buccal surfaces, and lower 2nd molars' mesial surfaces (tooth surfaces). In the infant formula group, dmfs increased after 3 years of feeding, but the difference was not significant. Caries prevention is necessary in case of breastfeeding more than two years.

가족성 정신분열병 환자에서 임상 특성의 가족내 연관성

최경숙,이유상,장용이,조은영,전현옥,김창현,김상욱,홍경수 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : This study aims at examining familial associations of symptoms and clinical characteristics in affected sibling or relative pairs of schizophrenia as an effort to identify genetically homogeneous phenotypes. Methods : Forty-seven relative pairs with DSM-IV diagnosis of schizophrenia from thirty-five Korean families multiply affected with schizophrenia were ascertained. Direct interviews were done using the Korean version of Diagnostic Interview for Genetic Studies (DIGS). The Krawieka Rating Scale and the Schedule for the Deficit Syndrome were also applied for further evaluation of psychopathologies. Intra-familial concordances and correlations of clinical characteristics and symptoms were tested using χ² -test and Spearman's correlation. Results : Significantly high concordance rate within relative pairs was found for the diagnosis of paranoid vs. non-paranoidsubtype (χ²=7.623, P=0.006, df=1). Deficit vs. non-deficit syndrome also showed significant concordance (χ² =3.850, p=0.0497, df=1). Among single symptom items in DIGS, only 'auditory hallucination' showed significant concordance rate ( χ² =5.503, P=0.019, df=1). Factor analysis for symptoms items in the Rrawiecka Rating Scale indicated three symptom dimensions ; negative, psychotic and affective, Psychotic (P =0.442, P=0.003) and affective dimension scores (p =0.427, P=0.004) showed significant intra-familial correlations. Age at onset of recognized psychotic symptoms showed significant correlation only within the male sibling pairs. Conclusion : Familial factors, Possibly genetic factor contribute to the phenotypic characteristics of paranoid vs. non-para-noid subtype, deficit vs. non-deficit syndrome, auditory hallucination, and affective syndrome, It supports their use in the delineation of homogeneous subgroups for future genetic studies.

Distributed memory access architecture and control for fully disaggregated datacenter network

Kyeong-Eun Han(Kyeong-Eun Han),Ji Wook Youn(Ji Wook Youn),Jongtae Song(Jongtae Song),Dae-Ub Kim(Dae-Ub Kim),Joon Ki Lee(Joon Ki Lee) 한국전자통신연구원 2022 ETRI Journal Vol.44 No.6

In this paper, we propose novel disaggregated memory module (dMM) architecture and memory access control schemes to solve the collision and contention problems of memory disaggregation, reducing the average memory access time to less than 1 μs. In the schemes, the distributed scheduler in each dMM determines the order of memory read/write access based on delay-sensitive priority requests in the disaggregated memory access frame (dMAF). We used the memory-intensive first (MIF) algorithm and priority-based MIF (p-MIF) algorithm that prioritize delay-sensitive and/or memory-intensive (MI) traffic over CPU-intensive (CI) traffic. We evaluated the performance of the proposed schemes through simulation using OPNET and hardware implementation. Our results showed that when the offered load was below 0.7 and the payload of dMAF was 256 bytes, the average round trip time (RTT) was the lowest, ~0.676 μs. The dMM scheduling algorithms, MIF and p-MIF, achieved delay less than 1 μs for all MI traffic with less than 10% of transmission overhead.

Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans.

Lee, Seung Hun,Lee, Sun-Young,Lee, Young-Sun,Kim, Beom-Jun,Lim, Kyeong-Hye,Cho, Eun-Hee,Kim, Sang-Wook,Koh, Jung-Min,Kim, Ghi Su Issued for the Endocrine Society by the Williams & 2012 The Journal of clinical endocrinology & metabolism Vol.97 No.8

<P>Several in vivo and in vitro studies suggest that sphingosine-1-phosphate (S1P) is known to act as a coupling factor, to stimulate osteoclastogenesis, to control the migration of osteoclast precursors between the blood and bone, and to stimulate the proliferation, migration, and survival of osteoblasts.</P>

Novel Aspect in Grain Size Control of Nanocrystalline Diamond Film for Thin Film Waveguide Mode Resonance Sensor Application

Lee, Hak-Joo,Lee, Kyeong-Seok,Cho, Jung-Min,Lee, Taek-Sung,Kim, Inho,Jeong, Doo Seok,Lee, Wook-Seong American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.22

<P>Nanocrystalline diamond (NCD) thin film growth was systematically investigated for application for the thin film waveguide mode resonance sensor. The NCD thin film was grown on the Si wafer or on the SiO<SUB>2</SUB>-coated sapphire substrate using the hot filament chemical vapor deposition (HFCVD). The structural/optical properties of the samples were characterized by the high-resolution scanning electron microscopy (HRSEM), high-resolution transmission electron microscopy (HRTEM), energy dispersive X-ray spectroscopy (EDS), near edge X-ray absorption fine structure (NEXAFS), X-ray diffraction (XRD), and ultraviolet–visible (UV–vis) spectroscopy. The waveguide modes of the NCD layer were studied by prism coupler technique using laser (wavelength: 632.8 nm) with varying incident angle. A novel aspect was disclosed in the grain size dependence on the growth temperature at the relatively low methane concentration in the precursor gas, which was important for optical property: the grain size increased with decreasing growth temperature, which was contrary to the conventional knowledge prevailing in the microcrystalline diamond (MCD) domain. We have provided discussions to reconcile such observation. An optical waveguide mode resonance was demonstrated in the visible region using the microstructure-controlled transparent NCD thin film waveguide, which provided a strong potential for the waveguide mode resonance sensor applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-22/am403066k/production/images/medium/am-2013-03066k_0015.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am403066k'>ACS Electronic Supporting Info</A></P>

Inflammation-based score (Glasgow prognostic score) as an independent prognostic factor in colorectal cancer patients

Kyeong Woon Choi,Seong Woo Hong,Yeo Goo Chang,Woo Yong Lee,Byungmo Lee,In Wook Paik,Hyucksang Lee 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.6

Purpose: This study was conducted to evaluate the systemic inflammatory response in colorectal cancer patients, and to estimate the usefulness of the Glasgow prognostic score (GPS) as a prognostic factor. Methods: Patients with biopsy-proven colorectal adenocarcinoma who were operated between April 2005 and December 2008 were enrolled in this study. The GPS was estimated based on the measurement of CRP and serum albumin level. The GPS was compared with other clinicopathological factors. Univariate and multivariate analyses were performed to evaluate the factors affecting cancer-specific survival. Results: GPS was significantly higher in patients with anemia, thrombocytosis, a high neutrophil to lymphocyte ratio, tumor of the colon, and large tumor. Patient age, gender, serum CEA level, tumor gross appearance, TNM stage, and tumor differentiation were not related with the GPS. In univariate analysis, hemoglobin, CEA, gross appearance of tumor, TNM stage, tumor differentiation, and GPS were associated with cancer-specific survival. In multivariate analysis, TNM stage (III or IV : I or II; hazard ratio [HR], 12.322; P = 0.015), tumor differentiation (poorly differentiated : well or moderately differentiated; HR, 3.112; P = 0.021), and GPS (GPS 2 : GPS 0 or 1; HR, 5.168; P = 0.003) were identified as independent prognostic factors in colorectal cancer. Conclusion: Our study showed that the GPS was an independent variable from tumor stage and a good and convenient prognostic factor in colorectal cancer patients.

Expression analysis of sweetpotato cinnamyl alcohol dehydrogenase genes in response to infection with the root-knot nematode Meloidogyne incognita

Lee Kyeong Hyun,Lee Kang-Lok,남기정,Yang Jung-Wook,이증주,Shim Donghwan,김윤희 한국식물생명공학회 2022 Plant biotechnology reports Vol.16 No.4

Sweetpotato (Ipomoea batatas L.) is a globally important food crop that is susceptible to infestation with the root-knot nema- tode, Meloidogyne incognita, which causes substantial crop losses. Previous transcriptomic analysis of the roots of susceptible and resistant sweetpotato cultivars identified genes that are likely to contribute to protection against root-knot nematode. The identified genes included cinnamyl alcohol dehydrogenase (CAD), which are related to monolignol biosynthesis in plants. In this study, the role of CAD genes in sweetpotato defense responses to root-knot nematode infection was examined in susceptible and resistant cultivars. Comparison with Arabidopsis thaliana CAD genes identified groups of sweetpotato genes orthologous to AtCAD1–AtCAD9. Genes of the two major sweetpotato CAD groups contained the highest number of unigenes that were highly responsive to nematode infection in sweetpotato roots. These results indicate that CAD genes play roles in protecting sweetpotato roots against root-knot nematode infection.

Common and rare variants in the exons and regulatory regions of osteoporosis-related genes improve osteoporotic fracture risk prediction.

Lee, Seung Hun,Kang, Moo Il,Ahn, Seong Hee,Lim, Kyeong-Hye,Lee, Gun Eui,Shin, Eun-Soon,Lee, Jong-Eun,Kim, Beom-Jun,Cho, Eun-Hee,Kim, Sang-Wook,Kim, Tae-Ho,Kim, Hyun-Ju,Yoon, Kun-Ho,Lee, Won Chul,Kim, Issued for the Endocrine Society by the Williams W 2014 The Journal of clinical endocrinology & metabolism Vol.99 No.11

<P>Osteoporotic fracture risk is highly heritable, but genome-wide association studies have explained only a small proportion of the heritability to date. Genetic data may improve prediction of fracture risk in osteopenic subjects and assist early intervention and management.</P>

Sex-specific association of sex hormones and gonadotropins, with brain amyloid and hippocampal neurodegeneration

Lee, Jun Ho,Byun, Min Soo,Yi, Dahyun,Choe, Young Min,Choi, Hyo Jung,Baek, Hyewon,Sohn, Bo Kyung,Lee, Jun-Young,Kim, Hyun Jung,Kim, Jee Wook,Lee, Younghwa,Kim, Yu Kyeong,Sohn, Chul-Ho,Woo, Jong Inn,Lee PERGAMON PRESS LTD 2017 NEUROBIOLOGY OF AGING Vol. No.

<P><B>Abstract</B></P> <P>This study aimed to examine the sex-specific association between serum sex hormones and gonadotropins and the cerebral beta-amyloid (Aβ) burden and hippocampal neurodegeneration in subjects with normal cognition and impaired cognition. Two hundred sixty-five older subjects received clinical assessments, serum measurements of sex hormones, gonadotropins, <SUP>11</SUP>C-Pittsburgh compound B-positron emission tomography, and magnetic resonance imaging. In females, higher free testosterone and gonadotropin levels were associated with lower cerebral Aβ positivity. In males, free testosterone was positively related to hippocampal volume with significant interaction with cognitive status. Further subgroup analyses showed that the association was significant only in impaired cognition but not in normal cognition. Free estradiol was not associated with Aβ burden or hippocampal neurodegeneration in either sex. These results suggest that testosterone might inhibit the early pathological accumulation of Aβ in females and delay neurodegeneration in males.</P>

HPLC DETERMINATION AND BIOAVAILABILITY OF BACAMPICILLIN IN HUMAN PLASMA IN HEALTHY VOLUNTEERS

Lee Byoung Moo,Yoon Mi Kyeong,Lee Sung Jae,Lee Yoon Jin,Lee Jaehwi,Choi Young Wook,Yong Chol Soon,Lee Kyung Tae 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.1