전통 장의 이용실태와 인식 및 태도에 관한 연구

이경연(Kyung Yeon Lee),염진희(Jin Hee Yum),고성희(Seong Hee Ko) 한국조리학회 2018 한국조리학회지 Vol.24 No.9

급성 및 만성 B형 간염환자의 위배출시간에 관한 연구

이경한(Kyung Han Lee),김호정(Ho Jong Kim),추길연(Kil Yeon Choo),김정한(Jung Han Kim),김재명(Jae Myung Kim),원종현(Chong Hyun Won),박권택(Gwun Taek Park),김승욱(Seoung Wok Kim) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2

N/A Anorexia, nausea, and vomiting are one of the most frequent symptoms in viral hepatits patients. These may be due to poorly detoxified substances by dysfunctioned hepatocytes or by gastritis, but the pathophysiology is not totally understood. The symptoms interfere with adequate nutrient intake and are managed by metoclopramide, which accelerates gastric emptying. Thus delayed gastric emptying may well be a contributing factor to such symptoms. To determine such a relationship, we measured gastric emptying time in 11 normal subjects, 9 acute (AVH), and 12 chronic B viral hepatitis (CVH) patients. All were males with a mean age of 23 years. An egg was labeled with 0.5 mCi of Tc-99m-sulfur colloid, fried, then eaten between 2 slices of bread with 100cc of water. Anterior and posterior images were taken at 20 minute intervals over a 2 hour period. A geometric mean of activity pertaining to the gastric region was measured, and T1/2 was calculated from the time activity curve. T1/2 for normal the group was 57.8±6.3 minutes while that for the AVH and CVH group was 58.2±8.2 (p=0.40) and 64.1±10.5 (p=0.09), respectively. There was 1 AVH patient and 4 CVH patients with prolonged T1/2. Anorexia and nausea was seen in 71% and 46% of the patients, respectively. 80% and 60% of the patients with prolonged T1/2 had anorexia and nausea, respectively.

임플란트주위염 처치에서 레이저의 이용

이경중(Kyung-Joong Lee),이종호(Jong-Ho Lee),금기연(Kee-Yeon Kum),임영준(Young-Jun Lim) 대한턱관절교합학회 2015 구강회복응용과학지 Vol.31 No.4

자발적 의약품 부작용 보고자료를 이용한 성별에 따른 부작용 발현 차이

연하림(Ha Rim Yeon),강상오(Sang Oh Kang),민경현(Kyung Hyun Min),최윤정(Yunjeong Choi),황보영(Boyoung Hwang),김현정(Hyun Jeong Kim),이경은(Kyung Eun Lee) 대한약학회 2020 약학회지 Vol.64 No.1

The aim of this study was to assess and characterize sex differences in adverse drug reactions (ADRs) reported to the Korea Institute of Drug Safety and Risk Management (KIDS). This retrospective pharmacoepidemiological study was performed using the Korea Adverse Event Reporting System (KAERS) database from the KIDS in 2014-2018. Variables used in the analyses include sex and age of patients, suspected drug, type and severity of ADR, and severity of ADR. A ratio of reports concerning women and men was calculated for ADRs reported. A dataset of 22 drugs selected from the FDA label and UpToDate?? database were requested to KIDS. Among 22 drugs, 17 of them were reported as suspected drugs to cause ADR and these were further analyzed in detail. The total reported number of ADRs was 241,974 and reports from female patients comprised of 54.5%. Aprepitant had the highest number of ADR reports (n=179,716), followed by fluorouracil (n=17,807), oxycodone (n=14,643) and cisplatin (n=14,191). Reports of serious adverse events were mostly from aprepitant and evidently high in female patients in aprepitant. Sex differences exist in ADRs based on KIDS-KAERS database which varies among drugs and type of ADRs. Further studies are warranted to examine details of clinical information of patients to conclude gender differences in adverse drug reactions.

에이젼트에 의한 건축 스케치의 벡터변환

서동연(Seo Dong-Yeon),안병욱(An Byong-Wook),이경회(Lee Kyung-Hoi) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

Many architects choose to begin projects using paper and pencil only to transfer that material to a computational environment for final polishing and presentation. This phenomenon can be credited to a prevalent misconception about the inherent nature of computer graphics: that digital tools inherently demand a high level of precision and a lack of ambiguity.<br/> The motivation behind this study is a desire to bridge the gap between initial sketching and digital design environment. This study presents a process exploring two methods for generating three-dimensional coordinates and digital model. The first method is digital image processing techniques by which the skeleton of feature is extracted. The second method makes use of an old machine vision algorithm, the Kanade labeling scheme. The third method is intelligent agent recognizing edge point types and generating solid objects.<br/> This study tends to present progressed vector conversion model of sketch and tries to find the meaning of CAAD system as design media in architectural concept.

미더덕 껍질 분말을 함유한 어묵의 제조 및 품질 분석

최소연(So-Yeon Choi),최은영(Eun-Yeong Choi),이경은(Kyung-Eun Lee),송애선(Ae-Sun Song),박소현(So-Hyeon Park),이승철(Seung-Cheol Lee) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.11

대부분 폐기되고 있는 미더덕 껍질을 활용한 고품질 어묵의 개발을 위하여 미더덕 껍질을 분말로 만들어서 이를 각각 0, 1, 2, 5%씩 첨가한 튀김어묵을 제조하였다. 미더덕 껍질분말의 함유량이 증가할수록 어묵 내부의 색도의 L값과 b값은 감소하는 경향, a값은 증가하는 경향을 보였으며, 어묵표면의 L값, a값, b값은 감소하는 경향을 보였다. 물성검사 결과에서는 함유량이 증가할수록 강도와 경도는 증가하는 경향을 보였고, 유연성을 나타내는 절곡 검사에서는 대조군을 포함한 모든 첨가 군에서 AA가 나와 유연성과 탄력성이 우수한 것으로 나타났다. 관능검사의 결과로는 미더덕 껍질분말을 1% 첨가한 어묵의 경우에서 냄새, 색깔, 맛, 전반적인 수용도면에서 대조군과 비교하여 높은 수치를 나타내었으며, 분말 함유량이 그 이상으로 증가할수록 관능수치가 낮아지는 경향을 보였다. 이상의 결과는 미더덕 껍질 분말을 1% 정도 어묵에 첨가하면 영양적, 물성적, 관능적으로 소비자들에게 호감을 얻을 수 있는 고품질의 어묵이 제조될 수 있음을 시사한다. Styela clava (Korean name: miduduk) tunic was produced as a byproduct after processing of S. clava. To utilize S. clava tunic, fish paste containing tunic powder was prepared, and quality characteristics were evaluated for color, textural properties, and sensory attributes. Increasing the amount of S. clava tunic in fish paste tended to decrease lightness (L), redness (a), and yellowness (b) values of the surface part of fish paste. Strength and hardness of fish paste increased with increasing amount of tunic. All test samples with 3 mm thickness showed good flexibility and did not break even after folding in half four times. For overall acceptance in the sensory evaluation, fish paste containing 1% S. clava tunic acquired a relatively higher score. These results suggest that S. clava tunic can be applied to fish paste products to improve quality and functionality.

난치성 소아 간질에서의 케톤생성 식이요법

고경남(Kyung Nam Koh) 박수연(Su Yeon Park) 임병찬(Byung Chan Lim) 강호석(Ho Seok Kang) 이경연(Kyung Yeon Lee) 황희(Hee Hwang) 채종희(Jong Hee Chae) 최지은(Ji Eun Choi) 김기중(Ki Joong Kim) 황용승(Yong Seung Hwang) 대한소아신경학회 2004 대한소아신경학회지 Vol.12 No.1

목적 : 케론생성 식이요법은 소차의 난치성 간질의 유효한 치료 방법 중 하나다. 저자들은 소아난치성 간질에서의 케톤생성 식이요법의 효과 및 부작용, 적용 간질 증후군의 유형 및 예후를 알아보고자 본 연구를 시행하였다. 방법 : 서울대학교 어린이병원 소아과에서 치료받던 난치성 간질 환자 중 1998년 8월부터 2003년 3월 사이에 케톤생성 식이요법을 시작한 57명(남자:31명, 여자: 25명)을 대상으로 후향적 연구를 시행하였다. 케톤생성 식이요법의 전반적인 효과와 식이요법의 시작 나이, 경련 유형, 초기 금식이 효과에 미치는 영향, 식이요법의 부작용과 중단 원인을 조사하였다. 결과 : 식이요법 시작 시의 환자의 평균 연령은 3.5±2.8세였으며, 평균 3.14±1.24개의 항경련제를 복용하고 있었다. 식이요법 시작 1개월 째에 49명(86.0%)의 환자가 케톤생성 식이요법을 유지하고 있었고, 이 중 37명(64.9%)의 환자가 50% 이상의 경련 감소 효과를 보였다. 6개월까지 식이요법을 유지한 25명(50%)의 환자 중 14명(28%)이 경련이 완전히 억제되었으며 22명(44%)이50% 이상의 경련 감소 효과를 보였다. 12개월까지 식이요법을 유지한 환자는 15명(34.9%)으로, 14명(32.6%)이 90% 이상의 경련 감소 효과를 보였다. 경련 유형, 초기 금식 여부, 식이요법 시작 시의 나이에 따른 효과의 유의한 차이는 보이지 않았다. 식이요법을 중단하는 원인은 효과가 낮거나 식이에 잘 적응을 하지 못한 경우가 대부분이었다. 결론 : 케톤생성 식이요법은 소아의 난치성 간질에 있어서 비교적 안전하면서도 효과적인 치료수단이다. Purpose : Ketogenic diet(KD) is an alternative treatment for children with intractable seizures. This study was performed to evaluate the efficacy and tolerability of ketogenic diet Methods : A retrospective study was performed for 57 patients(31 males, and 25 females), who were enrolled in a ketogenic diet program from 1998 to 2003 in Seoul National University Children´s Hospital. We investigated the overall efficacy, influencing factors such as age at diet onset, seizure type, initial fasting, adverse events and reasons for discontinuing the diet. Results : The patients mean age at diet onset was 3.5 years old. They had 3.14 medications on average at the diet initiation. One month after the diet initiation, 49 of 57(86%) remained on KD, with 37(64.9%) having more than 50% seizure reduction rates. At 6 months, half of the patients remained on KD, with 14(28%) seizure free and 22(44%) having more than 50% seizure reduction rates. At 12 months, 15 patients(34.9%) remained on KD, with 14(32.6%) having more than 90% seizure reduction rates. Seizure types, initial fasting and age at diet onset were not statistically related to the outcomes. There were a few complications during the diet. The most common reasons for discontinuing KD were ineffectiveness and poor tolerability. Conclusion : Ketogenic diet appears to be a relatively effective and safe treatment option for children with intractable epilepsies.

소아청소년에서 연령에 따른 일차두통의 임상적 특징

홍연주(Yeon Ju Hong),김민성(Min Sung Kim),이경연(Kyung Yeon Lee),심창선(Chang Sun Sim) 대한소아신경학회 2010 대한소아신경학회지 Vol.18 No.2

Purpose : Childhood headache is different from adulthood headache and according to their age in clinical aspects. This study investigated the clinical differences of pri- mary headache according to ages of children and adolescents. Methods : A 300 children who did not show abnormalities on neurologic exami- nation or brain CT or MRI were classified into two groups according to their ages. Results : The percentage of those in the migraine group (24.2% vs. 35.9% in Groups 1 and 2 respectively) was higher in Group 2, but it was not statistically signi- ficant. In relation to the duration of headache, pain lasting for less than one hour accounted for 59.8% and 40% in Groups 1 and 2, respectively (P =0.001). In relation to the location headaches developed, the frontal region (40.2%) and temporal region (48.1%) were the most common in Groups 1 and 2, respectively (P<0.001). In rela- tion to the nature of the headaches, tightening sensation accounted for the highest percentage in both groups; however, pulsating sensation were more common in Group 2 than in Group 1 (16.2% vs. 8.3%, P =0.038). In relation to the severity of head- aches, severe to profound headaches accounted for 35.5% and 61.1% in Groups 1 and 2, respectively (P <0.001). In relation to laterality, unilateral headaches accounted for 12.4% and 26.7% in Groups 1 and 2, respectively (P =0.002). In relation to accom- panying symptoms, the incidence of photophobia was higher in Group 2 than in Group 1 (P =0.047). Conclusion : Age factors should be considered in the diagnosis of childhood head- aches. Also, we consider that there may be a need to establish diagnostic criteria specifically for childhood headaches separately from those for adulthood headaches.

급성 이완성 마비 증상을 보인 엔테로바이러스 71 감염

김현경(Hyun Kyung Kim),이강원(Kang Won Rhee),이경연(Kyung Yeon Lee),오기원(Ki Won Oh),김자형(Ja Hyeong Kim),정진영(Jin Young Jeong),박상규(Sang Kyu Park),최성훈(Seong Hoon Choi) 대한소아신경학회 2011 대한소아신경학회지 Vol.19 No.1

수족구병은 손, 발 및 구강 내 특징적 피부 병변을 보이며 대부분 1주일 내에 저절로 호전되는 질환이지만, EV71 감염으로 인한 수족구병의 경우에는 뇌간 뇌염, 급성 이완성 마비, 뇌수막염 등의 신경학적 합병증이 발생할 수 있으며, 일부에서는 심폐 부전으로 사망에까지 이를 수 있다. 저자들은 18개월 여아에서 수족구병과 동반하여 우측 하지의 급성 이완성 마비 증상을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Hand-foot-mouth disease (HFMD) is characterized by distinctive skin lesions on the hand, foot, and mouth and in general, recovery occurs within one week. However, in cases of L-HFMD by enterovirus 71 (EV71) infection, the development of neurologic complications such as brainstem encephalitis, acute flaccid paralysis, and aseptic meningitis has been common. Moreover, it has been reported that some patients with neuologic complications have expired in severe cases. Here, we report a case of EV71 infection presented with acute flaccid paralysis of a single similar to paralytic poliomyelitis.

Duchenne/Becker 근이영양증에서의 Dystrophin 유전자 분석

박수연(Su Yeon Park) 고경남(Kyung Nam Koh) 임병찬(Byung Chan Lim) 강호석(Ho Seok Kang) 이경연(Kyoung Yeon Lee) 황희(Hee Hwang) 채종희(Jong Hee Chae) 최지은(Ji Eun Choi) 김기중(Ki Joong Kim) 황용승(Yong Seun Hwang) 대한소아신경학회 2004 대한소아신경학회지 Vol.12 No.1

목적 : 국내 Duchenne/Becker 근이영증에서의 dystrophin 유전자 결실은 빈도 및 그 분포를 알아보고 유전형과 임상형의 관계를 분석하여, 국내 유전 역학 자료를 마련하고 좀 더 효과적인 유전 상담 및 예방 방법을 모색해보고자 하였다. 방법 : 1999년 1월부터 2003년 7월까지 서을대학교병원에서 상기 질환으로 진단 후 추적 관찰중인 89명의 환자를 대상으로 하였다. 임상 진단 후 근생검을 시행, dystrophin 면역조직화학 염색을 하였으며 dystrophin 유전자 결실은 혈액에서 추출한 DNA를 이용, multiplex PCR 방법을 이용하여 진단하였다. 결과 : 국내 DMD/BMD 환자의 dystrophin 유전자 결실률은 54%였고, 결실 부위의 hot spot은 exon 44-54 부위로 전체 결실 환자의 80%를 차지하였다. 결실이 확인되지 않았던 22명의 환자에서 23개의 exon을 대상으로 직접염기서열 분석을 시행한 결과 6명의 환자에서 6종류의 점돌연변이를 발견하였다. 유전형과 임상형의 관계에 대한 분석 결과 중심형 결실이 근위형에 비해, 다중 결실이 단일 결실에 비해 증상 발생 연령이 어리고 진행이 다소 빠른 경향을 보였으나 통계적으로 유의한 관련성은 찾을 수 없었다. 결론 : 국내 DMD/BMD 환자의 결실률은 54%였으며 hot spot은 exon 44-54였다. 따라서 혈액 유전자 검사로 진단할 수 없는 약 50%의 환자의 진단을 위해서는 근생검 및 dystrophin 항체 면역 조직화학 검사를 통한 진단이 시행되어야 할 것이다. 또한 세밀한 가족력 조사를 포함하여 적절한 보인자 검사를 통해 합리적인 유전 강담을 진행하고 이에 기초한 질병 발생 예방 및 교육 등이 필요할 것으로 생각된다. Purpose : Duchenne/Becker muscular dystrophy(DMD/BMD) is an X-linked recessive disorder caused by mutations of dystrophin genes. The purpose of the present study is to determine the frequency and the patterns of dystrophin gene deletions and to investigate the correlation of genotypes and phenotypes. Methods : There were included a total of 89 children(88 boys and I girl) diagnosed as DMD/BMD by immunohistochemistry and/or genetic analysis from 1999 to 2003 at Seoul National University Children´s Hospital. We analyzed the genomic DNA by multiplex PCR using a 26 dystrophin exon primer set. Direct sequencing was performed on 23 exons(in which point mutations were detected in other previous reports) in 22 patients without deletions. Phenotype and genotype relationship analysis was performed on the basis of retrospective clinical reviews. Results : The frequency of dysmorphin gene deletions was 54%(32/59), which is lower than that of European and American data. Exon deletions were detected in 59 cases and the deletion "hot spots" were exon 44-54 constituting 80% of all deletions. In 6 cases without detectable deletions, 6 point mutations(3 nonsense mutations and 3 nucleotide variants) were detected The patients whose deletions were in the central parts or the patients with multiple exon deletions tended to show earlier symptom onsets and more rapid progressions of weakness but there were no statistical significances. Conclusion : Since deletions in dystrophin genes were detected in about 50% of the patients, studies on dystrophin protein expressions using muscle biopsy samples must be done for correct diagnosis.