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오인보,이지호,심창선,김양호,유철인,Oh, In-Bo,Lee, Ji-Ho,Sim, Chang-Sun,Kim, Yang-Ho,Yoo, Cheol-In 한국환경보건학회 2010 한국환경보건학회지 Vol.36 No.6
This study aims to investigate the relationship between air pollution exposure and the prevalence of allergic rhinitis in a young population in the Ulsan metropolitan region (UMR). Data on physician-diagnosed allergic rhinitis (past 12 months) in 1,449 infants and children aged 1-18 years who lived within 1.5 or 2 km of air quality monitoring sites were collected in a cross-sectional health interview survey conducted between January-February 2006 in the UMR. Comparisons of the spatial distribution of the prevalence rates for allergic rhinitis and annual average pollutant concentrations over the region showed that a relatively high prevalence rate occurred around the coastal industrial area, with high PM10 concentrations. A linear correlation analysis demonstrated a positive correlation relationship between them (R = 0.680, p = 0.04). Multiple linear regression analysis revealed that the combined effect of the PM10 and $SO_2$ variables accounts for approximately 81% of the variance (R-square: 0.81) in the prevalence rate. From the multiple logistic regression analysis after adjustment by age, sex, and air-pollutant factors, the PM10 and $SO_2$ which were mainly from industrialrelated emissions were found to be significantly associated with an increased risk of allergic rhinitis (aOR: 1.76, 95% CI: 1.15-2.70 for PM10 ; aOR: 1.63, 95% CI: 1.12-2.35 for SO2).
김양호,이지호,심창선,정경숙,Kim Yang Ho,Lee Ji Ho,Sim Chang Sun,Jeong Kyoung Sook 대한임상독성학회 2004 대한임상독성학회지 Vol.2 No.2
Arsenic poisoning has three types of poisoning. First, acute arsenic poisoning is usually caused by oral intake of large amount of arsenic compound with purpose of homicide or suicide. Second, chronic arsenic poisoning is caused by inhalation of arsenic in the occupational setting or by long-term oral intake of arsenic-contaminated well water. Third, arsine poisoning occurs acutely when impurities of arsenic in non-ferrous metal react with acid. Clinical manifestation of acute arsenic poisoning is mainly gastrointestinal symptoms and cardiovascular collapse. Those of chronic poisoning are skin disorder and cancer. Arsine poisoning shows massive intravascular hemolysis and hemoglobinuria with acute renal failure. Exposure evaluation is done by analysis of arsenic in urine, blood, hair and nail. Species analysis of arsenic is very important to evaluate inorganic arsenic acid and mono methyl arsenic acid (MMA) separated from dimethyl arsenic acid (DMA) and trimethyl arsenic acid (TMA) which originate from sea weed and sea food. Treatment with dimercaprol (BAL) is effective in acute arsenic poisoning only.
울산지역 초등학생 알레르기 질환 유병률: 지역적 차이와 환경위험인자
오인보,김양호,심창선,이지호,Oh, In-Bo,Kim, Yangho,Sim, Chang Sun,Lee, Ji Ho 한국환경보건학회 2012 한국환경보건학회지 Vol.38 No.6
Objectives: This study aims to investigate the AD (allergic diseases: asthma, allergic rhinitis and atopic dermatitis) prevalence among elementary schoolchildren in an industrial city, Ulsan, and identify major environmental risk factors associated with AD prevalence. Methods: Data on the physician-diagnosed prevalence over the past 12 months and potential risk factors of AD were collected through a questionnaire from a 2009-2010 survey of 4,067 schoolchildren living in different urban environments. The logistic regression analysis was performed to assess differences in AD prevalence among the areas and to determine which environmental factors impacted AD. Results: Our survey results showed that the AD prevalence rate ranged between 26.2% and 35.9%. Children living in polluted areas (near industrial and central urban areas) had about a 10% higher prevalence of AD than did those living in coastal or suburban residences. The Chi-Square test demonstrated that this local difference was statistically significant before and after adjustment of major confounders such as parental AD history and parental education. The results of the logistic regression analysis showed a statistically significant association between several environmental factors (ventilation in winter, odor conditions and exposure to traffic smoke, and outdoor $PM_{10}/O_3$ pollution) and the prevalence of AD found by multivariate model after adjusting confounders. Conclusion: These results suggest that local differences in AD prevalence are significantly associated with outdoor environmental factors. Although there are likely to be other risk factors for AD, living in a polluted area and exposure to high levels of air pollutants can contribute to an increased risk of childhood AD.
울산지역 초등학생의 알레르기비염 유병과 면역반응과의 상관성: 환자-대조군 연구
이지호,오인보,김아라,김민호,심창선,김양호,Lee, Jiho,Oh, Inbo,Kim, Ahra,Kim, Minho,Sim, Chang sun,Kim, Yangho 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.4
Objectives: This study aims to investigate the correlations between the prevalence of allergic rhinitis (AR) and cytokines among elementary school children in an industrial city, Ulsan, South Korea, and to identify major environmental risk factors associated with AR prevalence. Methods: We conducted a case-control study in June 2009 and February 2010 in order to evaluate the relationship between AR and related cytokines. Data on physician-treated prevalence over the past 12 months and potential risk factors for AR were compiled through a questionnaire from a survey of 339 schoolchildren living in different urban environments. Logistic regression analysis was carried out with propensity score matched data (n=180) to assess the influences of cytokines (IL-13, IL-33, IL-4 and IL-5) on AR prevalence and to determine which environmental factors affected AR. Results: In univariate analysis, the AR prevalence was influenced by family history of AR (mother and siblings), environmental factors (odor condition and irritated symptoms of air pollution), and indoor allergens (D. farinae and D. pteronyssinus). The t-test demonstrated that eosinophils, Immunoglobulin E (IgE), and interleukins (IL-13 and IL-5) were statistically significantly different according to treatment of allergic rhinitis over the preceeding 12 months. The results of the multiple logistic regression analysis showed that a statistically significant association between several factors (such as irritated symptoms of air pollution (OR 4.075, CI 1.735-9.568), IL-13 (OR 0.825, CI 0.734-0.928), odor condition (OR 2.409, CI 0.908-6.389), and AR history of siblings (OR 2.217, CI 0.999-4.921)) and the prevalence of AR was found after adjusting for confounders. Conclusion: These results suggest that AR prevalence is significantly associated with cytokine level, genetic background, and outdoor environmental factors. Although living in a polluted area and genetic background can contribute to an increased risk of childhood AR, cytokine level should be considered as an important factor in the treatment of AR in the last 12 months.
울산광역시 일개 초등학교 소아들의 알레르기 및 아토피질환의 유병률
윤재국 ( Jae Kook Yoon ),심창선 ( Chang Sun Sim ),최승원 ( Seung Won Choi ),오인보 ( In Bo Oh ),이지호 ( Ji Ho Lee ),김양호 ( Yang Ho Kim ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.2
Background: Ulsan is the most industrialized city in Korea. Although many investigations as to which factors are related to allergy and atopy have been performed so far, these factors are still uncertain. Studies of industrialized environment can help to understand an atopic disorder. Objective: This study was undertaken to investigate the prevalence of allergic and atopic disorders in an industrial city, Ulsan and to estimate the proportion of ``real`` atopyto so-called ``allergy and atopy``. Also, we examined the validity of some items of blood tests, such as serum total IgE levels and eosinophil counts for the diagnosis of the atopic disorder. Method: We conducted the questionnaire survey based on the ISAAC protocol along with demographic variables at an elementary school in the central area of Ulsan. The questionnaires were completed by patients of 1,323 children, of whom 570 participated in skin prick test and blood test. Atopic disorder was defined as the presence of allergic symptoms and the presence of sensitization to any allergens by skin prick test. Result: The lifetime prevalence of atopic wheeze was 8.8%and the proportion of atopy of asthma was 60.4%. The lifetime symptom prevalence of ``real`` atopic dermatitis (atopiceczema) was 16.1% and the proportion of atopy of atopic dermatitis was 49.4%. The prevalence of ``real`` allergic rhinitis (atopic rhinitis) was 28.0% and the proportion of atopy of allergic rhinitis was 51.8%. The prevalence of overall atopic disorder was 37.0%, and the proportion of atopy of overall allergic disorder was 51.4%. The area under receiver operating characteristic curve of serum total IgE for the diagnosis of the atopic disorder was 0.770. Also, we observed the selective bias from the differences in prevalence between groups of complete participants and incomplete participants. Conclusion: The prevalence of asthma was similar to those of other regions in Korea. However, atopic dermatitis and allergic rhinitis were more prevalent than other regions. About half of so-called allergic disorders may be an atopic disorder. (Korean J Asthma Allergy Clin Immunol 2011;31:105-115)
아토피 아동 가정내 집먼지 진드기 농도와 환경요인: 환자 대조군 연구
김성호,박동진,변혜정,이현수,오인보,심창선,김양호,윤충식,Kim, Sung-Ho,Park, Dong-Jin,Byun, Hyae-Jeong,Lee, Hyun-Soo,Oh, In-Bo,Sim, Chang-Sun,Kim, Yang-Ho,Yoon, Chung-Sik 한국환경보건학회 2012 한국환경보건학회지 Vol.38 No.3
Objectives: The purpose of this study was to determine house dust mite concentrations in living rooms and bedding materials in atopic case-control groups. Methods: Fifty four homes with children suffering atopic diseases as cases and fifty one homes without atopic diseases as controls were selected after diagnosis at three elementary schools in Ulsan City. Dust samples were collected from the living rooms and bedding materials in each home during summer and winter with a vacuum cleaner and analyzed for house dust mites using enzyme-linked immunosorbent assay (ELISA). Environmental factors and family history were surveyed during sampling. Results: Both species of house dust mite Dermatophagoides farina (Der f 1) and Dermatophagoides pteronyssinus (Der p 1) were found in all homes. Derf1 concentrations were much higher than Der P1 concentrations, both in atopic homes (1518.9 vs. 27.0 ng/g. dust, respectively) and non-atopic homes (810.8 vs. 44.3 ng/g. dust, respectively). Der f 1 concentrations were significantly higher in the atopic group than in the non-atopic group (atopic: 1518.9 ng/g.dust, non-atopic: 810.8 ng/g.dust, p = 0.035). However, total house dust mite Der p 1 concentrations were significantly higher in the non-atopic group than in the atopic group (atopic: 27.0 ng/g.dust, non-atopic: 44.3 ng/g.dust, p = 0.035). Multiple regression implied that mothers with family history of atopic diseases (OR = 4.79, 95% CI = 1.81-12.69), Der f 1 concentrations (OR = 1.74, 95% CI = 1.07-2.81), and air freshener use (OR = 4.60, 95% CI = 1.72-12.34) had significant associations with atopic children. Conclusion: House dust mite Der f 1 concentrations were associated with atopic children. This study suggests that parents should reduce house dust mite Der f 1 concentrations through environmental controls.