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윤정한(Jeong-Han Yun),김우년(Woon-Nyon Kim),서정택(Jung-Taek Seo) 한국정보보호학회 2012 情報保護學會誌 Vol.22 No.5
제어시스템에 대한 사이버테러는 사회적, 경제적으로 큰 혼란을 발생시킬 수 있기 때문에 최근 제어시스템은 사이버테러의 제 1목표로 부각되고 있다. 이에 발맞추어 제어시스템 보안을 위한 연구 및 제품 출시가 많이 이루어지고 있다. 특히 제어시스템 가용성에 영향을 주지 않을 수 있는 제어시스템 네트워크 보안기술이 그 중심에 있다고 하겠다. 본 논문에서는 제어시스템 네트워크 보안에 대한 연구 및 제품의 동향을 살펴본다. 그리고 앞으로 제어시스템 네트워크 보안기술 연구시 필요한 사항들을 짚어본다.
양측 액와 유방 접근 내시경 갑상선 절제술에 대한 5년간의 분석
박윤철(Yun Chul Park),유영재(Young Jae Ryu),조진성(Jin Seong Cho),윤정한(Jung Han Yoon),박민호(Min Ho Park) 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.2
Purpose: We investigated the efficacy and safety of endoscopic thyroidectomy using bilateral axillo-breast approach (BABA) by analyzing short term surgical outcomes. Methods: We retrospectively evaluated 355 patients who underwent BABA endoscopic thyroidectomy between August 2006 and December 2011 at Chonnam National University Hospital and Hwasun Chonnam National University Hospital. The age, sex, clinical and pathologic characteristics of tumors, extent of operation, conversion rate to open thyroidectomy, operation time, hospital stay, thyroglobulin levels after thyroidectomy, recurrence, and complications were analyzed retrospectively. Results: The mean age of the patients was 35 years. The 355 patients comprised 345 females (97.2%) and 10 males (2.8%). The benign tumor was 37 cases (10.4%) and the malignant tumor was 318 cases (89.6%). 28 patients (75.7%) of the benign tumor underwent lobectomy. In malignant tumor, 159 patients (50.0%) underwent lobectomy and 152 patients (47.8%) underwent total thyroidectomy. Mean operation time was 121.1±49.9 minutes, and mean hospital days were 3.4±1.1 days. 21 (6.0%) transient hypocalcemia and 7 (2.0%) permanent hypocalcemia were occurred. The transient voice change occurred in 5 patients (1.4%), but nobody suffered from the permanent recurrent laryngeal nerve injury. 4 patients of recurrent (1.3%) papillary thyroid carcinoma were treated by surgery. Conclusion: Compare to open thyroidectomy with long term follow up studies, BABA endoscopic thyroidectomy is a useful treatment option for both benign and malignant thyroid tumor.
Endothelin-1에 의한 phospholipase C 활성화와 세포내 Ca2+ 이동에 미치는 protein kinase 들의 효과
조중형(Jung Hyung Cho),김현준(Hyun Jun Kim),이윤혜(Yun Hye Lee),박진형(Jin Hyoung Park),장용운(Youn Un Jang),이승준(Seung June Lee),이준한(June Han Lee),윤정이(Jeong Yi Yoon),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2000 약학회지 Vol.44 No.2
To investigate the effects of protein kinases on endothelin-l-induced phospholipase C activation and Ca2+ mobilization in Rat-2 fibroblast, we measured the formation of inositol phosphates and intracellular Ca2+ concentration with [3H]inositol and Fura-2/AM, respectively. Endothelin-1 dose-dependently activated phospholipase C and increased intracellular Ca2+ concentration. Protein kinase C activator, PMA, significantly inhibited both phospholipase C activity and Ca2+ mobilization induced by endothelin-1. Tyrosine kinase inhibitor, genistein, inhibited both. On the other hand, cyclic nucleotide (cAMP and cGMP) did not have any influence on the signaling pathway of phospholipase C-Ca2+ mobilization induced by endothelin-1. These results suggest that protein kinase C and tyrosine kinase counteract on the signaling pathway of phospholipase C-Ca2+ mobilization induced by endothelin-1 in Rat-2 fibroblast.
유방암에서 유두침범을 예측할 수 있는 인자들에 대한 분석
윤상권(Sang-Kwon Yun),노혜원(Hye-Won Ro),조진성(Jin-Seong Cho),박민호(Min-Ho Park),윤정한(Jung-Han Yoon),제갈영종(Young-Jong Jegal) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.4
Purpose: After the first subcutaneous mastectomy with nipple preservation in 1974 at the Nottingham Breast Clinic in United Kingdom, many studies have shown that skin-sparing mastectomy (SSM) with the preservation of the nipple-areola complex (NAC) is an oncologically safe procedure with good cosmetic outcomes in selected mastectomy patients. However, the clinical indications for NAC preservation have not yet been precisely defined. This study was performed to investigate the predictive factors for NAC-based neoplastic involvement to determine the indications for NAC preservation. Methods: A retrospective study of 198 patients with invasive breast cancer who underwent modified radical mastectomy (MRM) at the Department of Surgery at Chonnam University Hospital from April of 2004 to April of 2006 was performed. Patients with bilateral breast cancer were excluded from the study. The predictive factors analyzed for NAC involvement were the hormone receptor status, tumor size, tumor localization, multiplicity, axillary lymph node status, nuclear grade, tumor-nipple distance (TND), and lymphovascular invasion (LVI). Results: The overall frequency of malignant NAC involvement was 19 out of the 198 patients (9.5%) as determined by definitive histology. Significant differences were found for tumor size (P=0.015), axillary lymph node status (P=0.008), TND (P=0.044), and LVI (P=0.014). There were no significant differences for the hormone receptor status, multiplicity, nuclear grade, and localization. Conclusion: Although the sample size in this study was small, the findings suggest that the clinical contraindications for NAC preservation should include tumors >2.4 cm, a positive axillary lymph node status, TND <4 cm, and positive LVI. NAC preservation can be offered in selected patients after preoperative or intraoperative evaluation of the tumor size, axillary node status, TND, and LVI.
급성 심근경색증 환자에서 조기에 적절한 재관류 요법을 시행받지못한 요인
유병수(Byung Su Yoo),윤정한(Jung Han Yoon),박금수(Keum Soo Park),여경구(Kyung Koo Yoh),조윤경(Yun Kyung Cho),안승찬(Seung Chan Ahn),이용규(Yong Kyu Lee),송광선(Kwang Seon Song),최경훈(Kyung Hoon Choe),이부수(Boo Soo Lee),황성오(Sung 대한내과학회 1995 대한내과학회지 Vol.48 No.6
N/A Objectives: Early application of reperfusion therapy such as thrombolytic agent or direct PTCA is utmost important to amximize the efficacy of reperfusion therapy in patients with aute myocardial infarction. However, early adequate reperfusion thearpy was given only in 15% to 36% pf patients with acute myocardial infarction and substantial patients were not benefited from reperfusion therapy, Therefore, we performed these study to evaluate the reasons for which patients with acute myocardial infarction cannot receive an adequate reperfusion therapy. Methods: We analyzed the initial electrocardiogram and various time delays from chest pain onset time, first hospital arrival time, transfer time, ER arrival time, and door to reperfusion time in 138 patients with acute myocardial infarction from Jan. 1991 to Oct. 1993 admitted to Wonju Christian Hospital. Patients were grouped as reperfusion group(n=55) who had reperfusion therapy such as thrombolytic trial or direct PTCA and conservative grou who had not received reperfusion therapy(n= 83). Results: 1) Eighty-three cases(60.1%) did not received an adequate reperfusion therapy. 2) Hospital arrival time of patients was 237±162min and 786±615min in reperfusion and conservative group(p<0.05) respectively. Patient time delay was 103±98min and 439±511min, first hospital time delay, 93±78min and 333±482min, and transfer time, 81±59min and 105±64min in reperfusion and conservative group respectively(p<0.05). Only 4.8% of patients was transferred from first hospital after reperfusion therapy. 3) Patient time delay was the most common reason of not receiving reperfusion therapy, and time delay and lack of adequate reperfusion therapy at the first hospital inspite of early arrival were the second place. Other reasons were contraindication to lytic therapy(4 cases), definite Q wave MI(11 cases), inconclusive EKG(4 cases), and delay in therapy(4 cases). Conclusion: The most common reason of not receiving reperfusion therapy was patient delay in seeking medical care(45.8%) and time delay at first hospital in 22 cases(26.5%). To maximize the effectiveness of reperfusion therapy, it is important to shorten hospital arrival time delay and widespread use of reperfusion therapy at first hospital is recommeded.
경피적 경혈관 관동맥 풍선성형술 후 관동맥 재협착의 양상
박시훈(Si Hoon Park),조승연(Seung Yun Cho),김현승(Heun Seung Kim),윤정한(Jung Han Yoon),김병옥(Byung Ok Kim),정남식(Nam Sik Chung),심원흠(Won Heum Shim),이웅구(Woong Ku Lee) 대한내과학회 1992 대한내과학회지 Vol.43 No.3
N/A Background and Methods: In a total of 40 patients who had undergone successful percutaneous transIuminal coronary angioplasty (PTCA) and were con- firmed as having restenosis by later coronary angiography, we observed time interval of restenosis and angiographic change of merphoiogy and severity of restenosis. The results were as follows. Results: 1) Restenosis was most prevalent in 2nd and 3rd months following PTCA 2) Angiographic morphology and severity of the restenotic lesion were similiar to those of pre-PTCA Conclusion: Repeat PTCA is justified for treatment of patients with restenostic lesions even considering of higher restenosis rate after second PTCA and optimal timing of angiographic restudy is at least 4months after successful PTCA.