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윤일,한석규,백승완,김남홍,강정숙,정준기,이은주,Yun, Il,Han, Suk-Kyu,Baik, Seung-Wan,Kim, Nam-Hong,Kang, Jung-Sook,Chung, Joong-Ki,Lee, Eun-Joo The Korean Society of Pharmacology 1988 대한약리학잡지 Vol.24 No.1
국소마취제의 약리학적 작용기전을 탐구키 위하여 소의 신선한 대뇌피질로부터 synaptosomal plasma membrane vesicles(SPMV)를 분리한 후 그 소수성 중심부의 microviscosity에 미치는 국소마취제의 영향을 pyrene 형광 probe법으로 측정한 결과 lidocaine HCI과 procaine HCI이 microviscosity를 낮춘다는 것을 알았고 그 정도는 procaine HCI에 비하여 tidocaine.HCI이 더욱 컸다. 또 국소마취 제 가 dimyristoylphosphatidylcholine (DMPC) multilamellar liposomes의 상전 이온도를 낮추며 cooperative unit크기를 감소시킨다는 것도 시차 열량분석법으로 알게 되었다. 상전이온도와 cooperative unit 크기의 감소 정도는 dibucaine HCI>tetracaine HCI>lidocaine HCI > procaine HCI의 순이었다. To elucidate the mechanism of action of local anesthetics, the effects of local anethetics on the microenvironment of the lipid bilayers of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine brain and dimyristoylphosphatidylcholine (DMPC) multilamellar liposomes were investigated employing the intermolecular excimer fluorescence technique and differential scanning calorimetry (DSC). The relative intensities of excimer and monomer fluorescence of pyrene are a simple linear function of the viscosity of a homologous series of solvents. The microviscosity(${\eta}$)of the hydrocarbon region of SPMV was measured by this method and the value was $57.3{\pm}5.3\;cP$ at $37^{\circ}C$. In the presence of lidocaine-HCl and procaine-HCl, the values decreased to $46.5{\pm}5.1\;cP$ and $54.7{\pm}4.8\;cP$, respectvely. The differential scanning thermograms of DMPC multilamellar liposomes showed that local anesthetics significantly lowered the phase transition temperature, broadened the thermogram peaks, and reduced the size of the cooperative unit. These results indicate that local anesthetics have significant fluidizing effects on biomembranes and perturbation of membrane lipids may produce some, but not all, of their pharmacological actions.
노른자모양황반변성 환자에서 유리체강내 베바시주맙 주입술을 시행한 환자 1예
문상우,이호영,윤일한,임성협,Sang Woo Moon,Ho Young Lee,Il Han Yun,Sung Hyup Lim 대한안과학회 2014 대한안과학회지 Vol.55 No.7
<b>Purpose:</b> To report a patient diagnosed with adult-onset vitelliform dystrophy (AOVD) who received an intravitreal injection of bevacizumab in both eyes. <b>Case summary:</b> A 47-year-old female presented with blurred vision and metamorphopsia in both eyes. On color fundus photograph, small, round, yellowish dots on the foveola and subreitnal fluid were observed. Optical coherence tomography (OCT) showed thick hyperreflective structures in the retinal pigment epithelium (RPE) layer with serous retinal detachment and subretinal fluid. Despite an intravitreal injection of bevacizumab on both eyes, anatomical improvement was not observed on fundus photography and OCT. J Korean Ophthalmol Soc 2014;55(7):1093-1098
망막중심정맥폐쇄에서 발생한 황반부종에 대한 유리체강내 베바시주맙 주입술의 효과
최성욱,김현웅,윤일한,Sung Wook Choi,Hyun Woong Kim,Il Han Yun 대한안과학회 2010 대한안과학회지 Vol.51 No.5
Purpose: To report the effect of intravitreal injection of bevacizumab for the treatment of macular edema due to central retinal vein occlusion (CRVO). Methods: In a retrospective study, 18 consecutive patients (18 eyes) with macular edema from CRVO received intravitreal bevacizumab (1.25 mg). Ophthalmic examination included best corrected visual acuity (BCVA) and central macular thickness (CMT) at baseline and follow-up visits. Fluorescein angiography was performed during follow-up visits if necessary. Primary outcomes included a change in BCVA and CMT. Results: The mean duration from symptom detection to the first bevacizumab injection was 32.5 days. The patients received a mean of 2.17 injections of bevacizumab per eye. The mean baseline visual acuity (LogMAR) was 1.27 and increased to a mean of 0.75 at 5 weeks, and 0.81 at 24 weeks. The mean central macular thickness at baseline was 640.5 μm and decreased to a mean of 295.6 μm at 5 weeks and 284.7 μm at 24 weeks (p<0.05). In the ischemic CRVO group, no significant changes in visual acuity were found after 24 weeks. The increase in visual acuity did not correlate significantly with the decrease in CMT after 24 weeks (p=0.205). The result from the non-ischemic group was similar to the preceding result (p=0.151). Conclusions: Intravitreal bevacizumab resulted in a significant decrease in CMT in patients with CRVO after a 6-month follow- up. The visual acuity in patients with non-ischemic CRVO improved, but there was no significant improvement in the ischemic CRVO group. J Korean Ophthalmol Soc 2010;51(5):707-715
망막분지정맥폐쇄에 의한 황반부종에서 유리체강내 베바시주맙 주입술의 장기효과
송인제,김현웅,윤일한,In Je Song,MD,Hyun Woong Kim,MD,PhD,Il Han Yun,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.2
Purpose: To report the long term effects of intravitreal bevacizumab injection (IVAI) for the treatment of macular edema due to branch retinal vein occlusion (BRVO). Methods: In this retrospective study, 47 consecutive patients (47 eyes) whose visual acuity under 20/40 and macular thickness over 250 μm from BRVO received IVAI (1.25 mg). All patients were observed over 12 months. The patients were classified into three groups: one, resolved macular edema after first injection, second, persistant, third, recurrant. At 12 months after injection, best corrected visual acuity (BCVA) and central macular thickness (CMT) were compared with one another. Results: Comparing with baseline BCVA (0.96 ± 0.32, 1.13 ± 0.42, 0.85 ± 0.24 log MAR unit), the mean at 12 months was significantly increased (0.50 ± 0.30, 0.76 ± 0.51, 0.55 ± 0.35) in each group. The mean CMT at baseline was 510.84 (± 171.07), 538.5 (± 216.87), 522.6 (± 101.82) μm decreased to 211.58 (± 42.74), 232 (± 132.68), 270.6 (± 85.27). Conclusions: IVAI was a result of significant decrease of CMT with improvement of BCVA in patients with BRVO after a follow- up of 12 months. J Korean Ophthalmol Soc 2012;53(2):283-290
한민,김현웅,윤일한,Min Han,Hyun-Woong Kim,Il-Han Yun 대한안과학회 2005 대한안과학회지 Vol.46 No.5
Purpose: To evaluate the correlation between lesional variation and visual outcome and natural course of idiopathic choroidal neovascularization (CNV) in the patient who had been treated with conservative treatment only. Methods: Best corrected visual acuity (BCVA), fluorescein and indocyanine angiographic examination (FAG and ICGA) and comparative analyses were performed for twenty eyes diagnosed with subfoveal and juxtafoveal idiopathic CNV and the long-term (mean, 24.7 months) natural course was followed. Results: Juxtafoveal CNV occurred in 12 eyes (60%) and final BCVA in 17 eyes (85%) improved over 1 line or remained unchanged. Minimal or no leakage of final FAG was shown in 12 eyes (60%). In final ICGA, dark rim was found in 16 eyes (80%), hyperfluorescent area in 12 (60%) and focal choroidal venous dilatation in 3 (15%). Juxtafoveal CNV had more favorable visual outcome than subfoveal CNV and the increased dark rim and decreased hyperfluorescent area in ICGA were significantly correlated with favorable visual outcome. Conclusions: Idiopathic CNV had a favorable visual outcome during long-term follow-up period with conservative treatment only.
후유리체막 및 망막내경계막 제거술을 시행한 황반원공 망막박리의 수술결과
최명근,김현웅,윤일한,Myoung-Geun Choi,Hyun-Woong Kim,Il-Han Yun 대한안과학회 2005 대한안과학회지 Vol.46 No.9
Purpose: To evaluate the postoperative surgical outcome of vitreous surgery with removal of the internal limiting membrane assisted by indocyanine green (ICG) and the epiretinal membrane assisted by triamcinolone acetonide (TA.) Methods: We examined the posterior vitreous state with ultrasound and OCT. The procedures performed included pars plana vitrectomy with internal limiting membrane removal assisted by ICG and epiretinal membrane peeling assisted by TA. We prospectively examined 9 eyes with retinal detachment resulting from a macular hole and with follow-up periods longer than 12 months. The main outcome was evaluated by the anatomical success rate, functional success rate, and postoperative complications. Results: In the 7 of 9 eyes, the retina was reattached with closure of the macular hole and without closure of the macular hole in 1 of 9 eyes. Successful retinal reattachment was achieved in 8 eyes (88%) after the initial surgery and in one eye after an additional operation. Visual acuity was improved in 7 eyes, was unchanged in one eye, and decreased in one eye. The functional success rate was 78%. Conclusions: In retinal detachment resulting from a macular hole, removal of the internal limiting membrane by ICG, and the posterior hyaloid membrane and epiretinal membrane by TA typically results in anatomical and functional success.