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오오진,민혜영,이상국 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.10
Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentrationdependent manner (IC50 = 1.1 µM). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione.
김은정,오오진,이상국,양기숙,Kim, Eun-Jeong,Oh, O-Jin,Lee, Sang-Kook,Yang, Ki-Sook 한국생약학회 2001 생약학회지 Vol.32 No.4
The root of Astragalus membranaceus Bunge (Leguminosae), which has been used for the treatment of hypertension, chronic hepatitis, duodenal ulcers, chronic nephritis and promotion of immunity in folk remedies. Cyclooxygenase (COX-2) is responsible for the production of large amounts of proinflammatory prostaglandins (PGs) at the inflammatory site. Thus, a logical approach to the treatment of inflammatory disease should involve the inhibitors of COX-2. To develop new COX-2 inhibitors from natural products, Astragali Radix was screened by inhibiting prostaglandin $E_2(PGE_2)$ generation in the culture medium using enzyme immunometric assay. Two isoflavone glycosides, $7,2'-dihydroxy-3',4'-dimethoxyisoflavan-7-O-{\beta}-D-glucoside$ and $calycosin-7-O-{\beta}-D-glucoside$ isolated from Astragali Radix inhibited COX-2 activity.
허봉구,김주현,오오진 경상대학교 농업생명과학연구원 2010 농업생명과학연구 Vol.44 No.2
This study was carried out to investigate the effects of the various soil textures and NPK fertilizer application rates on growth and yield of Ostericum koreanum by pot experiment. Mean temperatures during cropping seasons of May, June, August and October were higher than those of normal year, but also the values were equal or lower for the other period. The growth and yield of Ostericum koreanum in the 1.5 fertilization rates became higher as the fertilizer rates increased by different soil textures. The content of soil organic matter and available phosphorus were high by application of high fertilization levels, while another contents did not show any significant differece. The yield of Ostericum koreanum was high in the loam soil by 278kg/10a. Those for clay soil was lower. Therefore, these results suggested that optimum soil texture for cultivation of this plant could be loam soil. 강활의 재배체계를 확립하기 위하여 다섯 종류의 토성과 및 3요소 시용량을 표준, 1/2량, 1.5배량을 달리하여 포트시험으로 강활의 생육상황과 수량을 조사하였다. 재배기간 중 월별 평균기온은 평년에 비해 5, 6, 8, 10월만 높았으며 그 외는 같거나 낮았다. 그 결과 토성별 시비량에 있어서는 3요소 시비량이 많을수록 생육이나 수량이 많은 경향을 보였다. 토양 이화학성중 유기물, 인산은 시비량이 많을수록 높았으나 다른 화학성분들은 시비량과 유의성 있는 관계를 보이지 않았다. 강활의 수량은 양토에서 가장 많았으며 식토에서 가장 적었으므로 강활의 노두로 재배하는 북강활의 적정 재배 토성은 양토임이 밝혀졌다.
허봉구,정낙현,김주현,오오진,손성곤,강대용 韓國藥用作物學會 2007 한국약용작물학회지 Vol.15 No.1
야콘은 재배지역 적응성이나 과다시비에 강한 편이나 시비 종류나 시비량에 따라서 반응은 다르게 나타나는 작물인데 수피퇴비와 유기질비료를 주구로하여 3요소 시용량을 다르게 하여 준고냉지에서 야콘을 재배한 결과는 다음과 같다. 시험전 토양의 이화학성은 비옥도가 낮은 보통밭이었다. 재배기간중 월별 평균기온은 평년에 비해 7월만 높았을 뿐 그 외는 같거나 낮았다. 무비구보다는 무퇴비구가 생육이 양호하고 수량이 74% 많았다. 야콘 생육은 수피퇴비, 유기질비료 처리시 3요소 시비량이 증가할수록 초장, 엽수, 경태 등 생육이 양호했으며 수량도 많았다. 수량은 수피퇴비구보다는 유기질비료 처리구가 많은 경향이었으나 수피퇴비 3요소 1.5 배구가 수량이 6,905kg/10a 으로 가장 많았다. 야콘잎의 일반성분은 퇴비종류나 3요소 시용량구간에 일정한 경향이 없었으며 무퇴비구의 함량도 3요소 비료 시용구의 성분과 큰 차이가 없었다. This study was conducted to investigate the effect of various composts and NPK fertilization rates on the growth of yacon (Polymnia sonchifolia POEPP). Fertilization of used soil was low. Mean temperature of July was higher than that of normal year, but those of another months were same or the lower. The yield of the no-compost plot was higher by 74% than the no-fertilization plot. Increased NPK fertilization rates of bark compost and organic fertilizer plots increased the growth and yield of yacon. The yield of bark compost 1.5 times plot was highest by 6,905 ㎏/10a. The chemical contents of leaves in the various compost and NPK fertilization rates were not normal tendency, and also that of no-compost plot was not difference to the NPK fertilization rates plot.
허봉구,김찬용,손성곤,오오진 한국약용작물학회 2007 한국약용작물학회지 Vol.15 No.1
강활 주재배지인 봉화지역 밭토양의 토양 특성을 조사하고 강활재배지 토양의 특성을 분석하여 토양환경과 적정 이화학성을 구명하기 위하여 강활의 생육상황과 수량을 조사한 결과는 다음과 같다. 1. 봉화지역 밭토양의 토성은 사양토와 양토가 대부분이었고 경사는 7~15%가 가장 많았으며 다음이 15~30%이었다. 2. 토양 배수등급별 토성 분포에 있어서는 사양토와 양토는 배수 양호가 많았으나 양토는 불량등급도 있었다. 양질조사토나 양질사토는 매우 양호 등급이었다. 3. 강활 수량은 양토와 배수등급 약간양호에서 289kg/10a으로 가장 많았는데 식양토와 배수불량등급에서 수량이 가장 적었다. 4. 강활 재배지의 토양유기물, 칼리함량, EC는 배수등급이 불량할수록 적어졌으며 그 외 함량은 배수등급간에 일정한 경향이 없었다. This study was carried out to investigate the cultivated soil properties, the growth and yield of Ostericum koreanum Kit. in the Bonghwa area. The results were as follows: In Bonghwa area, soil texture of upland soil were mostly sandy loam and loam. Sloped areas of 7~15% were plentiful than the other slopes, that of next was 15~30% slope. Sandy loam and loam soil were mostly 'well' in the drainage class, but loamy coarse sand and loamy sand soil were 'excessively well' drainage class. In the 'moderately well' drainage class, yield of Ostericum koreanum was 289kg/10a, and that of 'poorly' drainage class was low. The yield of loam soil texture was 284kg/10a. Soil organic matter, Potassium and EC were lower in 'poorly' drainage, but the other constituents were not definite tendency by different drainage classes.
김도훈,한지수,김기은,김진효,김성건,김호경,오오진,황완균,Kim, Do-Hoon,Han, Chi-Su,Kim, Gi-Eun,Kim, Jin-Hyo,Kim, Sung-Gun,Kim, Ho-Kyoung,Oh, O-Jin,Whang, Wan-Kyunn 대한약학회 2009 약학회지 Vol.53 No.3
In this study, isolation of antioxidative compounds was performed for development of anti-oxidizing agent. $CHCl_3$, $H_2O$, 30%, 60% MeOH, MeOH fractions were examined antioxidative activity by DPPH, test of inhibition on NO production. It was revealed that 30%, 60% MeOH and $CHCl_3$ fractions had significant antioxidative activity. In 30% MeOH and 60% MeOH, $CHCl_3$ fraction, six compounds were isolated and elucidated as adenosine(I), guanosine(II), peucedanol 7-O-$\beta$-D-apiofuranosyl(1$\rightarrow$6)-$\beta$-glucopyranoside(III), peucedanol 7-O-$\beta$-D-glucopyranoside(IV), peucedanol(V) and scopoletin(VI) by physicochemical data and spectroscopic methods. (Negative FAB-MS, $^{1}H-NMR$, $^{13}C-NMR$). The results from antioxidative activity screening for the each compound showed that compound IV was relatively superior antioxidant ability. In anti-inflammatory activation assay, compound III, IV, VI had concentration-dependent-activity and compound IV had superior anti-inflammatory ability. These results suggest that Peucedani Radix might be developed as a potent anti-oxidative, anti-inflammatory agents and ingredients for related functional foods.