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『언해랍약증치방(諺解臘藥症治方)』의 납약에 대한 고찰 -『조선왕조실록(朝鮮王朝實錄)』과 『승정원일기(承政院日記)』를 중심으로-
연지혜,김정민,금가정,장아령,김상찬,송지청,Yeon, Jihye,Kim, Jungmin,Keum, Gajeong,Jang, Aryeong,Kim, Sangchan,Song, Jichung 대한한의학방제학회 2018 大韓韓醫學方劑學會誌 Vol.26 No.2
Objective : Napyak has known as the herbal medicine, that kings of the Joseon dynasty bestowed on the royal officers around the last day of the each year. There are several researches on Napyak but those are focused the meaning itself, bibliographical studies on Unhaenapyakjeungchibang(which is the text related to Napyak), system in Joseon dynasty related to Napyak and so on. This articles is subject to research the real usage and medical meaning thrugh record of Joseon dynasty Method : Prescriptions of Unhaenapyakjeungchibang were browsed from the Annals of the Joseon Dynasty and the Royal Records of Royal Secretariat of the Joseon Dynasty and compared the main disease of prescriptions with the records above. Result : The main disease of prescriptions were corresponded with real usage records of the Annals of the Joseon Dynasty and the Royal Records of Royal Secretariat of the Joseon Dynasty except a few cases. And the new meaning of Napyak could be defined as the herbal medicine, that kings of the Joseon dynasty bestowed on the royal officers and all people to cure emergent disease around the last day of the each year. Conclusion : This research is for focusing the real usage of the Napyak thrugh Unhaenapyakjeungchibang prescription but this research is for the medical records of the Annals of the Joseon Dynasty and the Royal Records of Royal Secretariat of the Joseon Dynasty. Hereafter, the medical records researches could be conducted by real usage of prescriptions.
효모에 의한 기능성 음료 변질 제어를 위한 천연항균물질 항균력 평가
연지혜,이지영,이희석,하상도,박철수,우문제,이상훈,김진수,이찬 한국식품위생안전성학회 2009 한국식품위생안전성학회지 Vol.24 No.3
We investigated eight active natural antimicrobials for preservation of functional beverages that are usually degraded by yeasts rather than by bacteria due to a high sugar content and a low pH. Five strains of yeasts (S. cerevisiae, Z. bailii, P. membranaefaciens, C. albicans, and P. Anomala) were tested with eight natural antimicrobial agents (ε-polylysine, yucca extract, vitamin B1 derivative, scutellaria baicalensis extract, chitooligosaccharid, allyl isothiocyanate, sucrose-fatty acid ester, and oligosaccharide). The lowest minimal inhibitory concentrations (MIC) were 10 ppm for oligosaccharide and sucrose-fatty acid ester against S. cerevisiae and Z. bailii, 10 ppm for allyl isothiocynate against P. membranaefaciens and C. albican, and 10 ppm for allyl isothiocynate and oligosaccharide against P. anomala . No growth were observed for five kinds of yeasts in functional beverages containing sodium benzonate at concentration of 0.015% or higher. The resistance of S. cerevisiae, Z. bailii, and P. Anomala against natural antimicrobial agents was lower than those of P. membranaefaciens and C. albican. Allyl isothiocyanate, oligosaccharide, and sucrose- fatty acid ester showed the highest antimicrobial activities among the eight tested antimicrobials. These results can be applied to develop new natural antimicrobial agents to improve microbial quality of functional beverages.
기능성 음료 중 효모 제어를 위한 천연항균제 혼합조성물 평가
연지혜,조서희,이희석,하상도,박철수,우문제,이상훈,김진수,이찬 한국식품위생안전성학회 2009 한국식품위생안전성학회지 Vol.24 No.3
The purpose of this study was to investigate the antimicrobial activities of natural antimicrobials (10 formulas, F1~F10) against yeasts in functional beverages. The growth rates of yeasts were different with the ten different natural antimicrobial formulas tested. Yeasts grew for 14 days and the antimicrobial effect was observed between 14 and 18 days. Levels of S. cerevisiae, Z. bailii, and P. membranaefaciens were reduced to the limit of detection (ND) < 10 CFU/mL) after 28 days. Resistance against the antimicrobial effect was greatest for P. membranaefaciens, which grew to a level of 0.12~1.48 log10 CFU/mL after 14 days and was reduced to a level of 1.61~3.55 log10 CFU/mL after 28 days. The resistance of C. albicans was also high with a growth level of 0.13~1.28 log10 CFU/mL after 14 days and reduction to 1.51~5.30 log10 CFU/mL after 28 days. The antimicrobial effect of F10 was strongest for P. membranaefaciens. Every treatment reduced the microbial levels to 2.68~5.62 log10 CFU/mL after 6 months. F2, F4, F5, F6, and F10 reduced the C. albicans level to ND after 28 days while F1, F3, F8, and F9 reduced yeasts to the ND level after 6 months. The antimicrobial activities observed here will be useful for development of natural antimicrobials.
지혜연,최다슬,김정한 한국지진공학회 2021 한국지진공학회논문집 Vol.25 No.1
The design response spectrum presented in the seismic design standard reflects the characteristics of the tectonic environment at a site. However, since the design response spectrum does not represent the ground motion with a specific earthquake magnitude or distance, input ground motions for response history analysis need to be selected reasonably. It is appropriate to use observed ground motions recorded in Korea for the seismic design. However, recently recorded ground motions in the Gyeongju (2016) or Pohang (2017) earthquakes are not compatible with the design response spectrum. Therefore, it is necessary to convert the recorded ground motion in Korea to a model similar to the design response spectrum. In this study, several approaches to adjust the spectral acceleration level at each period range were tested. These are the intrinsic and scattering attenuation considering the earthquake environment, magnitude, distance change by the green function method, and a rupture propagation direction's directivity effect. Using these variables, the amplification ratio for the representative natural period was regressed. Finally, the optimum condition compatible with the design response spectrum was suggested, and the validation was performed by converting the recorded ground motion.
하마오카 원자력 발전소 지진 기록 분석을 통한 지진응답의 공간적 변화 평가
지혜연,하정곤,김민규,함대기 한국지진공학회 2022 한국지진공학회논문집 Vol.26 No.5
In assessing the seismic safety of nuclear power plants, it is essential to analyze the structures using the observed ground motion. In particular, spatial variation in which the characteristics of the ground motion record differ may occur if the location is different within the site and even if the same earthquake is experienced. This study analyzed the spatial variation characteristics of the ground motion observed at the structure and site using the earthquake records measured at the Hamaoka nuclear power plant. Even if they were located on the same floor within the same unit, there was a difference in response depending on the location. In addition, amplification was observed in Unit 5 compared to other units, which was due to the rock layer having a slower shear wave velocity than the surrounding bedrock. Significant differences were also found in the records of the structure’s foundation and the free-field surface. Based on these results, the necessity of considering spatial variation in the observed records was suggested.