Itraconazole 중간체의 효율적 합성법과 그 유사체의 합성

안종일,명영찬,최하영,김승진,Ahn, Chong Il,Myoung, Young Chan,Choi, Ha Young,Kim, Seung Jin 대한화학회 1999 대한화학회지 Vol.43 No.6

Itraconazole is an important drug for oral treatment of histoplasmosis and blastomycosis. ltraconazole has been the targets of many synthetic efforts due to their diverse antifungal activities. ln this study, an efficient synthetic route for Itraconazole intermediates has been developed using new procedures. Also, ltraconazole analogues introducing 2- and 3-methoxy group instead of ltraconazole intermediates with 4-methoxy group were synthesized. Itraconazole은 다양한 항진균 활성을 가지고 있는 매우 중요한 화합물로써 histoplasmosis, blastomysosis의 경구용 항진균 치료제로 매우 중요하다. 본 연구에서는 Itraconazole 중간체 합성에 있어서 합성과정을 개선하고, 또 ltraconazole 중간체의 4-위치의 methoxy기 대신 2-, 3- 위치에 methoxy기를 가진중간체 화합물을 합성하고 이로부터 Itraconazole 유사체도 합성할 수 있었다.

분광학적 방법에 의한 계면활성제의 확인

안종일(Chong Il Ahn),조종희(Jong Hoi Cho),박신자(Shin Ja Park),김종길(Jong Kil Kim),전지혜(Ji Hye Jeon),이정복(Jung Bock Lee),박홍수(Hong Soo Park) 한국유화학회 2001 한국응용과학기술학회지 Vol.18 No.4

N/A Our study is aimed at proposal of systematic verification method of molecular structure using measuring method of selective ionic determination and spectrometry on 34 kinds of surfactants such as sodium dodecyl sulfate(SDS) which are most widely used today. In the IR spectrum, unsaturated fatty acids reveal themselves by HC= at 3000~3020㎝^-1, and intensity of 720㎝㎝^-1 depends on carbon length of alkyl group. Also ethylene oxide(EO) adducts exhibit weak characteristic bands by -CH_2-CH_2-O at 1350, 1100 and 950㎝^-1. Isethionate can be distinguished from diester succinate by intensity ratio of 1740 and 1200㎝^-1 spectrums, the ratio of latter is close to 1 due to 2 carboxylate radical in diester succinate. Quaternary ammonium salts exhibit characteristic band of C_4N^+ at 1000-900㎝^-1. In the case of dialkyl dimethyl ammonium salts in quaternary ammonium surfactants, the spectrum of 3000㎝^-1 by N-CH_3 collapses to a very weak band at 3020㎝^-1. In ammonium heterocyclic derivatives, pyridinium salts show characteristic bands at 1640 and 1460㎝^-1, while imidazolinium salts exhibit characteristic band at 1620-1610㎝^-1. In the characteristic spectrum at 1080-1050㎝^-1 on OH radicals of the alkyl esters, primary alcohol appears as weak band and the 2 bands show in almost same intensity when primary and secondary alcohols exist together in one molecule. Also, alkyl ester of polyhydric alcohols appears as various broad band.

철강용 알칼리탈지제의 제조 및 탈지효과

박홍수,임완빈,안종일 ( Hong Soo Park,Wan Bin Im,Chong Il Ahn ) 한국공업화학회 1995 공업화학 Vol.6 No.5

POE(6)-2-ethylhexyl ether(PEH-6), Newpol PE-68(PE-68), Na₂CO₃, tetrasodium pyrophosphate(TSPP), Demol C 및 MJU-100A를 블렌딩하여 알칼리탈지제(DA)를 제조하였다. 철강 시료편에 DA를 처리하여 탈지력을 시험해 본 결과 DA-6(PEH-6 45g/PE-68 45g/Na₂CO₃ 120g/TSPP 60g/Demol C 15g/MJU-100A 15g/Water 300g mixture)의 농도 4wt%일 때 70℃와 90℃에서의 프레스방청유 부착물에 대한 탈지율은 각각 94%와 96%였고, 70℃에서의 소입유 부착물에 대한 탈지율은 94%로 나타나 DA-6은 양호한 탈지력을 보여주었다. 또한 DA-6 농도 6wt%, 60℃에서의 Ross & Miles법에 의한 기포력 측정결과, 조작 1분 후의 포고가 8㎜와 77㎜로 각각 나타나 DA-6은 양호한 저기포성 탈지제임이 입증되었다. Alkaline degreasing agent(DA) was prepared by blending of POE(6)-2-ethylhexyl ether(PEH-6), Newpol PE-68(PE-68), Na₂CO₃, tetrasodium pyrophosphate(TSPP), Demol C, and MJU-100A. The degreasing power of DA`s was tested with steel specimens and the results are the following : A solution of 4wt% DA-6(PEH-6 45g/PE-68 45g/Na₂CO₃ 120g/TSPP 60g/Demol C 15g/MJU-100A 15g/Water 300g mixture) shows 94% and 96% of degreasing power for press-rust preventing oil at 70℃ and 90℃ respectively, and 94% for quenching oil at 70℃. The test results show that DA-6 was a better degreasing agent. Foam heights measured after lminute by Rose & Miles method and Rose & Clark method at 6wt%, 60℃ were 8㎜ and 77㎜, respectively. As the result, DA-6 was proven to be a goad, low-foaming, degreasing agent.

지방산 폴리아미드계 내구성 유연제의 제조와 나일론 섬유에의 응용

홍의석,고재용,전영제,박홍수,안종일 ( Eui Suk Hong,Jae Yong Ko,Young Je Jeon,Hong Soo Park,Chong Il Ahn ) 한국유화학회 1995 한국응용과학기술학회지 Vol.12 No.1

An O/W type softner(NDSA) was prepared by blending of three kinds of emulsifiers, polyoxyethylene(10) castor oil, polyoxyethylene(20) oleyl ether, polyoxyethylene(30) mono laurate, with 2, 2`-didocosamidodiethylarnine and tetra(2-docosamidoethyl) urea which were synthesized as the main component of a softner. Emulsion stability of NDSA was good, and mixed HLB value was 9.2. NDSA was found to be a good durable softner for nylon through the measurement of softness, lubrication, antistatic property, bending resistance, and color fastness.

아크릴계 하이솔리드 도료의 경화반응과 도막물성

박형진(Hyong Jin Park),김성래(Sung Rae Kim),정충호(Choong Ho Jung),안종일(Chong Il Ahn),박홍수(Hong Soo Park),김태옥(Tae Ok Kim) 한국유화학회 2001 한국응용과학기술학회지 Vol.18 No.4

N/A An ACR/HMMM film was prepared by blending high-solid ACR with curing agent, hexamethoxymethyl melamine (HMMM). An active curing reaction was observed at 170℃. The dynamic viscoelastic T_g of the final film increased with the static viscoelastic T_g of the film. The log damp value, which means a viscoelastic ratio, decreased with the increase in the curing temperature of the film. Physical properties of the films were within a suitable range for films, and by an accelerated weathering resistance test the films were proved weather resistible ones.

Calix[4]arene 계의 PS 판용 NQD 에스테르의 합성 및 감광 특성

명영찬(Young Chan Myoung),최현호(Hyun Ho Choi),구양서(Yang Seo Ku),안종일(Chong Il Ahn),정기원(Gee Won Chung),이정복(Jung Bok Lee) 한국공업화학회 2002 공업화학 Vol.13 No.2

본 연구는 ballast로서 calix[4]resorcinarene (C4-R4)과 calix[4]pyrogallene (C4-PA) 유도체를 합성한 후 naphthoquinone-(1,2)-diazide-5-sulfonic acid esters (NQD-ester)를 2-diazo-naphthoquinone-5-sulfonyl chloride (NQD-Cl)과의 에스테르화 과정을 통해 pre-sensitized offset printing plates (PS 판)에 쉽게 적용할 수 있는 포지티브형의 감광제를 합성하여 비교·고찰하였다. C4-RA 유도체는 resorcinol과 pyrogallol을 각각 아세트알데히드와의 축합 반응으로 합성하였다. C4-RA 유도체는 극성 용매와 수용성 염기에 매우 좋은 용해도를 가지며 또한 노블락 수지와 비슷한 광학적 성질를 가진다. C4-RA 유도체를 NQD-Cl과 부분적인 에스테르화하여 치환율이 각각 다른 NQD-ester 유도체를 합성하였다. 남아 있는 hydroxy group은 유기 용매에 대한 용해도를 좋게 해주었다. 각각의 NQD-ester 유도체들을 노블락 수지와 배합하여 PS판을 제조하였다. 용해도,열적 안정성, 감광성, 적합한 노광시간과 상대 감도를 각각 용해도 측정, TGA, UV spectrophotometry, UV lithographic method와 gray scale method를 사용하여 측정하였다. C4-RA 유도체를 ballast로 하여 합성한 NQD-ester 유도체는 적합한 용해도와 감광 특성을 보여주었으며 최적화된 lithographic 조건을 측정하여 이를 사용해 포지티브 이미지를 얻을 수 있었다. In this study, light sensitive naphthoquinone-(1,2)-diazide-5-sulfonic acid esters (NQD-ester) based on calix[4]resorcinarene (C4-RA) and calix[4]pyrogallene (C4-PA) derivatives, were used as a ballast. They were suitable for the positive working photoactive compounds in the use of pre-sensitized offset printing plates (PS plates). C4-RA derivatives were synthesized from resorcinol, pyrogallol, and acetaldehyde by the condensation reaction. C4-RA derivatives had a good solubility in highly polar solvents and aqueous alkaline bases, and their optical properties were similar to those of novolac resin. Synthesized C4-RA derivatives were partially esterified with 2-diazo-naphthoquinone-5-sulfonyl chloride (NQD-Cl) to give several NQD-esters. The hydroxyl groups left provided good solubility in the organic solvents. Each of NQD-ester was formulated with novolac base resin, and PS plates were manufactured. Solubility, thermal stability, photosensitivity, compatible exposed time, and relative sensitivity were determined by solubility test, TGA, UV spectrophotometry, imaged by UV lithographic techniques, and gray scale method, respectively, NQD-ester derivatives, which is synthesized with C4-RA derivatives, gave suitable solubilities and photochemical properties. We found the optimal lithographic properties, and obtained good images for PS plates.

지방산 카르바미드/왁스/아크릴 공중합체의 블렌드에 의한 내구유연발수제의 제조에 관한 연구(III)

김승진(Kim Seung Jin),임완빈(Im Wan Bin),안종일(Ahn Chong Il),박홍수(Park Hong Soo) 한국유화학회 1994 한국응용과학기술학회지 Vol.11 No.2

Durable softening water repellents for nylon fiber were synthesized, using two compounds: quaternized octadecyl methacrylate-2-diethylaminoethyl methacrylate copolymer as a mother resin of water repellent and quaternized fatty carbamide for improving softness and hydrostatic pressure, of which syntheses were studied in the previous papers. They were blended with waxes and emulsifiers in a variety of ratios and synthesized into water repellent PADWC, and it was nylon taffeta treated with and without textile finishing resin. The synthesized water repellents can be used either or without resin. The optimum curing temperature was 150 to 160℃ and the optimum concentration was 3 to 5wt%. In the independent and conjunct treatment, the water repellency of nylon taffeta samples have no remarkable changes between initial value and that after three times washing, so these prove that the synthesized compounds are durable water repellent. The water repellency of PADWC-3 and -4 were around 90. Also, comparison of crease recovery and tear strength after repelling treatment showed that the synthesized water repellents have a very high softening effect.

PS 판용 1,2-Naphthoquinone-(2) diazide-5-sulfonic Acid Ester Derivatives 의 합성 및 응용

구양서(Yang Seo Ku),명영찬(Young Chan Myung),안종일(Chong Il Ahn),김선호(Sun Ho Kim) 한국공업화학회 1999 공업화학 Vol.10 No.8

N/A N/A

그래프 상태와 시간 제약조건을 반영한 탐색 알고리즘의 개발에 관한 연구

안종일,정태충 慶熙大學校 1996 論文集 Vol.25 No.-

Recently, the hybridization of Artificial Intelligence techniques and Real-time technizues has been tried. A Real-time AI search performs a task in two phases: the planning phase and the executing phase. Under real-time constraints, a Real-time AI heuristic search must balance the operation between the planning and execution phases to comply with deadlines. Several real-time search algorithms such as RTA^*, SARTS and DYNORA have been proposed. These alorithms belong to a heuristic search algorithm like A^*. The performance of each algorithm depends on the quality of their heuristic functions, which provide an estimate of execution cost of a path. However. One of the difficulties in implementing these algorithms is to get perfect heuristic function. Hence, to determine the maximum time allowable for planning, we propose dynamic real-time search method using the concept of slack(i. e. ; the defference between heuristic all estimated value and search time).

키토산 올리고머를 이용한 기능성 염료개발

안종일,최하영,임완빈,김동화,임헌선 한국키틴키토산학회 1998 한국키틴키토산학회지 Vol.3 No.1

In order to obtain new functional materials, chito-oligosaccharides(COS) of chitopentaose and chitohexaose which show anti-fungal activity were introduced to dyestuffs. COS-cyanuric chloride (CY)-4,4-diaminostilbene-2,2-sulfunic acid(DAS) and COS-CY-1-amino-4-(p-phenylenediamino)anthraq uinon- 2-sulfonic acid(APAS)conjugates, that is, CO-CY-DAS and COS-CY-APAS were prepared by the reactions of DAS and APAS, as dye intermediates, with CY-activated COS modifiers. Also, glucosamine, as a mdel compound, was reacted with CY-COS modifiers to clarify the chemical structures of the COS-CY-DAS and COS-CY-APAS. As the IH-NMR spectrums of conjugates showed downfield shift of the aromatic protons of dye intermediates and anomeric protons of glucosamine. The reaction of COS-CY-DAS and COS-CY-APAS conjugates were completed by the reactions between another chlorine atom of the triazine ring of the COS-CY modifier and the amino groups of DAS and APAS through the reaction of the amino groups of COS and a chlorine atom of CY.