經營組織의 效率化를 위한 組織開發技法의 適用에 관한 硏究

안성국 (安聖國) 中央大學校 國際經營大學院 1988 국내석사

CEEMDAN 알고리즘을 이용한 자료 적응적 CRP 개발과 교통사고 잦은 곳 선정에의 적용방안

안성채 아주대학교 2014 국내박사

교통사고위험도가 높은 교통사고 잦은 곳을 선정하고 효과적인 교통안전 개선사업을 시행하는 일은 교통안전 보장을 위해서 매우 중요한 업무이다. 특히 교통사고 잦은 곳을 선정하는 단계는 교통안전관리의 첫 단추라 할 수 있다. 본 연구에서는 교통사고 잦은 곳 선정을 위한 방법으로 CRP_CEEMDAN 기법을 개발하였다. CRP_CEEMDAN 기법은 교통사고분야에서 최근 사용되는 기존의 연속적 위험 프로파일(CRP: Continuous Risk Profile) 기반 위에 Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) 알고리즘을 이용한 개선된 기법으로 볼 수 있다. 자료 적응적이며 비정상/비선형 데이터 분석에 용이한 장점을 가진 CRP_CEEMDAN 기법은 CRP의 이점을 유지하면서, CRP 계산과정에 있는 이동평균법의 제약을 해소한다. CRP는 단위거리 당 사고위험도를 연속적으로 표출하기 때문에, 기존의 Sliding Moving Window 기법이나 Peak Searching 기법들의 비현실적인 가정을 극복하고 더 낮은 잘못된 양성반응과 잘못된 음성반응의 결과를 얻을 수 있다. 본 논문에서는 우선, 개발된 CRP_CEEMDAN 기법을 검증하기 위하여 캘리포니아 주의 실제 교통자료를 이용하고 기존 CRP 기법의 도출 결과와 비교 검토하였다. 기법의 검증과 함께 CRP_CEEMDAN 기법의 지역적 적응성이 확인되고 있다. 또한 교통안전 개선사업 시 CRP_CEEMDAN 기법의 국내 적용방안을 제안하였다. 연도별 CRP_CEEMDAN 이력과 기존 개선사업내역을 비교 검토하였으며, 교통사고발생 특성별(기상요인, 인적요인) Potential for Safety Improvement (PSI)로 각각의 우선순위표를 작성하여 개선사업 선정 시 활용방안을 제안하였다. 아울러 기상요인에 대한 검토로 맑은 날씨와 우천 시 교통사고위험도를 분석하였으며, 주요 인적요인에 대한 검토로 졸음, 과속, 주시태만 요인을 분석하였다. CRP_CEEMDAN 기법은 자료 적응적이며, 교통사고자료만 있으면 그 지역의 교통사고위험도를 구현할 수 있는 강점이 있다. 더욱이 기존에 고민해야 했던 window 크기를 고려하지 않기 때문에, 교통사고 기반자료가 부족한 국가나 지역에서 그 효과가 클 것으로 기대된다. 연구의 한계와 향후 연구과제는 기술하였다.

습재(習齋) 최제학(崔濟學)의 생애와 항일활동

안성은 전주대학교 일반대학원 2018 국내석사

When the Protectorate Treaty between Korea and Japan was concluded in 1905, patriots such as Min Young-hwan, Cho Byeong-se, Hong Man-sik, and Song Byeong-seon chose to take their lives for the country. Inspired by this sacrifice, there arose movements throughout the nation to organize anti-Japanese struggles. The first military action of unofficial troops in Jeolla-do Province against the Protectorate Treaty is the Taein Righteous Army. Under the leadership of Myeonam Choi Ik-hyun and Im Byeong-chan, the former governor of Nakan County, the Taein Righteous Army arose in Moosung Seowon (Confucian auditorium) in April 23 of 1906. The Taein Righteous Army is significant due to the fact that about 1,000 people of Joella-do Province actively participated, and since the revolt of the Taein Righteous Army, the forces of anti-Japanese righteous army have gradually increased in many regions of Jeolla-do, and since the year 1907 the righteous army of Jeolla-do have come to lead the righteous army movements of the whole nation. Seupjae Choi Je-hak, the topic of this study, was from Jinan, Jeollabuk-do, and participated in the Taein Righteous Army as a closest aide to Myeonam Choi Ik-hyun. SeupjaeSilGi, the record of his activity in the righteous army, was partially translated into modern Korean to be compiled in the second edition of the The Source Book of Independence Movement published by the Compilation Committee of the Korean Independence Movement in 1971. The record is frequently quoted by researchers. SeupjaeSilGi is a record written by a leader of the independence movement, showing the vivid scene and activities of the Taein Righteous Army. Therefore, this study reviewed the life of Choe Jae-hak focusing on his SeupjaeSilGi and examined his anti-Japanese activities during and after the uprising of the Taein Righteous Army. The life of Choi Je-hak can be largely divided into three phases: the meeting with Choi Ik-hyun and activity for the Taein Righteous Army, the plot for the righteous army for the second time, and the retreat into Jirisan Mountain. In 1901, Choi established a master-disciple relationship with Choi Ik-hyun, and visited him frequently. In Choi Ik-hyun’s house, he heard about the Protectorate Treaty and suicide of patriots in 1905, which naturally inspired his anti-Japanese sentiment. In preparation for the Confucian society at Gwolrisa, Noseong-Hyun (魯城縣), which was designed to gather the strength of the Confucian scholars, Choi Je-hak delivered letter, notice, and the declaration to the Confucian scholars in Jeolla-do region. He also worked hard to arrange the meeting of Choi Ik-hyun and Im Byeong-chan, which was a decisive occasion for the formation of the Taein Righteous Army. In particular, he accompanied Choi Ik-hyun throughout the latter’s visit to Jeolla-do to raise an army against the Japanese, and arranged the schedule for Choi Ik-hyun’s accommodation and destinations. When the Taein Righteous Army arose, Choi Je-hak was appointed as a general to gather soldiers, recruiting righteous army soldiers and providing the property of his family as munitions. When the Taein Righteous Army was disbanded, Choi Je-hak was incarcerated in the Japanese military command for about six months. As soon as he was released, he went to Tsushima Island to visit Choi Ik-hyun, who was detained there. When Choi Ik-hyun died in November 1906, he participated in the procession of moving the body of the patriot and took charge of the librarianship. He was responsible for important duties for the righteous army against the Japanese including the procurement of munitions, letter delivery, liaison office, and librarianship. And he participated in anti-Japanese activities by helping the elderly Choi Ik-hyun as a closest aide. Then, in September 1907, he prepared for another uprising of the righteous army in cooperation with Yoon Ja-shin who was a Jinsa (進士) in Gosan (高山). However, his efforts were finally frustrated by the invasion of the Donghak peasant troops. After that, he retreated into Jirisan Mountain in 1915. Even after his retreat, he was imprisoned three times and never abandoned his anti-Japanese spirit until his death, despite the seemingly hopeless situation. By examining the life of Choi Je-hak who helped Choi Ik-hyun right beside him, this study was able to have a closer look into the movement of the Taein Righteous Army. By reviewing Choi Je-hak’s life and anti-Japanese activities which had been neglected so far, this paper attempted to get out of the framework of discussion focused on Choi Ik-hyun and Im Byeong-chan. The significance of this study would be found in that it has specifically explored the facts about exchange and collaboration between various people who participated in the righteous army movements.

幼兒敎育機關의 놀이資料 實態 調査硏究

안성 圓光大學校 1991 국내석사

건설공사의 공정률에 대한 제도 및 산정방법 개선방안

안성복 서울시립대학교 2016 국내석사

Abstract Improvement of Institution and Calculation Method for Construction Progress Rate Ahn Sung-Bok Graduate School of Urban Science University of Seoul Construction work has characteristics that it is large size compare to other industries, takes long time to completion and enormous costs are invested as a single product. Due to these characteristics, the constructor or the business operator makes great efforts in the cost management and the progress management of the project. Particularly, the progress management is important in the construction work, which has long production time, and the progress rate is an important evaluation factor for the construction progress management. However, there has been long dispute between the business operators related to whether the calculation of progress rate, which indicates the progress of the construction, is objective. The conflict and the dispute not only with the business operator (employer) and the constructor but also with the sales contractor, who bought the building, are occurring continuously. Nevertheless, in the current system, no official and public standard to calculate the progress rate is enacted. Therefore, different results are come out depending on whom to calculate, for which the dispute occurs and is often leaded to legal action. In this study, to minimize the dispute between the business operator and the sales contractor, the institutional improvement measures of progress rate and the calculation method using the performance recognition criteria are suggested. The summary of the contents and results of this study are as follows. First, the institution related to the progress rate in the domestic construction, the calculation method of progress rate and the amount of completed work were analyzed. Second, the calculation method of progress rate and the amount of completed work implemented in the private and the public constructions were analyzed. In addition, to analyze the dispute occurred by the progress rate, the precedents of supreme court , the Inquiry and Reply of Ministry of Land, Infrastructure and Transport, etc. were examined. Based on them, the problems were drawn and the improvement direction to improve them was established. Third, to draw the institution of progress rate and the improvement measure of calculation method, the questionnaire survey was performed from 40 working staffs who are working in the business operators, construction project managers, and the constructors. Fourth, based on the questionnaire survey results, the improvement measures in the aspects of institution and the calculation method were suggested. For the improvement measure in the aspect of institution, the 5 measures including the enactment of standard progress rate calculation method were suggested. The measure in the aspect of calculation method was suggested by dividing it into the calculation technique and the performance recognition criteria. Finally, through the expert interview, the validity, appropriateness and the applicability of the institutional improvement measure related to progress rate and of the improvement measure of calculation method were verified. The institutional improvement, calculation technique and the performance recognition criteria suggested in this study have meaning that they can be used as basic criteria to calculate the progress rate in the construction project. In addition, it is expected that they would contribute to reduction of social conflict and dispute between the business operator and the sales contractor due to progress rate and to securing the consistency of progress rate calculation at the working level. In the meantime, since the progress rate calculation method and the performance recognition criteria suggested in this study were prepared by selecting the representative item in the construction works, additional research on the detailed items in the construction work, civil work, electric work, etc. are deemed to be necessary. And since the study was performed based on the questionnaire survey, the improvement measure suggested in this study are needed to be verified and complimented empirically by applying them in the site operations. 국문초록 건설공사의 공정률에 대한 제도 및 산정방법 개선방안 안 성 복 서울시립대학교 도시과학대학원 건설공사는 타 산업에 비해 대규모이며 완공까지 장기간이 소요되고, 단일생산품으로는 막대한 비용이 투입되는 특성을 갖고 있다. 이러한 건설공사의 특성으로 건설회사나 발주자는 프로젝트의 원가관리와 진도관리에 많은 노력을 하고 있다. 특히 진도관리는 생산기간이 긴 건설공사에서 매우 중요하며 공정률은 공사의 진도관리에 있어서 중요한 평가요소다. 하지만 공사의 진척도를 표시하는 공정률 산정에 대한 객관성 여부와 관련하여 사업자간의 분쟁이 오래전부터 있어왔다. 시행자(발주자)와 시공사 관계뿐만 아니라 건축물을 분양받은 분양계약자도 갈등과 분쟁이 계속 발생되고 있다. 그럼에도 불구하고 현행 제도상으로는 공정률 산정에 대한 공식적이고 공인된 표준 산정방법이 제정되어 있지 않다. 따라서 산출자마다 다른 결과가 산정되며, 이로 인해 분쟁이 발생하고 법적 소송 까지 진행되기도 한다. 본 연구에서는 공정률로 인한 시행자와 분양계약자 간 분쟁을 최소화하기 위하여, 건설공사의 공정률에 대한 제도적 개선방안 및 성과 인정기준 등을 활용하는 공정률 산정방법 개선방안을 제안하였다. 본 연구의 연구내용 및 결과를 요약하면 다음과 같다. 첫째, 선행연구 고찰을 통하여 현재 국내 건설공사의 공정률 관련 제도, 공정률과 기성고의 산정방법을 분석하였다. 둘째, 민간공사, 공공공사에서 시행하고 있는 공정률과 기성고 산정방법을 분석하였다. 또한 공정률로 인하여 발생된 분쟁사례 분석을 위하여 대법원 판례와 국토교통부 질의회신 등을 검토하였다. 이를 토대로 문제점을 도출하고 이를 개선하기 위한 개선방향을 설정하였다. 셋째, 공정률에 대한 제도 및 산정방법 개선방안 도출을 위하여 설문조사를 실시하였다. 설문조사는 발주자, 건설사업관리자, 시공사에 근무하는 실무자 40명을 대상으로 실시하였다. 넷째, 설문조사 결과를 토대로 제도적 측면과 산정방법 측면의 개선방안을 제안하였다. 제도적 측면의 개선방안은 표준 공정률 산정방법 제정을 비롯하여 5가지를 제안하였다. 산정방법 측면의 개선방안은 산정기법과 성과 인정기준으로 구분하여 제안하였다. 마지막으로 전문가 면담을 통하여 공정률 관련 제도적 개선방안과 산정방법 개선방안의 타당성, 적정성 및 활용 가능성을 검증하였다. 본 연구에서 제안한 제도적 개선사항과 산정기법 및 성과 인정기준은 건설현장에서 합리적 공정률 산정을 위한 기본기준으로 사용할 수 있다는데 그 의의가 있다. 또한 공정률로 인한 사업주체와 분양계약자 간의 사회적 갈등과 분쟁을 줄이고, 실무적으로 공정률 산출의 일관성을 확보하는데 기여하기를 기대한다. 한편, 본 연구에서 제시하는 공정률 산정방법의 성과 인정기준은 건축공사 중 대표성 항목을 선정하여 제시하였으므로, 건축공사의 세밀한 항목, 토공사, 전기공사 등에 대한 추가적인 연구가 필요할 것으로 사료된다. 그리고 설문조사를 토대로 연구를 진행하였기 때문에, 본 연구에서 제안한 개선방안을 현업에서 적용하여 실증적으로 검증 및 보완할 필요가 있다.

SH-SY5Y 세포에서의 MPP+로 유도된 세포 독성에 대한 연자육의 보호효과에 관한 기전

안성 상지대학교 대학원 2019 국내석사

Objectives: The aim of this study is to evaluate protective effects of nelumbinis semen against neurotoxicity induced by MPP+ in SH-SY5Y cells and to clarify the mechanism of the effects. Methods: MTT assay was performed to evaluate cell viability of nelumbinis semen water extract (NSW) against neurotoxicity induced by MPP+ in SH-SY5Y cells. Western blot analysis was conducted to identify the expression of bax, cytochrome C and bcl-2 protein. Results: Comparing with control group, MPP+ only-treated group showed significant changes with cell viability, but all NSW–treated group showed no significant change. Comparing with MPP+ only-treated group, only NSW 25 μg/mL-treated group showed significant changes with cell viability in MTT assay and all NSW-treated group showed significant changes in western blot. NSW decreased the levels of bax and cytochrome C, whereas increased those of bcl-2. As a result, NSW decreased bax to bcl-2 ratio. Conclusions: NSW has neuroprotective effects against MPP+ in SH-SY5Y cells and it seems to suppress MPP+ induced apoptosis.

TCP/IP망 管理를 위한 시스템 分析 파라미터 計算 알고리즘

안성진 성균관대학교 1998 국내박사

In this paper, algorithms are proposed to define and calculate system analysis parameters using SNMP MIB-II on TCPm based Internet. To provide a user on TCP/IP network with QoS it is required that management activities are based on performance and fault related parameters. To this purpose, this paper has drawn management variables in relation to the system analysis parameters out of the numerous MIB-11 variables and suggested and established numerical formulas to apply the resultant management variable. In MIB-11, system, interfaces, ip, and snmp groups are analyzed according to Case diagrams and then analysis pararneters ,which are line utilization, error rate in link, I/O packet rate of a interface, I/O packet loss rate of a interface, VO traffic, YO nonunicast packet rate, VO packet rate of a system, YO packet loss rate of a system, resource load rate of a system, packet forwarding rate, routing fault rate, and utilization of management traffic, and its calculation algorithms are provided. There are several algorithms for calculating line utilization; they are namely, utilization accumulation method, utilization midterm calculation method, maximum calculation method and maximum accumulation method. Among them, utilization accumulation method and utilization midterm calculation method are not suitable for fault detection and have a difficulty dealing with transmission delays because both methods need to calculate line utilization whenever needed. In Comparison, maximum calculation method and maximum accumulation method can handle faults and compensate for the packet delays because calculations in these cases are based on accumulated amount of bytes. The practicality of calculating line utilization lies in the fact that it can be used in capacity planning. The best calculation algorithm for this purpose is the maximum accumulation method. Furthermore, this method can also be used as an indicator for line expansion. These algorithms can deal with system faults, line and routing faults, and wrap-around of MIB variables by the algorithm for line troubles. To show availability of these algorithms, some results are shown and analyzed about routers on real environments. Also, this paper has compared the two methods of maximum calculation and maximum accumulation by collecting the current traffic on a TCP/IP network and study the characteristics of the suggested algorithm. These algorithms for calculating Internet analysis parameters can give effects to analysis and diagnosis of a TCP/IP network for a manager and also, it is expected to provide QoS for Internet users. This will help a network manager grasp the current status of network elements and use the available data as indicators for line capacity planning, network redesigning, decision making of performance upgrade for a network device and things like that.

수심측량에 의한 새만금방조제 외해측 해저지형변화 분석(Estimation of Topographic Change of Seabed in front of Saemangeum Sea Dike by Bathymetric Surveying)

안성 군산대학교 2022 국내박사

본 연구에서는 2006년 새만금방조제 끝막이 공사 이후 2017년 까지 1호 및 2호 방조제 외해측 해저의 수심변화를 조사하기 위해 방조제로부터 외해측으로 5 ㎞ 까지 12년간 매년 1회씩 SBES에 의해 수심측량 하였으며, 방조제 바닥보호공과 근고공의 주변 해저의 정밀조사를 위하여 방조제 피복석부터 외해측으로 200m 구간에 대해 2013년 MBES에 의해 수심측량 하였다. 수심측량자료를 보정·처리하여 2006년 기준 측량년도별 수심차이로부터 방조제 외해측 해저지형의 변화를 조사·분석하였다. SBES에 의한 해저지형변화조사에서 2006년 방조제 최종체절년도를 기준으로 1호 방조제(연장 4.7 ㎞) 외해측 해저면의 기준 연도별 평균수심 차이는 –0.46 m ~ +0.30 m로 매년 평균수심은 ±0.5 m 범위 내에서 변화하며, 기준년도보다 약 0.45 m 상승하면 하강으로 전환되어 평형 상태(기준년도)로 복구되는 패턴을 보인다. 반면에, 2호 방조제(연장 9.9 ㎞)의 2006년 방조제 최종체절년도 수심기준 연도별 평균수심 차이는 –0.77 m ∼ +0.50 m로 매년 평균수심은 ±0.8 m 범위내에서 변화하며, 기준년도 보다 약 0.50 m 상승하면 하강으로 전환되어 평형 상태(기준년도)로 복구되는 패턴을 보였다. 단, 방조제 외해측 해저의 수심변화 패턴은 1호 방조제의 경우 쌍봉형인 반면에 2호 방조제의 경우 단봉형이었다. 새만금 1호 방조제 외해측 해저지형을 종횡단면도부터 살펴본 결과 가력배수갑문 부근에서 해저면의 하강과 상승이 큰 것을 알 수 있으며, 방조제와 거리가 멀어질수록 해저면은 평형상태를 유지하고 있음을 알 수 있었고, 새만금 2호 방조제 외해측 가까운 종단방향 해저면은 2006년 방조제 체절 때에는 끝막이 공사 구간(GAP1과 GAP2)에서 큰 변화가 있었으나, 방조제 체절 이후 평형상태를 보였으며, 방조제 외해측 먼 해저면은 신시배수갑문이나 끝막이 공사 구간의 영향이 점점 줄어들어 방조제 체절 이전의 평형상태를 유지하고 있음을 알 수 있다. 새만금방조제 외해측 해저지형변화는 방조제(바닥보호공, 근고공, 피복석 등) 형상 변화의 주요 원인이므로 본 연구결과는 방조제 유지관리를 위한 의사결정, 보수계획, 개발계획, 연구자료 등으로 활용할 수 있을 것이다. In this study, bathymetry was conducted once a year by SBES from the sea dike to 5 km outward for 12 years from the final closing of Saemangeum sea dike in 2006 to 2017 to investigate the changes in the depth of the seabed on the No. 1 sea dike and No. 2 sea dike and the 200 m section from the sea dike armour stage to the open sea was subjected to bathymetric survey by MBES in 2013 for a close examination of the surrounding seabed of sea dike bed pitching and bottom protection, In the seabed topography change survey by SBES, the average depth difference for each year of the seabed on the open sea of the No. 1 sea dike (extension of 4.7 km) was from –0.46 m to +0.30 m, based on the final completion year of the sea dike in 2006. Each year, the average water depth changed within ±0.5 m and it is converted into erosion and restored to the equilibrium state (base year) when sedimentation is about 0.45 m from the base year. On the other hand, the average depth difference for each year of the No. 2 sea dike (extension of 9.9 km) was from –0.77 m to +0.50 m based on the final completion year of the sea dike in 2006, and the average depth varies within the range of ±0.8 m every year. When sedimentation was about 0.50 m from the previous year, it was converted into erosion and restored to the equilibrium state (base year). The water depth change pattern of the seabed on the open sea of the sea dike was bimodal in the case of the No. 1 sea dike whereas it was monomodal in the case of the No. 2 sea dike. As a result of examining the seabed topography on the open sea of Saemangeum No. 1 sea dike from the cross and longitudinal sectional view, it can be seen that the decrease and rise of the seabed near Garyeok sluice gate are greater and that the seabed remains in equilibrium as the distance from the sea dike increases. The longitudinal section seabed near the open sea of the Saemangeum No. 2 sea dike showed significant changes in the final closing of sea dike section (GAP1 and GAP2) at the completion of the sea dike in 2006, but showed an equilibrium state after the final closing of the sea dike. It can be seen that the distant seabed on the open sea side of the sea dike maintains an equilibrium state before the completion of the sea dike as the effect of Sinsi sluice gate or the final closing section is gradually reduced. The change in the seabed topography of the Saemangeum sea dike is a major cause of sea dike (bed pitching, bottom protection, armour stone, etc.) shape change, so this study result can be used as decision-making for sea dike maintenance, repair plan, development plan, research data.

Clinical features of chronic obstructive pulmonary disease (COPD) according to fractional exhaled nitric oxide (FENO)

안성 전남대학교 대학원 2020 국내석사

Object: Fractional exhaled nitric oxide (FENO) test is useful in asthmatic patients. However, a few studies on its usefulness in chronic obstructive pulmonary disease (COPD) patients are reported. We analyzed FENO level distribution and clinical characteristics according to FENO level in COPD patients. Method: From December 2014 to June 2019, COPD patients who underwent pulmonary function and FENO tests at Chonnam National University Hospital were retrospectively evaluated for FENO concentration, comorbidities, asthma history, blood eosinophil, and pulmonary function test. High FENO group was defined as having FENO level > 25 ppb. Result: A total of 849 COPD patients (mean age, 70.3±9.4) were included. The mean forced expiratory volume at 1 s was 66.5±21.7% and mean FENO level was 24.3±20.5 ppb. Those with FENO level <25 ppb were 572 (68%) and FENO level >25 ppb were 277 (32%). In univariate analysis, blood eosinophil percent was higher (4.2±4.8 vs 2.7±2.5, p<0.001), frequency of patients with blood eosinophil count >3% increased significantly [odds ratio (OR)=1.66, p<0.001], and asthma history was frequent (p<0.001, OR=3.68) in high FENO group. Asthma history, eosinophil ratio >3%, and positive bronchodilator response (BDR) were independent risk factors for increased FENO level [adjusted odds ratio (AOR)=3.85, p<0.001; AOR=1.46, p=0.017; AOR=1.57, p=0.034, respectively] in multivariate analysis. In COPD group with asthma-related factors, higher FENO value was shown than COPD group without asthma-related factors (31.6±29.3 vs 21.3±14.8, p<0.001). Conclusion: FENO level distribution varied in COPD patients and mean FENO value was slightly elevated. Asthma history, eosinophil percent, and positive BDR were independent risk factors for increased FENO level. 목적: 천식 환자에서 호기산화질소(FENO)의 유용성은 잘 알려져 있다. 하지만 만성폐쇄성폐질환 (COPD) 환자에 대한 FENO의 유용성 연구는 적은 실정이다. 본 연구에서는, COPD 환자에 있어서 FENO 농도 분포를 분석하였고, FENO 수치에 따른 COPD 환자의 임상적 특성에 대해 알아보았다. 방법: 2014년 12월부터 2019년 6월까지 전남대학교병원에서 폐기능 검사 및 FENO 검사를 받은 환자 중 FEV1/FVC 가 70 미만인 만성 폐쇄성 폐질환 환자들을 후향적으로 FENO 농도, 동반 질환, 천식 병력, 혈액 호산구, 폐기능에 대해 분석하였다. 높은 FENO군은 FENO 값이 25 초과인 경우로 정의하였다. 결과: 본 연구에서는 총 849명의 COPD 환자를 포함하였다. 이 환자들의 평균 나이는 70.3±9.4, 평균 1초노력호기량 (%)는 66.5±21.7%, 평균 FENO 값은 24.3±20.5 (ppb) 이였다. FENO 값이 25 이하인 경우는 572명 (68%), 25초과인 경우는 277명 (32%) 이였다. 단변량분석에서, 높은 FENO군에서, 혈액 호산구 비율이 높았고 (4.2±4.8 vs 2.7±2.5, 유의확률 p<0.001), 천식 과거력 빈도도 높았다 (p<0.001, 교차비=3.68). 천식 과거력, 호산구 비율, 기관지확장제 투여 후 반응 등은 다변량분석 에서도 높은 FENO 값을 보일 수 있는 독립적인 위험 인자였다 (조정된 교차비 (AOD)=3.85, p<0.001, AOD=1.46, p=0.017, AOD=1.57, p=0.034). 천식과 연관된 인자를 가진 COPD환자들은 그렇지 않은 환자에 비해서 더 높은 FENO 값을 보였다. 결론: 전반적으로, FENO 값의 분포는 COPD 환자에서 다양하였다. COPD 환자에서 FENO의 평균값은 약간 상승되어 있었다. 천식 과거력, 호산구 비율 및 양성 기관지확장제 투여 후 반응 등은 증가된 FENO 값을 보일 수 있는 독립적인 위험 인자였다.

구아리노 구아리니의 작품에 관한 연구 : San Lorenzo聖堂을 중심으로

안성진 국민대학교 1996 국내석사