당뇨 신경병증

심정인,정진화,Shim, Jung-In,Chung, Jin-Wha 대한족부족관절학회 2013 대한족부족관절학회지 Vol.17 No.4

Neuropathy is a common complication of diabetes. It is characterized by a progressive loss of peripheral nerve fibers. The development of the neuropathy is linked to poor glycemic control, age, and the duration of diabetes. Peripheral sensory polyneuropathy is the most common type in neuropathy. Diabetic neuropathy is the most significant etiologic factor of the foot ulcer that may leads to amputation. Current treatments in diabetic neuropathy have no definitive effects on repair or reverse the damaged nerve but only to relieve of symptoms, especially on pain. When the focal compressive neuropathy is combined with diabetic neuropathy, the nerve would be more vulnerable and symptoms might get worse. Surgery is indicated for decompression of an entrapped nerve, like posterior tibial nerve in tarsal tunnel, after failure of the initial conservative treatments.

탈염과정 중 온도 및 염화칼슘이 단무지 품질에 미치는 영향

심정석,최원석 한국산업식품공학회 2012 산업 식품공학 Vol.16 No.4

본 연구에서는 단무지 가공초기인 탈염과정에서 온도변화(5oC, 25oC) 및 CaCl2 첨가(0.6%, w/w) 유무가 탈염 단무지의 품질에 미치는 영향을 조사함으로서, 단무지 품질 변화를 최소화 할 수 있는 기초자료를 제공하고자 하였다. 5oC에서 탈염한 경우 25oC 탈염과 비교하여 탈염기간이 증가하였으며, 특히 탈염기간 후반부에 상대적으로 탈염속도가 늦어지는 것으로 나타났다. 미생물(위생)적 측면에서 5oC 탈염이 바람직하였으며, 탈염시 CaCl2 첨가가 단무지의 총균수를 감소시키지는 않았다. pH 변화의 경우 5oC 탈염에서 감소폭이 적었고, 색깔의 경우 탈염기간동안 전반적으로 큰 변화는 나타나지 않았다. 조직감(굳기)은 5oC에서 CaCl2 처리하지 않고 탈염한 단무지에서 변화(감소)가 가장 적었으며, 25oC, CaCl2 처리한 탈염단무지에서 가장 큰 변화(감소)가 나타났다. 미세구조를 관찰한 결과, 탈염과정에서 CaCl2 처리 시 공극이 커져 구조가 상대적으로 엉성해 짐을 확인하였으며, 온도차에 의한 미세구조차이는 육안으로 구별할 수 없었다. 관능검사결과, 조직감 측면에서는 CaCl2 처리하여 탈염한 단무지를 다소 선호하였으나 비처리시료와 유의적 차이는 나타나지 않았다. This study was conducted to evaluate the effects of temperature (5oC & 25oC) and CaCl2 (0.6%, w/w) on the quality properties of salted radish (SR) during desalting period (DP). DP of SR at 5oC was increased by comparison with that of SR at 25oC, and desalting rate of SR at 5oC was reduced greatly at the end of the DP. In viewpoint of hygiene, desalting process of SR at 5oC was better than that of SR at 25oC, and the addition of CaCl2 did not decrease the number of total microorganism. Changes in pH of SR at 5oC were smaller than those of SR at 25oC. There were a little color changes of SR. There was the smallest changes in firmness of SR, which was not treated with CaCl2 at 5oC, and the most significant changes in firmness has occurred that the SR treated with CaCl2 at 25oC. Scanning electron micrographs of SR treated with CaCl2 showed many large holes. Sensory properties showed that there is no significant difference between the texture of SR treated with CaCl2 and not treated.

정신건강의학과 외래 환자들의 도착지연 관련요인 분석: 일개 대학병원 사례

심정화 ( Jung Hwa Shim ),이예슬 ( Ye Seol Lee ),이상규 ( Sang Gyu Lee ),박소희 ( So Hee Park ),김태현 ( Tae Hyun Kim ) 한국보건정보통계학회 2015 보건정보통계학회지 Vol.40 No.3

Objectives: The purpose of this study is to examine factors related to the delayed arrival of appointment time for outpatients of a psychiatric department in an academic medical center in Korea. Methods: This study investigated relationships of delayed arrival with demographic, appointment related, and practice related factors, by analyzing data related to outpatient appointments for about two years from November 1 in 2013 to October 30 in 2014 at a university hospital in Seoul. Results: Among 95,470 final research subjects, 80,871 outpatients arrival in their appointment time, 14,559 outpatients were late, thus, a rate of delayed arrival is 15.29%. As the results of multiple logistic regression analysis, the odds ratios of delayed arrival become greater as they are younger, male , living in the residence, In-cheon and Gyeong-gi area, and their health insurance types are industrial accident compensation insurance and car insurance. Also, the odds ratios of delayed arrival become greater as the appointment time is from 8:30 to 11:00, they appoint in December, January, and February, and temperature gap is over -2 degrees Celsius between the reserved day and average temperature. Similarly, the odds ratio of delayed arrival is higher as return patients, obsessive-compulsive disorder, and practice by doctor B. Conclusions: This study found that various factor influence delayed arrival of appointment time. Medical institutions should find various methods such as focusing continuously on patients who tend to late their arrival time, developing specific appointment system regulating the factors of delayed arrival, and developing guidelines of the patients who tend to late their arrival time.

탈염과정 중 온도 및 염화칼슘이 단무지 품질에 미치는 영향

심정석 ( Jung Seok Shim ),최원석 ( Won Seok Choi ) 한국산업식품공학회 2012 산업 식품공학 Vol.16 No.4

본 연구에서는 단무지 가공초기인 탈염과정에서 온도변화(5oC, 25oC) 및 CaCl2 첨가(0.6%, w/w) 유무가 탈염 단무지의 품질에 미치는 영향을 조사 함으로서, 단무지 품질 변화를 최소화 할 수 있는 기초자료를 제공하고자 하였다. 5oC에서 탈염한 경우 25oC 탈염과 비교하여 탈염기간이 증가하였으며, 특히 탈염기간 후반부에 상대적으로 탈염속도가 늦어지는 것으로 나타났다. 미생물(위생)적 측면에서 5oC 탈염이 바람직하였으며, 탈염시 CaCl2 첨가가 단무지의 총균수를 감소시키지는 않았다. pH 변화의 경우 5oC 탈염에서 감소폭이 적었고, 색깔의 경우 탈염기간 동안 전반적으로 큰 변화는 나타나지 않았다. 조직감(굳기)은 5oC에서 CaCl2 처리하지 않고 탈염한 단무지에서 변화(감소)가 가장 적었으며, 25oC, CaCl2 처리한 탈염단무지에서 가장 큰변화(감소)가 나타났다. 미세구조를 관찰한 결과, 탈염과정에서 CaCl2 처리 시 공극이 커져 구조가 상대적으로 엉성해 짐을 확인하였으며, 온도차에 의한 미세구조차이는 육안으로 구별할 수 없었다. 관능검사결과, 조직감 측면에서는 CaCl2 처리하여 탈염한 단무지를 다소 선호하였으나 비처리시료와 유의적 차이는 나타나지 않았다. This study was conducted to evaluate the effects of temperature (5oC & 25oC) and CaCl2 (0.6%, w/w) on the quality properties of salted radish (SR) during desalting period (DP). DP of SR at 5oC was increased by comparison with that of SR at 25oC, and desalting rate of SR at 5oC was reduced greatly at the end of the DP. In viewpoint of hygiene, desalting process of SR at 5oC was better than that of SR at 25oC, and the addition of CaCl2 did not decrease the number of total microorganism. Changes in pH of SR at 5oC were smaller than those of SR at 25oC. There were a little color changes of SR. There was the smallest changes in firmness of SR, which was not treated with CaCl2 at 5oC, and the most significant changes in firmness has occurred that the SR treated with CaCl2 at 25oC. Scanning electron micrographs of SR treated with CaCl2 showed many large holes. Sensory properties showed that there is no significant difference between the texture of SR treated with CaCl and not treated.

‘청년정치 팬덤’ 뜯어 읽기

심정용 우리신학연구소 2022 가톨릭 평론 Vol.36 No.-

보육교사의 교직윤리 인식과 영,유아권리존중과의 관계

심정선 ( Jung Sun Shim ) 한국윤리학회 2011 倫理硏究 Vol.83 No.1

The purpose of this study is to find out relationship between child-care teacher`s teaching ethical consciousness and respect for infants and children`s rights. The subject we surveyed was 159 child-care teachers who works in Seoul and Gyung-gi. As instruments of research, we used ``Child-care Teacher`s Ethical Consciousness``(2007), Jo Pil-Su and ``Respect for Infants and Children`s Rights``(2009), Kim Jin-Sook. We measured four parts-Ethics of Children, Ethics of Children`s Family, Ethics of Coworker & Institute, and Ethics of Society- for child-care teachers` teaching ethical consciousness, and three parts-Respect for Daily life, Respect for Caring Activity, and Superior Benefit for children - for respect of children`s rights. According to correlation analysis, the result on this study is positively summarized as follow : ⅰ) Positive relationship between child-care teacher`s teaching ethical consciousness and Respect for infants and children`s rights ⅱ) The child-care teacher`s teaching ethical consciousness positive effects on respect for infants and children`s rights.

생물학적 제제에서 PCR-ELISA법을 이용한 HIV-1 오염 검색

심정현,김종완,이경애,권두한,명평근,김재옥,이석호,박순희,윤도영 대한진단검사의학회 2004 Annals of Laboratory Medicine Vol.24 No.1

배경 : 생물학적 제제는 때로 인체에 위해를 주는 부작용을 일으킨다. 따라서 생물학적 제제를 오염시켰을 수도 있는 위해 바이러스들을 효과적으로 검출하는 것은 긴급한 일이다. 위험한 오염물질이 생물학적 제제의 생산과 제조과정 중에 들어갈 수도 있으므로 인체에 위해한 바이러스를 효과적이고 민감도 높게 검출해내는 방법을 수립해야할 것이다.방법 : 이 연구에서는 HIV-1의 제거 확인을 위한 회수 검사를수행하였다. 생물학적 제제를 제조하는 다양한 배지(DMEM, RP-MI 1640, IMDM, GICM, SDM)에 10% FBS 유(+), 무(-)에HIV-1 플라스미드를 연속적으로 첨가한 후 PCR-ELISA로 측정하였다. 결과 : HIV-1을 DMEM, RPMI과 IMDM 배지에 첨가하였을때 PCR 산물을 아가로스 겔 상에서 4×10-2 ng 이하의 농도에 서는 밴드를 확인하기 어려웠으며, GICM과 SDM의 배지에서는 FBS 유무에 상관없이 4 ng 농도 이하에서의 HIV-1을 측정할 수 없었다. 그러나, PCR-ELISA에서는 여러 배지로 연속적으로 첨 가된 HIV-1 플라스미드로부터의 1,875배까지 희석된 PCR산물이 검출되었다. 결론 : 생물학적 제제를 제조하는 다양한 배지 DMEM, RPMI과 IMDM에서 바이러스 오염 여부를 판단하는데 더욱 유용하며, PCR을 하여 아가로스 겔에서는 4×10-2 ng까지 측정할 수 있지만 PCR-ELISA 방법을 사용할 경우 1×10-3 ng을 1,875배 희석하여도 검출할 수 있으므로 생물학적 제제를 오염시키는 바이러스들을 효과적으로 검출하는데 유용하다고 사료 된다. Background : Biomedical products such as viral vaccines can be contaminated with hazardous viruses during manufacturing processes and storage, thus causing harmful side effects. To assure the safety of biomedical products, highly effective and sensitive methods should be available to detect contaminating viruses. In this study, we performed recovery tests to determine the limit of detection of HIV-1. Methods : An HIV-1 plasmid preparation was serially diluted and spiked into various culture media (DMEM, RPMI-1640, IMDM, GICM, and SDM) containing 10% fetal bovine serum (FBS). The HIV-1 plasmid was detected by PCR alone or a combination of PCR and ELISA (PCR/ELISA). Results : When spiked into DMEM, RPMI, and IMDM, less than 4×10-2 ng of HIV-1 plasmid was not detectable as HIV-1 PCR products in agarose gel. Intra- and inter-assays (n=6) showed that the PCR-ELISA system could detect PCR products diluted as much as 1,875 times from HIV-1 plasmid serially spiked in various media. Conclusions : The PCR/ELISA system can be useful for the detection of trace amounts of hazardous viruses which may be present as contaminants in biological products. (Korean J Lab Med 2004; 24: 60-6)

다중파일 전송방식 기반의 P2P프로그램에서 데이터 전송상황의 시각화에 관한 연구

심정현(Shim Jung-Hyun),정지홍(Jung Ji-Hong) 한국디자인학회 2003 한국디자인학회 학술발표대회 논문집 Vol.- No.-

수용성 β-1,3-glucans의 면역 활성 효능에 대한 연구

심정현,최원아,김종완,이해숙,백태웅,조민철,이경애,상병찬,윤도영,Shim, Jung-Hyun,Choi, Won-A,Kim, Jong-Wan,Lee, Hae-Sook,Baek, Tae-Woong,Cho, Min-Cheol,Lee, Kyung-Ae,Sang, Byung-Chan,Yoon, Do-Young 대한면역학회 2003 Immune Network Vol.3 No.2

Background: $\beta$-1,3-glucans are well known to enhance the immune reactions, resulting in antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. $\beta$-1, 3-glucans have various activities depending on molecular weight, degree of branching, conformation, water-solubility and intermolecular association. However, the $\beta$-1,3-glucan linked backbone structure is essential and $\beta$-D-glucopyranosyl units are required for immuno-potentiating activities. Result: In this study, we tested the immunophamacological activities of soluble $\beta$-1,3-glucans and confirmed the following activities: (1) $IFN-{\gamma}$ production in PBMCs in the presence or the absence of PHA, LPS, or IL-18; (2) induction of various cytokines in the spleen and thymus; (3) adjuvant effect on the antibody production; (4) nitrogen oxide synthesis in macrophages; (5) the cytotoxic and antitumor effects on cell lines and ICR mice. Conclusion: These results strongly suggested that $\beta$-1,3-glucans possessed various immuno-pharmacological activities.

프로축구 선수의 시즌 중 운동 수행 분석

심정현,주창화,주호진 한국스포츠학회 2023 한국스포츠학회지 Vol.21 No.2

The purpose of this study is to analyze the difference in the performance of professional soccer players according to season stage, home and away matches, and results of matches. The professional soccer players in the K2-League participated in this study, and goalkeepers were excluded due to different play style during the match. Changes in the body composition by season stages and differences in exercise performance according to home and away matches, game results, rest periods between matches, and playing positions were analyzed. Muscle mass decreased in July compared to March (p<.05), there was no difference in weight, body fat, and body circumferences according to season stages. Total movement distance, jogging, low-intensity running, and medium-intensity running were performed more in the first half than in the second half season (p<.001). There was no difference in players' exercise performance according to home and away matches, and game results. Low-intensity walking distance was highest in groups of three days period compared to longer periods between matches (p<.05). Most variables, including the total movement distance were the lowest in the CB position compared to other positions. As a result of the study, the decrease in performance of the match along with the decrease in muscle mass in the second half, which includes the hot summer period, reflects the failure to manage players’ condition and inappropriate training methods in summer. Therefore, appropriate nutrition strategies and training methods should be applied to prevent a decrease in performance in the second half. 본 연구의 목적은 프로축구 선수의 시즌 시기별, 홈·원정 경기, 승·패에 따른 운동 수행력 차이를 분석하는 데 있다. K리그 2에 참가하는 프로축구팀을 대상으로 연구를 시행하였으며, 포지션의 특성상 플레이 형태가 다른 골키퍼 포지션은 제외하였다. 프로축구 선수의 시즌별 체성분 변화와 전·후반기, 홈·원정 및 경기 결과에 따른 운동 수행, 경기 사이 휴식 기간, 포지션에 따른 운동 수행의 차이를 분석하였다. 근육량은 3월에 비해 7월에 감소하였으며(p<.05), 체중, 체지방량, 신체 둘레는 시즌 시기에 따라 차이가 발생하지 않았다. 총 움직임 거리, 조깅, 저강도 달리기, 중강도 달리기는 후반기보다 전반기에 더욱 많이 수행하였다(p<.001). 홈·원정 및 경기 결과에 따른 선수들의 운동 수행의 차이는 없었다. 경기 사이의 기간에 따른 운동 수행은 강도가 낮은 걷기 수행 거리가 경기를 치르고 3일 후 다시 경기를 수행했을 때 가장 높게 나타났다(p<.05). 포지션별 운동 수행의 차이는 총 움직임 거리를 비롯해 대부분의 변인에서 CB 포지션에서 가장 낮게 나타났다. 연구 결과 더운 여름철이 포함된 후반기에 근육량 감소와 더불어 경기 수행량이 감소한 것은 여름철 선수들의 컨디션 관리 실패와 부적절한 트레이닝 방법을 반영한다고 할 수 있다. 따라서 후반기의 체력 저하로 인한 경기력 감소를 방지하기 위해서는 적절한 영양 섭취 전략과 트레이닝 방법이 적용되어야 할 것이다.