SM-2015의 혈중 알코올 분해 및 숙취 개선 효과

신선미,박선영,김태연,Shin, Seon-mi,Park, Sun-young,Kim, Tae-yeon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.1

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

WeXGene: 웹 기반 XML 데이터 생성기

신선미,정회진,이상호,Shin Sun Mi,Jeong Hoe Jin,Lee Sang Ho 한국정보처리학회 2005 정보처리학회논문지D Vol.12 No.2

XML 데이터베이스 시스템 성능 평가를 수행하기 위해서는 다양한 형태의 XML 데이터 생성을 필요로 한다. 기존 XML 데이터 생성기들은 특정 성능 평가에 적용 가능한 데이터만을 생성하고, 그 기능 또한 매우 제한적이다. 본 논문에서는 기존 XML 데이터 생성기들의 제한된 기능을 보완하고 동시에 새로운 기능들을 추가한 새로운 XML 데이터 생성기인 "WeXGene"을 제안한다. WeXGene은 열 단위 또는 행 단위의 데이터를 포함하는 사용자 데이터 화일 및 "SDTD(Symbolic DTD)" 또는 입력 파라미터를 명시한 구조 정의 화일을 이용하여 XML 데이터를 생성한다. 또한 사용자 데이터 화일 없이도 임의의 데이터론 포함하는 XML 데이터 생성이 가능하다. 본 논문은 WeXGene의 구체적인 설계 내용, 구조, 데이터 생성과정 등을 기술한다. 또한 타 XML 데이터 생성기와 기능을 비교 분석하였다. We need XML generate various kinds of XML data to evaluate XML database systems. Existing XML data generators are developed to generate XML data that are suitable for particular evaluation methods, and their functionalities are limited in terms of generating XML data This paper introduces a new XML data generator, WeXGene, that not only improves the drawbacks of existing data generators but also adds new data generation functionalities. For generating XML data WeXGene uses the user data files and the structure definition files, which specify SDTD(Symbolic DTD) or input parameters. The user data file is a text data file that has column data or row data. It is also possible that WeXGene generates XML data without accessing the user data file. This paper presents the design details, overall system architecture, and data generation process of WeXGene. An analytic comparison with other XML data generators is also presented.

의료급여 과다 이용 수급권자 중 장애인의 의료이용

신선미,김의숙,박창기,이희우,Shin, Sun-Mi,Kim, Eui-Sook,Park, Chang-Ki,Lee, Hee-Woo 대한예방의학회 2010 예방의학회지 Vol.43 No.1

Objectives: In Korea, the top 10% of Medical Aid recipients represent nearly 60% of total payment, with the costs for those disabled for over 365 days representing approximately 30% of total payment. The purpose of this study was to compare Medical Aid use of the disabled with non-disabled recipients, and to identify contributing factors to the total payment in the top 2% of recipients identified as Medical Aid overusers. Methods: Subjects (n=2,211) selected were ${\geq}18$-years-of-age and received >1000 days of co-payment-free type I Medical Aid. Case managers (n=200) conducted interviews in December 2006, and collected data from Health Insurance Review & Assessment Service. Amounts over the 9 months from January September 2006 were analyzed descriptively and using Chi-square, ANCOVA, and robust multiple linear regression. Results: Disabled individuals (mean age 61.3 years) composed 36.6% of subjects; 44.8% of the disabled were male. On a monthly basis per capita, the disabled group averaged 10.5 outpatient days, total payment of 523,000 Korean Won(￦), inpatient payment of ￦359,000, and outpatient payment of ￦183,000. All values exceeded the monthly average for non-disabled individuals. Contributing factors were identified as male gender (￦82,000), elementary school or lower educational level (￦64,000), residence in a small city (￦82,000), lack of family support (￦61,000), kidney disability (￦673,000), intellectual disability (￦151,000), and multiple disabilities (￦119,000). Conclusions: The identification of contributing factors to Medical Aid use by those defined as disabled supports the adoption of comprehensive alternative policies such as strengthening of education and consultation services, provision of alternative facilities, and promotion of self-care.

의료급여 장기이용 수급권자의 잉여약물 실태와 관련요인

신선미,김의숙,이희우,Shin, Sun-Mi,Kim, Eui-Sook,Lee, Hee-Woo 대한예방의학회 2009 예방의학회지 Vol.42 No.6

Objectives : The amount of medical utilization by Medical Aid recipients was 3.7 times that of patients with Korean Medical Insurance. This study aims to describe the surplus medicine and the medication-related utilization, and to determine factors contributing to surplus medicine. Methods : Among those who used copayment-free Class I Medical Aid in 2005, 146,880 subjects who were $\geq19$ year-old and received >365 days medical treatment per year were studied with their case managers by conducting face-to-face interviews. The analytic methods were description, chi-square, t-tests, ANCOVA and multiple logistic regressions. Results : Most subjects were female (68.6%), the elderly (62.5%), and the separated (61.6%), had an elementary graduation or less (74.8%), and had disabilities (33.2%). The percentage of subjects with surplus medicine was 18.5%. However, the percentage of females, the elderly, those with non-disabilities, the separated, the uneducated, those with a very poor perceived health status and those with an economical burden for medical treatment was 19.3%, 18.9%, 19.0%, 19.3%, 19.0%, 20.2% and 24.3%, respectively. For subjects with surplus medicine, averages for the number of used pharmacies, the pharmacy-visit days and the medication costs were 4.6 drugstores, 34.9 days and approximately 1,124 thousand Won(￦). These values were higher than those without surplus medicine (4.4 drugstores, 33.8 days, and ￦1,110 thousand, respectively). The odds ratios of the contributing factors to surplus medicine were female 1.11 (95% CI=1.07-1.14), the elderly 1.06 (95% CI=1.02-1.10), those with non-disabilities 1.08 (95% CI=1.05-1.12), the separated 1.14 (95% CI=1.10-1.18), the unmarried 1.12 (95% CI=1.07-1.18), the uneducated 1.03 (95% CI=1.01-1.08), those with a very poor perceived health status 1.04 (95% CI=1.01-1.08) and experiencing an economical burden for medical treatment 2.33 (95% CI=2.26-2.40). Conclusions : 18.5% of subjects had surplus medicine with a higher mean of medication cost. Therefore, health education and health promotion programs to prevent surplus medicine and to improve the appropriate usage of medication are necessary.

학생 건강에 대한 OECD와 한국의 통계지표

신선미,Shin, Sun-Mi 한국학교보건학회 2012 韓國學校保健學會誌 Vol.25 No.1

Purpose: The purpose of this study was to identify the statistical indicators of OECD and Korea for student health among Korea's approval statistics. Methods: Searching for health indicators by using Health at a Glance 2009, Society at a Glance 2009, and Education at a Glance 2009 through the formal OECD web site in 2010, and investigating the approval statistics through the Korean formal organizational web sites and published data in 2012. Results: Among OECD indicators, indicators for adolescent health were smoking and alcohol consumption, nutrition, physical activity, overweight and obesity, bullying, risk behaviors, and poverty children. However, most of Korea student health indicators were missing except poverty children and life satisfaction, because OECD has taken chiefly data from Health Behavior in School-aged Children survey (HBSC), international study, which has not been carried out in Korea. The Ministry Of Education, Science And Technology (MEST) and the Ministry of Health and Welfare, and National Youth Policy Institute in Korea have produced the major statistics for student health which was only 11 (1.3%) among 858 approval statistics. Conclusion: Identifying a current Korea school health is essential through participating actively to OECD whose statistic indicators are internationally comparable with Students Physical Development Survey, MEST's approval statistics, using Korea Student Health Examination. It was also suggested that quantitative and qualitative expansions for Korea student health statistics by the activation of approval statistics including processed statistics, and by researchers' easy expanded access to a raw data.

발기부전 처방에 사용되는 쇄양(鎖陽)이 음경해면체 이완에 미치는 영향

신선미,박선영,Shin, Seon-mi,Park, Sun-young 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4

Objective: This study aimed to examine the relaxation effects and underlying mechanisms of Cynomorii herba (CH) extract in isolated rabbit corpus cavernous tissues.Methods: We experimented with CH extract (0.01-3.0 mg/mL). Nω-nitro-L-arginine (L-NNA) was experimented before the CH extract to contracted strips induced by phenylephrine (PE, 1 μM)and compared with nonexperimented. In addition, we experimented with calcium chloride (Ca²⁺, 1 mM) after pretreatment of the CH extract in Ca²⁺-free Krebs-Ringer solution to contracted strips induced by PE. The cell viability and nitric oxide (NO) concentration of human umbilical vein endothelial cells (HUVECs) were measured by an methylthiazol-2-yl-2, 5-diphenyl tetrazoliumbromide (MTT) assay and Griess reagent system. The ratio of smooth muscles to collagen fibers, in addition to eNOS- and PDE-5-positive reactions, was examined by histochemical and immunohistochemical staining.Results: The CH extract significantly induced the relaxation of the cavernous strips, and the pretreatment with L-NNA inhibited CH extract-induced relaxation. The L-NNA pretreatment reduced the increased contraction induced by the addition of Ca²⁺in Ca²⁺-free solution. Furthermore, the NO concentration of the HUVECs increased. When the CH extract was applied to the corpus cavernosum of the penis (CCP) of Sprague Dawley rats, the ratio of smooth muscles to collagen fibers by PE and the formation of eNOS around the helicine artery increased. However, the CH extract treatment decreased PDE-5 positive reactions.Conclusions: These results show that the relaxation effects induced by the CH extract are associated with the suppression of the influx of extracellular Ca²⁺ via the production of NO and eNOS and inhibition of PDE-5.

학생건강검사를 통해 본 강남지역 초등학생의 정신건강 증상과 신체건강 증상의 관련성

신선미(Sun Mi Shin),조성숙(Sung Sook Cho),이희우(Hee Woo Lee) 대한스트레스학회 2011 스트레스硏究 Vol.19 No.4

본 연구의 목적은 강남지역 초등학생의 정신건강 및 신체건강 증상분포와 그 관련성을 파악하는 것이다. 연구대상자는 2010년 강남지역 1개 공공 어린이 병원에서 학생건강조사를 받은 7개 초등학교의 학생 1,636명(남학생 53.9%, 여학생 46.1%)이었다. 연구자료는 교육과학기술부에서 개발한 학생건강조사 문진표 중 최근 1달간 경험한 5개의 정신건강증상과 22개의 신체건강증상 문항으로 기술통계, 상관분석, 다중로지스틱 회귀분석을 이용하여 분석하였다. 연구결과 학생의 22.7%가 1개 이상의 정신증상을 보유하고 있었고, 여학생(19.1%)보다는 남학생(25.8%)에게, 1학년(20.3%)보다는 4학년 학생(24.8%)의 증상보유율이 높았다. 정신건강증상 중 지나친 활동이 14.0% (남학생 16.5%, 여학생 11.1%)로 가장 높았다. 신체건강증상의 유병율을 보면, 학생의 59.1%가 1개 이상의 증상 보유하고 있었는데, 가장 빈번하게 보고된 신체건강증상은 재채기와 콧물 21.7%. 또 정신건강과 신체건강증상은 상관성이 높았으며(r .20 ∼.31), 정신건강증상과 가장 많이 동반되는 신체건강증상은 두통이었고, 뒤이어 운동시 호홉곤란, 그리고 잦은 멍이었다. 따라서 학생 증상에 대한 관리방안이 원인별로 개발되어 학교현장에서 사용될 필요가 있으며, 특히 남학생과 고학년 학생의 증상관리방안이 우선 고려될 필요가 있다. We explored prevalence of symptoms, and association of mental symptoms with physical symptoms among elementary school students at South-river region in Seoul. The study population consisted of 1,636 schoolchildren (53.9% for boys and 46.1% for girls) in the 1st and 4th grades of 7 elementary schools receiving Student Health Examination in Seoul Metropolitan Children"s Hospital in 2010. We used questionnaire, Medical History Form, developed by Ministry of Education, Science and Technology. The questionnaire had 5 questions of mental symptoms and 22 questions of physical symptoms experienced during last one month. Students" parents or guardian filled out the Form. We conducted Chi-square, correlation and multiple logistic regression. Of students, 22.7% had one or more mental symptoms (25.8% for male and 19.1% for female, and 24.8% for the 4th grade students and 20.3% for the 1st grade). Students" most frequent mental symptom was hyperactivity (16.5% for male and 11.1% for female). 54.4% of students had one or more physical symptoms. The most frequent symptom was sneezing with watery nasal discharge (21.7%) among physical symptoms. Mental symptom cluster was also associated with physical symptom cluster (correlation coefficient 0.20~0.31). This coexistence strongly means that considerable physical symptoms are psychosomatic symptoms. The most associated physical symptom with mental symptoms was headache followed by short of breath during exercise, and getting bruises very easily on one"s body. Therefore, it is essential to develop plans to manage symptoms and to use at school field for student"s mental symptoms associated with physical symptoms especially for male and higher grade elementary students. (KoreanJ Str Res 2011;19:293∼301)

암환자가족이 지각하는 수술대기중 불안과 불확실성 및 의료인의 지지

신선미(Shin Sun-Mi),이은남(Lee Eun-Nam),강지연(Kang Ji-Yeon) 대한종양간호학회 2006 Asian Oncology Nursing Vol.6 No.1

Purpose: This study was to assess relationships among the uncertainty, medical staff's support, and anxiety perceived by family members with cancer patients while the family members were waiting for their patients undergoing surgery. Method: The data were collected from the family members of cancer patients who were undergoing surgery in D University Hospital at B city from February 1 to April 12, 2005. The used instruments were the State Anxiety Scale of Spielberger's(1975) STAI, Mishel's Uncertainty in Illness Scale (MUIS)(1981), and Relationship Questionnaires (Lee, 1978). The collected data was analyzed by using t-test, ANOVA, Pearson's coefficients, and stepwise multiple regression. Results: As the result, the most influential variable explaining anxiety of family members was uncertainty (ß=0.37), followed by perceived illness state (ß=-0.27). These two variables simultaneously explained 29.3% of the variance in anxiety. Conclusion: We suggest to develop a nursing intervention program to reduce the uncertainty through the medical staff's support and to test its effects.

중학생의 수면습관과 건강행동 및 외상이나 사고로 인한 치료경험

신선미(Sun Mi Shin) 대한스트레스학회 2015 스트레스硏究 Vol.23 No.1

본 연구는 청소년의 수면습관과 건강행동, 그리고 사고나 외상으로 인한 치료경험과의 관계를 파악하기 위해 2010년에 조사된 서울시 학생건강조사의 이차자료 중 중학생 7,167명의 수면습관과 건강행동 및 치료경험과의 단면적 관계를 범주형 및 다변량 분석을 통해 파악하였다. 연구결과 12.5%의 학생이 하루 6시간 이내로 수면하고 있었고, 10.0%의 학생이 8시간 이상 수면을 취하고 있었다. 하루 6시간 이내 수면자는 잠재적인 혼란변수를 통제 후의 교차비에서 남자일 때보다 여자일 때 2.1배, 중학교 1학년에 비해 2학년 및 3학년은 각각 1.5배, 1.9배, 손을 씻지 않는 습관일 때 1.8배, 이를 하루 2회 이상 닦지 않을 때 1.4배, 음주나 흡연에 대한 상담요구가 있을 때 2.3배 높았다. 또 수면습관과 사고나 외상에 의한 치료경험을 볼 때 사과나 외상에 의한 치료경험이 없을 때보다 있을 때 하루 6시간 이내 수면자의 교차비는 1.7배이었다. 그러므로 수면습관은 청소년의 건강행동 또는 사고나 외상과 관련이 있는 주요 건강지표라는 인식이 필요함을 알 수 있었다. The aim of this study was to investigate associations of adolescent"s sleep habit with health behavior and experience of accident and injury treated among middle school students in seoul. Cross-sectional, secondary data, representative sample of 7,167 middle school students in seoul was used and categorical analysis and multiple logistic regression was conducted. 12.5% of students had less than 6 hours of sleep a day and 10.0% of those had ≥8 hours. After adjusting for confounding variables, odds ratios of students with less than 6 hours of sleep a day were 2.1 times in female students, 8th grade 1.5 times, 9th grade 1.9 times (reference, 7th grade), 1.8 times in no handwashing with soap before eating or after returning home, 1.4 times in toothbrushing less than twice a day, 2.3 times in requiring consult against drinking and smoking, 1.7 times in experience of accident, and injury treated. Therefore, it is necessary to recognize that sleep habit is an important indicator for health promotion.

『동의수세보원(東醫壽世保元),성명론(性命論)』의 용어(用語) 정의(定義) 및 영역(英譯) 연구(硏究)

신선미 ( Sun Mi Shin ),강구 ( Goo Kang ),백진웅 ( Jin Ung Baek ) 대한한의학원전학회(구 대한원전의사학회) 2011 대한한의학원전학회지 Vol.24 No.4

Based on the previous translation studies and 『WHO-IST』, we selected terminology, which are required the definition and explanation among jargon expressed in 『Dongeuisusebowon· Discourse on Nature and Act』, and the procedure of the definition, explanation, and translation in Korean and English has been followed. The outcomes of this study are presented as below: First, based on the existing translation studies, Korean and English translation of 『Dongeuisusebowon· Discourse on Nature and Act』is provided. Second, few of Terminology in 『Dongeuisusebowon(東醫壽世保元)』have been written in WHO-IST, even most of them have been standardized in terms of 『Huang Di Nei Jing(黃帝內經)』. Therefore, terminology related to Four-constitution medicine in WHO-IST would be required to be corrected, and unattatched terminology should be added in the future. Third, in order to standardize and globalize Four-constitution medicine, further definition, explanation, and translation studies of the rest of Dongeuisusebowon should be continued.