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孫賢哲(손현철) 관훈클럽 2003 관훈저널 Vol.- No.89

갑상선에 혼재한 유두상암종과 편평세포암종의 세포학적 소견 - 1 증례 보고 -

손현이,서강석,Son, Hyun-I,Suh, Kang-Suek 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2

Mixed squamous cell carcinoma and papillary carcinoma in the thyroid gland is a very rare malignant tumor characterized by rapidly progressive clinical course and radioresistance. A 63-year-old woman had mixed squamous cell carcinoma and papillary carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology (FNA), and the diagnosis was confirmed by histological examination. She had complained of a fixed, egg-sized mass of the anterior neck with hoarseness for 1 year. The findings of FNA consisted of sheets and clusters of polygonal epithelial cells with hyperchromatic, pleomorphic nuclei and eosinophilic, abundant, laminated cytoplasm. These findings were consistent with squamous cell carcinoma. Also, fool of papillary carcinoma were noted, and the cells exhibited nuclear groovings and intranuclear cytoplasmic inclusions. Total thyroidectomy specimen showed a diffusely infiltrating tumor in the left thyroid which was composed of mixed papillary carcinoma and well-differentiated squamous cell carcinoma. In junction between two components, squamous metaplasia of papillary carcinoma was noted.

Development of a System Observing Worker's Physiological Responses and 3-Dimensional Biomechanical Loads in the Task of Twisting While Lifting

손현목,선우훈,김장호,임기택,정종훈 한국농업기계학회 2013 바이오시스템공학 Vol.38 No.2

Purpose: The purpose of this study is to provide analysis of physiological, biomechanical responses occurring from the operation to lifting or twist lifting task appears frequently in agricultural work. Methods: This study investigated the changes of physiological factors such as heart rate, heart rate variability (HRV) and biomechanical factors such as physical activity and kinetic analysis in the task of twisting at the waist while lifting. Results: Heart rates changed significantly with the workload. The result indicated that the workload of 2 kg was light intensity work, and the workload of 12 kg was hard intensity work. Physical activity increased as the workload increased both on wrist and waist. Besides, stress index of the worker increased with the workload. Dynamic load to herniated discs was analyzed using inertial sensor, and the angular acceleration and torque increased with the workload. The proposed measurement system can measure the recipient’s physiological and physical signals in real-time and analyzed 3-dimensionally according to the variety of work load. Conclusions: The system we propose will be a new method to measure agricultural workers’ multi-dimensional signals and analyze various farming tasks.

영가철(Fe⁰)과 UV를 이용한 1,4-dioxane 분해 반응시 철농도의 변화와반응 메커니즘의 연구

손현석(Hyun Seok Son),임종권(Jong Kwon Im),조경덕(Kyung Duk Zoh) 大韓環境工學會 2008 대한환경공학회지 Vol.30 No.3

본 논문은 1,4-dioxane의 분해를 위한 F⁰와 Fe²⁺의 반응에서 UV의 영향을 평가하기 위해 반응 중 [Fe²⁺]와 용액 중 총철이온 농도에 대한 [Fe²⁺]의 비([Fe²⁺]/[Fe(t)])의 변화를 조사하였다. UV, F⁰, 그리고 Fe²⁺의 단독반응에 의한 1,4-dioxane의 분해효율은 10% 이하였으며 그 반응 동안 [Fe²⁺]와 [Fe²⁺]/[Fe(t)]의 변화 또한 거의 일어나지 않았다. 그러나 UV 조사에 의해 F⁰의 산화는 약 25% 정도 증가하였을 뿐만 아니라 1,4-dioxane의 분해 효율 또한 개선되었다. Fenton 반응(Fe²⁺+H₂O₂)의 경우 반응초기 90 분까지는 매우 빠른 분해율을 보인 반면 90분 이후에는 1,4-dioxane의 분해가 거의 정지되었다. Fe²⁺와 UV 반응에서는 [Fe²⁺]/ [Fe(t)]가 반응 시작부터 감소하다가 90분 이후부터 완만한 증가를 보였다. F⁰와 UV 반응의 경우 반응속도 상수는 반응시작 90 분 동안 1.84×10-3 min-1에서 Fe²⁺의 변화가 일어나는 시간인 90분 이후 9.33×10-3 min-1로 큰 상승을 보였고 이 변화는 [Fe²⁺]/ [Fe(t)]이 감소이후에 일어났다. [Fe²⁺]/[Fe(t)]는 Fe²⁺와 UV 반응에서 계속적으로 감소하였다. 그러나 그 반응에 ClO₄-를 첨가한 경우 [Fe²⁺]/[Fe(t)]는 완만한 상승을 보였다. 이 결과들은 1,4-dioxane의 분해는 주로 F⁰이 Fe²⁺로 산화되는 기간이 아닌 Fe²⁺가 Fe³⁺로 산화, 환원되는 반응 동안 일어났음을 보여준다. 즉, 1,4-dioxane의 주요 분해는 철순환에서 생성되는 라디칼에 의한 산화작용이라 할 수 있다. 또한 UV와 ClO₄-는 Fe³⁺의 환원에 큰 작용을 하는 것으로 관찰되었고 이는 radical의 지속적인 생산이라는 측면에서 1,4-dioxane의 분해효율을 증가시키기 위해 매우 중요한 부분이라 할 수 있다. The study presents the results of 1,4-dioxane degradation using zero valent (F⁰) or Fe²⁺ ions with and without UV. During the reaction, the change of [Fe²⁺] and [Fe²⁺]/[Fe(t)], the concentration ratio of ferrous ion to total iron ion in solution was measured. Less than 10% degradation of 1,4-dioxane was observed by UV-only, F⁰-only, and Fe²⁺-only conditions, and also the changes of [Fe²⁺] and [Fe²⁺]/[Fe(t)] were minimal in each reaction. However, the oxidation of F⁰ was enhanced with the irradiation of UV by approximately 25% and the improvement of 1,4-dioxane degradation was observed. Fenton reaction (Fe²⁺+H₂O₂) showed higher degradation efficiency of 1,4-dioxane until 90 min, which of the degradation was stopped after that time. In the reaction of Fe²⁺ and UV, the ratio of [Fe²⁺]/[Fe(t)] decreased then slowly increased after a certain time indicating the reduction of Fe³⁺ to Fe²⁺. In case of F⁰ in the presence of UV, the first-order rate constant was found to be 1.84×10-3 min-1 until 90 min, and then changed to 9.33×10-3 min-1 when the oxidation of Fe²⁺ mainly occurred. In this case [Fe²⁺]/[Fe(t)] kept decreasing for the reaction. However, the addition of perchlortae (ClO₄-) in the reaction of F⁰ and UV induced the continuous increase of [Fe²⁺]/[Fe(t)] ratio. The results mean the primary degradation factor of 1,4-dioxane is the oxidation by the radicals generated from the redox reaction between Fe²⁺ and Fe³⁺. Also, both UV and ClO₄- played the role inducing the reduction of Fe³⁺, which is important to degrade 1,4-dioxane by enhancing the generation of radicals.

테렌스 맬릭 영화의 앙각 내레이션 디자인

손현석 ( Hyun Seok Son ) 커뮤니케이션디자인학회 2012 커뮤니케이션 디자인학연구 Vol.41 No.-

테렌스 맬릭 Terrence Malick의 앙각 내레이션은 2011년 칸 영화제 황금종려상 수상작인 <트리 오브 라이프 The Tree of life>에서 완성된 것으로 보인다. 그러나 실은 1973년의 첫 장편인 <황무지 Badlands>로부터 감독의 철학적인 세계관과 꾸준히 연결되어 있었다. 본 논문은 테렌스 맬릭이 삶의 본질에 접근하는 방식으로 구축한 앙각 내레이션의 흐름을 분석하고 그 성과를 밝히는데 목적을 둔다. 두 편의 초기작은 그를 신화적인 인물로 만들었는데, 10대 소녀의 순진한 내레이션 방식과 카메라 위치의 정밀함에서 비롯된 비전통적 완성도가 비결이었다. 20년의 침묵 이후 1998년에 발표된 <씬 레드 라인 The Thin Red Line>은 그의 세계관이 집약된 성찰적인 영화였다. 여기서 선보인 다중 내레이션은 나무와 하늘을 우러러 보는 카메라의 앙각과 결합하여 영화의 주된 정서를 지배했다. 이는 보이는 세계를 무한 확장하고 철학, 나아가 종교적인 내면을 세계의 표면으로 밀어내는 효과적인 장치였다. <트리 오브 라이프>는 앙각 내레이션이 핵심 주제인 영화이다. Terrence Malick`s Low Angle Narration seems to be completed in the film The Tree of Life awarded the Palm d`Or at the 64th Cannes Film Festival. In fact, his Low Angle Narration has steadily reflected his philosophical world-view since the first feature film, Badlands in 1973 was screened. This paper aims to analyze his Low Angle Narration hitherto kept up in the manner of approaching to the substance of life and reveal its outcomes. His early two films, which made him a legendary director, adapted teenage girls` naive narration style and accurate camera positions to reach to the non-traditional completion. After the twenty-year silence, he directed The Thin Red Line. The film reflected himself and summed up his view of the world with the cinematic device of multiple narrations combined with low angle looking up trees and the sky. Due to this core skill, the visible world has been extended limitlessly. Furthermore, his philosophical and thus religious inner world came up to the surface of the real world. The design of Low Angle Narration is the main theme in the film, The Tree of Life.

시장참여자별 혼잡 및 손실 비용 산정

손현일(Hyun-Il Son),배인수(In-Su Bae),김진오(Jin-O Kim) 대한전기학회 2011 전기학회논문지 Vol.60 No.11

Recently the power system consists of the more complicated structure, due to increase of power demands. In this circumstance, the congestion and loss capacity in transmission line is also increased. Accordingly, the investment planning of transmission system is required to reduce the congestion and loss of the transmission line. This paper proposes a method to compute the congestion and loss costs which are the key elements in economic assessment of the power system planning. And the benefit of market participants in CBP (Cost Based Pool) is computed. To demonstrate the efficient of the suggested methods, these methods are applied to peak load system of 2016 in the 4th Basic plan of Long-Them Electricity Supply and Demand.

일부 지역 여성들의 일반적 특성에 따른 피부관리실 이용 실태 및 만족도에 관한 연구

손현진 ( Hyun Jyn Son ),김주덕 ( Ju Duck Kim ),김은주 ( Eun Ju Kim ) 한국미용학회 2009 한국미용학회지 Vol.15 No.1

The purpose of this study was to analyze their sociodemographic characteristics and skin conditions, determine actual profile of skin care conditions in female customer group, and analyze possible correlations among their preference for skin care, consumers` sentiment and customer satisfaction, so that it could obtain useful data for domestic skin care industry. The results of this study can be outlined as follows: First, for general sociodemographic characteristics of our respondents, it was found that most of them belonged to married housewife group at age 30-39 and graduated from 4-year university course. And 27% respondents answered that their monthly household income ranged from ￦ 2 to 3 million. Second, overall, our respondents didn`t have so much good skin and physical health conditions. 34.6% respondents belonged to dry skin type and 41.6% respondents had skin problems like wrinkle and lower elasticity. It was found that most respondents had many interests in skin care and relied on skin care service for ca. 1-1 hour 30 minutes once a week at the cost of ￦ 50,000 to 70,000. Third, it was found that most respondents obtained information on skin care shop from their friends or family members, and 58.2% respondents had experiences in using skin care services. Most respondents relied on skin care shop for their skin beauty and preferred meridian massage for healthcare more than anything else, but didn`t show so high intentions to keep relying on skin care shop due to financial limitation. Forth, it was found that most of our respondents valued skin trouble improvement for customer satisfaction, but were dissatisfied with service cost. Their turnover to other shops came primarily from push marketing of beauty care products and the unfledged professionalism of skin care staffs, while most of our respondents wanted lasting care and skin care counseling as a part of after-sales services.

한국인에서 수장족저농포증과 흡연의 연관성에 대한 연구

손현호 ( Hyun Ho Son ),이영석 ( Young Seok Lee ),이숙경 ( Sook Kyung Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.11

Background: Palmoplantar pustulosis (PPP), a skin disease, is characterized by chronically recurring sterile pustules on the palms and the soles. Although the etiology of PPP is unknown, it is interesting to note high prevalence of tobacco use in these patients. It would seem that there may be a relationship between PPP, autoimmune disease and alterations of thyroid function. However, this fact was never verified among Korean. Objective: This study aims to explore smoking as a risk or exacerbation factor for PPP in Korean patients with PPP, and confirm the relationship between PPP and other factors, including thyroid disease. Methods: We studied a total of 109 patients (M:F=38:71) with ages ranging from 20 to 70 years, diagnosed with PPP. A control group was matched according to gender and age: 109 patients with other dermatologic problem. Patients were interviewed about tobacco use, and thyroid disease, and autoimmune diseases. The data were analyzed to determine whether there was any association between PPP and various factors. Results: The proportion of PPP patients using tobacco was much higher than that of the control group (p<0.05). Smoking was more strongly associated with PPP among women. Although there was no association between the quantity of cigarettes smoked daily and the severity of PPP, there was a dose-dependent correlation between the pack*year and the severity of PPP (p<0.05). Furthermore, 14 patients had been diagnosed with thyroid disease. In addition, all of them were smokers. Conclusion: There was significant association between PPP and smoking. However, the impact of giving it up in the clinical course of the disease remains to be established. In addition, it would seem that there may be a relationship between PPP and alteration of thyroid function. (Korean J Dermatol 2012;50(11):945∼950)

1P-594 BOG 재액화 공정의 동적 모델 개발 및 공정 동특성 연구

손현수,곽동훈,김진국 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

LNG (Liquefied natural gas) 추진용 선박은 환경 친화적라는 장점으로 인해 최근 많은 관심을 받고 있다. 하지만 LNG 저장탱크의 외부 조건에 의해 BOG (Boil-off gas)가 발생하기 때문에 이를 회수하고 활용하기 위한 액화 공정이 수반되어야 한다. 특히, 해상 환경에서는 BOG 재액화 공정에 영향을 줄 수 있는 다양한 요인이 있기 때문에 공정의 안정적인 운전을 위해 강건하고 효과적인 공정 제어 방안 제시가 필요하다. 따라서 본 연구에서는 BOG 재액화 공정의 동적 모델링을 수행하여 공정의 운전 거동을 분석하고 최적의 공정 운전 방안을 제시하는 것을 목표로 한다. 동적 모델링을 기반으로 제어 로직을 구성하여 공정의 운전 목표를 도달할 수 있음을 확인하고 공정 운영 시 예측되는 주요 외란을 분석하여 최적의 운전 가이드라인을 도출하고자 한다. ^**이 논문은 중소기업청의 재원으로 한 WC300 R&D 사업의 지원을 받아 수행된 연구입니다. (과제번호: S2305678)

Apoptotic Effect of Co-Treatment with Chios Gum Mastic and Eugenol on SCC25 Human Tongue Squamous Cell Carcinoma Cell Line

손현진,예병호,김인령,박봉수,정성희,안용우,고명연,Sohn, Hyeon-Jin,Yea, Byeong-Ho,Kim, In-Ryoung,Park, Bong-Soo,Jeong, Sung-Hee,Ahn, Yong-Woo,Ko, Myung-Yun Korean Academy of Orofacial Pain and Oral Medicine 2011 Journal of Oral Medicine and Pain Vol.36 No.3

Eugenol (4-allyl-2-methoxyphenol) is a natural phenolic constituent extensively used in dentistry as a component of zinc oxide eugenol cement and is applied to the mouth environment. Chios gum mastic (CGM) is a resinous exudate obtained from the stem and the main leaves of Pistacia lenticulus tree native to Mediterranean areas. This study was undertaken to investigate the synergistic apoptotic effect of co-treatment with a natural product, CGM and natural phenolic compound, eugenol on SCC25 human tongue squamous cell carcinoma cell line. To investigate whether the co-treatment with eugenol and CGM compared to each single treatment efficiently reduces the viability of SCC25 cells, MTT assay was conducted. Induction and augmentation of apoptosis were confirmed by Hoechst staining, TUNEL staining and DNA hypoploidy. Westen blot analysis and immunofluorescent staining were performed to study the alterations of the expression level and the translocation of apoptosis-related proteins in co-treatment. In this study, co-treatment of with eugenol and CGM on SCC25 cells showed several lines of apoptotic manifestation such as nuclear condensations, DNA fragmentation, the increase and decrease of Bax and Bcl-2, decrease of DNA content, the release of cytochrome c into cytosol, translocation of AIF and DFF40 (CAD) onto nuclei, and activation of caspase-3, caspase-6 caspase-7, caspase-9, PARP, Lamin A/C and DFF45 (ICAD) whereas each single treated SCC25 cells did not show or very slightly these patterns. Although the single treatment of 40 ${\mu}g$/ml CGM and 0.5 mM eugenol for 24 h did not induce apoptosis, the co-treatment of these reagents prominently induced apoptosis. Therefore our data provide the possibility that combination therapy with CGM and eugenol could be considered as a novel therapeutic strategy for human oral squamous cell carcinoma.