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손성연,임태성,김동훈,이성준,최문희,김현아,문소영 대한신경과학회 2010 대한신경과학회지 Vol.28 No.3
A 50-year-old woman presented with a 4-day history of apathy, perseveration, and confusion. These symptoms appeared 16 days after she had started taking sulfasalazine for rheumatoid arthritis. Brain MRI showed bilateral symmetrical discoid lesions involving the corona radiata. She fully recovered 7 days after stopping the medications. Follow-up brain MRI revealed remarkable improvement of the lesions. The pathomechanisms related to sulfasalazine-induced leukoencephalopathy may be demyelinating processes due to impaired T-cell-mediated immunity.
위험감수와 충동성 및 불확실성에 대한 인내력 부족의 관련성
손성연,강지인,남궁기,김세주,Sohn, Sung Yun,Kang, Jee In,Namkoong, Kee,Kim, Se Joo 대한생물정신의학회 2014 생물정신의학 Vol.21 No.3
Objectives Risk taking has been implicated in the development of various psychiatric disorders. Previous studies have indicated that risk taking behavior is associated with high levels of impulsiveness. Risk taking entail uncertain situation that outcome probability is unknown. This study tested impulsivity, intolerance of uncertainty and risk taking behavior. Methods A total of 73 participants completed a test battery comprised of the UPPS-P scale as a psychometric measurement of five dimensions of impulsivity, Intolerance of Uncertainty Scale, and Balloon Analog Risk Task (BART) as a behavioral measure of risk taking. The Pearson correlation analysis was used. Results The sensation seeking factor was positively correlated with BART measure (r = 0.27, p = 0.02). Specifically, the relationship between sensation seeking and BART was significant in females. Conclusions Among the five factors of UPPS-P, only the sensation seeking factor predicts risk taking propensity.
쉐그렌증후군과 항 갑상선 항체의 상승을 동반한 비혈관염 자가면역 염증성 뇌병증 1예
이성준,손성연,임태성,문소영 대한치매학회 2011 Dementia and Neurocognitive Disorders Vol.10 No.3
Background: Nonvasculitic autoimmune inflammatory meningoencephalitis (NAIM) is known to be one of the causes of potentially reversible dementia. NAIM can be accompanied by various autoimmune diseases. Methods: A 65 year-old woman had been treated with stable bipolar disorder and presented with rapid cognitive decline, visual hallucination and myoclonus. Anti-thyroid antibodies were elevated. Her symptoms were responsive to steroid therapy. Her diagnostic evaluation also revealed Sjögren’s syndrome. Although her symptoms recovered, a manic episode reappeared and was responsive to psychiatric treatment. Conclusions: Patients presenting with rapidly progressive dementia should be thoroughly evaluated for the diagnosis of NAIM, a potentially treatable form of dementia, and the possible various underlying autoimmune etiologies.
손목굴증후군 환자의 신경생리학적 소견과 혈청 지질 수치와의 상관관계
여승현,김동훈,손성연,홍윤희,박재범,주인수 대한임상신경생리학회 2010 Annals of Clinical Neurophysiology Vol.12 No.2
Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve beneath the transverse carpal ligament. CTS can be correctly diagnosed by the patients' description of symptoms and electrophysiological tests that measure nerve conduction through the wrist. Many previous studies reported various risk factors of CTS, such as obesity, diabetes mellitus, thyroid disease and trauma. Obesity is associated with both hyperlipidemia and CTS. This study focused on the relationship between severity of CTS and serum lipid level. Methods: One hundred fourteen patients with CTS and 74 controls were divided into four groups according to the severity; normal, mild,moderate and severe. And then serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) were measured in each group. Results: There was a positive correlation between TG and CTS severity (p<0.001). But TC, LDL-C and HDL-C were not correlated with CTS severity. Conclusions: These results suggest that high serum TG may act as an aggravating factor of CTS.