http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 손서영 (검색결과 43 건)
- 무료
- 기관 내 무료
- 유료
-
-
손서영,김한성,주미,김민경,박성혜 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.3
Primary carcinoid tumor of the kidney is a very rare disease. Until now, only 41 cases have been reported worldwide, and nine of these arose in a horseshoe kidney. In Korea, 3 cases have been reported to date, and all of these arose in a horseshoe kidney. We present a case of primary carcinoid tumor occurring in a normal kidney of a 45 year old man. A tumor was incidentally found close to the hilum of the left kidney. Histologically, the tumor exhibited trabecular and ribbon-like pattern of cuboidal or columnar cells. Mitotic activity was rarely seen. The tumor cells were positive for synaptophysin and chromogranin A. Numerous dense-core neurosecretary granules were observed by the electron microscopic examination. To our knowledge, the present case is the first report of primary renal carcinoid tumor arising in a normal kidney in Korea.
-
Zinc Ion-Mediated Concentration of Glycated Hemoglobin for Electrochemical Biosensing
손서영,윤현철 한국바이오칩학회 2009 BioChip Journal Vol.3 No.2
We developed a biosensing strategy for glycated proteins in red blood cells. Glycated hemoglobin (HbA1C) is recognized as an important target molecule to improve the control and longterm treatment of diabetes mellitus. We employed ferrocene boronic acid (FcBA) as a signaling molecule for electrochemical biosensing, since it possesses both signaling capability and biospecificity toward the target glycated proteins. FcBA was reacted with samples containing HbA1C, and the resulting conjugate was purified and highly concentrated through treatment with zinc (Zn) ions. Zn binds to hemoglobin with an association constant of 1.3×107 M-1. By employing Zn-mediated concentration/ separation, we were able to purify HbA1C easily and rapidly. After the solution-phase purification and concentration step, electrochemical signaling was performed for HbA1C. Using cyclic voltammetry, the dynamic detection range obtained for HbA1C was around 3-15% (HbA1C per total hemoglobin), which covered the clinically important range. This technology could be implemented in a diagnostic biosensor and would be applicable to other glycoproteins that need to be analyzed. We developed a biosensing strategy for glycated proteins in red blood cells. Glycated hemoglobin (HbA1C) is recognized as an important target molecule to improve the control and longterm treatment of diabetes mellitus. We employed ferrocene boronic acid (FcBA) as a signaling molecule for electrochemical biosensing, since it possesses both signaling capability and biospecificity toward the target glycated proteins. FcBA was reacted with samples containing HbA1C, and the resulting conjugate was purified and highly concentrated through treatment with zinc (Zn) ions. Zn binds to hemoglobin with an association constant of 1.3×107 M-1. By employing Zn-mediated concentration/ separation, we were able to purify HbA1C easily and rapidly. After the solution-phase purification and concentration step, electrochemical signaling was performed for HbA1C. Using cyclic voltammetry, the dynamic detection range obtained for HbA1C was around 3-15% (HbA1C per total hemoglobin), which covered the clinically important range. This technology could be implemented in a diagnostic biosensor and would be applicable to other glycoproteins that need to be analyzed.
-
-
손서영,장혜원,조윤영,김선욱,정재훈 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.4
Background: Previous studies have suggested that recombinant human thyroid stimulating hormone (rhTSH) stimulation is an acceptable alternative to thyroid hormone withdrawal (THW) when radioiodine remnant ablation is planned for thyroid cancer treatment, based on superior short-term quality of life with non-inferior remnant ablation efficacy. This study evaluated the cost-effectiveness of radioiodine remnant ablation using rhTSH, compared with the traditional preparation method which renders patients hypothyroid by THW, in Korean perspective. Methods: This economic evaluation considered the costs and benefits to the Korean public healthcare system. Clinical experts were surveyed regarding the current practice of radioiodine ablation in Korea and their responses helped inform assumptions used in a cost effectiveness model. Markov modelling with 17 weekly cycles was used to assess the incremental costs per quality-adjusted life year (QALY) associated with rhTSH. Clinical inputs were based on a multi-center, randomized controlled trial comparing remnant ablation success after rhTSH preparation with THW. The additional costs associated with rhTSH were considered relative to the clinical benefits and cost offsets. Results: The additional benefits of rhTSH (0.036 QALY) are achieved with an additional cost of Korean won ₩961,105, equating to cost per QALY of ₩26,697,361. Sensitivity analyses had only a modest impact upon cost-effectiveness, with one-way sensitivity results of approximately ₩33,000,000/QALY. Conclusion: The use of rhTSH is a cost-effective alternative to endogenous hypothyroid stimulation prior to radioiodine ablation for patients who have undergone thyroidectomy in Korea.
-
갑상선분화암 환자에서 방사성요오드 치료 전 적절한 저요오드식이 평가를 위한 혈중 요오드 측정의 유용성 평가
손서영,김혜정,장혜원,김선욱,정재훈 대한갑상선학회 2012 International Journal of Thyroidology Vol.5 No.2
Background and Objectives: Low-iodine diet (LID) is generally recommended prior to radioactive iodine (RAI)therapy to increase RAI uptake. Recently, we suggested spot urine iodine/creatinine (I/Cr) ratio as a good alternative method replacing measurement of 24 hr urine iodine excretion for the evaluation of appropriate LID preparation. In next step, we studied to evaluate the usefulness of serum iodine concentration comparing with urine iodine concentration and urine I/Cr ratio to assess LID preparation status. Materials and Methods:We prospectively measured serum iodine concentration, spot urine iodine concentration, and urine I/Cr ratio in 419 patients with differentiated thyroid carcinoma undergoing LID. Appropriate LID preparation was defined as urine I/Cr ratio less than 66.2 ug/gCr. Results: There were significant correlations between serum iodine and the spot urine iodine concentrations or urine I/Cr ratio; the correlation coefficient was 0.51 for urine iodine concentration and 0.62 for I/Cr ratio (p<0.001). Calculated R2 after log-log transformation was 0.45 for I/Cr ratio. The cutoff value of serum iodine concentration was 20.4 ug/L (sensitivity 79.3%, specificity 81.5%) for the evaluation of appropriate LID. Conclusion: Measurement of serum iodine concentration may be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively low compared to the urine I/Cr ratio.
-
Fludrocortisone으로 조절되지 않는 부신피질기능저하증 개를 DOCP로 치료한 1례
손서영,서경원,김새움,황철용,윤화영 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.5
A 3-year old, female Cocker Spaniel dog was referred to Seoul National University Hospital for Animals with depression and vomiting. The dog was diagnosed as hypoadrenocorticism based on the typical electrolyte alteration and the result of adrenocorticotropic hormone (ACTH) stimulation test. Initial treatment with oral fludrocortisone at a dose rate of 0.02 mg/kg/q24h for 6 weeks period was ineffective at maintaining serum electrolyte concentrations within normal limits. Although a dose rate of oral fludrocortisone was significantly increased up to 0.06 mg/kg/q24h during 24 weeks period, the treatment was still ineffective. Moreover, the patient showed side effects related to the glucocorticoid excess including PU/PD, weight gain and lipemia. After alternation with desoxycorticosterone pivalate (DOCP, 2.2 mg/kg, IM) every 25 day, the clinical signs was disappeared and the electrolyte balance was maintain with no side effect. Therefore, DOCP may be suggested as an effective drug in canine hypoadrenocorticism uncontrolled with oral fludrocortisone.
-
손서영,정지영,조윤영,박선미,진상만,정재훈,김선욱 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.3
Background: There are limited data about whether patients who receive initial treatment for differentiated thyroid cancer (DTC) gain or lose weight during long-term follow-up under thyroid stimulating hormone (TSH) suppression. This study was aimed to evaluate whether DTC patients under TSH suppression experience long-term weight gain after initial treatment. We also examined the impact of the radioactive iodine ablation therapy (RAIT) preparation method on changes of weight, comparing thyroid hormone withdrawal (THW) and recombinant human TSH (rhTSH). Methods: We retrospectively reviewed 700 DTC patients who underwent a total thyroidectomy followed by either RAIT and levothyroxine (T4) replacement or T4 replacement alone. The control group included 350 age-matched patients with benign thyroid nodules followed during same period. Anthropometric data were measured at baseline, 1 to 2 years, and 3 to 4 years after thyroidectomy. Comparisons were made between weight and body mass index (BMI) at baseline and follow-up. Results: Significant gains in weight and BMI were observed 3 to 4 years after initial treatment for female DTC but not in male patients. These gains among female DTC patients were also significant compared to age-matched control. Women in the THW group gained a significant amount of weight and BMI compared to baseline, while there was no increase in weight or BMI in the rhTSH group. There were no changes in weight and BMI in men according to RAIT preparation methods. Conclusion: Female DTC patients showed significant gains in weight and BMI during long-term follow-up after initial treatment. These changes were seen only in patients who underwent THW for RAIT.
-
손서영,윤현철 한국바이오칩학회 2008 BioChip Journal Vol.2 No.2
We have developed a biosensing strategy for glycated proteins in red blood cells. Glycated hemoglobin (HbA1C) is recognized as an important target molecule to improve diabetes control and treatment. We employed ferroceneboronic acid (FcBA) as the signaling molecule, having both a signaling capability and biospecificity for target proteins. The boronic acid functional group in FcBA has an ability to form a covalent bond between its diol group and the cisdiol group from the carbohydrate chain on the surface of HbA1C. The FcBA was reacted with samples containing HbA1C, and the resulting conjugate was purified by a CENTRICON® membrane. After the solution-phase purification and concentration adjustment step, the electrochemical signal was registered. From the cyclic voltammetry, the detection range obtained for HbA1C was around 0.1-1,000 μg/mL. By employing bioelectrocatalytic signal amplification on the glucose oxidase (GOX)-modified electrode, we were able to enhance the biosensor sensitivity. This study can be implemented in a diagnostic biosensor and is applicable to other glycoproteins having analytical needs. We have developed a biosensing strategy for glycated proteins in red blood cells. Glycated hemoglobin (HbA1C) is recognized as an important target molecule to improve diabetes control and treatment. We employed ferroceneboronic acid (FcBA) as the signaling molecule, having both a signaling capability and biospecificity for target proteins. The boronic acid functional group in FcBA has an ability to form a covalent bond between its diol group and the cisdiol group from the carbohydrate chain on the surface of HbA1C. The FcBA was reacted with samples containing HbA1C, and the resulting conjugate was purified by a CENTRICON® membrane. After the solution-phase purification and concentration adjustment step, the electrochemical signal was registered. From the cyclic voltammetry, the detection range obtained for HbA1C was around 0.1-1,000 μg/mL. By employing bioelectrocatalytic signal amplification on the glucose oxidase (GOX)-modified electrode, we were able to enhance the biosensor sensitivity. This study can be implemented in a diagnostic biosensor and is applicable to other glycoproteins having analytical needs.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
