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2 channel 보행성식도산도검사의 병적역류 환자에서의 상부식도의 역류와 식도내압검사와의 비교분석
조돈현 ( Jo Don Hyeon ),박수헌 ( Park Su Heon ),김형근 ( Kim Hyeong Geun ),정지성 ( Jeong Ji Seong ),손동균 ( Son Dong Gyun ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),선희식 ( Seon Hui Sig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 위식도 역류질환에서의 병태생리학적 원인으로 저압성 하부식도괄약근, 일시적인 하부식도괄약근이완, 식도연동운동의 장애등의 식도운동질환이 생각되고 있다. 그러나 상부식도의 역류와 식도운동질환의 연관성에 대한 연구는 알려지지 않았다. 저자들은 2 channel 보행성 식도산도검사를 실시하여 하부 식도에서의 병적역류가 확진된 환자에서 상부식도의 병적역류여부와 식도내압검사의 결과를 비교 분석하고자 하였다. <방법> 하부식도의 역류를 보기 위한 원위부 탐침
위암화과정에서 Helicobacter pylori 감염이 위점막 세포 역동학과 아포토시스 관련 단백질 발현에 미치는 영향
이강문 ( Lee Gang Mun ),이동수 ( Lee Dong Su ),양진모 ( Yang Jin Mo ),안병민 ( An Byeong Min ),이은희 ( Lee Eun Hui ),유진영 ( Yu Jin Yeong ),김유정 ( Kim Yu Jeong ),정인식 ( Jeong In Sig ),선희식 ( Seon Hui Sig ),박두호 ( Park Du 대한소화기학회 2003 대한소화기학회지 Vol.42 No.1
Background/Aims: We investigated apoptosis, cell proliferation and the expression of apoptosis-related proteins in the gastric epithelial cells of Helicobacter pylori (H. pylori)-negative and positive patients. Methods: TUNEL staining, immunohistochemical staining for Ki-67, p53, Bcl-2, Bcl-XL and Bax were performed on paraffin-embedded specimens obtained from 11 H. pylori-negative controls, 20 H. pylori-positive chronic gastritis, 10 chronic gastritis with intestinal metaplasia (IM), 11 adenoma, and 7 adenocarcinoma patients. Apoptosis and proliferation were expressed as apoptosis index (AI) and proliferation index (PI). Results: In H. pylori-positive groups, apoptosis and proliferation were increased compared with controls. However, an AI/PI ratio was highest in chronic gastritis cases and then gradually reduced according to the progress from IM to cancer. p53 was expressed in 28.6% of adenocarcinoma cases. Expression of Bax was significantly increased in chronic gastritis and IM patients compared with controls. Conclusions: H. pylori infection induces marked increase in apoptosis and proliferation of gastric mucosa. In the premalignant lesions, the balance between apoptosis and proliferation is altered, and this imbalance may play a key role in the gastric carcinogenesis. (Korean J Gastroenterol 2003;42:12-19)
대한간학회지 제6차 춘계학술대회 초록집 : 구연 ; 국내 Amatoxin 중독증의 연간발생률과 원인균종
안병민 ( An Byeong Min ),이동수 ( Lee Dong Su ),이강문 ( Lee Gang Mun ),박영민 ( Park Yeong Min ),이영석 ( Lee Yeong Seog ),정규원 ( Jeong Gyu Won ),선희식 ( Seon Hui Sig ),박두호 ( Park Du Ho ),김부성 ( Kim Bu Seong ),이종명 ( Le 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
1996년도 제35차 대한소화기학회 추계학술대회 / 일반연제 : 위장관 ; 비궤양성소화불량환자에서 위배출시간지연과 자율신경기능실조의 임상적 의의
박수헌,김진일,나종순,채현석,김재광,한준열,최규용,정인식,정규원,선희식,박두호,손형선 ( Soo Heon Park,Jin Il Kim,Jon Soon Na,Hiun Suk Chae,Jae Kwang Kim,Jun Yul Han,Kyu Yong Choi,In Sik Chung,Kyu Won Chung,Hee Sik Sun,Doo Ho Park,Hyung Su 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
위장관 종양의 진단에서 혈장 Tumor M2-Pyruvate Kinase의 유용성
김창환 ( Kim Chang Hwan ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),정규원 ( Jeong Gyu Won ),선희식 ( Seon Hui Sig ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.5
Pyruvate kinase (PK) is a key enzyme of glycolysis. Different isoforms of this enzyme are tissue-specifically expressed (M2-PK, M1-PK, R-PK, L-PK). The concentration of the dimeric M2-PK is increased in a metabolic state of tumor cells. In this case, the dimeric M2-PK is termed Tumor M2-PK. We investigated EDTA-plasma of 73 patients with gastrointestinal (GI) cancer and 61 healthy controls to evaluate its significance in diagnosing GI cancer. Methods: Plasma Tumor M2-PK was measured using an ELISA assay based on two monoclonal antibodies which specifically react with the dimeric Tumor M2-PK. Results: The sensitivity of Tumor M2-PK was 67.1% for all GI cancers, that of CA 19-9 was 38.4% and that of CEA was 34.3%. The specificity of Tumor M2-PK was 91.8% (cutoff=20 U/mL). Tumor M2-PK showed a high sensitivity in gastric cancer (62.2%), colorectal cancer (66.7%) and bile duct cancer (75.0%). In colorectal cancer, the combination of Tumor M2-PK with CEA resulted in a remarkable increase in the sensitivity (86.2%). The average Tumor M2-PK levels were generally elevated in the metastatic GI cancer patients compared to nonmetastatic patients, especially in stomach cancer with statistical significance (p=0.005). Conclusions: Tumor M2-PK in EDTA-plasma seems to be a new valuable tumor marker in GI cancer. (Korean J Gastroenterol 2003;42:387-393)
위장관 종양의 진단에서 혈장 Tumor M2-Pyruvate Kinase의 유용성
김창환 ( Kim Chang Hwan ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),한석원 ( Han Seog Won ),정인식 ( Jeong In Sig ),정규원 ( Jeong Gyu Won ),선희식 ( Seon Hui Sig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> Pyruvate kinase (PK)는 당분해에 중요한 역할을 하는 효소로 조직 특이성을 가지는 여러 가지 동종효소(R-PK, L-PK, M1-PK, M2-PK)들이 존재한다. 이들 모든 동종형들은 활성상태에서 동형 사중체(homotetramer)로 존재하나 종양 세포에서는 대부분 이중체(dimeric) M2-PK로 존재하여 Tumor M2-PK로 명명되었다. Tumor M2-PK의 진단적 가치는 신장암, 췌장암, 폐암, 위암, 유방암 등에서
강기문(Ki Mun Kang),최일봉(Ihl Bohng Choi),계철승(Chul Seung Kay),최병옥(Byung Ok Choi),정수미(Su Mi Chung),김인아(In Ah Kim),한성태(Sung Tae Han),선희식(Hee Sik Sun),정규원(Kyu Won Chung),신경섭(Kyeong Sub Shinn) 대한방사선종양학회 1994 Radiation Oncology Journal Vol.12 No.2
Purpose : This study was undertaken to show the clinical resuts of combined radiotherapy and hyperthermia in primary hepatoma Materials and Methods : Between December 1989 and March 1993, 50 patients with hepatomas were treated by combined radiotherapy and hyperthermia. Among them, we analyzed retrospectively 33 patients who received the complete course of treatment. The ages of the patients ranged from 36 to 75(mean age : 55.5 years). Twenty six patients (78.8%) were men and 7 (21.2%) were women. According to Child's classification. nine patients (27.3%) were A group 9 (27.3%) were B group 15(45.4%) were C group. Radiation therapy was done by a 6 MV and 15 MV linear accelerator. Patients were treated with daily fractions of 150-180 cGy to doses of 2550 cGy-4950 cGy (median : 3000 cGy). Local hyperthermia was done by 8 MHZ RF capacitive heating device (Cancermia, Green Cross Co., Korea), 50-60 min/session, 1-2 sessions/wk, and 8.5 sessions (median number)/patient. We analyzed the prognostic factors including age, sex, tumor type, Child's classification, α-fetoprotein, liver cir-rhosis, ascites, portal vein invasion, esophageal varix, number of hyperthermia, chemotherapy, total bilirubin level, Karnofsky performance status. Results : The overall 1-year survival was 24.2% with a mean survival of 10 months. Of 33 patients, tumor regression (PR+MR) was seen in 30.4% no response was seen in 52.2%, 17.4% patient was progressed. In patients who had tumor regression, the overall 1 year survival was 42.1% with a mean survival of 14 months. Factors influencing the survival were sex (p=0.05), tumor type (p=0.0248). Child's classification (p=0.0001), liver cirrhosis (p=0.0108), ascites (p=0.0009), and Karnofsky performance status (p=0.0028). Complications developed in 28 patients, including 18 hot pain 5 fat necrosis, 3 transient fever, 2 nausea and vomiting. Conclusion : In this study the results suggests that combined radiotherapy and hyperthermia may improve the survival rate of hepatoma.
일반 성인남자군에서 7일간 YH1885 복용이 24시간 위내산도와 혈장 가스트린 농도의 변화에 미치는 영향
손동균 ( Son Dong Gyun ),정지성 ( Jeong Ji Seong ),김형근 ( Kim Hyeong Geun ),조돈현 ( Jo Don Hyeon ),박수헌 ( Park Su Heon ),김재광 ( Kim Jae Gwang ),선희식 ( Seon Hui Sig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> YH1885은 750여가지의 화합물중에서 선택된 산분비 억제제로 유한연구소에서 개발한 새로운 acid pump antagonist (APA)인데, 비가역적 proton pump inhibitor인 omeprazole과 달리 H+/K+-ATPase (acid pump)에 대해 가역적으로 작용한다. 이번연구는 두 기관에서 무작위 이중맹검법을 통해, YH1885 100, 150, 200 mg이 24시간 위내산도와, 순응도, 약동학, 혈중 가스트린 농
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 최소증상 간성 뇌증 환자에서 신경인지검사의 유용성 연구
남순우 ( Nam Sun U ),양동원 ( Yang Dong Won ),김지훈 ( Kim Ji Hun ),김창환 ( Kim Chang Hwan ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),정규원 ( Jeong Gyu Won ),선희식 ( Seon Hu 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
최소 증상 간성 뇌증에서 신경인지검사와 뇌 자기공명분광검사의 유용성
남순우 ( Nam Soon Woo ),김진일 ( Kim Jin Il ),박수헌 ( Park Soo Heon ),한남익 ( Han Nam Ik ),한준열 ( Han Joon Yeol ),안병민 ( Ahn Byung Min ),김재광 ( Kim Jae Kwang ),최상욱 ( Choi Sang Wook ),정규원 ( Chung Kyu Won ),선희식 ( Su 대한소화기학회 2003 대한소화기학회지 Vol.42 No.1
Background/Aims: The aim of the study was to correlate neuropsychological test results with regional cerebral biochemistry determined by magnetic resonance spectroscopy (MRS) in patients with minimal hepatic encephalopathy (MHE). Methods: The patients with liver disease were divided into 4 groups; group 1 chronic hepatitis; group 2, liver cirrhosis (LC) without a history of HE; group 3, LC with a history of HE of no manifestation, and group 4, LC with overt HE. All patients were examined using neuropsychological tests and brain MRS. Results: Trail making, Digit span, Digit symbol, and Peg board test in groups 2 and 3 were significantly different compared with control. These neuropsychological tests were regarded more available test for diagnosis of MHE. In the LC patients, compared with control, MRS results showed a typical pattern with decrease of myoinositol/Cr (0.24±0.24 vs. 0.68±0.10, p<0.05) and increased glutamine-glutamate/Cr (2.97±0.80 vs. 1.94±0.47, p<0.05). The difference of myoinositol/Cr and glutamine-glutamate/Cr between patients with MHE and control was statistically significant (0.16±0.15 vs. 0.68±0.10, 3.11±0.72 vs. 1.94±0.47, p<0.05). Conclusions: Neuropsychological tests and MRS maybe useful for diagnosing MHE. (Korean J Gastroenterol 2003;42:50-56)