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      • KCI등재

        국내 공동주택의 CPTED 연구 경향 분석

        서혜민 한국문화공간건축학회 2016 한국문화공간건축학회논문집 Vol.- No.56

        Due to all the recent crimes at residential neighborhoods, it has become a social issue lately. As a result people have started to pay attention to safeguard residential environments. Not only we need to implement crime prevention activities as a solution but also we need to establish an environment that can quickly identify and control the factors behind all crimes. The concept of CPTED begins with the early stages of urban environment and construction design to create spaces that can eliminate the factors behind all the crimes. After 2000’s, the research for CPTED in Korea has progressed and continues to actively enhance further research. However, we do not have enough case studies applicable to city construction because of its early stages in development. In order for CPTED in Korea to reach a level of success, we would need to examine formal case studies of its application else where and determine the areas of deficiencies to compensate beforehand. Also, we would need a proposal to further the research of CPTED in the most sensible path. The research will help us understand studies in CPTED for Korean multi-family housing related to residential environment; reveal dwellers lifestyles, especially their circumstances. This research analyzes and establishes domestic research on designing crime prevention environments in multi-unit dwells which is focused on CPTED. Based on the review of precedence study content and method, it may suggest fundamental references for the direction of the study in Korean CPTED. After an extensive analysis of Korean CPTED, it has been determined that studies with surveys and case studies are primarily focused on outdoor in complex and block in public spaces. Those studies are hardly considered with respect to Korean CPTED. In order to implement as soon as possible a systematic application of CPTED in Korean multi housing, we should establish guidelines and a checklist that adequately addresses the issues.

      • Temperature-responsive surface wettability of emulsion thin films by controlled Spinodal decomposition

        서혜민,김진웅 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

        We fabricate the emulsion thin film by utilizing the layer-by-layer (L-b-L) deposition. The nanoemulsion used in our study was fabricated through assembly of amphiphilic block copolymer and lecithin at the oil-water interface. The development of extremely stable charged nanoemulsions allowed us to employ L-b-L assembly by taking advantage of the electrostatic attraction. The thickness of the nanoemulsion films was tunable to few micrometer scales by solely changing the number of alternate emulsions and polyelectrolytes layers. It was remarkable that the nanoemulsion films had the thermally responsive Spinodal decomposition, thus enabling manipulation of surface wettability. These results highlight that a new type of controlled drug delivery can be developed based on the patch-type soft film cargos.

      • 1P-537 Layer-by-layer deposition of nanoemulsions for thermally responsive soft matter films

        서혜민,신경희,김진웅 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

        We first successfully produced multilayered nanoemulsion films by using the layer-by-layer deposition of negatively charged nanoemulsion and positively charged polyelectrolytes. The nanoemulsion used in our study was fabricated through assembly of amphiphilic block copolymer and lecithin at the oil-water interface. Basically, the thickness of the nanoemulsion films was tunable to few micrometer scales by solely changing the number of alternate emulsions and polyelectrolytes layers. We figured out that the emulsion films had the thermally responsive heterogeneous phase separation, which is typically referred to as Spinodal decomposition. Taking advantage of this intriguing phase separation behavior, we were able to regulate film wettability and drug release. This result highlighted that many more new applications could be explored for the controlled drug delivery from patch-type soft emulsion film cargos.

      • KCI등재

        건조마늘과 기름에 볶은 마늘의 향기성분

        서혜민,주광지,Seo, Hye-Min,Joo, Kwang-Jee 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.3

        마쇄한 생마늘과 생마늘을 동결건조한 분말의 함황화합물과 휘발성 향기성분의 변화를 관찰하기 위하여 마늘을 동결 건조시켜 분말로 제조하고, 마늘과 동결건조 마늘을 콩기름과 참기름에 $180^{\circ}C$에서 각각 5분간 볶은 6개의 시료를 제조하여 향기성분을 추출하였다. 마늘의 독특한 향기를 나타내는 sulfur compounds로서 methyl allyl sulfide, diallyl sulfide, methyl allyl disulfide, diallyl disulfide, methyl allyl trisulfide, diallyl trisulfide 등이 확인되었으며 diallyl disulfide와 diallyl trisulfide의 함량이 풍부하였다. 이 sulfur compounds 성분들은 마늘의 총 향기성분의 98%를 차지하여 마늘의 주요 구성분임을 다시 한 번 확인하였다. 건조마늘에서 확인된 향기성분은 마늘에서 검출되지 않았던 aldehyde, alcohol, furans, esters가 생성되어 개별 향기성분의 수는 마늘의 것보다 더 많았으나 sulfur compounds와 향기성분의 총 함량이 마늘의 것보다 감소하였다. 콩기름에 볶은 건조마늘의 sulfur compounds 함량은 크게 감소하여 건조마늘의 sulfur compounds 함량의 20%에 불과하여 그 함량이 크게 감소하였다. 마늘을 콩기름과 참기름으로 가열하였을 때 allicin의 분해 생성물인 많은 양의 3,4-dihydro-3-vinyl-1,2-dithiin과 2-vinyl-4H-1,3-dithiin이 확인되었다. 그리고 건조마늘을 콩기름과 참기름에 가열하였을 때 마늘의 아미노산과 당류의 반응에 의하여 생성된 2-methyl pyrazine, 2,6-dimethyl pyrazine, 2-ethyl-5-methyl pyrazine 등 17개의 pyrazine이 관찰되었다. 건조마늘을 참기름에 볶은 시료에서 확인된 개별 향기성분의 수는 모든 마늘시료 중에서 가장 많았고 향기성분의 총 함량도 마늘의 것과 거의 동일하여 차이가 없었으나 sulfur compounds의 함량은 마늘의 27%에 해당되었다. 건조마늘을 콩기름과 참기름으로 가열함으로써 그 함량이 마늘 자체의 것보다 오히려 증가한 것은 diallyl sulfide, methyl allyl disulfide, dimethyl trisulfide이었다. 마늘에서 그 함량이 가장 많았고 마늘의 독특한 향기성분을 내는 diallyl disulfide는 건조하여 참기름으로 가열함으로써 파괴되어 완전히 소멸되었다. The purpose of this study was to investigate the change of flavor compounds of freeze-dried garlic and garlic roasted with soybean oil and sesame oil. Freeze-dried garlic and ground raw garlic roasted with oils was prepared at $180^{\circ}C$ for 5 minutes. Volatile compounds of garlic samples were obtained by Likens-Nickerson distillation/solvent extraction and identified by GC and GC/MS. Sulfur compounds, methyl allyl sulfide, diallyl sulfide, methyl allyl disulfide, dimethyl trisulfide, diallyl disulfide, methyl allyl trisulfide and diallyl trisulfide were the major volatile in garlic flavor which was more than 98% of the total volatile compounds. The total amount of sulfur compounds in freeze-dried garlic roasted with soybean oil was decreased to 20% compare to that of garlic flavor; however, 10 pyrazines such as 2-methyl pyrazine, 2,6-dimethyl pyrazine, 2-ethyl-5-methyl pyrazin and 3-ethyl-2,5-dimethyl pyrazine which were not originated from both freeze-dried garlic and soybean oil were identified. They might be generated from thermal interactions of sugars and nonvolatile flavor precursors of garlic. In freeze-dried garlic roasted with sesame oil, the amount of diallyl sulfide, methyl allyl disulfide, dimethyl trisulfide increased whereas diallyl disulfide completely disappeared. The amount of two cyclic compounds 3,4-dihydro-3-vinyl-1,2-dithiin and 2-vinyl-4H-1,3-dithiin, which were artifacts from allicin, increased in roasted garlic with sesame oil.

      • KCI등재

        ATP5B regulates mitochondrial fission and fusion in mammalian cells

        서혜민,이익수,정학숙,배규운,장민선,송은숙,김민정 한국통합생물학회 2016 Animal cells and systems Vol.20 No.3

        Mitochondria are essential organelles that produce ATP and regulate cell growth, proliferation, and cell death. To maintain homeostasis, fusion and fission of mitochondria must be strictly regulated. Even though oligomerization of ATP synthase could affect the mitochondrial morphology, the exact mechanism is not clear. We confirmed that structure and function of ATP5B, which is a major component of the catalytic center of ATP synthase complexes, are closely connected to the mitochondrial morphology. ATP5B itself can enhance elongation of mitochondria. Moreover, mutations of the threonine residue at β-barrel domain, and the serine residue at nucleotidebinding domain of ATP5B, produce the opposite effect on the fission and fusion of mitochondrial networks. Here, we demonstrate that ATP5B is clearly involved in the mechanism of regulation for mitochondrial fusion and fission in mammalian cells.

      • The first approach to fabricate multilayered smart emulsion films by layer-by-layer deposition

        서혜민,신경희,김진웅 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1

        We first successfully prepared thermally responsive multilayered nanoemulsion films consisting of charged nanoscale emulsion drops and polyelectrolytes by utilizing the layer-by-layer deposition technology. Basically, we used extremely stable nanoemulsions that fabricated through co-assembly of amphiphilic block copolymer and lecithin. These emulsions were specialized in offering both mechanically robust polymeric membrane and charged emulsion drops. The thickness of the nanoemulsion films was tunable in submicron scales by solely changing the number of alternate emulsions and polyelectrolytes layers. It was remarkable to experimentally figure out that the emulsion films had the thermally responsive heterogeneous phase separation, which could be understood by the spinodal decomposition. This intriguing behavior enabled the controlled release of active compounds from the emulsion films.

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