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정신분열병 환자에서 Aripiprazole 교체 방법에 따른 임상 결과 분석:1년 후향적 의무기록 조사 연구
서태연,강민희,이정섭,배재남,김철응 대한정신약물학회 2009 대한정신약물학회지 Vol.20 No.5
aripiprazole. Methods:Patients confirmed DSM-IV diagnoses of schizophrenia who had been treated with aripiprazole after switching from previous antipsychotics were recruited from inpatient and outpatient departments of Inha Hospital from March 2005 to February 2007. We classified patients according to three switching strategies (crosstapering, abrupt-switching, tapering-switching) and, over the course of a one-year period, collected data for intervals during which medications were being switched. Results:A total of 48 patients with an average age of 36.25±8.58 years participated in this study. The sample consisted of 20 patients in the cross-tapering group, 23 in the abrupt-switching group, and five in the tapering-switching group. The previous antipsychotics were risperidone, olazapine, amisulpride, quetiapine, and ziprasidone. The reasons for switching included weight gain (26.1%), hyperprolactinemia (23.9%), lack of effectiveness (20.8%), and over-sedation (13.0%). The rates at which patients continued aripiprazole after one year were 55% (11/20) for the cross-tapering group, 48.7% (11/23) for the abrupt-switching group, and 40% (2/5) for the tapering-switching group. In addition, 25% of cross-tapering patients (5/20), 43.5% of abrupt-switching patients (10/23), and 60% of tapering-switching patients (3/5) switched to other antipsychotics. Continuation of aripiprazole was higher in the cross-tapering group than in the abrupt switching group, but this difference did not reach statistical significance (p=0.351). The average aripiprazole retention duration was 10.75±3.29 months in the cross-tapering group, 10.39±3.29 months in the abrupt-switching group, and 10.00±4.77 months in the tapering-switching group. Cross-tapering was associated with a relatively longer retention period, but this difference did not reach statistical significance (p=0.653). Conclusion: All three switching strategies were associated with tolerable clinical outcomes after the shift to aripiprazole. The rate and duration of aripiprazole retention was higher in the cross-tapering group than in the abrupt switching group, but this result did not achieve statistical significance. 본 연구는 정신분열병 환자를 대상으로 이전 항정신병약물에서 aripiprazole로 교체할 때,“중단-시작 교체 방법”,“교차-교체 방법”,“시작-감량 교체 방법”에 따른 임상 결과 차이를 1년 후향적 의무기록 조사를 통하여 좀 더 효과적인 교체 방법을 제시하고자 하였다. 총 48명의 환자의 의무기록을 1년간 추적 조사하여 교체 이유, 교체 이전 약물, 교체 방법에 따른 aripiprazole 유지 비율과 유지 기간, 타 항정신병 약물 교체율, 추적 관찰 실패율, 부작용의 비율 등을 조사하였다. 각 교체방법에 따른, aripiprazole 유지 비율과 기간, 타 항정신병 약물 교체율, 추적 관찰 실패율, 부작용의 발생 비율 등은 통계학적으로 유의미하지는 않았다. 본 연구 결과는 후향적 의무기록 연구라는 점에서 여러 가지 연구의 제한점들이 있지만, 세 가지 교체 방법 모두 실제 임상에서 이전 약물에서 aripiprazole 교체시 유용한 방법으로 사용될 수 있음을 의미한다. 그러나 본 연구는 후향적 의무기록 연구의 제한점이 있으므로, 향후 본 연구의 제한점들을 보완한 체계적인 연구를 통하여 보다 효과적이고 안전한 aripiprazole 교체 방법을 제시할 필요가 있을 것으로 기대한다.
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윤경현,서태연,민용식,오삼권 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-
본 연구는 골프 수행 능력(핸디캡)을 향상시키기 위한 도구 개발로서, 자신의 스코어를 통계적인 측면에서 관리를 보다 과학적으로 하고자 하는데 도움을 주는 소프트웨어를 개발하는데 그 주된 목적이 있다.
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김영원,Tong Zhou,고은아,김성태,이동희,서예림,권나희,최태연,임희정,조성빈,배관희,황유성,김도진,박혜원,이민자,장은경,최정윤,배혜미,임인자,방효원,고재홍 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be divided as acute or chronic by duration of symptoms. In this study, we investigated whether skin injury caused by chemical (contact hypersensitivity, CHS) or physical (skin-scratching stimulation, SSS) stimuli causes initial pruritus and analyzed gene expression profiles systemically to determine how changes in skin gene expression in the affected area are related to itching. In both CHS and SSS, we ranked the Gene Ontology Biological Process terms that are generally associated with changes. The factors associated with upregulation were keratinization, inflammatory response and neutrophil chemotaxis. The Kyoto Encyclopedia of Genes and Genomes pathway shows the difference of immune system, cell growth and death, signaling molecules and interactions, and signal transduction pathways. Il1a , Il1b and Il22 were upregulated in the CHS, and Tnf , Tnfrsf1b, Il1b, Il1r1 and Il6 were upregulated in the SSS. Trpc1 channel genes were observed in representative itching-related candidate genes. By comparing and analyzing RNA-sequencing data obtained from the skin tissue of each animal model in these characteristic stages, it is possible to find useful diagnostic markers for the treatment of itching, to diagnose itching causes and to apply customized treatment.
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