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      • SCOPUSKCI등재

        크롬친화성세포종과 비슷한 증상을 동반한 급성 간헐성 포르피리아

        이병권(Byoung Kwon Lee),배희동(Hee Dong Bae),박효진(Hyo Jin Park),정준근(Jun Keun Jung),정준표(Jun Pyo Chung),이관식(Kwan Sik Lee),이상인(Sang In Lee),박인서(In Suh Park) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.1

        Acute intermittent porphyrla(AIP) is a disorder that results frorn partial deficiency of porpbobi- linogen dearninase an has varlable clinical manifestations, such as acute abdominal pain, vomiting, nausea, constipation, perlpheral neuropathy, seizure, abnormal psychic symptoms, respiratory failure, tachycardia, and hypertension. If cases present severe acute hypertension, their clinical signs may mimick pheochromocytoma and the diagnosis of AIP would be delayed. We experienced a case of acute intermittent porphyria presenting with acute hypertension, mimicking pheochromo- cytoma in a 35 year-old female patient. She had history of two admissions to different hospitals with acute hypertension and abdominal pain. An extensive investigations had been done but no specific diagnosis was made. She had previously responded well to atenolol but after continuous treatement this led to hypotention. Her blood pressure was 210/140mmHg in both arms at admision to this hospital. She complained of acute abdominal pain and constipation, and she also had psychotic episodes. She had intermittent severe hypertension with the feature of pheochro- mocytorna. Tests for pheochromocytoma(including 24h urinary catecholamines, clonidine-inhibition test) were negative. Apart from slightly increased urinary excretion of catecholamines on one occasion, her symptoms were provoked by starvation and emotional stress and neurologic exami- nation revealed peripheral neuopathy. A screening test for porphobilinogen was strongly positive, but tests for uroporphyrin and coproporphyrin were negative. AIP was confirmed by clinical features and increased 24 hour urine delta-aminolevulinic acid(60.2 mg/1). Also, screening test for porphobilinogen was strongly positive in her mother and her brother. Supportive treatment with high glucose solution infusion and cimetidine resulted in symptomatic recovery and she was discharged after being educated on precipitating factors. The presenting feature of acute hypertension in this case baffled several doctors and the diagnosis of AIP was long delayed. AIP should be considered as one of the differential diagnosis of acute hypertension, especially when pheochrornocytoma is suspected but cannot be demonstrated. (Korean J Gastroenterol 1997;29: 113- 117)

      • KCI등재후보

        만성 염증성 장질환 환자에서 항호중구 세포질 항체의 의의

        문윤재(Yoon Jae Moon),배희동(Hee Dong Bae),박효진(Hyo Jin Park),김원호(Won Ho Kim),정석훈(Suk Hoon Chung),김현숙(Hyun Sook Kim),전재윤(Chae Yoon Chon),박인서(In Suh Park) 대한내과학회 1997 대한내과학회지 Vol.52 No.5

        N/A Objective: Anti-neutrophil cytoplasmic antibody (ANCA), known as a useful diagnostic marker in patients with ulcerative colitis (UC), are specific for granule proteins of granulocytes and monocytes and induce distinct fluorescence patterns. To evaluate the significance of ANCA in chronic inflammatory bowel disease (IHD), the presence of ANCA in chronic IBD was studied using indirect immunofluorescent test (IIF), Methods: Between March, 1994 and September 1995, 51 patients with chronic inflammatory bowel disease were subjected in this study. We had analysed the correlation between duration, disease activity, location by colonoscopy and radiologic examinations, steroid treatment. Results: 1) Among 34 patients with ulcerative colitis (UC), ANCA was demonstrated in 23 patients (67.6%). Among 19 patients with other chronic IBD (4 Crohn's disease, 6 Behcet's colitis, 7 intestinal tuberculosis and 2 radiation colitis) 2 patients (10.5%) had ANCA. The positivity of ANCA in patients with UC was significantly higher than in patients with other chronic IBD. 2) In patients with UC, c-ANCA was positive in 2 (5.9%) patients and p-ANCA was positive in 21 (61.8%) patients. In patients with other chronic IBD, ANCA was positive in one patient with Behcet's colitis or one patient with intestinal tuberculosis but negative in all patients with Crohn's disease or radiation colitis. 3) The mean duration of disease in ANCA positive patients was 42.4±39.4 months and the mean duration of disease in ANCA negative patients was 44.9±36.8 months, but there was no significant difference. 4) The number of patients in clinically mild, moderate and severe group were 23 (37.6%), 6 (83.2%) and 5 (14.7%) respectively. Among these groups the number of ANCA positive patients were 15 (65.2%), 5 (83.2%) and 3 (60%) respectively, but there was no significant difference. 5) The number of patients with proctitis, left side colitis and pancolitis were 9 (26.5%), 14 (41.2%) and 11 (32.4%) respectively, Among these groups the number of ANCA positive patients were 4 (44.4%), 10 (71.4%) and 9 (81.8%) respectively, but there was no significant difference. 6) Among 13 patients with steroid treatment 9 patients (69.2%) were ANCA positive. Among 21 patients without steroid treatment 16 patients (76.2%) were ANCA positive, but there was no significant difference. Conclusion: Although there was no correlation between ANCA and duration, disease activity, location or steroid treatment in UC patients, ANCA could be a diagnostic marker of UC in chronic IBD patients.

      • SCOPUSKCI등재

        경련성 골반상 증후군의 임상적 연구

        박효진(Hyo Jin Park),조재식(Jae Sik Cho),배희동(Hee Dong Bae),정준표(Jun Pyo Chung),이상인(Sang In Lee),박인서(In Suh Park),지훈(Hoon Ji),손승국(Seung Kook Sohn) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3

        N/A The spastic pelvic floor syndrome is a functional disorder due to abnormal contraction in- stead of relaxation of the pelvic floor muscle during straining. This inhibits defecation and gives rise to constipation. We carried out the clinical and psychologic analysis, defecogram, electrophysiologic tests, and treatment in 17 patients with spastic pelvic floor syndrome. The mean age of patients was 48.2+10.1 years. The male to female ratio was 1:7.5. Prirnary com plaints were incomplete evacuation 82.3%, constipation 52.9%, tenesmus 41.2%, straining 41.2 %, and dysuria 29.4%. The patterns of personality using the MMPI showed somatization type in 7 cases and psychophysiologic reaction type in 4 cases. Defecogram revealed paradoxical contraction of puborectalis in 100.0% of cases,incomplete evacuation 76.5%, rectocele 58.8%, incontinence 17.6%, intussusception 5.9%, and excessive pelvic floor descent 5.9%. The ano- rectal angle in patients did not increase during straining and rernained about 90. The mean maximum resting and squeezing anal canal pressures were 94.4 + 48.4mmHg, and 136.4 + 28.8 mmHg. Seven patients(70.0%) were unable to expel a balloon. The pudendal neuropathy re- vealed in 4 patients(40.0%). Seven patients underwent a EMCr-based biofeedback therapy. Four among them(57.1%) had increased bowel frequency and improved the symptom of in- complete evacuation. In conclusion, careful history taking, physical examination and colorectal motility tests perrnit diagnosis of spastic pelvic floor syndrome. This disease is related with incoordination of pelvic floor muscle, so treatment should be aimed at restoration of normal muscle function through biofeedback.(Korean J Gastroenterol 1994; 26: 482 490)

      • 國産 제2인산 칼슘 添加가 브로일러의 生産性 및 燐의 利用率에 미치는 影響

        辛炯泰,裵熙東,鄭棋煥 성균관대학교 생명과학자원연구소 1994 生命資源科學硏究 Vol.1 No.1

        This experiment was carried out to compare biological availability of phosphorus(P) in locally produced dicalcium phosphate(DCP), tricalcium phosphate(TCP) and sodium acid phosphate (SAP) with 210 broiler-type chicks(Arbor Acres). Chicks were divided into 7 treatments consisted of DCP_1(low), DCP_2(high), TCP_1(low), TCP_2(high), SAP_1(low), SAP_2(high) and Control group for a period of 4 weeks. The results obtained are summarized as follows: 1. Liveability of Control, DCP_1, DCP_2, TCP_1, TCP_2, SAP_1 and SAP_2 were 90.0%, 96.7%, 96.7%, 93.3%, 93.3% 96.7% and 96.7%, respectively. 2. Body weight gain, feed intake and feed efficiency for 4 weeks feeding period were not significantly affected by the source of phosphorus supplements. However, it was found that chicks received DCP gained more body weight than the birds fed TCP or Control diet. 3. The relative biological availability of P in DCP, TCP and SAP fed broiler chicks were 98.1%, 94.23% and 100%, respectively. The results obtained from the present experiment indicated that the availability of P in DCP were better than that in TCP.

      • 볏짚의 가성소다 處理水準이 재래산양의 볏짚섭취량 飮水量 및 腸內 通過速度에 미치는 影響

        辛炯泰,裵熙東,孫鎭漢 成均館大學校 科學技術硏究所 1988 論文集 Vol.39 No.1

        These experiments(I, II) were conducted to determine the nutritive value of NaOH-treated rice straw by voluntary intake, water consumption, rate of passage and retention time in goat's gastrointestinal tracts. The results which were obtained with these experiments (I, II) as follows; 1. Volutary intake of 0%, 3% and 6% NaOH-treated rice straw by goats was 1,012ml, 1,427ml and 1,612 ml, respectively. 2. Water consumption of 0%, 3% and 6% NaOH-treated rice straw by goats was 1,012ml, 1,421ml and 1,612ml, respectively. 3. The first excretion time of stained rice straw particles in goat's feces was 0% NaOH, 20 hours: 3% NaOH, 18 hours and 6% NaOH, 16 hours, respectively. 4. Total mean retention time (R value) of 0%, 3% and 6% NaOH-treated rice straw by goats was 72.0 hours, 61.2 hour, and 56.8 hours, respectively. 5. The optimal level of NaOH for increasing the nutritive value of rice straw was 3% in goat's rations.

      • 蛋白質 水準 및 供給源이 泌乳初期搾乳牛의 産乳量에 미치는 影響

        辛炯泰,韓泳根,金秉泰,裵熙東,孫重天 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.2

        Eighteen Holstein cows capable of producing at least 23㎏ of milk per day were assigned randomly in equal numbers and fed one of three isocaloric total rations of 15.8 (soybean meal), 15.8 (urea), or 14.1% (urea) crude protein in dry basis. All cows were fed their assigned ration continuously for 63 days beginning on the 20 day postpartum. This experiment was designed to determine the influence of concentration and source of dietary protein on milk production(kg) and milk fat(%) during early lactation. The results which were obtained in this experiment as follows: 1. Milk yields (4.0% fat corrected milk, FCM) of cows for 42 day trial in early lactation were 23.80, 20.32, 18.44kg for the respective treatment. In this experiment the higher protein concentration (15.8% vs 14.1%) increased milk production, and source of protein influenced milk production. 2. Milk fat of 3.63, 3.52, and 3.39% showed that dietary protein concentration and source influenced milk fat in early lactating cows. 3. Income above feed cost for 42 day trial was greatest for the group fed the 15.8% crude protein from soybean meal (5,406 won/cow/day) and lowest for the group fed the 14.1% crude protein from urea (3,919.5 won/cow/day). income above feed cost for 15.8% crude protein from urea was 4,154.4 won /cow/day.

      • SCOPUSKCI등재

        뇌하수체에 전이된 십이지장 팽대부주위 선암종 1 예

        이경미,배희동,허갑범,이현철,임승길,이은직,김경래,안광진,정윤석,이관식,신은택 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1

        Pituitary metastais is a rare condition of distant metastasis of systemic cancer. Pituitary metastasis may present headache, hypopituitarism, and diabetes insipidus resulting from metastatic site. We report a 42 year-old man with pituitary metastasis from periampullary adenocarcinoma who developed diplopea follwing headache and importence. He also had widespreak lymph node metastasis. Diagnosis was made by endoscopy with biopsy, abdominal ultrasonogram, abdominal CT scan, and brain CT scan. Brain CT scan showed tumor in the pituitary gland with invasion into sphenoid bone and cavernous sinus. Light microscopic fingdings revealed moderately differentiated adenocarcinoma in periampullary mass, and metastatic adenocarcinoma in the cevical lymph node. The combined pituitary stimulation test showed decreased reserve capacity of pituitary hormones. We report a case of pituitary metastasis from periampullary adenocarcinoma with the revies of the literature.(J Kor Endocrino 8:88~93, 1993)

      • SCOPUSKCI등재

        복강내 농양에 대한 임상적 고찰

        이상인,배희동,문영명,이관식,최흥재,황의석,권선옥 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3

        We reviewed 21 surgically and 17 percutaneously drained abdominal abscesses at Yong Dong Severance Hospital, Yonsei University College of Medicine from March 1983 to January 1990. The results were as follow: 1) The most common location of abscesses was right paracolic (25.0%), followed by subhepatic (22.2%), right subphrenic (19.4%), left subphrenic (19,4%) and lesser sac space (11.1%). 2) The most common causative aerobic microorganism was E. coli, followed by Streptococcus, Enterococcus, Klebsiella and the most common anaerobic microorganism was Bacteroides fragilis, followed by Peptostreptococcus, Bifidobacterium. 3) The most common cause of pyogenic abscesses was postoperative complication (58.3%), followed by original intraperitoneal disease without operation (22.2%), trauma (5.6%). 4) Among the total 36 cases, we had 95.2% success rate with 21 cases drained surgically, 76.4% success rate with 17 cases drained percutaneously. We conclude that if percutaneous drainage is possible, percutaneous drainage under US or CT guide is an effective method for treatment of intraabdominal abscesses and avoids the risks of a major operative procedure.

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