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임신 주기에 따른 산소라디칼 생성계 및 해독계 활성도의 변화
김종호(Jong Ho Kim),심재철(Jae Chul Sim),배철성(Cheol Seong Bae),윤혜원(Hae Won Yoon),이영기(Young Gee Lee),박윤기(Yoon Ki Park),이두진(Doo Jin Lee),이승호(Sung Ho Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objective; This study was conducted to evaluate the effect of pregnancy on the activities of oxygen hee radical generating and scavenging system in the female rats. Material & Method; Rats weighing 200-220 gm were grouped to non-pregnant, 2nd trimester and 3rd trimester of pregnancy. The experiment was carried out following overnight fasting. Animals were anesthetized by administration of pentothal sodium, and blood was drawn via abdominal aorta. After exsanguination, the liver, kidney, heart, lung, with or without placenta tissues were excised immediately. The excised tissue was frozen in liquid nitrogen rapidly, and stored in liquid nitrogen for analysis. Results; The gain in body weight was higher in pregnant rats than in normal rats. Lipid peroxidation was not significantly different among all groups in the liver, kidney, heart, lung, and placenta tissue. Xanthine oxidase activity of the kidney in the 3rd trimester of pregnancy was lower than that of non-pregnant rats. Superoxide dismutase activity of the liver was significantly decreased in the 2nd and 3rd trimester of pegnancy compared with that of non-pregnant rats, and that of lung was also decreased than that of non-pregnant rats. Catalase activity of the kidney was decreased in the 2nd and 3rd trimester of pregnancy compared with that of non-pregnant rats. Glutathione content of the liver was markedly decreased in the 2nd and 3rd trimester of pregnancy compared with that of non-pregnant rats. Conclusion; In conclusion, these results suggest that oxygen free radical will not increase in the liver, kidney, heart, lung, and placenta during normal pregnancy, but in the cases of overproduction of oxygen free radical, the liver, kidney, and lung will have me chance of tissue damage because of decreased activity of some anti-oxidant enzymes and/or decreased amount of anti-oxidant materials.
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강민아,김도균,최석철,양회생,배철성,윤혜원,심재철,하달봉 동국대학교 경주대학 1997 東國論集 Vol.16 No.1
Prenatal ultarsound represents an accurate and reliable method for the detection of intrauterine anomalies, especially urinary tract anomalies. Hydronephrosis is the most common congenital condition detected by prenatal ultrasound. Prenatal ultrasonographic diagnosis allows a good condition and therapeutic assessment of the patients prior to serious impairment of renal function so that in most cases the urological surgeon can opt for a parenchymal conserving procedure. The authors have experienced a case of congenital ureteropelvic obstruction with hydronephrosis diagnosed at 32 weeks of pregnancy and report our experience with a brief review of literature.
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정상 임신에서 Doppler 초음파를 이용한 제대동맥 혈류속도 파형에 관한 연구
배철성,이두진,권기진,이승호,박윤기,조길호 영남대학교 의과대학 1991 Yeungnam University Journal of Medicine Vol.8 No.1
저자들은 1990년 5월 1일부터 1992년 4월 30일까지 영남대학교 의과대학 부속병원 산부인과에 정기검진을 위해 내원한 157명의 정상 임산부를 대상으로 제대동맥에서 시행한 도플러 초음파 160회의 검사결과를 임신 주수에 따라 분석하여 다음과 같은 결과를 얻었다. 제대동맥의 최고 수축기 혈류속도는 임신이 진행함에 따라 증가 양상을 보임으로써 임신이 증가함에 따라 제대 동맥 혈류량은 증가함을 관찰 할 수 있었다. 임신이 진행함에 따라 제대태반 순환계 말초 저항이 점차적으로 감소함으로 인해 제대동맥이완기말 혈류속도도 증가 양상을 보였다. S/D rtatio는 최고 수축기 혈류속도의 증가에도 불구하고 이완기말 혈류속도의 점차적인 증가로 인하여 임신이 진행함에 따라 오히려 감소함을 관찰할 수 있었다. 임신이 지속함에 따라 PI, RI도 감소하는 양상을 보였다. Noninvasive techniques for antenatal detection of the fetal development and well-being such as biophysici profile, non-stress and stress test remain major challenges in modern obstetric practice. To obtain and analyze umbilical artery velocity waveform by pulsed-wave doppler ultrasound. a total 160 detetminations were carried out on 157 normal pregnant women between 16th to 41st week gestation. The ratio of peak systolic to end-diastolic flow velocity(S/D ratio) . pulsatility index and resistance index were mesured as indices of the resistance in feto-placental circulation. The results were as follows : As gestation advances, the. mean values for peak systolic and end-diastolic, velocities raised progressively. As gestation advances. the mean values for the S/D ratio declined progressively, exhibiting high diastolic flow velocity caused by low resistance. Pulsatility index, and resistance index were also declined progressively, as gestation advances. The analysis of umbilical artery blood fold velocity waveforms provides a new noninvasive technique to evaluate fetal development and well-being, and may be expected a reliable method for assessment of fetal life.
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정해관,이민석,이현경,임문환,김용탁,이성우,임현술,황선보,오연희,배철성,심재철,김승현,도은형,윤혜원 東國大學校醫學硏究所 1995 東國醫學 Vol.3 No.-
동국대학교 의료원 산부인과에서는 1991년 10월 1일부터 1994년 12월 31일까지 약 39개월동안 자궁외 임신으로 진단된 79명의 환자에게 골반경 수술을 시행하였다. 골반경수술은 수술후 입원기간의 단축, 개복으로 인한 불필요한 출혈의 방지 및 수술시간의 단축, 수술후 유착감소 및 반복수술의 용이성, 미용상의 효과가 좋았다. 특히 비파열성 자궁외 임신에서 골반경을 이용한 난관개구술과 MTX 국소투여법 같은 보존적 치료는 매우 효과적이었다. 그리고 난관파열이 되어 어느정도 복강내출혈이 있는 파열성 자궁외 임신에서도 골반경수술의 장점을 살리면서 시술을 할 수 있을 것으로 생각된다. Prevalence of extrauterine pregnancy has increased. With the availability of the rapid quantitative B human chorionic gonadotropin titers and more accurate sonograms, the diagnosis of probable extrauterine pregnancy is being made earlier and often before tubal rupture. Salpingectomy at the time of laparotomy has been the standard treatment for tubal pregnancy, even when the tube was not ruptured. Recently conservative surgery via salpingotomy/salpingostomy or fimbrial expression has been advocated. The pelviscopy is an essential tool in making the diagnosis and, given certain criteria, can be useful for management as well. Pelviscopic management of extrauterine pregnancy has been described extensively in last several years. These methods have been associated with low morbidity, early recovery, and short hospital stay. Although the role of medical therapy for extrauterine pregnancy is still uncertain, medical therapy of early, unruptured extrauterine pregnancy can be safe and cost effective and even result in improved fertility, compared with the standard surgical therapy. Conservative treatment of unruptured type tubal pregnancy, which have been diagnosed early, salpingotomy and salpingostomy and MTX local injection are highly effective. We have experienced 80 cases of pelviscopic surgery in 79 patients with extrauterine pregnancy. Among the procedures, salpingectomy was peformed most frequently(78.5%). Salpingotomy was also performed(12.5%), salpingectomy was performed(1.3%), pelviscopy guided MTX local injection was performed(1.3%), and fimbrial expression was performed(1.3%). Of 79 patients, complication occurred in 7 patients. In one patient with liner salpingotomy, additional pelviscopic salpingectomy was needed for bleeding control from previous salpingotomy sites. Hospital stay was averaged 3.8 days. Pelviscopic treatment of extrauterine pregnancy was simple and effective with fast recovery even in patients with pelvic adhesions due to prior operations, ruptured extrauterine pregnancies with moderate intraperitoneal free blood.
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