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      • KCI등재후보

        일산화탄소 중독의 역학적 특징: 전국 20개 병원 응급실 손상환자 표본 심층조사

        배소현 ( Sohyun Bae ),이지숙 ( Jisook Lee ),김경환 ( Kyunghwan Kim ),박준석 ( Junseok Park ),신동운 ( Dongwun Shin ),김현종 ( Hyunjong Kim ),박준민 ( Joonmin Park ),김훈 ( Hoon Kim ),전우찬 ( Woochan Jeon ) 대한임상독성학회 2016 대한임상독성학회지 Vol.14 No.2

        Purpose: This study was conducted to describe the characteristics of patients with carbon monoxide (CO) poisoning. Methods: We retrospectively surveyed data from the Emergency Department based Injury In-depth Surveillance of 20 hospitals (2011-2014). We included patients whose mechanism of injury was acute CO poisoning caused by inhalation of gases from charcoal or briquettes. We surveyed the annual frequency, gender, age, result of emergency treatment, rate of intensive care unit (ICU) admission, result of admission, association with alcohol, and place of accident. We also surveyed the cause and experience of past suicide attempts by intentional poisoning. Results: A total of 3,405 patients were included (2,015 (59.2%) and 1,390 (40.8%) males and females, respectively) with a mean age of 39.83±18.51 year old. The results revealed that the annual frequency of CO poisoning had increased and the frequency of unintentional CO poisoning was higher than that of intentional CO poisoning in January, February and December. The mean age of intentional CO poisoning was younger than that of unintentional CO poisoning (38.41±13.03 vs 40.95±21.83) (p<0.001). The rates of discharge against medical advice (DAMA), ICU care and alcohol association for intentional CO poisoning were higher than for unintentional CO poisoning (36.4% vs 14.0%, 17.8% vs 4.7%, 45.2% vs 5.6%) (p<0.001). The most common place of CO poisoning was in one`s residence. Conclusion: The annual frequency of total CO poisoning has increased, and unintentional CO poisoning showed seasonal variation. DAMA, ICU care, and alcohol association of intentional CO poisoning were higher than those of unintentional CO poisoning.

      • KCI등재
      • KCI등재

        그룹 운동을 통해 본 년대 1960-1970 프랑스 미술의 정치성

        배소현(Bae Sohyun) 서양미술사학회 2010 서양미술사학회논문집 Vol.33 No.-

        In the 1960s and 1970s, French art gave birth to artist groups with diverse dispositions from extreme conceptual art to politically participating art that aligned its actions with political organizations. This study focuses on artist groups that expressed strong political viewpoints by voicing direct opinions on political phenomena and events, including those involved in the Nouvelle Figuration movement, the affichistes of Nouveau Realisme , the Atelier Populaire, and Grapus. Although these groups all emerged during the 1960s and 1970s under similar political circumstances, they produced distinct and independent art works that can be formatively distinguished. It is worth noting that while the artist groups pursued an identical goal of making political points through figurative illustration, they displayed unique formative characteristics and participated in a wide range of social activities while not being absorbed into or offset by each other. However, most studies on the Nouvelle Figuration movement and the affichistes of Nouveau R alisme e have focused their discussions on the formative and aesthetic aspects. Furthermore, despite the fact that multiple attributes of poster works done since the 18<SUP>th</SUP>century have been frequently studied in art history, the political posters of Atelier Populaire and Grapus groups have been examined only from their sociological perspective while their formative significances and implications in art history have been largely overlooked. The objective of this study is to escape from the restrictive approach taken by previous studies and examine the artist groups with a comprehensive viewpoint that encompasses the duality of formativeness and social participation for a multidimensional discussion. From the formative perspective, the political artist groups of the 1960s and 1970s maintained the concept of embodiment that had been constantly used by the artists engaged in social participation since the 19<SUP>th</SUP>century realism. However, the French political artist groups implemented variation on top of figurative illustration to produce their unique individual embodiment, making political statements. From the social participation point of view, the groups went beyond the realm of art and became directly involved in politics. In turn, they made diverse attempts with their strategic approaches to express political concerns in a more effective manner. In other words, the political art groups that formed in France in the 1960s and 1970s can be regarded as an achievement of French participatory art stemming from three elements that became tightly intertwined - the concept of embodiment that provided the basis for socially participatory art amidst the political circumstances of the era, the unique formative properties of each group, and the strategic means of exposure executed through artist group movements.

      • KCI등재

        비만의 사회윤리와 비만윤리 교육 방안에 대한 연구

        배소현 ( Bae Sohyun ) 한국초등도덕교육학회 2021 초등도덕교육 Vol.- No.72

        본 연구는 비만에 대한 사회적 책임과 비만의 사회윤리에 대하여 살펴보고, 도덕과의 비만윤리 교육 방안을 제안한다. 비만에 대한 사회적 책임에는 비만함에 대한 책임과 비윤리적인 비만 인식에 대한 책임이 있다. 이를 바탕으로 비만의 사회윤리가 등장한다. 비만의 사회윤리는 개인에게의 책임 전가 방지, 기본권 보장, 공익 향상이라는 세가지 관점에서 정당성과 필요성을 갖는다. 갈래와 구체적인 내용으로는 ‘비만함에 대한 윤리’ 갈래에서 좋은 음식 및 운동·여가에의 접근성 향상과 비만 예방 교육을, ‘비만 인식에 대한 윤리’ 갈래에서 미디어 정화, 비만윤리 교육, 미디어 리터러시 교육을 생각할 수 있다. 비만에 대한 사회적 책임 이행으로서, 도덕과에서 비만윤리 교육을 해야 한다. 그 방안으로 ‘우리가 만드는 도덕 수업’ 단원을 비만윤리를 주제로 하는 주제 중심 실천 단원으로 구성하는 것을 제안한다. This study examines social responsibility for obesity, considers social ethics of obesity, and proposes a moral education method of obesity ethics. As social responsibility for obesity, there is responsibility for the causes of obesity and for the unethical perception of obesity. Based on this, social ethics of obesity appears. Its justification and necessity is demonstrated in three ways: preventing the transfer of responsibility to individuals, ensuring basic rights, and improving the public interest. In terms of its section and specific contents, one can think of ‘ethics of being obese’ and ‘ethics of perception of obesity’ as its section. As contents, improved access to good food, exercise and leisure, and obesity prevention education belongs to the first section, and media purification, obesity ethics, and media literacy education belongs to the other. Based on these discussions, it is necessary to provide education on obesity ethics as moral education. As an education method, it is proposed to organize "Moral Class We Make(우리가 만드는 도덕 수업)" unit as a central practice unit on the theme of obesity ethics.

      • BNL·CL2 세포에서 간절제 후 혈청에 의한 유도성 Nitric Oxide Synthase 유전자의 전사 활성화에 관한 연구

        허강민,김안나,배소현,박지선,홍장희,이재흔,석정호 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

        An activation of transcription factors involved in the transactivation of inducible nitric oxide synthase (iNOS) gene occurred after partial hepatectomy (PH), resulting in the transient expression of iNOS. The effect of serum after PH on iNOS gene expression has been investigated with RT-PCR, elctrophoretic mobility shift assay (EMSA) and chloramphenicol acetyltransferase (CAT) assay. Stimulation of iNOS mRNA expression reached a maximum with serum from 3 h and 5 h of PH. This stimulation was preceded by an early and transient activation of NF-κB complex composed of p50/p65 heterodimer, which was rapidly activated with serum from 1 h and 3 h of PH, and tend to decline with serum after 5 h of PH. The stimulatory effects of serum after PH were does-dependently inhibited by treatment of PDTC. Transfection of BNL-CL2 cells with iNOS promoter linked to a CAT reporter gene was followed by stimulation with serum after PH. Site-specific mutation of three conserved nucleotide within the upstream NF-κB site showed no difference in CAT activity by serum after PH compared with that of cells transfected with wild type iNOS promoter. In contrast, site-specific mutation of the downstream NF-κB caused remarkable reduction in the reporter gene expression by serum after PH. These results suggest that serum after PH regulates the iNOS gene transcription via NF-κB complex (p50/p65 heterodimer) activation, and downstream NF-κB site is the essential component in transcription of iNOS gene during hepatic regeneration.

      • 백서 재생간에서의 NF-kB의 활성화에 따른 유도성 Nitric Oxide Synthase 유전자의 전사에 관한 연구

        허강민,김준영,유영수,배소현,홍장희,이재흔,석정호 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

        A concerted activation of transcription factors and inducible nitric oxide synthase (iNOS) gene expression by the transcription factors were observed after partial hepatectomy (PH) of rats. To define the molecular mechanism of transcriptional control of iNOS gene during the hepatic regeneration, expression of iNOS, interleukin-6 (IL-6) and tumor necrosis-alpha (TNF-α) mRNA and the binding pattern of nuclear transcriptional factor (NF-κB and STAT-3) in the iNOS gene promoter region have been investigated. The expression of iNOS mRNA was initiated at 1 h post-PH and reached a maximum at 3 h and 5 h post-PH. This induction was preceded by an early and transient activation of NF- KB complex composed of p50/p65 heterodimer, which was rapidly activated within 30 min post-PH and remained elevated for up to 1 h post-PH, and tend to decline after 3 h post-PH. Administration of N-acetylcysteine (NAC) significantly inhibited the expression of iNOS mRNA. Expression of IL-6 and TNF-α, activators of iNOS and STAT-3, were also increased after PH, but the activation of STAT-3 binding during hepatic regeneration was found at 3 h or 5 h post-PH, which shows a different time kinetic pattern of transcriptional factor activation of iNOS gene between NF-κB and STAT-3. These results suggest that there is an important role of the NF-κB complex (p50/p65 heterodimer) activation in the transcriptional control of iNOS gene during hepatic regeneration.

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