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고콜레스테롤혈증 토끼에서 녹차추출물의 동맥경화 치료효과
채희열(Hee-Youl Chai),권운(Woon Kwon),김태명(Tae Myoung Kim),김한얼(Haneul Kim),이남진(Nam Jin Lee),신지순(Ji-Soon Sin),이덕근(Deok Keun Lee),박종범(Jong Bum Park),박승경(Sung-Kyeong Park),황석연(Seock-Yeon Hwang),김윤배(Yun-Bae Kim 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Cholesterol-lowering and antiatherosclerotic effects of green tea extract were evaluated in hypercholesterolemic rabbits produced by feeding on high-cholesterol diet. Male New Zealand White rabbits were fed on only hypercholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then green tea extract (1%) or lovastatin (0.002 %) were added to the diet for additional 8 weeks. Blood cholesterol level was greatly increased by 2-week feeding on the hypercholesterol diet to 25 fold (mean 1,057.8 ㎎/㎗) of control level (42.5 ㎎/㎗), and maintained high for additional 8 weeks, in spite of slight reduction to 92.2 % of initial hypercholesterolemia. Such a hypercholesterolemia was significantly reduced by 8-week feeding on green tea extract and lovastatin to 62.6% and 67.4% of initial levels, respectively. Low-density lipoproteins were also markedly enhanced by hypercholesterol diet for 2 weeks to 34 fold (mean 533.3 ㎎/㎗) of control (15.8 ㎎/㎗), and increased further by 181.9 ㎎/㎗ during 8-week feeding on the diet. Compared to no effect of green tea extract (181.3 ㎎/㎗), lovastatin (63.0 ㎎/㎗) significantly attenuated the increase in the level of low-density lipoproteins during 8 weeks. On the other hand, triglycerides were not affected by hypercholesterol diet, and the level of high-density lipoproteins, which had been increased (3.6 fold of control) by hypercholesterol diet, were not considerably affected by green tea extract or lovastatin. Interestingly, thick atheromatous plaques on the wall of aorta of rabbits fed on hypercholesterol diet were markedly attenuated by green tea extract or lovastatin, leading to the decreases in athrosclerosis indices to 1.75 and 1.25, respectively, from 2.25 of rabbits fed on hypercholestrol diet alone. In addition, green tea extract lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. Taken together, it is suggested that green tea extract exert antiatherosclerotic effect by reducing blood cholesterol level.
방사성(放射性) 원소(元素)의 이동현상(移動現象)에 관(關)한 실험적(實驗的) 연구(硏究) : 방사성(放射性) 폐기물(廢棄物) 처리(處理)를 위한 기초연구(基礎硏究)
김옥배,박희열,Kim, Oak Bae,Park, Hee Youl 대한자원환경지질학회 1989 자원환경지질 Vol.22 No.3
For the study of attenuation phenomena of the radioactive elements in solution, the adsorption experiment of thorium, uranium, barium and strontium on kaolinite, gibbsite, quartz, granite and shale as a function of time, pH and the surface area was conducted under the competition condition each other. There are two steps of adsorption kinetics. The first step is faster and completes in hours or a day, and the second step is slower eqiulibrium reaction. The adsorption rate which is considered to be related to CEC differs with adsorbent and decreases in the order of shale, kaolinite, granite, gibbsite and quartz. On the other hand, the adsorption rate for the same adsorbent differs with elements in the order of thorium,uranium, barium and strontium in decreasing rate. It is also affected by pH of the solution and the surface area of adsorbent. In conclusion, we didn't find any different between noncompetition condition and competition condition, and this means that we only have to consider the pH of ground water, the characteristics of the geological materials and the kinds of radioactive element in the case of selection of the places for the radioactive waste disposal.
나춘기,이무성,이인성,박희열,김옥배,Na, Choon-Ki,Lee, Mu-Seong,Lee, In-Sung,Park, Hee-Youl,Kim, Oak-Bae 대한자원환경지질학회 1997 자원환경지질 Vol.30 No.1
The purpose of this study is to examine the feasibility of using stable isotopes as a hydrologic tracer, and to elucidate the groundwater circulation system and the source of S component dissolved in thermal water of the Chonju Jukrim thermal spring district based on the O, H and S isotopic variabilities of environmental materials including bedrock, rainwater, surface water, shallow subsurface water and thermal spring water. The ${\delta}^{18}O$ and ${\delta}D$ of subsurface waters and surface water show highly restricted range and plotted on the same meteoric water line as a ${\delta}D=8{\delta}^{18}O+19$ line, and derivate from the mean annual isotopic composition of the rain water but are analogous to those of rain waters precipitated during winter season, indicating that ground waters are originated from the meteoric water and are strongly affected by the seasonal variation of air mass. Thermal spring waters are more depleted in ${\delta}^{18}O$ and ${\delta}D$ than those of shallow ground water and surface water. It can be explained by the difference of recharge area. The hydrochemical properties of subsurface waters and surface water devide into two groups: $Ca(HCO_3)_2$ type including shallow subsurface water and surface water, and $Na(HCO_3)$ type of thermal spring waters. The ${\delta}^{34}S$ values of thermal spring water show very high positive and quitely distinct from those of shallow subsurface water and surface water that are similar to those of bed rocks, indicating that sulfate dissolved in thermal spring water has not only a terrigenic origin, but also originates partially from the foreign source containing very heavy ${\delta}^{34}S$ component such as an ancient sea water. However, the presence of $H_2S$ can not be ignore the affact of the isotopic fractionation to explaine the heavy ${\delta}^{34}S$ of thermal spring water. Overall, the Oxygen and Hydrogen stable isotopes can identify the source and the circulation system of the natural waters and the S-isotopes can provide a crucial clue on tracing the dissolved material transports in the circulation system of the natural water.
李基完,朴喜烈 東新大學校 1997 論文集 Vol.9 No.-
Recently, the importance of groundwater is higher as the use of groundwater for drinking, agriculture and industry sisnificantly increases. However, groundwater has been contaminated by industrial waste, domestic sewage, landfill leachate and seawater intrusion. Therefore, it is necessary to understand the chemical characteristics and water-rock interaction of groundwater for the preservation of groundwater resources. The purpose of this study is to find out the magnitude of groundwater contamination, and its water-rock interaction characteristics in granitic regions. The Cretaceous Palgongsan granitic regions are selected as the study area. The results are as follows : Groundwater is contamimated by NO_3^- in a Part (CP-3, CP-4, CP-5) of study region. K^+/Na^+ in groundwater of study legion is equivalent to 1/10 for K_2O/Na_2O of rock. Groundwater's evolution is being progressed to noncarbonate hardness tupe of Ca^2+ -HCO_3^-, continuously noncabonate alkali type of Ca^2+, Cl^-, SO_4^2-. Saturation index of aluminosilicate minerals for groundwater is dominated kaolinite. This indicates the initial evolution process of groundwater.