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갑상선의 세침흡인 세포학적 오진에 대한 세포병리학적 분석
박찬필,금주섭,이원미,박문향,이중달,Park, Chan-Pil,Keum, Joo-Seob,Lee, Won-Mi,Park, Moon-Hyang,Lee, Jung-Dal 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
Fine needle aspiration cytology(FNAC) has been used effectively as the initial modality in evaluating various thyroid lesions. We correlated cytologic and histopathologic features to investigate the diagnostic pitfalls of FNAC of the thyroid. A total of 1,593 FNACs of the thyroid were diagnosed at the Department of Pathology, Hanyang University Hospital, from January 1993 to December 1997 There were 963 cytologically benign cases(60.5%), 97 suspicious cases(6.1%), and 75 malignant cases(4.71%). The remaining 458 cases(28.8%) were unsatisfactory. Subsequent surgical resection was done in 192 cases. Seventy-two cases(37.5%) were cytologically diagnosed as benign, 45 cases(23.4%) suspicious, 56 cases(29.2%) malignant, and 19 cases(9.9%) unsatisfactory. Histopathologically, 101 cases were benign(11 thyroidites, 52 adenomatous hyperplasias, 34 follicular adenomas, and four Hurthle cell adenomas), and 91 cases malignant(72 papillary carcinomas, 16 follicular carcinomas, one medullary carcinoma, one anaplastic carcinoma, and one granular cell tumor). After excluding 19 unsatisfactory cases, 63 were misdiagnosed. They included 17 benign(three thyroidites and 14 adenomatous hyperplasias), 27 suspicious(10 follicular adenomas, four Hurthle cell adenomas, and seven follicular carcinomas), and 19 malignant(16 papillary carcinoma, one medullary carcinoma, one anaplastic carcinoma. and one granular cell tumor) lesions. The accuracy rates in the benign, suspicious, and malignant categories were 54.9%, 49.8%, & 92.8%, respectively. The cytological pitfalls were as follows: (1) background, (2) crowded follicular cell clusters indistinguishable between follicular neoplasia and adenomatous hyperplasia, (3) papillary structure, irregular nuclear membrane and pleomorphism mimicking those of papillary carcinoma, (4) indistinct eosinophilia in follicular epithelial cells, (5) unusual cellular components not commonly seen in FNACS of the thyroid.
측정방식에 따른 목조 및 RC조의 지역별 주택 온열 환경 비교 연구
박찬필 ( Chan Pil Park ),강연심 ( Yeon Sim Kang ),전진숙 ( Jin Suk Jun ),임만택 ( Mann Taek Lim ),김수인 ( Soo In Kim ) 조선대학교 공학기술연구원 2008 공학기술논문지 Vol.1 No.2
This study is concerned with the influence of house-warming (thermal) environment of region built of wood and RC on private residential housing in Okinawa, Japan. Here, wooden tile houses, which have been affected by China, are conglomerated. However, housings built of RC are provided due to the problems of wooden housing. Nonetheless, given the latest house-warming (thermal) environment, a new problem has emerged in both housing structure and living. In order to discover any differences between indoor and outdoor housing-warming (thermal) environments during the summer and the winter in housing with a slanted roof and a plain roof, built of wood and RC in this condition, the study used a vertical thermometer and a globe thermometer and conducted a comparative analysis of the housing-warming (thermal) conditions in paces according to the structure of each building as well as examining indoor temperatures both vertically and horizontally. As a result, it was found that housing with a plain roof built of wood was more beneficial than housing with a slanted tile roof, which furnished a clue for solving the problem of housing-warming (thermal) environment in residential housing.
이중달,박찬필,이상국,Lee, Jung-Dal,Park, Chan-Pil,Lee, Sang-Kook 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.1
A case of invasive cribriform carcinoma of the breast is presented with fine needle aspiration cytologic features. The aspiration was performed from a papable 2.0 cm mass in the upper outer quadrant of the right breast in a 53 year-old woman. The aspirate showed cellular smear composed of larger three dimensional tight clusters, smaller monolayered loose clusters, and many individual cells on the clean background. In the clusters, the tumor cells were bordering central lumina, quite similar to the cribriform in histology. The tumor cells in the clusters and individual tumor cells had uniform, small and round nuclei. The chromatin was finely granular, and nuclear membrane was smooth No discernible nucleoli were present (nuclear grade $1\sim2$). Unless the abundance of individual cells and the cribriform growth pattern are recognized in the smear, the cytologic diagnosis of invasive cribriform carcinoma is difficult.
고영혜,박찬필,이중달,Ko, Young-Hyeh,Park, Chan-Pil,Lee, Jung-Dal 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.1
Cytologic findings from five cases with variable types of Hodgkln's disease were reviewed with special emphasis on the Reed-Sternberg (R-S) cells and their variants. Typical R-S and Hodgkin's cells were mono- or binucleated, and nuclei had rounded smooth contour, Acidophilic prominent nucleoli with perinucleolar halo were conspicuous in comparison to typical Reed-Sternberg cells, L & H (lymphocytic and histiocytic) cells in the lymphocyte predominant type tended to show pop-corn like irregular nuclear contour and to lack the prominent nucleoli. Lacunar cells in the nodular sclerosis type had multilobated nuclei with prominent acidophilic nucleoli. There was no prominent perinucleolar halo in L & H and lacunar cells. In conjuction with the number of Reed-Sternberg cells and back ground findings observed on the smears, the characteristic features of R-S cells and their variants allowed to make typing of Hodgkin's disease.
만성 염증성 탈수초 다발성 신경근병증이 동반된 낭창성 신염
이규백(Kyu Beck Lee),김향(Hyang Kim),이상종(Sang Jong Lee),박찬필(Chan Pil Park),박문향(Moon Hyang Park),박범준(Bum Joon Park),김현승(Hyun Seung Kim),이한보(Han Bo Lee),이준(Jun Lee),오재인(Jae In Oh) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
Systemic lupus erythematosus(SLE) is a multisys-temic disease. Peripheral neuropathy occurs in about 10% of patients with SLE. Chronic inflammatory demyelinating polyneurpathy has been reported rarely in SLE. We experienced a case of chronic inflammatory polyneuropathy in lupus nephritis. 32-year-old housewife presented to chronic progressive muscle weakness and heavy proteinuria. Kidney biopsy showed compatible with lupus nephritis (WHO Class V, membranous nephropathy). Nerve conduction studies showed reduction in conduction velocity and sural nerve biopsy revealed demyeli-nating polyneuropathy. Steroid therapy led to improvement in clinical symptoms and proteinuria.