낭종성 부갑상선 선종에 의한 부갑상선 기능 항진증 1예

금주섭,이상종,최권,권순호,서원태,김명숙,성기철 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.1

Cystic parathyroid adenoma is one of the rare causes of hyperparathyroidism, and is usually located in neck and mediastinum. This type of adenoma tends to cause increased serum level of parathyroid hormone and alkaline phosphatase, similar serum calcium level when compared to those of solid adenoma. Thanks to current radioimmunoassay and easy accessibility to serum autoanalyzer, serum calcium level and parathyroid hormone level are more easily measured, which in turn lead to more easier diagnosis of hyperparathyroidism. Also improvement in imaging and nuclear diagnostic method of parathyroid lesion are suggested to enable easy diagnosis of cystic parathyroid adenoma. A 35-year-old male presented with easy fatigability for 12 months. The serum calcium, phosphate, alkaline phosphotase were 11.5mg/dL, 1.4mg/dL, 194IU/L respectively and his parathyroid hormone level in serum was 126.42pg/mL. Neck CT showed enlargement of right lobe of thyroid gland with well defined inhomogenously enhanced density inside the right thyroid gland. The patient was diagnosed of hyperparathyroidim due to parathyroid adenoma and was surgically removed. The surgical biopsy showed cystic parathyroid adenoma. After operation his general condition was improved and serum calcium, phosphate, parathyroid hormone level were normalizd. We report a case of hyperparathyroidism caused by cystic parathyroid adenoma with brief review of literature. (J Kor Soc Endocrinol 12:75-80, 1997)

주변부로부터의 선교

금주섭 대한기독교서회 2023 基督敎 思想 Vol.770 No.-

Fullness of Life : Search for a New Vision of Ecumenical Mission Thinking and Practice in the 21 st Century

금주섭 장로회신학대학교 2009 국제학술대회 Vol.9 No.-

흉막의 고립성 섬유성 종양의 세침 흡인 세포학적 검색

금주섭,이중달,Keum, Joo-Seob,Lee, Jung-Dal 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2

Localized or solitary fibrous tumor (SFT) of the pleura has been classified as a type of mesothelioma, arising from the submesothelial connective tissue cells. The preoperative diagnosis of the tumor at the cytologic or histologic level is very important for the proper handling of the lesion. This preoperative diagnosis is now possible by means of the advance in the transthoracic fine needle aspiration biopsy (FNA) techniques and in the very experience of the cytopathologists. We describe FNA cytologic feature of two cases of SFT arising from the pleura. Cytologic, histologic, immunohistochemical, and electron microscopic characteristics of pleural SFT are discussed. The tumor cells of SFT are spindle or oval in shape with a variable amount of cytoplasm. They are arranged in irregular trabeculae intimately associated with capillaries. A unique cytologic feature observed in this tumor is that thick, eosinophilic, amorphous collagen bundles are scattered between tumor cells.

특집 WCC와 교회교육 : WCC 부산총회와 에큐메니칼 운동

금주섭 장로회신학대학교 기독교교육연구원 2013 교육교회 Vol.427 No.-

[나의 목회 수기] WCC와 함께, 세계교회와 함께

금주섭 대한기독교서회 2018 基督敎 思想 Vol.716 No.-

생명의 충만 : 21세기 에큐메니칼 선교 이해와 실천의 새로운 비전

금주섭 장로회신학대학교 2009 국제학술대회 Vol.9 No.-

실험적 간암 및 전암병변에서 H-ras, bcl-2 및 p53 종양유전자의 발현에 관한 연구

이중달,김우경,공구,금주섭 한양대학교 의과대학 1996 한양의대 학술지 Vol.16 No.2

Various changes in percancerous lesions during the hepatocarcinogenesis of rats fed with 2-acetylaminofluorene have been reported. They include oval cells, altered cell lesions, regenerating nodules and adenomatoous nodules. Recently, studies have been conducted in animals to clarify the role of oncogenes in the precancerous and cancerous lesions during hepatocarcinogenesis. In this study, the authors has evoked hepatocellular cercinoma in Sprague-Dawley rats and performed immunohistochemical stains on various precancerous and hepatocellular carcinoma lesions for H-ras, Bcl-2, and p53 oncogenic proteins. The followings were results: 1. No immunoreaction for three oncoproteins tested was detected in the normal control, perilesional hepatocytes, or oval cells. 2. The positive rates of immunoreactivity in altered cell lesions, regenerating nodules, adenomatous nodules, and hepatocellular carcinomas were 26.7%, 45.8%, 60%, 50% for H-ras, adn 26.7%, 41.7%, 60%, 50% for Bcl-2, respectively. 3. No expression for p53 was noted in all precancerous lesions and hepatocellular carcinoma lesions studied. In conclusion, the p53 tumor suppressor gene appears not involved in the 2-AAF-induced hepatocarcinogenesis. H-ras and bcl-2 oncogene are involoved in the early precancerous lesions, and the oncogenes may play an important role to promote cell proliferation and maintain the number of mutant clones through blocking apoptosis.

2-Acetylaminofluorene으로 유발된 실험적 간암의 세포 동태학적 연구

금주섭,고영혜,이중달 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

Kinetics of hepatocytes in various precancerous and cancer iesions during hepatocarcinorenesis was evaluated in 38 Sprague-Dawley rats fed with 0.075% 2-acetylaminofluorene diet. The rats were sacrificed after 4, 7, 10 days. 2, 3, 4, 6, 8 weeks, and 3, 4, 5, 6, 7, 8 months of the experiment. The lesions were divided as altered cell lesions (clear cell focus, acidophilic cell focus, and basophilic cell focus). regenerating nodules. neoplastic nodules, and hepatocellular carcinomas. Cell kinetics was studied by intraperitoneal bromodexyuridine(BrdU) injection 2 hours before sacrifice. After detection of the BrdU-incorporated nuclei with monoclonal antibody kit, the BrdU labelling index(BLI) was measured as percentage of BrdU labelled cells among about 1000 cells. The liver cells in the altered cell lesions showed significantly increased BLI(clear cell 1.66: acidophilic 2.39: basophilic 2.41) in comparion with normal control(0. 18) or non-lesional hepatocytic lobules (0. 47), and lower BLI than hepatocellular carcinoma(8.61∼27.07) (P<0.05). Regenerating and neoplastic nodules did not differ in their BLI (1.54 and 1.70), and were significantly lower in their proliferating kinetics than acidophilic or basophilic cell foci (P<0.05). It was suggested from this study that the altered cell lesion should be true premalignant lesion, which was composed of at least initiated cells by the chemical carcinogen. The basophilic and acidophilic foci in altered cell lesions were suggestive of close correlation with the hepatocellular carcinoma in that they had greatest proliferative cell kinetics of all the lesions occurred before cancer developed.

제 II형 교원질 유발성 관절염의 염증성 변화에 관한 실험적 연구

김경목,금주섭,이중달 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2

Homologous or heterologous native type Ⅱ collagen can induce peripheral diarthrodial polyarthritis by intradermal immunization in experimental animals including rats, mice and other strains of rodents. Type Ⅱ collagen induced-arthritis (Co Ⅱ arthritis) is histologically similar to the chronic proliferative synovitis characteristic of rheumatoid arthritis(RA) in human. However, important differences between RA and Co Ⅱ arthritis are noted in terms of clinical course and pathogenesis, and immunohistochemical characteristics of inflammatory cells of Co Ⅱ arthritis have been not well evaluated. In the present study, CoⅡ arthritis was induced in Spraque-Dawley rats by intradermal immunization of native heterologous type Ⅱ collagen emulsified in incomplete Freund's adjuvant. Histologic changes were chronologically studied, and immunohistochemical characteristics of inflammatory infiltrates were compared with those of human RA biopsy specimen. 1. Co Ⅱ arthritis occurred in seven of 22 rats immunized (31.8%) and developed one week after immunization. Maximum severity on the external examination was characterized by edema, redness and immobilization of the hindpaws. The CoⅡ arthritis persisted throughout the course of two months. 2. In the early phase (one to two weeks after immunization), edema and hyperemia of the synovium and neutrophilic infiltrates characteristic of acute exudative inflammation were conspicuous. 3. In the mid-phase(three to four weeks) new formation of capillaries, proliferation of endothelium and lymphocyte aggregates in the synovium resulted in proliferative inflammation. 4. In the late phase of the experiment(five weeks to two months after immunization), fibroblastic proliferation and ankylosis of joint spaces were noted. At this stage, periosteitis and rheumatoid nodules in pannus of the synovium were present. 5. In comparison with RA, exudative inflammation in the early phase and periosteitis in the late phase were more conspicuous in Co Ⅱ arthritis than in RA, whereas villous hypertrophy of the synovium was more pronounced in human RA. In conclusion, Co Ⅱ arthritis have relevance to human RA, because both Co Ⅱ arthritis and RA have more histologic similarities than discrepancies. The Co Ⅱ arthritis may be used as an animal model of rheumatoid arthritis of human.