가토안에서 전방내 트리암시놀론 주입술이 각막에 미치는 영향

박주연,김훈동,최경식.Joo Youn Park. M.D.. Hoon Dong Kim. M.D.. Kyung Seek Choi. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.4

Purpose: To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas. Methods: Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining. Results: No statistically significant differences were found among control, 0.5, and 1 mg triamcinoloneinjected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05). Conclusions: The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.

설사 자돈으로부터 분리한 Escherichia coli의 특성에 관한 연구 ; 항균제 감수성, 장독소 및 섬모의 유전형의 분포 및 plasmid profiles

박주연,신나리,박용호,유한상,Park, Joo-youn,Shin, Na-ri,Park, Yong-ho,Yoo, Han-sang 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.2

The antimicrobial susceptibility, genotypes of enterotoxins(LT, STa) and pili(K88, 987P), and plasmid profiles were investigated with 102 Escherichia coli isolated from piglets showing diarrhea in Korea. Almost of them were susceptible to ceftiofur(99%), cefquinone(97.1%). However they showed resistance to bacitracin(100%), streptomycin(98%), vancomycin(97%), trimethoprim/sulfamethoxazole(87.2%), tetracycline(84.3%) in antimicrobial susceptibility test. Moreover, all of the isolates demonstrated resistance to more than 2, and 78% of them were resistant to more than 8 of total 17 drugs. Multiplex PCRs for genotyping of enterotoxins(LT, STa) and pili(K88, 987P) were established with primers designed based on sequences from Genebank. Seventeen strains(16.6%) of the isolates had STa gene, 11 strains(10.8%) of them had both STa and LT genes, and 18 strains(17.8%) had K88 gene. But none of the isolates harbored a gene exclusively encoding LT. The gene encoding 987P pili was not found in all isolates. Fifty-four strains of 102 isolates(52.9%) had plasmid with various sizes ranging from 125kb to 1.1kb. Numbers of plasmid per isolates were also various, from 1 to 9. Distinctive relationship between plasmid profiles and genotypes of enterotoxins and pili in the isolates was not found. These results might provide the basic knowledge to establish strategies for the treatment and prevention of colibacillosis in piglets.

약시에서 10 프리즘디옵터 주시 검사

박주연,박성희,Joo Youn Park,MD,Song Hee Park,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To evaluate the clinical usefulness of the 10-prism-diopter (PD) fixation test in the diagnosis of amblyopia. Methods: The study comprised 132 children (42 normal, 90 amblyopes) who underwent the 10-PD fixation test and stereoacuity test. The sensitivity, specificity, false-positive and false-negative rates of the 10-PD fixation test were analyzed according to the clinical diagnosis. Results: The 10-PD fixation test sensitivity was 86%, the specificity was 61%, the false-positive rate was 17% and the false-negative rate was 24%. Data showed agreement between the 10-PD fixation test and the stereoacuity test (γ=0.737, p=0.000). The results in the 10-PD base-down test and base-out test also showed agreement (γ=0.779, p=0.000). Conclusions: The 10-PD fixation test is a simple and useful method in detecting amblyopia.

황반부종의 유리체강내 트리암시놀론 주사 후 빛간섭단층촬영에서 나타난 국소 악화

박주연,성미선,이성진,Joo Youn Park,M,D,Mi Sun Sung,M,D,Sung Jin Lee,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: To evaluate the relationship between focal aggravation of the macular edema on retinal thickness change analysis (RTCA) of optical coherence tomography (OCT) and fluorescein angiographic findings in patients after an intravitreal triamcinolone injection (IVTA). Methods: From May 2004 to April 2005, RTCA in a fast macular thickness map (FMTM) of OCT was performed before and 4 weeks after IVTA in patients who had macular edemas caused by diabetic retinopathy and retinal vein occlusion. Patients underwent IVTA, and focal aggravation of the edema was detected. After overlapping the OCT findings onto angiographic pictures, the relationship between the focal aggravation on OCT and the leaking point on angiography was investigated. Result: In the patient group, focal aggravation was found in 5 of 27 eyes (18.5%); in the control group, only 2 of 30 eyes (6.7%) showed focal aggravation. As compared with angiographic pictures, 4 eyes with focal aggravation showed no relation to the leakage on angiography. Conclusions: Focal aggravation of macular edemas after IVTA on RTCA are not related to the leakage on angiography and could be an error from several artifacts. J Korean Ophthalmol Soc 49(5):753-762, 2008

미진동 발파공법 적용사례에 관한 연구

박주연 ( Joo Youn Park ),이천식 ( Choun Sik Lee ),윤성현 ( Seong Hyun Youn ),안명석 ( Myung Seog Ahn ),류창하 ( Chang Ha Ryu ) 대한화약발파공학회 2002 화약발파 Vol.20 No.3

2D기반과 3D 환경의 인상 형성 요소 비교

박주연(Park Joo-Youn),이미선(Lee Mi-Sun),한미지(Han Mi-Gi),박수이(Park Su-e) 한국디자인학회 2009 한국디자인학회 학술발표대회 논문집 Vol.2009 No.5

골다공증성 골절 예방에 대한 지불의사금액 추정

박주연 ( Joo Yeon Park ),안정훈 ( Jeong Hoon Ahn ),서혜선 ( Hae Sun Suh ),박선영 ( Sun Young Park ),현민경 ( Min Kyung Hyun ),성윤경 ( Yoon Kyoung Sung ),이의경 ( Eui Kyung Lee ),김윤희 ( Youn Hee Kim ) 한국보건경제정책학회(구 한국보건경제학회) 2011 보건경제와 정책연구 Vol.17 No.3

본 연구는 적절한 급여기준 설정과 관련한 의사 결정에 근거를 제공하기 위해 일반인을 대상으로 골다공증 골절 위험 감소에 대한 편익의 가치를 추정하고자 수행되었다. 서울특별시와 충청도의 중소도시에 거주하고 있는 일반인 101명을 대상으로 조건부 가치측정법을 사용하여 골절예방에 대한 지불의사금액(Willingness To Pay, WTP)을 조사하였다. Generalized Linear Model(GLM)을 사용하여 WTP에 영향을 미치는 요인을 확인하였으며 남성과 여성에 대하여 별도로 분석하였다. 분석 결과 척추골절 위험률을 10%, 50% 낮춰주는 치료법에 대한 WTP로 본인의 경우 연평균 66만원, 135만원을, 가족의 경우 82만원, 160만원을 각각 제시하였다. 대퇴부골절의 경우 각각 연평균 116만원, 235만원을 본인에 대한 WTP로 응답하였으며 가족에 대해서는 10% 더 높은 수준의 금액을 제시하였다. WTP에 대한 회귀분석 결과 성별에 따라 유의미한 인자가 달랐으나 두 집단 모두 골절 감소 효과가 높을수록 WTP 수준이 더 높은 것으로 나타났다. 골다공증성 골절 위험 감소에 대한 WTP는 골다공증 약물 치료 선택에 기초자료로 활용될 수 있으며, 약물치료를 골감소증 환자에게 확대하고자 할 때도 기준으로 활용할 수 있어 궁극적으로 합리적인 의료비 지출을 위한 정책 결정과정에 기여할 수 있을 것으로 기대한다. This study was performed to estimate willingness to pay(WTP) for treatment that would reduce osteoporotic fractures to provide evidence-based decision making related to the reimbursement of osteoporosis use. 101 people in Seoul and Chung Cheong-Do were interviewed face to face and asked about their WTP for treatment that would reduce their or their family``s risks of vertebral or hip fracture by 10% or 50%. Each question was repeated for the fracture risk of a family member. A generalized Linear Model(GLM) was used to identify factors affecting the level of WTP in male and female group separately. The WTP for treatment that would reduce the risk of vertebral fracture by 10% and 50% were 660,000 and 1,350,000 Korean won, respectively, per year; and the WTP for treatment that would reduce the risk of hip fracture by 10% and 50% was 1,160,000 and 2,350,000 Korean won, respectively, per year. The average WTP for a family member was around 10% higher than the WTP for oneself. The factors affecting the WTP have differences in male and female group but the WTPs of both groups were associated with higher effect of reducing fracture. These consumers``WTPs would provide information regarding the treatment of osteoporosis and contribute to appropriate drug use and rational pharmaceutical spending.

시중 판매중인 Fresh-Cut 채소 제품의 품질평가

조순덕,박주연,김은정,김동만,김건희,Cho, Sun-Duk,Park, Joo-Youn,Kim, Eun-Jeong,Kim, Dong-Man,Kim, Gun-Hee 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.5

Most fresh-cut agri-food products are less stable than unprocessed materials from which they are made. The objective of this study was the development of a quality control system for fresh-cut agri-food products. In this study, vitamin C, minerals, residual heavy metals, and pesticides of various fresh-cut agri-food products were analysed. Sensory evaluation revealed that overall acceptability scores were less than expected in most products since fresh-cut products are likely to cause browning and easily lose their freshness. Therefore, the postharvest technologies that can maintain the quality, freshness and appearance must be supplied. Although vitamin C and minerals are main nutrients that can be supplied from salads, the results showed that vitamin C and mineral contents were very small and extremely small compared with the values from the food composition tables. It is possible that vitamin C and most minerals that are easily destroyed were lost through minimal processes like peeling and cutting. In safety side, the remaining heavy metal contents of fresh-cut agri-food were investigated and the results showed that copper and lead existed in some products because only cadmium in agricultural produce is controlled by the minimum standard of heavy metal contents in Korea. No residual pesticides were detected in all products. Fresh-cut 채소 제품이 소비자에 의해 선택되어 소비되려면 이의 친환경적 원료생산과 가공, 포장, 서빙에 이르는 전 과정에서 체계적인 품질관리가 이루어져야 하며 갈변제어, 연화제어 및 미생물적 제어 등 관련 기술의 연구개발이 요구된다. 본 연구에서는 시중 유통 판매되고 있는 fresh-cut 채소제품의 품질을 비교평가하기 위해 현재 유통되고 있는 9개사 제품을 선정하였으며, 관능검사를 포함하여 vitamin C, 무기질, 중금속 함량, 잔류농약 및 미생물오염 정도를 조사하였다. 관능평가에서는 갈변 등 품질변화로 인해 전반적인 기호도가 그다지 높지 않았다. 채소류에서 중요 영양성분인 vitamin C 함량은 9개사 모든 제품의 주재료인 양상추에서 거의 검출되지 않았고 다른 채소류의 vitamin C 함량 역시 식품성분표보다 소량이었다. 무기질 함량 역시 극히 소량이었는데, 이는 박피, 절단 등의 최소 가공 공정을 거치면서 파괴되기 쉬운 vitamin C와 무기질이 대부분 손실되었기 때문으로 사료된다. 안전성측면에서 평가한 잔류 중금속 함량의 경우 몇 개의 제품에서 구리와 납이 소량 검출되었으며 잔류농약은 검출되지 않았다.

건강개선 정도에 따른 지불의사금액 추정 연구

김윤희 ( Youn Hee Kim ),신상진 ( Sang Jin Shin ),박선영 ( Sun Young Park ),송현진 ( Hyun Jin Song ),박주연 ( Joo Yeon Park ),배은영 ( Eun Young Bae ),안정훈 ( Jeong Hoon Ahn ) 한국보건경제정책학회 2010 보건경제와 정책연구 Vol.16 No.2

한국에서 경제성 분석의 활용이 점차 확대되고 있으나 비용-효과성을 판단할 기준에 대한 정보가 부족하여 의사결정의 불확실성이 존재하고 갈등의 요인이 되고 있다. 본 연구는 사회적으로 수용 가능한 비용-효과비의 범위를 추정하고자 수행되었다. 이를 위해 관련 방법론을 검토하고 일반인 100명을 대상으로 조건부 가치측정법을 사용하여 지불의사금액(Willingness To Pay: WTP)을 조사하였다. 분석 결과 건강개선 정도, 효용 계측 방법, EQ-5D 환산수식의 다양함을 고려하였을 때 l QALY(Quality Adjusted Life Years)당 WTP는 1,050만원에서 3,642만원 수준으로 산출되었다, 노인집단, 저소득집단에서 낮은 지불의사금액을 제시하였고 건강개선 수준이 낮을수록 1 QALY당 WTP가 높았다. 본 연구를 시작으로 우리나라에서 경제성 분석과 관련된 많은 연구들이 축적된다면 비용-효과성 기준에 대한 정보의 부재로 인한 의사결정의 불확실성은 점차 줄어들고, 이를 통해 비용-효과성 결과를 이용한 보다 투명한 정책집행이 가능해져서 사회적으로 갈등요인이 줄어들게 될 것으로 기대한다. This study was performed to search for cost-effectiveness threshold in Korea. A survey questionnaire using EQ-5D to measure QALY improvements and WTP in hypothetical scenarios were developed. 100 citizens in Seoul were interviewed face-to-face with this questionnaire in 2009. Each person`s WTP was asked for five scenarios chosen from each health improvement level based on Korean EQ-SD tariff: 0-0.2, 0.2-0.4, 0.4-0.6, 0.6-0.8, 0.8-1.0. The questionnaire also included questions on demographics, disease status, and a visual analog scale (VAS) measure of each scenario presented. Consistency of each respondent was checked by matching ranks of five scenarios between WTPs and QALY improvements either by VAS or Korean EQ-5D tariff. The WIP for an additional QALY (calculated by VAS and three existing Korean EQ-5D tariffs) was around 10.5-36.4 million won on average for those (N=70) who passed consistency check and not under medical assistance program. The relationship between WTP and QALY improvements measured by VAS was monotonic (people more appreciate significant improvements) whereas the relationship between WTP and QALY improvements measured by Korean tariffs were highest in 0-0.2 level. The choice of method to calculate QALY improvement seems crucial in cost-effectiveness threshold study in Korea. However, we expect this study can contribute to resolve the frictions over the interpretation of CEA in Korea.

스펙트럼 영역 빛간섭단층촬영기를 이용한 근시 정도에 따른 황반 구조의 정량적 분석

김승훈,박주연,박태관,온영훈,Seung Hoon Kim,Joo Youn Park,Tae Kwann Park,Young-Hoon Ohn 대한안과학회 2011 대한안과학회지 Vol.52 No.11

Purpose: To investigate the correlation of macular retinal thickness and refractive error using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 120 eyes with no posterior abnormalities were enrolled in the present study. Subjects were divided into 3 groups based on their spherical equivalent. Visual acuity, refraction, slit lamp examination, tonometry and fundus examination were performed. Retinal thickness between the RPE and IS/OS junction was measured at the fovea, 1 mm (inner ring) and 2 mm (outer ring) superiorly, inferiorly, nasally and temporally using SD-OCT. Overall average thickness, average foveal thickness, and the inner and outer ring macular thickness were measured. Results: The average foveal thickness was significantly greater in the high myopic eyes than in the low to moderate myopic and emmetropic eyes (p = 0.001). However, the RPE-IS/OS junction thickness of the foveola and the outer macular thickness were significantly lower (p = 0.001, p = 0.002) in the high myopic eyes. There was a weak, but significant negative correlation between refractive error and average foveal thickness (r = -0.38, p = 0.001). A positive correlation was found between refractive error and the RPE-IS/OS junction thickness (r = 0.40, p = 0.001). Conclusions: Macular retinal thickness is related to refractive error in normal subjects. Effects of eyeball elongation are more apparent in high myopic eyes than in low to moderate myopic eyes. A significant decline in the RPE-IS/OS junction thickness suggests the photoreceptor outer segments in the foveola are damaged in high myopic eyes. J Korean Ophthalmol Soc 2011;52(11):1286-1295