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성미선,박태관,온영훈,Mi-Sun Sung,Tae-Kwann Park,Young-Hoon Ohn 대한안과학회 2005 대한안과학회지 Vol.46 No.11
Purpose: To report on the classification of congenital stationary night blindness (CSNB) and multifocal ERG findings. Methods: We studied three patients (case 1-3) with night blindness but normal fundus and one patient (case 4) with decreased vision after trauma with respect to the patients` medical history, familial history, refraction, slit lamp examination, fundus examination, FAG, ERG, and multifocal ERG. Results: The ERG in case 1 showed a decreased rod response, and this patient was diagnosed with Riggs-type CSNB. The typical “negative ERG” was found in all three cases of ERG (except case 1), and these cases were diagnosed with Schubert-Bornschein-type CSNB. Based on Miyake`s classification, case 2 was incomplete, and cases 3 and 4 were complete. The mfERG of the cases with complete Schubert-Bornschein type had delayed implicit times of the first-order kernel and decreased amplitudes of the second-order kernel. The delayed implicit times and the decreased amplitudes of the first- and second-order kernels were found in the cases of Riggs- type and incomplete Schubert-Bornschein-type.
안와가성종양의 임상양상과 스테로이드 반응성에 대한 분석
성미선,오한진,고병이,윤경철,Mi Sun Sung,Han Jin Oh,Byung Yi Ko,Kyung Chul Yoon 대한안과학회 2013 대한안과학회지 Vol.54 No.2
Purpose: To evaluate the clinical features and treatment outcomes of steroid therapy for orbital inflammatory pseudotumor. Methods: Sixty-four patients diagnosed with orbital inflammatory pseudotumor were reviewed retrospectively. Patients with a follow-up period of less than 6 months were excluded from the study. The pseudotumor was classified into myositic, lacrimal, anterior, diffuse, or apical type according to orbital computed tomography findings. All patients were initially treated with systemic corticosteroids and evaluated for response to the treatment. Treatment outcome was considered a “success” if the patient had complete relief of symptoms with no recurrence, and a “failure” if the patient had no or only partial relief of symptoms or showed relapse. Factors affecting the treatment outcome were analyzed. Results: The most frequent lesion subtype was myositis. Periorbital edema was the most common symptom and was evident in 53.1% of the patients. Thirty-eight patients (59.4%) showed treatment success. Age, sex, bilaterality, and mean follow- up length did not correlate with the treatment outcome. A short interval from symptom onset to treatment time and apical subtype were significantly associated with good steroid response (p < 0.05). Conclusions: In orbital inflammatory pseudotumor, myositis was the most common subtype. A short interval from symptom onset to treatment time and apical subtype were associated with good steroid response.
성미선,박성선,김성수,한찬규,허정무 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.5
The antioxidant activities and hepatoprotectiveeffects of Schizandra chinensis Baill. extracts (SCE) wereevaluated. The contents of the active components schisandrin,schisandrin C, gomisin A, and gomisin N in SCE were8.802±1.390, 1.011±0.203, 0.954±0.191, and 3.351±0.829mg/g, respectively. The antioxidant activity of SCE wasmeasured based on the DPPH free radical scavengingactivity and the superoxide dismutase (SOD)-like activity. The IC50 values for the DPPH radical scavenging activityand SOD-like activity were 18.1 and 44.2mg/mL, respectively. The protective effect of SCE against alcohol-inducedoxidative injury in HepG2 cells was investigated. Cellspretreated with SCE (100-400 μg/mL) showed an increasedresistance to oxidative stress in a dose-dependent manner. Expressions of Bcl-2 and pro-caspase-3 proteins wereinduced by SCE in HepG2 cells. SCE can be useful formanagement of antioxidant and hepatoprotective effects.