실내 위치 측위를 통한 D2D 통신 성공 확률 (Opportunity Probability) 측정 및 예측

한규원(Kyuwon Han),남혜린(Hyelin Nam),박지훈(Jihoon Park),성명훈(Meonghoon Seong),김성륜(Seong-Lyun Kim) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

본 논문에서는 실내 측위를 진행하고, 그 결과를 바탕으로 D2D 통신 성공 확률인 Opportunity probability (OP)를 예측 및 측정하여 그 값을 비교하는 실험을 소개한다. 실내 측위를 위해서 스마트폰의 관성 측위 센서와 이를 보정하기 위한 딥러닝 네트워크, 그리고 WiFi RTT를 융합한 측위 기법이 사용되었다. 그 결과 OP값을 중위값 90% 이상으로 예측하는 데 성공하였다.

배양망막색소상피세포에서 젤라틴아제의 발현에 대한 산화스트레스의 영향

박영철,최광주,Young-Chul Park,Gwang-Ju Choi 대한안과학회 2005 대한안과학회지 Vol.46 No.11

Purpose: To evaluate the expression pattern of gelatinases in the human retinal pigment epithelial cell line ARPE-19 in response to oxidative stress. Methods: ARPE-19 cells were exposed to paraquat for 72 hours. The cells were assayed for the mRNA expression of gelatinase A and gelatinase B by reverse transcriptase polymerase chain reaction (RT-PCR). The conditioned media were assayed for the production of gelatinases protein by Western blotting. Also, the inhibitory effect of the antioxidants against oxidative stress to the cells was evaluated. Results: The gelatinase levels in the RPE cells increased under oxidative stress compaired with the control (p〈 0.05). Also, the levels decreased when the cells were incubated with the antioxidant N-acetylcysteine (NAC). Conclusions: Oxidative stress upregulates gelatinase expression in ARPE-19 cells.

A phase 1/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3

박영철,오영택,MOON-HEE SUNG,Hong-Gyu Park,김태진,조치흠,박종섭,이재관 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6

Objective: Persistent infection of HPV increases the chance of carcinoma in situ of cervixthrough stages of cervical intraepithelial neoplasia (CIN) 1, 2, and 3, and finally progressesinto cervical cancer. We aimed to explore the safety and efficacy of BLS-M07 which is orallyadministered agent expressing human papillomavirus (HPV) 16 E7 antigen on the surface ofLactobacillus casei in patients with CIN 3. Methods: Patients with CIN 3 were recruited in our clinical trial. Reid Colposcopic Index(RCI) grading and serum HPV16 E7 specific antibody production were used to evaluateefficacy of BLS-M07. In phase 1, BLS-M07 was administered orally, 5 times a week, on weeks1, 2, 4, and 8 with dosages of 500 mg, 1,000 mg, and 1,500 mg. In phase 2a, patients weretreated with 1,000 mg. The primary endpoints were the safety and the pathologic regressionon colposcopic biopsy. Results: Nineteen patients were enrolled in the CIN 3 cohort. In phase 1, no patientsexperienced dose limiting toxicity. No grade 3 or 4 treatment-related adverse events or deathswere observed. At 16 weeks after treatment, RCI grading was improved and serum HPV16E7 specific antibody production increased (p<0.05). Six of 8 (75%) patients with CIN 3 werecured in phase 2a. Conclusions: Oral immunization with BLS-M07 increases production of serum HPV16 E7specific antibody which induces protective humoral immunity. The safety of this oral vaccinewas proved and could be a competitive non-surgical therapeutic agent of CIN 3. Trial Registration: ClinicalTrials.gov Identifier: NCT02195089

틸트 로터형 무인항공기의 손상허용 설계

박영철,임종빈,박정선,Park, Young Chul,Im, Jong Bin,Park, Jung Sun 항공우주시스템공학회 2007 항공우주시스템공학회지 Vol.1 No.2

The Damage Tolerant Design is developed to help alleviate structural failure and cracking problems in aerospace structures. Recently, the Damage Tolerant Design is required and recommended for most of aircraft design. In this paper, the damage tolerant design is applied to tilt rotor UAV. First of all, the fatigue load spectrum for the tilt rotor UAV is developed and fatigue analysis is performed for the flaperon joint which has FCL (fatigue critical location). Tilt rotor UAV has two modes: helicopter mode when UAV is taking off and landing; fixed wing mode when the tilt rotor UAV is cruising. To make fatigue load spectrum, FELIX is used for helicopter mode. TWIST is used for fixed wing mode. Fatigue analysis of flaperon joint is performed using fatigue load spectrum. E-N curve approach is used for picking crack initiation point. The LEFM(Linear Elastic Fracture Method) is considered for analyzing crack growth or propagation. Finally, including the crack initiation and propagation, the fatigue life is evaluated. Therefore the Damage Tolerant Design can be done.

육미지황탕(환)의 약리와 독성에 대한 문헌고찰

박영철,김종봉,국윤범,이선동,Park, Yeong-Chul,Kim, Jong-Bong,Kook, Yoon-Boom,Lee, Sun-Dong 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

Objectives : Yukmijihwang-tang(Wan), a well-known formula for invigorating yin-particular kidney yin, was first recorded in "Xiao er Yao Zheng Zhi Jue", consisting of Radix Rehmanniae Preparata, Fructus Macrocarpii, Rhizoma Dioscoreae Oppositae, Poria, Rhizoma Alismatis and Cortex Moutan Radicis with dose proportion of 8:4:4:3:3:3. Although clinical trials have been lacking, various pharmacological actions for Yukmijihwang-tang has been identified newly using animal models. In addition, it was reported that Yukmijihwang-tang increases structural chromosome aberrations significantly in Chinese hamster lung cells. In this article, it is purposed that new studies for pharmacology and toxicology of Yukmijihwang-tang are reviewed. Insight into new studies of Yukmijihwang-tang at the cellular and animal levels will enhance our understanding of Yukmijihwang-tang against various diseases will provide new tools to diagnose and treat patients. Methods : Recent researches for Yukmijihwang-tang were reviewed and summarized in terms of pharmacological action and toxicity. All sources for review were based on recent studies loaded on data base of web sites such as Science Direct and National Center for Biotechnology Information. Results and Conclusions : Recently, reports showed that YMJ had antiaging effects, antioxidant and free radical scavenging activities, anti-renal hypertension and prevented tumors, and diabetes mellitus. However, there is little information on its safety except general toxicity, acute and sub-chronic oral toxicity, or genotoxicity. In addition, clinical trial for Yukmijihwang-tang was limited even though Yukmijihwang-tang has been used extensively in Korean traditional medicine. Thus, further studies are necessary to focus on safety evaluation and clinical trial for Yukmijihwang-tang.

한약의 안전성 등급화를 위한 evidence-based approach : Human equivalent dose-based the margin of safety

박영철,이선동,Park, Yeong-Chul,Lee, Sundong 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.3

This study was aimed to develop a new formula for herbal medicine-safety classification in terms of evidence-based medicine. Recently, human equivalent dose(HED)-based therapeutic index was developed for herbal medicine-safety classification by transforming $LD_{50}$ to HED. However, the use of the $ED_{50}$ and $LD_{50}$ to derive the therapeutic index may be misleading as to safety, depending on the slope of the dose-response curves for therapeutic and lethal effects. To overcome this deficiency, HED-based MOS(Margin of Safety)was developed and suggested in this study. The HED-based MOS developed by using $LD_1$, changing to ALD(approximate lethal dose), and $ED_{99}$. The HED-based MOS seems to be more useful and safer than HED-based therapeutic index since its values for several herbal medicines are basically two times less than the values from HED-based therapeutic index. Thus, HED-based MOS can be a good example of Evidence-based approach for herbal medicine-safety classification.

세라믹/금속접합재의 고온 열사이클에 따른 잔류응력분포 및 굽힘강도 특성

박영철,허선철,부명환,김현수,강재욱,Park, Young-Chul,Hue, Sun-Chul,Boo, Myoung-Hwan,Kim, Hyun-Su,Kang, Jae-Wook 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.10

Since the ceramic/metal joint material is made at a high temperature, the residual stress develops when it is cooled from bonding temperature to room temperature due to remarkable difference of thermal expansion coefficient between ceramic and metal. As residual stress at ceramic/metal joints influences the strength of joints, it is important to estimate residual stress quantitatively. In this study, it is attempted to estimate joint residual stress of Si$_3$N$_4$STS304 joints quantitatively and to compare the strength of joints. The difference of residual stress is measured when repeated thermal cycl is loaded, under the conditions of the practical use of the ceramic/metal joint. The residual stress increases at 1 cycle of thermal load but decreases in 3 cycles to 10 cycles of thermal load. And 4-point bending test is performed to examine the influence of residual stress on fracture strength. As a result, it is known that the stress of joint decreases as the number of thermal cycle increases.

한약재의 대사 및 독성의 기전과 예방

박영철,김종봉,이선동,Park, Yeong-Chul,Kim, Jong-Bong,Lee, Sun-Dong 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.1

In recent years, there has been a globally increasing application of herbal medicines and dietary supplements to treat various chronic diseases and to promote health. However, there are increasing clinical reports on the organ toxicities associated with consumption of herbal medicines. In general, most xenobiotics are metabolized by Phase I reaction(the main enzyme : cytochrome P450) and Phase II reaction. However, reactive oxygen species, free radicals and electrophils are produced inevitably during xenobiotics metabolism. These toxic species and metabolites are increased whenever the endogenous substances and enzymes for Phase II reaction not available. In addition, herbal-drug interactions are pharmacokinetic, with most actually or theoretically affecting the metabolism of the affected product by way of the cytochrome P450 enzymes. This review updated the knowledge on metabolic activation of herbal components and its clinical and toxicological implications. Also, the possible way for preventing the side-effects by herbal-medicine use was suggested.

광대역 잡음의 전역 감쇠를 위한 에너지 밀도 제어

박영철,윤정현,윤대희,차일환,Park, Young-Cheol,Yun, Jeong-Hyeon,Youn, Dae-Hee,Cha, Il-Whan 한국음향학회 1996 韓國音響學會誌 Vol.15 No.2

본 논문에서는 일차원 밀폐함 내의 광대역 소음을 제어하기 위한 에너지 밀도(energy density)제어 알고리듬의 성능을 평가한다. 주파수 영역에서 최적 능동 소음 제어 필터를 설계할 경우 종종 시간 영역에서 물리적으로 실현할 수 없는 결과를 얻게 된다. 이런 문제를 피하기 위해 본 논문에서는 시간 영역에서 문제를 해석한다. 이러한 접근 방법은 항상 물리적으로 실현 가능한 최적 제어기를 얻을 수 있게 해준다. 능동 소음 제어 시스템의 성능을 예측하기 위해 실시간 모의 실험 결과로부터 음압을 최소화 하는 것보다 에너지 밀도를 최소화 하는 것이 광대역 소음의 전역적인 감쇠(global attenuation)에 있어서 향상된 결과를 얻을 수 있음을 확인할 수 있다. 또한 특정 지점에서, 검출된 에너지 밀도를 최소화할 경우 밀폐함 내에 있는 위치 에너지를 최소화하는 방법에서 얻을 수 있는 결과와 유사한 정도의 소음 전역 감쇠를 얻을 수 있었다. 그리고 음압 자승 제어 방법과는 달리 에너지 밀도 제어 방법은 일차원 음장에서 사용하는 경우 오차 센서의 위치에 영향을 받지 않음을 알 수 있다. 본 논문은 또한 에너지 밀도 제어 알고리듬의 실제 구현시에 일반적으로 사용되는 두 개의 센서를 사용하는 구현 기술을 살펴보고, 이 기술이 큰 성능 저하 없이 에너지 밀도 제어 알고리듬을 구현할 수 있음을 보인다. The performance of the energy density control algorithm for controlling a broadband noise is evaluated in a one-dimensional enclosure. To avoid noncausality problem of a control filter, which often happens in a frequency domain optimization, analyses presented in this paper are undertaken in the time domain. This approach provides the form of the causally constrained optimal controller. Numerical results are presented to predict the performance of the active noise control system, and indicate that imp개ved global attenuation of the broadband noise can be achieved by minimizing the energy density, rather than the squared pressure. It is shown that minimizing the energy density at a single location yields global attenuation results that are comparable to minimizing the potential energy. Furthermore, unlike the squared pressure control, the energy density control does not demonstrate any dependence on the error sensor location for this one-dimensional field. A practical implementation of the energy-based control algorithm is presented. Results show that the energy density control can be implemented using the two sensor technique with a tolerable margin of performance degradation.

MPEG-4 오디오 구현 기술 동향

박영철,Park Yeong-Cheol 한국통신학회 2006 정보와 통신 Vol.23 No.7