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1996년도 제35차 대한소화기학회 추계학술대회 / 일반연제 : 위장관 ; 비궤양성소화불량환자에서 위배출시간지연과 자율신경기능실조의 임상적 의의
박수헌,김진일,나종순,채현석,김재광,한준열,최규용,정인식,정규원,선희식,박두호,손형선 ( Soo Heon Park,Jin Il Kim,Jon Soon Na,Hiun Suk Chae,Jae Kwang Kim,Jun Yul Han,Kyu Yong Choi,In Sik Chung,Kyu Won Chung,Hee Sik Sun,Doo Ho Park,Hyung Su 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
‘부대 속의 감자’ 또는 ‘혁명의 코러스’ : 마르크스의 농민관 재고찰
박수헌(Soo-Heon Park) 한국슬라브유라시아학회 2009 슬라브학보 Vol.24 No.3
Peasants cannot play an important role in Marx' general theory of capitalist development. They are doomed to disappear as a transitional intermediate class with the growth of the two major classes, capitalists and proletarians. However, the continued existence of the peasant class and the weakness of the workers' movements in Europe in the 19th century raised new questions that had not been dealt with in his general theories in appropriate way. Can the peasants be revolutionary during the period of their “transitional” existence? Is an alliance of the working class with the peasants possible against other “counter-revolutionary” forces? With regard to these serious issues in the development of theories and practices of socialism, Marx finds a strong revolutionary potential of the peasant class in his analysis of the revolutionary situations in the mid-19th century Germany and France. The peasants could contribute to the cause of the working class in allying with the latter, first, against the feudal landlords in making bourgeois revolutions, and then against the bourgeoisie in preparation for socialist revolutions. They could also be very instrumental in the proletariat's seizure of power and its maintenance. Despite this recognition of the revolutionary potential of the peasant class, however, the teleological implications in Marx's theory of historical development imposed certain basic restrictions in his evaluation of the nature and role of the peasantry. The peasants were understood by Marx as being able to be revolutionary from the viewpoint of their imminent transformation into the proletariat and as being led by the progressive force of the working class in the revolutionary situations. In other words, even though Marx saw a high degree of revolutionary potential in the peasants, the latter were approached by him not on the basis of a social composition equipped with its own developmental dynamics but from the ultimate standpoint of his historical materialism.
박수헌(Soo Heon Park),최명규(Myung Gyu Choi),조세현(Se Hyun Cho),한준열(Jun Yeul Han),최규용(Gyu Yong Choi),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),강창석(Chang Suck Kang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
A 34-year old female was admitted to St. Mary Hospital because of indigestion. E,ndoscopy showed cobble stone appearance of gastric mucosa on the antrum. Computed tomography showed normal gastric wall thickness and no evidence of lymph node enlargement. Upper gastrointestinal barium study showed poorly defined granular depressed lesion on the antrum. Gastric mucosectomy specimen showed centrocyte-like cells of small lymphocytes, collection of lymphocytes infiltrating and partially destroying isolated glands(lymphoepithelial lesion). After the gastric resection, she was diagnosed as a malignant lymphoma of mucosa-associated lymphoid tissue(MALTOMA) with submucosal infiltration. In analogy to the early gastric cancer, early gastric lymphoma is defined as a tumor with a maximum depth of infiltration extending into the submucosa. After chernotherapy with a regimen of cyclophosphamide, vincrisiine, adriamycin, bleomycin, H-lone, procabazine, she was discharged with complete remission. Hence we present a case of MALT-lymphoma wilh literature. (Korean J Gastroenterol 1996;28: 111 - 117)
한국인에서 Helicobacter pylori 중복 감염의 검출
박수헌(Soo Heon Park),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park),김병욱(Byung Wook Kim),이학성(Hak Sung Lee),최황(Hwang Choi),최규용(Kyu Yong Choi),이인석(In Seok Lee),한 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: The aim of this study was to determine intra-variation of Helicobacter pylori (H. pylori) strains of each patient and to investigate the affection of multiple strains of H. pylori infection to the disease outcome in Korea. Methods: Thirty patients who were H. pylori-positive and had gastritis (n=10), duodenal ulcer (n=10) and gastric adenocarcinoma (n=10) were included in this study. Their disease were confirmed endoscopically and histologically. Their H. pylori were cultured. Five H. pylori colonies were picked randomly from the primary cultures. Using primer 1254, random amplified polymorphic DNA fingerprinting (RAPD) analysis was carried out. Restriction fragment length polymorphism (RFLP) patterns for the subtypes of ureC, cagA, and vacA were also investigated. Results: RAPD method confirmed that four of gastritis patients (40%), four of duodenal ulcer patients (40%), and five of gastric adenocarcinoma patients (50%) were infected with multiple strains of H. pylori. The intra-variation of RFLP patterns for the subtypes of ureC, cagA, and vacA were detected in the three groups. Conclusions: Multiple strains of H. pylori and the subtypes of cagA and vacA may not affect the outcome of the gastrointestinal disease. (Korean J gastroenterol 2001;38:411-418)
박수헌(Soo Heon Park),박선숙(Sun Sook Park),최명규(Myung Gyu Choi),조세현(Se Hyun Cho),한준열(Jun Yeul Han),최규용(Gyu Yong Choi),정인식(In Shik Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),강창석(Chang Suck Kang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
A 58-year old man was admitted to our hospital because of right upper quadrant pain and tingling sensation of both wrists. On physical examination, liver was palpable below thie low costal margin at the right mid-clavicular line. Liver biopsy and gastric mucosal biopsy clemonstrated amyloid deposition. EMG showed the denervated pattern in both median nerves and partial muscular atrophy. On his hospital day, his renal function deteriorated with gastrocolic symptoms. Hemodialysis was initiated. But the patient's condition was not recovered and he died l week after initiation of hemodialysis. Hence, we reported a case of gastrointestinal amyloidosis with carpal tunnel syndrome with the literature. (Korean J Gastroenterol 1995;28: 286 - 291)
위궤양환자에서 Rebamipide의 자유산소유리기제거에 의한 궤양치료효과
박수헌(Soo Heon Park),정운태(Woon Tae Jung),서정한(Jung Han Suh),정명희(Myung Hee Chung),정인식(In Sik Chung),이용찬(Yong Chan Lee),박인서(In Suh Park),송근암(Guen Am Song),양웅석(Ung Suk Yang),유종선(Jong Sun Rew),윤종만(Chong Mann 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
N/A Background/Aims: Helicobacter pylori has been shown to be an important pathogen of gastric disorder including gastritis and gastric ulcer. One of the potential toxic factors involving gastric mucosal cell injury is reactive oxidants, which are released from activated neutrophils. Rebamipide had been reported to promote mucus synthesis, mucosal prostaglandin content, and rapid ulcer healing, It has recently been reported to inhibit the production of oxygen derived free radicals from stimulated neutrophils. We conducted this study to evaluate the effects of rebamipide on gastric ulcer healing and reactive oxygen metabolite production. Methods: In this multicenter study conducted in Korea, combination treatment of rebamipide and ranitidine was compared with ranitidine alone in 108 patients with gastric ulcer patients. Pre- and post-treatment endoscopic findings and concentration of reactive oxygen metabolite produced were used to evaluate efficacy. The efficacy of rebamipide and ranitidine versus ranitidine was evaluated using endoscopy results, and tissue lipid peroxides by thiobarbituric acid and myeloperoxide concentration. Results: The percentage of ulcer size reduction was significantly higher with rebamipide and ranitidine group than with placebo and ranitidine group(size reduction: 71.5% vs 58.3% P=0.04556). The myeloperoxidase activities at ulcer margin in rebamipide and ranitidine group patients were 96.7+-13.4 unit/mg protein in baseline and 53.8+9.9 unit/mg protein in follow up (P=0.0065). The myeloperoxidase activities at ulcer margin in placebo and ranitidine group patients were 90.2+9.1 unit/mg protein in baseline and 63.1+6.7 unit/mg protein in follow up (P=0.0668). The thiobarbituric acid activities at ulcer margin in rebamipide and ranitidine group patients were 34.7+5.3 nmol of MDA/mg protein in baseline and 24.1W3.1 nmol of MDA/mg protein in follow up. The thiobarbituric acid activities at ulcer margin in placebo and ranitidine group patients were 14.8+1.5 nmol of MDA/mg protein in baseline and 24.3+2.7 nmol of MDA/mg protein in follow up (P=0.0059). The thiobarbituric acid activities at ulcer margin in H. pylori positive and negative patients were 28.1+2.1 nmol of MDA/mg protein and 25.3+4.7 nmol of MDA/mg protein, respectively. The myeloperoxidase activities at ulcer margin in H. pylori positive and negative patients were 79.9+5.3 unit/mg protein and 40.4+25.3 unit/mg protein, respectively (P=0.0001). The cumulative relapse rate was examined starting at 24 week after ulcer treatment. The rate was lower in rebamipide and ranitidine group patients, but insignificantly(19.2% vs 27.3%, P=0.0857). Conclusions: These results suggest that rebamipide promote gastric ulcer healing by decreasing reactive oxygen metabolite production in patients with gastric ulcer. (Korean J Gastroenterol 1997;29:569-578)
박수헌 ( Soo Heon Park ) 대한내과학회 2008 대한내과학회지 Vol.74 No.5
The incidence of peptic ulcer bleeding decreased slowly in duodenum, but slight rised in gastric ulcer. Endoscopic treatment is being performed as a treatment algorithms. Endoscopic treatment for ulcer bleeding has become a standard therapy with injections of epinephrine and saline solutions, thermocoagulation, mechanical devices such as hemoclips and banding ligator. With these treatment modalities, the mortality of nonvariceal bleeding decreased significantly during last 2 decades. Early intensive management could affect the therapeutic results. The time to hemodynamic stabilization correlated with mortality reduction. Combined endoscopic therapy is the treatment of choice for high-risk bleeding peptic ulcers. With the combined therapy, recurrent bleeding was reduced and surgery was obviated. Pharmacologic treatment with high-dose proton pump inhibitors stabilizes blood clot and has been proven to further improve the success of hemostasis. The studies using high-dose proton pump inhibitors as an adjuvant to endoscopic therapy, recurrent bleeding and surgery rate were reduced. Recently therapeutic effects of endoscopic treatment and pharmacologic management for peptic ulcer bleeding was published. Endoscopy was carried out within 24 hours in 86.6% of the patients. High risk endoscopic stigmata was reported in 70.7%. The rebleeding, surgery, and mortality rates were 4.5%, 0% and 0%, respectively. Proton pump inhibitor use and endoscopic combination therapy were associated with reduced rebleeding and mortality in patients with peptic ulcer bleeding.(Korean J Med 74:478-480, 2008)