IL-17-deficient allogeneic bone marrow transplantation prevents the induction of collagen-induced arthritis in DBA/1J mice

박민정,Mi-La Cho,Hyun-Sil Park,Hye-Joa Oh,윤보영,임정연,조미라,조석구 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.11

IL-17-producing CD4+ T cells (Th17) play important functions in autoimmune diseases and allograft rejection of solid organs. We examined the effects of IL 17 and its mechanism of action on arthritis in a murine collagen-induced arthritis (CIA) model using bone marrow transplantation (BMT) system. DBA/1J mice were administered a lethal radiation dose and then rescued with bone marrow derived from either wild-type (WT) or IL-17-/- mice on C57BL/6 background mice. CIA was induced after the bone marrow transplant, and disease progression was characterized. DBA/1J mice with CIA that received IL-17-/- donor bone marrow showed potently inhibited development and severity of clinical arthritis as compared with CIA mice that received WT bone marrow. Reduced secretion of the pro-inflammatory cytokines tumor necrosis factor-α,IL-1β, and IL-6, and collagen-specific T cell responses were observed in mice that received IL-17-/- bone marrow. IL-17 blockade also inhibited effector T cell proliferation by reciprocally regulating the Treg/Th17ratio. IL-17 blockade prevented joint destruction in mice with CIA. These findings suggest that CIA with BMT is a viable method of immunological manipulation and that IL-17 deficiency suppresses severe joint destruction and inflammation in CIA mice. There may be clinical benefits in blocking IL-17 and BMT in the treatment of rheumatoid arthritis.

한양방치료를 병행한 안성 대상포진 환자 치험 1례

박민정,양정윤,김수현,조기호,문상관,권승원,정우상,Park, Min-jeong,Yang, Jung-yun,Kim, Soo-hyun,Cho, Ki-ho,Moon, Sang-kwan,Kwon, Seung-won,Jung, Woo-sang 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.2

A case of a 72-year-old Korean male with herpes zoster ophthalmicus revealed. He was treated with Korean-Western cooperative treatment. We used the Numeric Rating Scale (NRS) to evaluate forehead and eye pain. Pain was improved after the administration of Korean medical treatments and disappeared after eight days. Korean-Western cooperative treatment may be effective in treating acute herpes zoster ophthalmicus.

퇴행성 슬관절염 환자에 대한 슬관절방(膝關節方) 1호(號)의 제형변화 유효성 임상연구

박민정,서진우,성인형,김남옥,성수민,정애경,신대희,박쾌환,Park, Min-Jung,Seo, Jin-Woo,Sung, In-Hyung,Kim, Nam-Ok,Sung, Su-Min,Chung, Ae-Kyung,Shin, Dae-Hee,Park, Koae-Hwan 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.2

Objective: This study is designed to compare the effects of Sulguanjul-Bang No.1 on osteoarthritis in knee joint according to formulation. Methods: 47 patients with symptomatic osteoarthritis of the knee joint were enrolled in a open clinical trial. The 47 patients were devided into two groups at random and taken Sulguanjul-bang No.1 with decoction type, suspension type respectively for8 weeks. After 8-week treatment period, the following parameters were analyzed ; Visual analogue Scale(VAS), Lysholm index score, patients' global assessment. Results: Sulguanjul-bang No.1 treatment led to significant improvement in the pain and symptoms of osteoarthritis as determined by all efficacy measures. After 8 weeks of therapy, there was significant improvement in VAS, Lysholm index and patients' global assessment. But there is no significant difference between two groups. Conclusions: Sulguanjul-bang No.1 was very beneficial pain relief effect and functional improvement irrespect of formulation, decoction type or suspension type.

퇴행성 슬관절염 환자에서 슬관절방(膝關節方) 1호(號)의 유효성 연구

박민정,이경윤,박쾌환,정애경,신대희,Park, Min-jung,Lee, Kyung-yun,Park, Koae-hwan,Chung, Ae-kyung,Shin, Dae-hee 대한침구의학회 2004 대한침구의학회지 Vol.21 No.3

Objective : This study is designed to find out the effects of Sulguanjul-Bang No.1 on osteoarthritis in knee joint. Methods : 45 patients with symptomatic osteoarthritis of the knee joint were enrolled in a short term 8-week open clinical trial. The 45 patients were taken Sulguanjul-bang No.1 two times a day before meals for 8 week. After 8 week treatment period, the following parameters were analyzed ; Visual analogue Scale(VAS) as first effective parameter, Lysholm index score, patient's global assessment, passive movement range of the knee joint. Results : Sulguanjul-bang No.1 treatment led to significant improvement in the pain and symptoms of osteoarthritis as determined by all efficacy measures. After 8 weeks of therapy, there was significant improvement in VAS and Lysholm index; squat, sit down and up, crepitaion, swelling. The range of motion was improved in 6 of 9 cases. The improvement in patient's global assessment was seen in 84%. Conclusion : Sulguanjul-bang No.1 was very beneficial effect in pain relief and improvement functions on osteoarthritis.

졸-겔법에 의한 나노크기 Au 미립자 분산 TiO₂ 박막의 특성

박민정,구세나,이경석,문종수,Park, Min-Jung,Koo, Se-Na,Lee, Kyoung-Seok,Mun, Chong-Soo 한국세라믹학회 2006 한국세라믹학회지 Vol.43 No.2

Nano-size Au particle doped $TiO_2$ films were prepared with $Ti(OC_3H_7^i)_4$, polyvinylpyrrolidone(PVP), $HAuCl_4$ and $C_3H_7OH$ etc. by sol-gel method. $TiO_2$ gel films were obtained by the dip-coating method on the $SiO_2$ glass substrates, and then heat-treated at $700^{\circ}C$ for 10 min. The thickness of $TiO_2$ films were $0.7\~1.8\;{\mu}m$. It was found that the thickness of films prepared from PVP containing solution was about $2\~8$ times higher values than that of thin films without PVP. The size of Au particles doped in the films were about $350\~750\;nm$. Nano-size Au particle dispersed $TiO_2$ films showed high absorption peak at visible region 450nm, which made them good candidates for non-linear optical materials and photo-catalytic materials. The contact angle of $TiO_2$ film for water was $12.5^{\circ}$, and therefore it is clear that $TiO_2$ films have very high hydrophilic properties and the self-cleaning effects.

마이크로데이터 공표를 위한 통계적 노출제어 방법론 고찰

박민정,김항준,Park, Min-Jeong,Kim, Hang J. 한국통계학회 2016 응용통계연구 Vol.29 No.6

학술 연구나 정책 입안 등을 위한 심층적 자료 활용의 확대는 동시에 개별 정보 노출에 대한 염려도 증가시킨다. 때문에 최근 이십여 년 간 통계적 노출제어(정보보호) 분야에서 많은 논문들이 발표되었다. 본 논문은 그러한 연구 내용들을 정리하여 국내 통계인들과 기관들에게 소개하고자 한다. 주요 내용으로 국소통합이나 잡음추가와 같은 전통적인 매스킹 기법 뿐만 아니라, 온라인 자료 분석 시스템에서의 정보보호 처리, 차등정보보호를 통한 노출제어 및 재현자료를 활용한 정보보호 대안 모색에 대해 다룬다. 또한 각각의 주제에 대한 방법론 소개와 함께 활용 사례 및 장단점을 논의하였다. 본 논문이 실제적인 통계적 노출제어 문제를 고민하는 통계인들에게 도움이 되기를 바란다. The increasing demand from researchers and policy makers for microdata has also increased related privacy and security concerns. During the past two decades, a large volume of literature on statistical disclosure control (SDC) has been published in international journals. This review paper introduces relatively recent SDC approaches to the communities of Korean statisticians and statistical agencies. In addition to the traditional masking techniques (such as microaggregation and noise addition), we introduce an online analytic system, differential privacy, and synthetic data. For each approach, the application example (with pros and cons, as well as methodology) is highlighted, so that the paper can assist statical agencies that seek a practical SDC approach.

실손형 민간보험의 비급여 보장축소가 한방의료이용에 미친 영향

박민정,고성규,Park, Minjung,Ko, Seong-Gyu 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : Private health insurance coverage in Korean medicine has been reduced since October 2009 for preventing unnecessary utilization. The aim of this study is to identify how private health insurance coverage reduction affects on the Korean medicine utilization. Method : We analyzed the Korea Health Panel data from 2008 to 2012. Panel negative binominal regression model was used to analyze the relationship between private health insurance coverage reduction and utilization of outpatient service. Panel tobit regression analysis was used to identify the relationship between private health insurance coverage reduction and health expenditure of outpatient service. Results : Private health insurance coverage reduction significantly dropped both utilization and health expenditure of outpatient service by 9%, 9.22% respectively. In addition, therapeutic utilization significantly decreased up to 10%. Conclusion : Private health insurance coverage reduction seems to have an effect to reduce both utilization and the health expenditure of Korean medicine outpatient service. This effect was more noticeable in the therapeutic utilization. Thus, more elaborate policy will be needed to prevent unnecessary utilization of Korean medicine.

불면을 호소하는 Lewy's body dementia 환자 치험 1례

박민정,이미림,김경묵,조기호,문상관,권승원,정우상,Park, Min-jeong,Lee, Mi-rim,Kim, Gyeong-muk,Cho, Ki-ho,Moon, Sang-kwan,Kwon, Seung-won,Jung, Woo-sang 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

The patient was a 69-year-old Korean male with Lewy's body dementia and insomnia. He was treated with acupuncture and a herbal medicine, Ukan-san. To evaluate insomnia, the patient's total sleeping time was recorded. The patient's sleeping time increased after the administration of the Korean medicine treatments. Treatment with Korean medicine may be effective in treating insomnia in cases of Lewy's body dementia.

적외선체열촬영을 통한 편측 경항상지통환자의 임상적 고찰

박민정,이경윤,조원영,박쾌환,Park, Min-jung,Lee, Kyung-yun,Cho, Won-young,Park, Koae-hwan 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2

Objectives : We studied to discover the patterns of DITI of the patients having a both neck and upper extremity pain on one side without any nerve root compression sign and the history of cervical disc herniation. Method : We selected 26 patients as an experimental group, who had visited for a both neck and upper extremity pain on one side without any nerve root compression sign, at the department of acupunture and moxibustion in Conmaul oriental medical hospital, during 2001. 01. - 2003. 09. And 31 normal adults were selected as a control group, not having any neck or arm pain and any history of cervical disease. We analyzed the segmental temperature statistically with t-test. Results & Conclusion : There was a significant change of temperatures in the scapula, posterior brachium, lateral forearm and dorsal hand area. And the experimental group showed cold spot and disruption of normal thermographic shape that were usually shown on the cervical sprain.

경제활동인구조사 자료를 위한 다중대체 방식 연구

박민정,배윤종,김정연,Park, Min-Jeong,Bae, Yoonjong,Kim, Joungyoun 한국통계학회 2021 응용통계연구 Vol.34 No.5

경제활동인구조사는 고용 관련 통계를 생성하는 국가조사로서, 국민의 경활상태(취업/실업/비경활)를 파악하는 것이 주요 목적이다. 정확한 통계를 내기 위해 무응답률을 낮추는 것이 중요하고, 이미 발생한 무응답을 보완하기 위한 방법으로 무응답 대체가 가능하다. 경제활동인구조사는 응답 방식이 순차적 흐름을 따라가기 때문에 구조적인 무응답이 존재한다. 또한 전체 가구원내 무응답 항목이 하나라도 있으면 해당 가족 구성원 전체를 무응답 처리하기에 최종 자료에는 항목 무응답이 아닌 단위 무응답만 존재한다는 특징이 있다. 본 연구에서는 구조적 무응답 이해 및 연계자료를 통한 과거 자료의 활용 등을 통해 기존의 방법보다 효과적인 무응답 대체 모형을 제시하고자 한다. 대체 모형의 성능을 일치도/비일치도를 기반으로 평가한다. 이를 위해, 2019년 11월 경제활동인구조사 자료를 기반으로 모의실험을 실시한다. 총 59,996명의 응답자 중 일부를 랜덤하게 선택한 뒤, 경활상태를 판정하는데 결정적인 설명변수 6개와 경활상태를 무응답 처리한다. 기존 무응답 대체 모형에서 사용하였던 설명 변수 이외에 산업변수와 종사상지위 변수를 추가함으로써 모형을 개선한다. 이는 과거자료의 연계 및 활용을 가정한 것으로, 기존의 모형모다 성능이 향상되는 것을 확인한다. 또한, 경활상태별 무응답자 수에 대한 다양한 시나리오를 고려한다. The Korean Economically Active Population Survey (KEAPS) is a national survey that produces employment-related statistics. The main purpose of the survey is to find out the economic activity status (employed/ unemployed/ non-employed) of the people. KEAPS has a unique characteristics caused by the survey method. In this study, through understanding of structural non-response and utilization of past data, we would like to present an improved imputation model. The performance of the proposed model is compared with the existing model through simulation. The performance of the imputation models is evaluated based on the degree of mathing/nonmatching rates. For this, we employ the KEAPS data in November 2019. For the randomly selected ones among the total 59,996 respondents, the six explanatory variables, which are critical in determining the economic activity states, are treated as non-response. The proposed model includes industry variable and job status variable in addition to the explanatory variables used in the precedent research. This is based on the linkage and utilization of past data. The simulation results confirm that the proposed model with additional variables outperforms the existing model in the precedent research. In addition, we consider various scenarios for the number of non-responders by the economic activity status.