http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
민창호,민영실,이상준,손의동 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
It has been reported that several aminoglycosideantibiotics have a potential of prolonging the action of nondepolarizingmuscle relaxants by drug interactions actingpre-synaptically to inhibit acetylcholine release, butantibiotics itself also have a strong effect on relaxing thesmooth muscle. In this study, four antibiotics of aminoglycosidessuch as gentamicin, streptomycin, kanamycinand neomycin were compared with skeletal muscle relaxantsbaclofen, tubocurarine, pancuronium and succinylcholine,and a smooth muscle relaxant, papaverine. Themuscle strips isolated from the rat bladder were stimulatedwith pulse trains of 40 V in amplitude and 10 s in duration,with pulse duration of 1 ms at the frequency of 1–8 Hz, at1, 2, 4, 6, 8 Hz respectively. To test the effect of fourantibiotics on bladder smooth muscle relaxation, each ofthem was treated cumulatively from 1 lM to 0.1 mM withan interval of 5 min. Among the four antibiotics, gentamicinand neomycin inhibited the EFS response. The skeletalmuscle relaxants (baclofen, tubocurarine, pancuronium andsuccinylcholine) and inhibitory neurotransmitters (GABAand glycine) did not show any significant effect. However,papaverine, had a significant effect in the relaxation of thesmooth muscle. It was suggested that the aminoglycosideantibiotics have inhibitory effect on the bladder smoothmuscle.
민창호,Yi-Yi Wang,배진형,한정훈,손의동 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5
To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide, a non-selective 5-HT1, 5-HT2 receptor antagonist was also treated but had on effect. Kinase inhibitors, such as chelerythrine (PKC inhibitor), ML-9 (MLCK inhibitor), or Y27632 (rho kinase inhibitor) were pretreated before gentamicin treatment, but did not have effect. For U73122, a phospholipase C (PLC) inhibitor however, the inhibitory effect to gentamicin was significantly attenuated in all frequencies given by the EFS. Therefore gentamicin induced inhibitory effect on EFS response in rat bladder smooth muscle was not mediated by the activation of adrenergic, cholinergic, or serotonergic receptor. The inhibition of gentamicin might be mediated through the PLC dependent pathway, but not through the PKC, MLCK or rho kinase dependent pathway.
민창호 ( Changho Min ),하헌수 ( Heonsu Ha ),전종호 ( Jongho Jeon ) 한국공업화학회 2021 공업화학 Vol.32 No.1
알츠하이머병은 신경퇴행질환으로 뇌조직에서 발생하는 아밀로이드 베타(amyloid-β, Aβ) 펩타이드의 축적과 응집, 타우 단백질의 초인산화, 고농도의 특정 금속이온 축적에 의해 발병하는 것으로 알려져 있다. 현재까지 효과적인 치료제가 개발되지 못하였기 때문에, 알츠하이머병을 초기에 정확하게 진단하는 기술은 매우 중요하다. 알츠하이머병의 진단을 위해 개발된 다양한 기법 중 형광 프로브를 이용한 알츠하이머병의 바이오마커 영상화는 많은 연구자들의 관심을 받고 있다. 본 리뷰 논문에서는 최근 개발된 알츠하이머병 진단용 형광 프로브의 구조와, 체내 뇌 영상화에의 적용을 소개하고자 한다. 본 논문은 향후 새로운 프로브를 개발하고자 하는 연구자들에게 많은 도움이 될 것으로 기대된다. Alzheimer’s disease (AD), an irreversible degenerative disorder, is associated with accumulation and aggregation of amyloid-β peptides, hyperphosphorylated tau proteins, and high level of metal ions in the brain. Up to date, there is no effective therapeutic agent to stop the progress of the disease and thus early and accurate diagnosis of AD has gained increasing attention in recent years. Among several diagnostic methods, an optical imaging using fluorescent probes is one of the most promising tools to visualize AD biomarkers. In this review, we will introduce fluorescent probes that can be applied to in vivo brain imaging of AD models and also their structure. It is expected that the present review will provide useful information to many scientists in the related research fields.
Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats
이세은,송현주,박선영,남윤진,민창호,이도연,정준영,하현수,김현정,왕완균,정지훈,김인겸,김학림,민영실,손의동 대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.5
This study investigated effect of extract containing quercetin-3-O-β-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.