The comparative effects of aminoglycoside antibiotics and muscle relaxants on electrical field stimulation response in rat bladder smooth muscle

다국어 초록 (Multilingual Abstract)

It has been reported that several aminoglycosideantibiotics have a potential of prolonging the action of nondepolarizingmuscle relaxants by drug interactions actingpre-synaptically to inhibit acetylcholine release, butantibiotics itself also have a strong effect on relaxing thesmooth muscle. In this study, four antibiotics of aminoglycosidessuch as gentamicin, streptomycin, kanamycinand neomycin were compared with skeletal muscle relaxantsbaclofen, tubocurarine, pancuronium and succinylcholine,and a smooth muscle relaxant, papaverine. Themuscle strips isolated from the rat bladder were stimulatedwith pulse trains of 40 V in amplitude and 10 s in duration,with pulse duration of 1 ms at the frequency of 1–8 Hz, at1, 2, 4, 6, 8 Hz respectively. To test the effect of fourantibiotics on bladder smooth muscle relaxation, each ofthem was treated cumulatively from 1 lM to 0.1 mM withan interval of 5 min. Among the four antibiotics, gentamicinand neomycin inhibited the EFS response. The skeletalmuscle relaxants (baclofen, tubocurarine, pancuronium andsuccinylcholine) and inhibitory neurotransmitters (GABAand glycine) did not show any significant effect. However,papaverine, had a significant effect in the relaxation of thesmooth muscle. It was suggested that the aminoglycosideantibiotics have inhibitory effect on the bladder smoothmuscle.

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