http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 왕완균 (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
이은주,홍준기,왕완균 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
Gardeniae fructus is one of the medicinal herbsthat have been used in Far Eastern countries, such asKorea, China, and Japan. Gardeniae fructus is the dried ripefruit of Gardenia jasminoides Ellis (Rubiaceae) and hasbeen used as a yellow dye. It is widely used as traditionalherbal medicine for reducing fever, cholagogue, diureticand antiphlogistic effects. We established an analyticalmethod that was useful to evaluate the quality control, andstandardize quantification monitoring of 68 samples ofGardeniae fructus collected from Korea and China. Whilenumerous previous studies have focused on the simultaneousanalysis of geniposide, which constitutes the higherproportion of Gardeniae fructus, and crocin, which determinesits color, no simultaneous analysis of gardenosideand geniposide, the major components of GardeniaeFructus, has been performed. However, previously reportedmethods are not considered accurate enough because onlygeniposide or gardenoside was chosen to be the markercomponent for the quality control of Gardeniae fructus. Thus, we developed the method using simultaneousdetermination of four components including geniposide,gardenoside, geniposic acid and chlorogenic acid. Againstthis backdrop, this study aims to propose a new calculationfor gardenoside and geniposide concentrations by analyzingtheir concentrations in Gardeniae fructus.
-
김용성,송현주,박선영,민영실,임병옥,고성권,왕완균,손의동 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
We investigated the signaling pathway on sphingosinephosphorylcholine (SPC) -induced contraction in cat esophageal smooth muscle cells. SPC induced in a dose-dependent manner contractile effect. We have previously shown that lysophospholipid (LPL) receptor subtypes including the S1P1, S1P2, S1P3, and S1P5 receptor are present in esophageal smooth muscle. Only EDG-5 (S1P2) receptor antibody penetration into permeablilized cells inhibited the SPCinduced contraction. Pertussis toxin (PTX) and specific antibodies to Gi1, Gi2, Gi3 and Go inhibited the contraction, implying that SPC-induced contraction depends on PTX-sensitive Gi1, Gi2, Gi3, and Go protein. A phospholipase inhibitor U73122 and incubation of permeabilized cells with PLC-β3 antibody inhibited SPC-induced contraction. The PKC-mediated contraction may be isozyme specific since only PKCε antibody inhibited the contraction. Preincubation with MEK inhibitor PD98059 blocked the SPC-induced contraction, but p38 MAPK inhibitor SB202190 did not. Cotreatment with GF109203X and PD98059 did not show synergistic effects, suggesting that these two kinases are involved in the same signaling pathway in the SPC-induced contraction. The data suggest that S1P-induced contraction in feline esophageal smooth muscle cells depends on activation of the Gi1, Gi2, Gi3 and Go proteins and the PLCβ3 isozyme via the S1P2 receptor, leading to stimulation of a PKCε pathway, which subsequently activates a p44/p42 MAPK pathway.
-
민영실,이세은,홍승태,김현식,최병철,심상수,왕완균,손유동 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.4
It was evaluated the inhibitory action of quercetin-3-O-β-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.
-
Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats
이세은,송현주,박선영,남윤진,민창호,이도연,정준영,하현수,김현정,왕완균,정지훈,김인겸,김학림,민영실,손의동 대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.5
This study investigated effect of extract containing quercetin-3-O-β-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
