노인의 안질환 분포에 대한 임상 고찰

문연성(Yeon Sung Moon) 대한안과학회 1986 대한안과학회지 Vol.27 No.4

트리암시놀론 아세토나이드의 유리체강내 주사 농도에 따른 유리체강내의 잔류 기간 및 제거율 변화

김태환,문연성,진희승,Tae-Hwan Kim,Yeon-Sung Moon,Hee-Seung Chin 대한안과학회 2005 대한안과학회지 Vol.46 No.9

당뇨 환자와 정상인의 스펙트럼 영역 빛간섭단층촬영을 통한 신경절세포-내망상층 두께 차이

박상준,문연성,김나래.Sang Jun Park. MD. Yeon Sung Moon. MD. PhD. Na Rae Kim. MD. PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.10

Purpose: To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA). Methods: The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects. Results: The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber layer (RNFL) thickness. The GCIPL thickness tended to be thinner especially in the superior sector GCIPL. The GCIPL thickness of normal subjects, diabetes patients without diabetic retinopathy, and diabetic retinopathy patients was 82.24 ± 7.21 μm, 81.86 ± 9.53 μm, and 76.77 ± 14.13 μm, respectively, especially in the superior sector GCIPL (<EM>p</EM> = 0.029). Conclusions: Retinal ganglion cell layer thinning was induced by diabetes and diabetic retinopathy, and originated specifically from the superior part of the retina. J Korean Ophthalmol Soc 2014;55(10):1476-1480

망막분지정맥폐쇄 황반부종에서의 유리체강내 트리암시놀론 주입술 후 시력호전의 예후인자

김숙진,문연성,Suk Jin Kim,Yeon Sung Moon 대한안과학회 2012 대한안과학회지 Vol.53 No.1

Purpose: To evaluate prognostic factors for improvement of visual acuity after intravitreal triamcinolone acetonide injection (IVTA) for treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Methods: Sixty-eight eyes of 68 consecutive patients treated with IVTA for ME due to BRVO were retrospectively reviewed. Patients were categorized into 2 groups according to the final visual acuity. The ‘gainer group’ consisted of eyes with a gain of 2 or more Snellen chart lines and the ‘non-gainer group’ consisted of eyes with less than 2 lines improvement or which had worsened at the last follow-up visit. Comparative clinical characteristics and ophthalmoscopic examinations were analyzed between the 2 groups. Results: Out of the 68 eyes, 38 (56%) showed improved vision and were categorized as the gainer group; 30 eyes (44%) were categorized as the non-gainer group. The duration of symptoms in the non-gainer group was longer than the gainer group. Additionally, patients with a better baseline vision were expected to show greater improvement. The number of early visual acuity gainers who showed visual improvement at 1 month after IVTA was significantly higher in the gainer group. The number of eyes with angiographically documented macular ischemia was significantly higher in the non-gainer group. Existence of subretinal fluid has been identified as a positive factor for visual improvement. Conclusions: The cases with early treatment, good baseline visual acuity, case of favorable response to the initial IVTA, absence of macular ischemia, and baseline subretinal fluid are favorable prognostic factors for the outcome of visual acuity after IVTA for ME due to BRVO. J Korean Ophthalmol Soc 2012;53(1):49-58

한국인 나이관련황반변성 환자의 우울 및 불안에 대한 조사 및 그 영향에 대한 고찰

정지원,문연성,Ji Won Jung,Yeon Sung Moon 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To examine the degree of depression and anxiety in Korean patients with age-related macular degeneration (AMD) and to evaluate the influence of mood disturbance on patient’s treatment satisfaction and compliance. Methods: Forty-four patients with AMD and thirty-three controls comprised the study populations. Patients and controls rated themselves on the Korean Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). The effect of mood disturbance on the patient’s satisfaction and compliance was evaluated. Results: The depression and anxiety scores were significantly higher in patients with AMD. The mood disturbance was negatively correlated with the patient’s satisfaction and compliance. 14 patients (31.8%) were lost to follow-up 1 year later. The depression and anxiety scores of these patients were higher than those of remaining thirty patients. Conclusions: Depression and anxiety of patients with AMD affect on patient’s satisfaction and compliance. So recognition and management of mood disturbance may help improving visual function and maintaining quality of life in patients. J Korean Ophthalmol Soc 2012;53(6):792-800

Valganciclovir를 이용한 거대세포바이러스망막염의 치료

김나래,문연성,진희승,윤준호.Na Rae Kim. M.D.. Yeon Sung Moon. M.D.. Hee Seung Chin. M.D.. Jun Ho Yoon. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.3

`Purpose: To report a case of a patient with cytomegalovirus (CMV) retinitis who was treated with oral valganciclovir. Case summary: A 34-year-old man who had undergone anti-cancer chemotherapy for Non-Hodgkin lymphoma was referred to the ophthalmologic oncology clinic because of decreased vision in both eyes. Fundus examination showed white, opaque, and granular retinal lesions in both eyes, and a serologic test showed a positive response to CMV antibody IgG and a negative response to CMV antibody IgM. The patient received induction therapy with intravenous ganciclovir and maintenance therapy with oral valganciclovir 900 mg once daily. CMV retinitis reactivated 4 weeks after maintenance therapy was discontinued. At that point, the patient received induction therapy with oral valganciclovir 900 mg twice daily for 3 weeks and maintenance therapy with 900 mg once daily for 5 weeks. The retinal lesion disappeared and did not recur after oral administration of valganciclovir. The patient discontinued valganciclovir after 5 weeks of maintenance therapy, and CMV retinitis did not reactivate during 6 months of follow-up. Conclusion: Oral valganciclovir was clinically effective in the treatment of CMV retinitis in a patient who was treated with anti-cancer chemotherapy for non-Hodgkin lymphoma.`

동맥관개존증과 그 치료 방법이 미숙아망막병증에 미치는 영향

윤명헌,백완기,문연성,Myung Hun Yoon,MD,Wan Ki Baek,MD,PhD,Yeon Sung Moon,MD,PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.5

Purpose: This study investigated the influence of patent ductus arteriosus (PDA) and its treatment on incidence and progression of retinopathy of prematurity (ROP). Methods: The authors retrospectively reviewed the medical records of 408 infants who underwent screening examinations for ROP at the Neonatal Intensive Care Unit of our hospital. Results: The total incidence of ROP was 23.5% (96 out of 408) and the patients that needed treatment were 7.4% (30 out of 408). The mean birth weight and gestational age was 1406.1 grams and 30.67 weeks in patients without ROP, and 979.8 grams and 27.46 weeks in patients with ROP, respectively. In both total and very low birth weight (VLBW) patients, the incidence of ROP was higher in the PDA group than the non-PDA group, but the PDA group was an independent risk factor only in the VLBW group (p = 0.033). The incidence of threshold disease was not significantly different between the PDA and control groups (p = 0.757). There was no significant difference of incidence of ROP and threshold disease among the 3 treatment groups for PDA. Conclusions: In VLBW patients, the presence of PDA increased the risk of ROP and its progression, thus more attention is needed for PDA patients. However, there was no significant difference in ROP incidence and progression according to different PDA treatment methods.

급성 중심성 장액맥락망막병증에서 망막전위도검사결과, 형광안저혈관조영 및 색각검사결과 상호비교

정진규,진희승,문연성,Chin Kyu Chung,Hee Seung Chin,Yeon Sung Moon 대한안과학회 2005 대한안과학회지 Vol.46 No.1

Purpose: This paper investigates the correlation of the electroretinogram (ERG) with fluorescein angiography (FAG) and the color vision test among those who have acute central serous chorioretinopathy (CSCR). Methods: The study was performed with 30 patients who had one CSCR-affected eye but the other unaffected. Results: ERG showed that the b-wave amplitudes in the affected eyes decreased significantly compared to those in the unaffected eyes (P<0.05) and that there were no significant changes in a-wave or implicit time. FAG revealed that the b-wave amplitude decreased significantly when the leaking point was within a distance of 1/4 disk diameter from the fovea center, compared to when it was more distant (P<0.05). The amplitude also reduced significantly when the size of retinal detachment was more than 1 disk diameter compared to when it was less (P<0.05). The affected eyes which showed abnormality in color vision test decreased significantly a- and b-waves compared to the unaffected eyes in the test (P<0.05). Conclusions: In acute CSCR patients, the correlation of ERG with FAG showing size of retinal detachment, the location of leaking point and the color vision test was statistically significant. Therefore, ERG could be used to assess the affecting degree of the disease.

당뇨황반부종 환자에서 유리체 절제술시 내경계막 절제술의 유용성

강성모,진희승,문연성,Sung Mo Kang,Hee Seung Chin Yeon Sung Moon 대한안과학회 2007 대한안과학회지 Vol.48 No.6

Purpose: To evaluate the effectiveness of a combined procedure of peeling the internal limiting membrane with vitrectomy in diabetic macular edema. Methods: This study comprised 16 eyes of 16 patients hospitalized during a 1-year period. They were randomized to either a vitrectomy group (10 eyes in 10 patients) or to a combined procedure group (6 eyes in 6 patients). Preoperative and postoperative macular center thickness, best corrected visual acuity and postoperative complications 4 months postoperative were investigated. Results: There were no statistically significant differences in the mean values of preoperative and postoperative best corrected visual acuity (logMAR) between the two groups. The mean values of preoperative and postoperative macular center thickness in the vitrectomy group were respectively 509.50±36.77 and 332.60±91.73; while in the combined procedure group, they were 516.17±55.43 and 333.83±51.64. Again, there were no statistically significant differences between the two groups. At the 4-month follow-up, decreased visual acuity was found in 3 eyes of the vitrectomy group and in 2 eyes of the combined procedure group. Vitreous hemorrhage (3 eyes) and tractional retinal detachment (1 eye) were found in the vitrectomy group and vitreous hemorrhage (2 eyes) was diagnosed in the combined group. Conclusions: In our study, vitrectomy with peeling of the internal limiting membrane was not more effective than vitrectomy alone in decreasing macular edema or in improving best corrected visual acuity. Additional studies of the combined procedure are needed to verify this result.

황반박리를 동반한 열공성망막박리환자에서 공막돌륭술 후 시력결과에 미치는 수술전 요인

강성모,윤상원,진희승,문연성,Sung Mo Kang,M,D,Sang Won Yoon,M,D,Hee Seung Chin,M,D,Yeon Sung Moon,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.6

Purpose: To investigate the factors affecting the visual outcome after a scleral buckle in a rhegmatogenous retinal detachment involving the macula. Methods: A retrospective survey of 70 eyes was carried out. The preoperative factors examined in this study included the preoperative visual acuity, the patient‘s age, the duration of macular detachment, the extent of the detached retina, the location of the retinal hole, and the surgical procedure. The correlation between these factors and the postoperative visual outcome were investigated. Results: The factors related to a favorable visual outcome were the preoperative visual acuity, age, the duration of macular detachment, surgical procedure, and the location of the retinal hole. A preoperative visual acuity of 0.1 or more, an age of 30 years or less, a detached retina of 2 quadrants or less, and duration of macular detachment of 7 days or less were factors that indicated a favorable visual outcome. The surgical procedure and the location of the retinal hole were not associated with the visual outcome. Conclusions: The factors related to a favorable visual outcome were a preoperative visual acuity of 0.2 or higher, an age of 30 or less, a detached retina of 2 quadrants or less, and duration of the macular detachment of 7 days or less. The location of the retinal hole, however, did not affect the visual outcome.