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Valganciclovir를 이용한 거대세포바이러스망막염의 치료
김나래,문연성,진희승,윤준호.Na Rae Kim. M.D.. Yeon Sung Moon. M.D.. Hee Seung Chin. M.D.. Jun Ho Yoon. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.3
`Purpose: To report a case of a patient with cytomegalovirus (CMV) retinitis who was treated with oral valganciclovir. Case summary: A 34-year-old man who had undergone anti-cancer chemotherapy for Non-Hodgkin lymphoma was referred to the ophthalmologic oncology clinic because of decreased vision in both eyes. Fundus examination showed white, opaque, and granular retinal lesions in both eyes, and a serologic test showed a positive response to CMV antibody IgG and a negative response to CMV antibody IgM. The patient received induction therapy with intravenous ganciclovir and maintenance therapy with oral valganciclovir 900 mg once daily. CMV retinitis reactivated 4 weeks after maintenance therapy was discontinued. At that point, the patient received induction therapy with oral valganciclovir 900 mg twice daily for 3 weeks and maintenance therapy with 900 mg once daily for 5 weeks. The retinal lesion disappeared and did not recur after oral administration of valganciclovir. The patient discontinued valganciclovir after 5 weeks of maintenance therapy, and CMV retinitis did not reactivate during 6 months of follow-up. Conclusion: Oral valganciclovir was clinically effective in the treatment of CMV retinitis in a patient who was treated with anti-cancer chemotherapy for non-Hodgkin lymphoma.`